Enhancing the regeneration of cartilage defects remains challenging owing to limited innate self-healing as well as acute inflammation arising from the overexpression of reactive oxygen species(ROS)in post-traumatic m...Enhancing the regeneration of cartilage defects remains challenging owing to limited innate self-healing as well as acute inflammation arising from the overexpression of reactive oxygen species(ROS)in post-traumatic microenvironments.Recently,stem cell-derived exosomes(Exos)have been developed as potential cell-free therapy for cartilage regeneration.Although this approach promotes chondrogenesis,it neglects the emerging inflammatory microenvironment.In this study,a smart bilayer-hydrogel dual-loaded with sodium diclofenac(DC),an anti-inflammatory drug,and Exos from bone marrow-derived mesenchymal stem cells was developed to mitigate initial-stage inflammation and promote late-stage stem-cell recruitment and chondrogenic differentiation.First,the upper-hydrogel composed of phenylboronic-acid-crosslinked polyvinyl alcohol degrades in response to elevated levels of ROS to release DC,which mitigates oxidative stress,thus reprogramming macrophages to the pro-healing state.Subsequently,Exos are slowly released from the lower-hydrogel composed of hyaluronic acid into an optimal microenvironment for the stimulation of chondrogenesis.Both in vitro and in vivo assays confirmed that the dual-loaded bilayer-hydrogel reduced post-traumatic inflammation and enhanced cartilage regeneration by effectively scavenging ROS and reprogramming macrophages.The proposed platform provides multi-staged therapy,which allows for the optimal harnessing of Exos as a therapeutic for cartilage regeneration.展开更多
Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affec...Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life quality.Consequently,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA.Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging.Herein,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.展开更多
Introduction:Enterococci are considered opportunistic pathogens.However,they can serve as a reservoir of antibacterial resistance(ABR)traits and transfer these to humans through the food chain.Methods:Antibiotic susce...Introduction:Enterococci are considered opportunistic pathogens.However,they can serve as a reservoir of antibacterial resistance(ABR)traits and transfer these to humans through the food chain.Methods:Antibiotic susceptibility testing and multilocus sequence typing were used to characterize the ABR and population structure of 488 enterococcal isolates recovered along the food chain from four provincial-level administrative divisions(PLADs)in China.Results:Enterococcus faecalis(E.faecalis)was the dominant species cultured from pig farms and retail meat,while Enterococcus faecium(E.faecium)and Enterococcus casseliflavus were dominant in patients with diarrhea and retail fruits and vegetables,respectively.Approximately 67%of all Enterococcus isolates were multidrug-resistant(MDR).E.faecium resistance to ampicillin and penicillin was significantly higher than that of E.faecalis.The E.faecalis isolates exhibited substantially heterologous sequence types(STs),whereas E.faecium isolates were clearly divided into clonal complex(CC)CC17 and CC94 clades.E.faecium isolates were mainly detected in hospitalized children and were identified as the hospital-associated CC17 clade with ampicillin and penicillin resistance.Notably,E.faecalis ST16 and ST65 and E.faecium ST60 and ST94 detected in patients with diarrhea were also detected in farm and food samples,indicating that these STs should be closely monitored.The community-lineage E.faecium CC94 clade was detected in patients with diarrhea,implying that community isolates might find their way into hospitals.Conclusion:This study highlights the One Health challenges posed by enterococci important to human health and the need to implement integrated preventive measures for their control.展开更多
Yimeng red culture is an important part of the excellent culture of the Chinese nation.It is of great practical significance and long-term strategic significance to build the demonstration area for the inheritance and...Yimeng red culture is an important part of the excellent culture of the Chinese nation.It is of great practical significance and long-term strategic significance to build the demonstration area for the inheritance and development of Yimeng red culture.Combining digital empowerment with the inheritance and development of Yimeng red culture is a new idea that conforms to the development of the times.In this paper,on the basis of combing Yimeng red cultural resources and combining with the current situation of inheritance and development of Yimeng red culture,the strategic layout and implementation approach of the demonstration area for the inheritance and development of Yimeng red culture were put forward from the perspective of digital empowerment.展开更多
