Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA v...Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and herpes simplex virus (HSV). Most of the research work related to RIPs has been focused on antiviral activity against HIV; however, the exact mechanism of antiviral activity is still not clear. The mechanism of antiviral activity was thought to follow inactivation of the host cell ribosome, leading to inhibition of viral protein translation and host cell death. Enzymatic activity of RIPs is not limited to depurination of the large rRNA, in addition they can depurinate viral DNA as well as RNA. Recently, Phase I/II clinical trials have demonstrated the potential use of RIPs for treating patients with HIV disease. The aim of this review is to focus on various RIPs from plants associated with anti-HIV activity.展开更多
The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new app...The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these methods.Chronic hypoxia exerts both positive and adverse effects.The positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in reperfusion.The adverse effects are pulmonary hypertension and right ventricular hypertrophy.This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion.It is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.展开更多
Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3...Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position.The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activities along with less gastric toxicity profile.Two series of coumarin–benzimidazole derivatives(4a–e and 5a–e)were synthesized and evaluated for anti-inflammatory activity and antioxidant activity.Compounds 4c,4d and 5a displayed good anti-inflammatory(45.45%,46.75%and 42.85%inhibition,respectively,versus 54.54% inhibition by indomethacin)and antioxidant(IC_(50) of 19.7,13.9 and 1.2 mmol/L,respectively,versus 23.4 mmol/L for butylatedhydroxytoluene)activities.Evaluation of ulcer index and in vivo biochemical estimations for oxidative stress revealed that compounds 4d and 5a remain safe on gastric mucosa and did not induce oxidative stress in tissues.Calculation of various molecular properties suggests the compounds to be sufficiently bioavailable.展开更多
In recent years, huge amounts of structured, unstructured, and semi-structured data have been generated by various institutions around the world and, collectively, this heterogeneous data is referred to as big data. T...In recent years, huge amounts of structured, unstructured, and semi-structured data have been generated by various institutions around the world and, collectively, this heterogeneous data is referred to as big data. The health industry sector has been confronted by the need to manage the big data being produced by various sources,which are well known for producing high volumes of heterogeneous data. Various big-data analytics tools and techniques have been developed for handling these massive amounts of data, in the healthcare sector. In this paper, we discuss the impact of big data in healthcare, and various tools available in the Hadoop ecosystem for handling it. We also explore the conceptual architecture of big data analytics for healthcare which involves the data gathering history of different branches, the genome database, electronic health records, text/imagery, and clinical decisions support system.展开更多
In this investigation,all-optical Toggle flip-flop event-driven memory is explored with data rate of 16 Gbit/s.Single mode optical fiber model is used as a nonlinear medium to generate the output set and reset pulses ...In this investigation,all-optical Toggle flip-flop event-driven memory is explored with data rate of 16 Gbit/s.Single mode optical fiber model is used as a nonlinear medium to generate the output set and reset pulses of a Toggle flip-flop,and the model is based on the bidirectional optical transmission principle,considering the fundamental effects of cross phase modulation and self-phase modulation with change in polarization state.The performance of a flip-flop is evaluated using truth table conditions and performance parameters such as Q factor,which is obtained as 380.92 d B for Q and 272.9 d B for■,and rising and falling times of 7.304 ps and 5.79 ps,respectively are obtained,which makes flip-flop design fast as compared to earlier design techniques.展开更多
In the age of online workload explosion,cloud users are increasing exponentialy.Therefore,large scale data centers are required in cloud environment that leads to high energy consumption.Hence,optimal resource utiliza...In the age of online workload explosion,cloud users are increasing exponentialy.Therefore,large scale data centers are required in cloud environment that leads to high energy consumption.Hence,optimal resource utilization is essential to improve energy efficiency of cloud data center.Although,most of the existing literature focuses on virtual machine(VM)consolidation for increasing energy efficiency at the cost of service level agreement degradation.In order to improve the existing approaches,load aware three-gear THReshold(LATHR)as well as modified best fit decreasing(MBFD)algorithm is proposed for minimizing total energy consumption while improving the quality of service in terms of SLA.It offers promising results under dynamic workload and variable number of VMs(1-290)allocated on individual host.The outcomes of the proposed work are measured in terms of SLA,energy consumption,instruction energy ratio(IER)and the number of migrations against the varied numbers of VMs.From experimental results it has been concluded that the proposed technique reduced the SLA violations(55%,26%and 39%)and energy consumption(17%,12%and 6%)as compared to median absolute deviation(MAD),inter quartile range(IQR)and double threshold(THR)overload detection policies,respectively.展开更多
Big data analytics and data mining are techniques used to analyze data and to extract hidden information.Traditional approaches to analysis and extraction do not work well for big data because this data is complex and...Big data analytics and data mining are techniques used to analyze data and to extract hidden information.Traditional approaches to analysis and extraction do not work well for big data because this data is complex and of very high volume. A major data mining technique known as data clustering groups the data into clusters and makes it easy to extract information from these clusters. However, existing clustering algorithms, such as k-means and hierarchical, are not efficient as the quality of the clusters they produce is compromised. Therefore, there is a need to design an efficient and highly scalable clustering algorithm. In this paper, we put forward a new clustering algorithm called hybrid clustering in order to overcome the disadvantages of existing clustering algorithms. We compare the new hybrid algorithm with existing algorithms on the bases of precision, recall, F-measure, execution time, and accuracy of results. From the experimental results, it is clear that the proposed hybrid clustering algorithm is more accurate, and has better precision, recall, and F-measure values.展开更多