As the global elderly population increases,depression within this group has become a significant public health concern.Although exercise has been recognized for its potential to improve depression in the elderly,the b...As the global elderly population increases,depression within this group has become a significant public health concern.Although exercise has been recognized for its potential to improve depression in the elderly,the benefits,risks,and implementation strategies remain contentious.This review attempts to examine the impact of exercise on depression in older adults,including potential benefits,risks,and suggestions for application.Our analysis highlights the benefits of aerobic and resistance training,which can significantly alleviate depressive symptoms and enhance overall quality of life.Despite these benefits,the review acknowledges the complexity of the exercise-depression interaction in the elderly,necessitating personalized exercise regimens.Potential risks,such as muscle and joint pain,are pointed out,emphasizing the importance of tailored,supervised exercise programs.The review calls for future research to focus on identifying the most effective types of exercise and regimens for this population,considering factors such as age,gender,and existing health conditions.Lastly,it advocates for the inclusion of exercise in comprehensive treatment plans for depression in older adults,viewing it as a promising step toward achieving holistic mental health care in a growing demographic.展开更多
Stimulus-sensitive surfaces with tunable morphologies exhibit a wide range of applications in the fields of surface science and engineering.Herein,a cost-effective yet practical strategy is proposed to fabricate photo...Stimulus-sensitive surfaces with tunable morphologies exhibit a wide range of applications in the fields of surface science and engineering.Herein,a cost-effective yet practical strategy is proposed to fabricate photo-sensitive patterning surface on film/substrate wrinkle system based on an azo-containing polyblend.By manipulating the stress field of the bilayer system globally and/or locally upon the stress relaxation triggered by the reversible cis-trans isomerization of the azobenzene,heating/cooling triggered surface wrinkles on the polyblend films could be tailor-made with visible-light-irradiation.Notably,upon selective photo-irradiation,bespoke surface patterns may be cyclically generated or eliminated,allowing these reconfigurable patterned polyblend surfaces to be used as rewritable information storage media for non-ink printing.The as-prepared photo-printed information patterns with high-resolution are shown to be rewritable for multiple cycles and legible for over 90 d in dark ambient conditions.This study not only provides a versatile strategy for flourishing the stimulus-sensitive systems,but also sheds light on the stress relaxation-triggered morphological evolution of the wrinkling polyblend films.展开更多
To the Editor:Total knee arthroplasty(TKA)is a safe and effective treatment for patients with end-stage knee osteoarthritis,with the conventional medial parapatellar(MP)approach for TKA,good visualization of the knee ...To the Editor:Total knee arthroplasty(TKA)is a safe and effective treatment for patients with end-stage knee osteoarthritis,with the conventional medial parapatellar(MP)approach for TKA,good visualization of the knee can be obtained,helping to achieve correct osteotomy,proper ligament balance and good prosthesis position,which are all important for good long-term results.[1]To improve functional recovery and rehabilitation,some studies have adopted a relatively small incision operation to improve operation.展开更多
Anterior cruciate ligament （ACL） injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this revie...Anterior cruciate ligament （ACL） injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this review is to summarize the relevant literature on ACL loading mechanisms, ACL injury risk factors, and current ACL injury prevention programs for soccer players. Literature has shown that tibial anterior translation due to shear force at the proximal end of tibia is the primary ACL loading mechanism. No evidence has been found showing that knee valgus moment is the primary ACL loading mechanism. ACL loading mechanisms are largely ignored in previous studies on risk factors for ACL injury. Identified risk factors have little connections to ACL loading mechanisms. The results of studies on ACL injury prevention programs for soccer players are inconsistent. Current ACL injury prevention programs for soccer players are clinically ineffective due to low compliance. Future studies are urgently needed to identify risk factors for ACL injury in soccer that are connected to ACL loading mechanisms and have cause-and-effect relationships with injury rate, and to develop new prevention programs to improve compliance.展开更多
Purpose： The purpose of this study was to determine the effect of horizontal and vertical velocities at the landing of the last step of approach run on the performance and optimal phase ratio of the triple jump. Meth...Purpose： The purpose of this study was to determine the effect of horizontal and vertical velocities at the landing of the last step of approach run on the performance and optimal phase ratio of the triple jump. Methods： Three-dimensional kinematic data of 13 elite male triple jumpers were obtained during a competition. Computer simulations were performed using a biomechanical model of the triple jump to determine the longest actual distance using the optimal phase ratio with altered horizontal and vertical velocities at the landing of the last step of approach run. Results： The actual distance obtained using the optimal phase ratio significantly increased as the horizontal velocity at the landing of the last step of approach run increased （p = 0.001） and the corresponding downward vertical velocity decreased （p = 0.001）. Increasing horizontal velocity at the landing of the last step of approach run decreased optimal hop percentage and increased optimal jump percentage （p = 0.001）, while decreasing corresponding downward vertical velocity increased optimal hop percentage and decreased optimal jump percentage （p = 0.001）. Conclusion： The effects of the velocities at the landing of the last step of approach run on the optimal phase ratio were generally small and did not qualitatively alter optimal techniques.展开更多
In recent years,leisure individual travel has become a trend of tourism development.Visitors are highly dependent on the public service system of scenic spots.The educational circles at home and abroad are paying more...In recent years,leisure individual travel has become a trend of tourism development.Visitors are highly dependent on the public service system of scenic spots.The educational circles at home and abroad are paying more and more attention to the study of tourism public services.Based on the theory of tourist satisfaction evaluation,this paper made an empirical study on the tourism public service system of Kunyu Mountain National Forest Park.It was found that there was a contradiction between the demand for tourism public services and the actual supply in Kunyu Mountain National Forest Park.Based on this,some measures were put forward,such as strengthening the construction of tourist information signs in scenic spots,strengthening the construction of communication facilities and convenient services for tourists,strengthening the training and supervision of service practitioners,and construction of organizations for protecting the legitimate rights and interests of tourists.展开更多
Non-contact anterior cruciate ligament(ACL)injury can occur in many sports.It is interrelated with gender,anatomy,biomechanics,and neuromuscular control.Taekwondo athletes have a higher incidence of ACL injury than at...Non-contact anterior cruciate ligament(ACL)injury can occur in many sports.It is interrelated with gender,anatomy,biomechanics,and neuromuscular control.Taekwondo athletes have a higher incidence of ACL injury than athletes from other sports.Objective:This study aimed to determine the biomechanical gender differences and mechanism of taekwondo athletes with ACL injury.Methods:A total of 28 taekwondo athletes(aged 14–19 years)were randomly selected and grouped by gender.Feet high floor,one foot high floor,and single leg squat were analyzed by a Vicon motion analysis system and Kistler 3D force platform for action.The knee joint angle and ground force were evaluated.Results:Results demonstrated biomechanical differences in knee joint between male and female athletes.Conclusion:ACL injury in taekwondo female athletes indicated the biomechanical mechanism of the knee joint,and it can be prevented by neuromuscular control training.展开更多
Objective:To explore the mechanism of Simiao Yong'an Decoction in treating deep venous thrombosis based on the method of network pharmacology.Methods:Through TCMSP database,the effective components of each traditi...Objective:To explore the mechanism of Simiao Yong'an Decoction in treating deep venous thrombosis based on the method of network pharmacology.Methods:Through TCMSP database,the effective components of each traditional Chinese medicine in Simiao Yong'an Decoction were obtained and their targets were predicted.The targets of deep venous thrombosis were collected by CTD database,and the key targets were obtained by intersection of the component targets and the disease targets;Protein-Protein Interaction(PPI)network was constructed by String database.The drugs-components-targets-disease network map was constructed by using the software of Cytoscape 3.7.2.GO function and KEGG pathway enrichment of Simiao Yong'an Decoction in the treatment of deep venous thrombosis were analyzed by using the plug-in of ClueGo.Results:121 effective components and 137 potential targets of Simiao Yong'an Decoction were obtained.There were 1172 targets of deep venous thrombosis.There were 214 biological processes analyzed by GO Biological Process and 72 pathways analyzed by KEGG analysis.Conclusion:Simiao Yong'an Decoction may act on ESR1,AR,PTGS2 and other key targets,as well as AGE-RAGE signaling pathway,PI3K-Akt signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,RLX signaling pathway and other pathways to treat deep venous thrombosis.展开更多
The 21st century is the era of marine economy.The Chinese government attaches great importance to the development and utilization of marine resources.With the support of national marine policies,the development of mar...The 21st century is the era of marine economy.The Chinese government attaches great importance to the development and utilization of marine resources.With the support of national marine policies,the development of marine tourism industry in Yantai has changed with each passing day,and the content of tourism products developed by Yantai is also constantly innovating.In this study,by using literature research,data analysis and other methods,the development of marine tourism resources in Yantai was analyzed.The results show that the marine tourism products in Yantai are not well-known,less competitive,and are difficult to form a scale advantage.Therefore,some measures to promote the development of tourism industry in Yantai were proposed,such as optimizing and upgrading marine tourism products in Yantai,strengthening regional cooperation to increase product awareness,improving the structure scale of products in scenic spots to enhance competitiveness,attaching importance to the application of science and technology and strengthening product innovation.展开更多
Tourism performing art is the product of the integration of culture and tourism.With the arrival of the experience economy era,tourism performing art products will be an important link in the development of tourism,wi...Tourism performing art is the product of the integration of culture and tourism.With the arrival of the experience economy era,tourism performing art products will be an important link in the development of tourism,with strong development potential,which can better meet the needs of tourists’ in-depth experience and promote the long-term development of regional tourism.This paper studied the development of Tai’an tourism performing art products from the perspective of experience.Through the survey of tourists and statistics of data,this paper discussed the development strategy of Tai’an tourism performing art products,aiming to provide reference for the development of Tai’an tourism performing art products.展开更多
Objective:To infer the training load from the characteristics of heart rate changes of elite sprinters during maximum intensity training.Methods:Different training loads were determined according to different running ...Objective:To infer the training load from the characteristics of heart rate changes of elite sprinters during maximum intensity training.Methods:Different training loads were determined according to different running distances.Multi-person running in the same group was used to collect the heart rate data of elite sprinters during speed training.Results:the heart rate level was directly related to the exercise load.During the maximum intensity exercise,the heart rate generally increased for about 12 s after the race,which was about 110%of the end-point heart rate.Compared with the low load group(60m),the heart rate of the high load group(100m)continued to rise,but the maximum heart rate level was higher than that of the low load group.The exercise intensity and heart rate change rate of the low load group are greater,the work done by the high load group is more,and the envelope area of the heart rate curve is larger.During intermittent training,under the condition of controlling the interval between groups,the heart rate curve envelope area of the low load group is small,the physical recovery is good,the parameter consistency of each group is good,the heart rate curve envelope area of the high load group is large,and the heart rate response decreases gradually.展开更多
As a database that allows data to be stored in XML format, XML database suffers from some similar attacks as traditional relational database does. These attacks include injection attack by XQuey function in applicatio...As a database that allows data to be stored in XML format, XML database suffers from some similar attacks as traditional relational database does. These attacks include injection attack by XQuey function in application software. These include BaseX, eXist and MarkLogic. In order to defeat these attacks, countermeasures are proposed.展开更多
基金supported by National Natural Science Foundation of China(Nos.52002223,81672185 and 81702152)Key Technology Research and Development Program of Shandong(Major Science and Technology Innovation Project)(2020CXGC010502)+1 种基金Taishan Scholar Foundation of Shandong Province(No.tsqn202211348)the Shandong Province Natural Science Foundation(Grant Nos.ZR2022MH222 and ZR2023MH209).
文摘Enhancing the regeneration of cartilage defects remains challenging owing to limited innate self-healing as well as acute inflammation arising from the overexpression of reactive oxygen species(ROS)in post-traumatic microenvironments.Recently,stem cell-derived exosomes(Exos)have been developed as potential cell-free therapy for cartilage regeneration.Although this approach promotes chondrogenesis,it neglects the emerging inflammatory microenvironment.In this study,a smart bilayer-hydrogel dual-loaded with sodium diclofenac(DC),an anti-inflammatory drug,and Exos from bone marrow-derived mesenchymal stem cells was developed to mitigate initial-stage inflammation and promote late-stage stem-cell recruitment and chondrogenic differentiation.First,the upper-hydrogel composed of phenylboronic-acid-crosslinked polyvinyl alcohol degrades in response to elevated levels of ROS to release DC,which mitigates oxidative stress,thus reprogramming macrophages to the pro-healing state.Subsequently,Exos are slowly released from the lower-hydrogel composed of hyaluronic acid into an optimal microenvironment for the stimulation of chondrogenesis.Both in vitro and in vivo assays confirmed that the dual-loaded bilayer-hydrogel reduced post-traumatic inflammation and enhanced cartilage regeneration by effectively scavenging ROS and reprogramming macrophages.The proposed platform provides multi-staged therapy,which allows for the optimal harnessing of Exos as a therapeutic for cartilage regeneration.
基金supported by the National Natural Science Foundation of China(82072432)the China-Japan Friendship Hospital Horizontal Project/Spontaneous Research Funding(2022-HX-JC-7)+1 种基金the National High Level Hospital Clinical Research Funding(2022-NHLHCRF-PY-20)the Elite Medical Professionals project of China-Japan Friendship Hospital(ZRJY2021-GG12).
文摘Rheumatoid arthritis(RA)is a systemic autoimmune disease that is primarily manifested as synovitis and polyarticular opacity and typically leads to serious joint damage and irreversible disability,thus adversely affecting locomotion ability and life quality.Consequently,good prognosis heavily relies on the early diagnosis and effective therapeutic monitoring of RA.Activatable fluorescent probes play vital roles in the detection and imaging of biomarkers for disease diagnosis and in vivo imaging.Herein,we review the fluorescent probes developed for the detection and imaging of RA biomarkers,namely reactive oxygen/nitrogen species(hypochlorous acid,peroxynitrite,hydroxyl radical,nitroxyl),pH,and cysteine,and address the related challenges and prospects to inspire the design of novel fluorescent probes and the improvement of their performance in RA studies.
基金Supported by the National Natural Science Foundation of China(32172314 and 22193064).
文摘Introduction:Enterococci are considered opportunistic pathogens.However,they can serve as a reservoir of antibacterial resistance(ABR)traits and transfer these to humans through the food chain.Methods:Antibiotic susceptibility testing and multilocus sequence typing were used to characterize the ABR and population structure of 488 enterococcal isolates recovered along the food chain from four provincial-level administrative divisions(PLADs)in China.Results:Enterococcus faecalis(E.faecalis)was the dominant species cultured from pig farms and retail meat,while Enterococcus faecium(E.faecium)and Enterococcus casseliflavus were dominant in patients with diarrhea and retail fruits and vegetables,respectively.Approximately 67%of all Enterococcus isolates were multidrug-resistant(MDR).E.faecium resistance to ampicillin and penicillin was significantly higher than that of E.faecalis.The E.faecalis isolates exhibited substantially heterologous sequence types(STs),whereas E.faecium isolates were clearly divided into clonal complex(CC)CC17 and CC94 clades.E.faecium isolates were mainly detected in hospitalized children and were identified as the hospital-associated CC17 clade with ampicillin and penicillin resistance.Notably,E.faecalis ST16 and ST65 and E.faecium ST60 and ST94 detected in patients with diarrhea were also detected in farm and food samples,indicating that these STs should be closely monitored.The community-lineage E.faecium CC94 clade was detected in patients with diarrhea,implying that community isolates might find their way into hospitals.Conclusion:This study highlights the One Health challenges posed by enterococci important to human health and the need to implement integrated preventive measures for their control.
基金Sponsored by the Achievements of Social Science Planning Research Project of Shandong Province(22CYMJ11)Phased Achievements of the key project of the Party School of Shandong Provincial Committee of the Communist Party of China(Shandong Administration College).
文摘Yimeng red culture is an important part of the excellent culture of the Chinese nation.It is of great practical significance and long-term strategic significance to build the demonstration area for the inheritance and development of Yimeng red culture.Combining digital empowerment with the inheritance and development of Yimeng red culture is a new idea that conforms to the development of the times.In this paper,on the basis of combing Yimeng red cultural resources and combining with the current situation of inheritance and development of Yimeng red culture,the strategic layout and implementation approach of the demonstration area for the inheritance and development of Yimeng red culture were put forward from the perspective of digital empowerment.
基金the 2021 Undergraduate Education and Teaching Reform Project of Shandong Province“Research on the Model of Integrated Education Inside and Outside of College Physical Education”(M2021107).
文摘As the global elderly population increases,depression within this group has become a significant public health concern.Although exercise has been recognized for its potential to improve depression in the elderly,the benefits,risks,and implementation strategies remain contentious.This review attempts to examine the impact of exercise on depression in older adults,including potential benefits,risks,and suggestions for application.Our analysis highlights the benefits of aerobic and resistance training,which can significantly alleviate depressive symptoms and enhance overall quality of life.Despite these benefits,the review acknowledges the complexity of the exercise-depression interaction in the elderly,necessitating personalized exercise regimens.Potential risks,such as muscle and joint pain,are pointed out,emphasizing the importance of tailored,supervised exercise programs.The review calls for future research to focus on identifying the most effective types of exercise and regimens for this population,considering factors such as age,gender,and existing health conditions.Lastly,it advocates for the inclusion of exercise in comprehensive treatment plans for depression in older adults,viewing it as a promising step toward achieving holistic mental health care in a growing demographic.
基金supports from the National Natural Science Foundation of China (Nos.21704033,52173168)the Natural Science Foundation of Shandong Province (Nos.ZR2020LFG009,SZR1946)the China Postdoctoral Science Foundation (No.2019M662441).
文摘Stimulus-sensitive surfaces with tunable morphologies exhibit a wide range of applications in the fields of surface science and engineering.Herein,a cost-effective yet practical strategy is proposed to fabricate photo-sensitive patterning surface on film/substrate wrinkle system based on an azo-containing polyblend.By manipulating the stress field of the bilayer system globally and/or locally upon the stress relaxation triggered by the reversible cis-trans isomerization of the azobenzene,heating/cooling triggered surface wrinkles on the polyblend films could be tailor-made with visible-light-irradiation.Notably,upon selective photo-irradiation,bespoke surface patterns may be cyclically generated or eliminated,allowing these reconfigurable patterned polyblend surfaces to be used as rewritable information storage media for non-ink printing.The as-prepared photo-printed information patterns with high-resolution are shown to be rewritable for multiple cycles and legible for over 90 d in dark ambient conditions.This study not only provides a versatile strategy for flourishing the stimulus-sensitive systems,but also sheds light on the stress relaxation-triggered morphological evolution of the wrinkling polyblend films.
基金National Natural Science Foundation of China(No.52003008)National Key Research and Development Program(No.2017YFB1303001)
文摘To the Editor:Total knee arthroplasty(TKA)is a safe and effective treatment for patients with end-stage knee osteoarthritis,with the conventional medial parapatellar(MP)approach for TKA,good visualization of the knee can be obtained,helping to achieve correct osteotomy,proper ligament balance and good prosthesis position,which are all important for good long-term results.[1]To improve functional recovery and rehabilitation,some studies have adopted a relatively small incision operation to improve operation.
基金partially supported by Shandong Province Research Development(No.2012G0030039)China Sports Administration Research(No.2012B012)
文摘Anterior cruciate ligament （ACL） injuries are common in soccer. Understanding ACL loading mechanisms and risk factors for ACL injury is critical for designing effective prevention programs. The purpose of this review is to summarize the relevant literature on ACL loading mechanisms, ACL injury risk factors, and current ACL injury prevention programs for soccer players. Literature has shown that tibial anterior translation due to shear force at the proximal end of tibia is the primary ACL loading mechanism. No evidence has been found showing that knee valgus moment is the primary ACL loading mechanism. ACL loading mechanisms are largely ignored in previous studies on risk factors for ACL injury. Identified risk factors have little connections to ACL loading mechanisms. The results of studies on ACL injury prevention programs for soccer players are inconsistent. Current ACL injury prevention programs for soccer players are clinically ineffective due to low compliance. Future studies are urgently needed to identify risk factors for ACL injury in soccer that are connected to ACL loading mechanisms and have cause-and-effect relationships with injury rate, and to develop new prevention programs to improve compliance.
基金partially supported by a research grant from China Sport Administration (No. 2014B057)
文摘Purpose： The purpose of this study was to determine the effect of horizontal and vertical velocities at the landing of the last step of approach run on the performance and optimal phase ratio of the triple jump. Methods： Three-dimensional kinematic data of 13 elite male triple jumpers were obtained during a competition. Computer simulations were performed using a biomechanical model of the triple jump to determine the longest actual distance using the optimal phase ratio with altered horizontal and vertical velocities at the landing of the last step of approach run. Results： The actual distance obtained using the optimal phase ratio significantly increased as the horizontal velocity at the landing of the last step of approach run increased （p = 0.001） and the corresponding downward vertical velocity decreased （p = 0.001）. Increasing horizontal velocity at the landing of the last step of approach run decreased optimal hop percentage and increased optimal jump percentage （p = 0.001）, while decreasing corresponding downward vertical velocity increased optimal hop percentage and decreased optimal jump percentage （p = 0.001）. Conclusion： The effects of the velocities at the landing of the last step of approach run on the optimal phase ratio were generally small and did not qualitatively alter optimal techniques.
基金Sponsored by National Natural Science Foundation of China(41907050)Natural Science Fundation of Shangdong Province(ZR2019MD031)+1 种基金Scientific Research Projects in Colleges and Universities in Shandong Province(J18KA197)Key Subject of Art Science in Shandong Province(201806512)
文摘In recent years,leisure individual travel has become a trend of tourism development.Visitors are highly dependent on the public service system of scenic spots.The educational circles at home and abroad are paying more and more attention to the study of tourism public services.Based on the theory of tourist satisfaction evaluation,this paper made an empirical study on the tourism public service system of Kunyu Mountain National Forest Park.It was found that there was a contradiction between the demand for tourism public services and the actual supply in Kunyu Mountain National Forest Park.Based on this,some measures were put forward,such as strengthening the construction of tourist information signs in scenic spots,strengthening the construction of communication facilities and convenient services for tourists,strengthening the training and supervision of service practitioners,and construction of organizations for protecting the legitimate rights and interests of tourists.
文摘Non-contact anterior cruciate ligament(ACL)injury can occur in many sports.It is interrelated with gender,anatomy,biomechanics,and neuromuscular control.Taekwondo athletes have a higher incidence of ACL injury than athletes from other sports.Objective:This study aimed to determine the biomechanical gender differences and mechanism of taekwondo athletes with ACL injury.Methods:A total of 28 taekwondo athletes(aged 14–19 years)were randomly selected and grouped by gender.Feet high floor,one foot high floor,and single leg squat were analyzed by a Vicon motion analysis system and Kistler 3D force platform for action.The knee joint angle and ground force were evaluated.Results:Results demonstrated biomechanical differences in knee joint between male and female athletes.Conclusion:ACL injury in taekwondo female athletes indicated the biomechanical mechanism of the knee joint,and it can be prevented by neuromuscular control training.
基金General Project of the National Natural Science Foundation of China(No.81774311)Traditional Chinese Medicine Technology Development Foundation of Shandong Province,China(No.2019-0149,2019-0764)Shandong Youth Education Scientific Planning Project College Students Academic Subjects(No.20BSH086)。
文摘Objective:To explore the mechanism of Simiao Yong'an Decoction in treating deep venous thrombosis based on the method of network pharmacology.Methods:Through TCMSP database,the effective components of each traditional Chinese medicine in Simiao Yong'an Decoction were obtained and their targets were predicted.The targets of deep venous thrombosis were collected by CTD database,and the key targets were obtained by intersection of the component targets and the disease targets;Protein-Protein Interaction(PPI)network was constructed by String database.The drugs-components-targets-disease network map was constructed by using the software of Cytoscape 3.7.2.GO function and KEGG pathway enrichment of Simiao Yong'an Decoction in the treatment of deep venous thrombosis were analyzed by using the plug-in of ClueGo.Results:121 effective components and 137 potential targets of Simiao Yong'an Decoction were obtained.There were 1172 targets of deep venous thrombosis.There were 214 biological processes analyzed by GO Biological Process and 72 pathways analyzed by KEGG analysis.Conclusion:Simiao Yong'an Decoction may act on ESR1,AR,PTGS2 and other key targets,as well as AGE-RAGE signaling pathway,PI3K-Akt signaling pathway,MAPK signaling pathway,IL-17 signaling pathway,TNF signaling pathway,RLX signaling pathway and other pathways to treat deep venous thrombosis.
基金Sponsored by Scientific Research Project of Colleges and Universities in Shandong Province,China(J18KA197)Science and Technology Innovation Development Project of Tai’an(Policy Guidance)(2020ZC322)Key Project of Art Science in Shandong Province,China(ZD202008364)。
文摘The 21st century is the era of marine economy.The Chinese government attaches great importance to the development and utilization of marine resources.With the support of national marine policies,the development of marine tourism industry in Yantai has changed with each passing day,and the content of tourism products developed by Yantai is also constantly innovating.In this study,by using literature research,data analysis and other methods,the development of marine tourism resources in Yantai was analyzed.The results show that the marine tourism products in Yantai are not well-known,less competitive,and are difficult to form a scale advantage.Therefore,some measures to promote the development of tourism industry in Yantai were proposed,such as optimizing and upgrading marine tourism products in Yantai,strengthening regional cooperation to increase product awareness,improving the structure scale of products in scenic spots to enhance competitiveness,attaching importance to the application of science and technology and strengthening product innovation.
基金Social Science Project of Tai’an City (22-YB-086)The 14^(th) Batch of Teaching Reform and Research Project of TaiShan University (JG202166)。
文摘Tourism performing art is the product of the integration of culture and tourism.With the arrival of the experience economy era,tourism performing art products will be an important link in the development of tourism,with strong development potential,which can better meet the needs of tourists’ in-depth experience and promote the long-term development of regional tourism.This paper studied the development of Tai’an tourism performing art products from the perspective of experience.Through the survey of tourists and statistics of data,this paper discussed the development strategy of Tai’an tourism performing art products,aiming to provide reference for the development of Tai’an tourism performing art products.
文摘Objective:To infer the training load from the characteristics of heart rate changes of elite sprinters during maximum intensity training.Methods:Different training loads were determined according to different running distances.Multi-person running in the same group was used to collect the heart rate data of elite sprinters during speed training.Results:the heart rate level was directly related to the exercise load.During the maximum intensity exercise,the heart rate generally increased for about 12 s after the race,which was about 110%of the end-point heart rate.Compared with the low load group(60m),the heart rate of the high load group(100m)continued to rise,but the maximum heart rate level was higher than that of the low load group.The exercise intensity and heart rate change rate of the low load group are greater,the work done by the high load group is more,and the envelope area of the heart rate curve is larger.During intermittent training,under the condition of controlling the interval between groups,the heart rate curve envelope area of the low load group is small,the physical recovery is good,the parameter consistency of each group is good,the heart rate curve envelope area of the high load group is large,and the heart rate response decreases gradually.
文摘As a database that allows data to be stored in XML format, XML database suffers from some similar attacks as traditional relational database does. These attacks include injection attack by XQuey function in application software. These include BaseX, eXist and MarkLogic. In order to defeat these attacks, countermeasures are proposed.