Jasmonates are class of plant growth regulators act as signal molecule that intercede various components in physiological and metabolic regulation, stress responses and possibly communication through signal transducti...Jasmonates are class of plant growth regulators act as signal molecule that intercede various components in physiological and metabolic regulation, stress responses and possibly communication through signal transduction. Oxidative stress due to heavy metal exposure stimulates synthesis and activity of antioxidant metabolites and enhances antioxidant enzyme activities that could protect plant tissues. The aim of this study was to investigate the exogenous effect of JA at seed level which can transduce throughout seedling growth and regulate antioxidant activities such as superoxide dismutase (SOD;EC 1.15.1.1) and guaiacol peroxidase (POD;EC 1.11.1.7) in 12 days old seedlings of pigeon pea (Cajanus cajan (L.) Millsp.) in presence and/or absence of copper. The activity of SOD and POD increased significantly in presence of Cu2+ after seed priming with JA. JA also helps in chlorophyll and carotenoid accumulation and neutralizes the toxic effect of Cu2+ on seedlings. This is the first report of JA effect on photosynthetic pigment accumulation and H2O2 mitigating enzymes i.e. SOD and POD and it could be recommended that seed priming with JA help in ameliorating toxic effect of Cu2+.展开更多
Blur is produced in a digital image due to low passfiltering,moving objects or defocus of the camera lens during capture.Image viewers are annoyed by blur artefact and the image's perceived quality suffers as a re...Blur is produced in a digital image due to low passfiltering,moving objects or defocus of the camera lens during capture.Image viewers are annoyed by blur artefact and the image's perceived quality suffers as a result.The high-quality input is relevant to communication service providers and imaging product makers because it may help them improve their processes.Human-based blur assessment is time-consuming,expensive and must adhere to subjective evaluation standards.This paper presents a revolutionary no-reference blur assessment algorithm based on reblurring blurred images using a special mask developed with a Markov basis and Laplacefilter.Thefinal blur score of blurred images has been calculated from the local variation in horizontal and vertical pixel intensity of blurred and re-blurred images.The objective scores are generated by applying proposed algorithm on the two image databases i.e.,Laboratory for image and video engineering(LIVE)database and Tampere image database(TID 2013).Finally,on the basis of objective and subjective scores performance analysis is done in terms of Pearson linear correlation coefficient(PLCC),Spearman rank-order correlation coefficient(SROCC),Mean absolute error(MAE),Root mean square error(RMSE)and Outliers ratio(OR).The existing no-reference blur assessment algorithms have been used various methods for the evaluation of blur from no-reference image such as Just noticeable blur(JNB),Cumulative Probability Distribution of Blur Detection(CPBD)and Edge Model based Blur Metric(EMBM).The results illustrate that the proposed method was successful in predicting high blur scores with high accuracy as compared to existing no-reference blur assessment algorithms such as JNB,CPBD and EMBM algorithms.展开更多
Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related death.The introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate ...Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related death.The introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in AMI.Adverse cardiac remodeling is a serious problem in cardiology.An increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac remodeling.Inhibition of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic syndrome.Therefore,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered cardiomyopathy.It was demonstrated that pyroptosis interacts closely with apoptosis and autophagy.Pyroptosis could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.展开更多
This study reports the investigations for repair of thermoplastic based automotive bumpers and bars with modified friction stir welding(MFSW)process.For MFSW,consumable tool of polyamide6(PA6)composite has been used f...This study reports the investigations for repair of thermoplastic based automotive bumpers and bars with modified friction stir welding(MFSW)process.For MFSW,consumable tool of polyamide6(PA6)composite has been used for joining of acrylonitrile butadiene styrene(ABS)composites.The dissimilar thermoplastics were processed for maintaining a useful range of melt flow properties followed by preparation of feed stock filament for fused deposition modeling(FDM)process through screw extrusion.Finally,3D printed PA6 based consumable rapid tool(RT)was prepared for MFSW.The joints prepared were subjected to flexural,hardness,morphological and thermal testing.The study has suggested the that maximum mechanical strength was obtained for sample welded at 1400 r/min,50 mm/min transverse speed and 3 mm plunge depth,whereas the minimum mechanical strength was obtained for sample welded at 1000 r/min,30 mm/min transverse speed and 2 mm plunge depth.The results are also supported with thermal analysis and photomicrographs.展开更多
In this study, aluminum oxide （Al2O3） nanoparticles （NPs） were synthesized via an electrochemical method. The effects of reac- tion parameters such as supporting electrolytes, solvent, current and electrolysis tim...In this study, aluminum oxide （Al2O3） nanoparticles （NPs） were synthesized via an electrochemical method. The effects of reac- tion parameters such as supporting electrolytes, solvent, current and electrolysis time on the shape and size of the resulting NPs were investi- gated. The Al2O3 NPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, thermogravimetric analysis/differential thermal analysis, energy-dispersive X-ray analysis, and ultraviolet-visible spectroscopy. Moreover, the Al2O3 NPs were explored for photocatalytic degradation of malachite green （MG） dye under sunlight irradiation via two processes： ad- sorption followed by photocatalysis; coupled adsorption and photocatalysis. The coupled process exhibited a higher photodegradation effi- ciency （45%） compared to adsorption followed by photocatalysis （32%）. The obtained kinetic data was well fitted using a pseudo-first-order model for MG degradation.展开更多
The present work investigates the hot-corrosion behavior of carbon nanotube(CNT)-reinforced chromium oxide coatings on boiler steel in a molten salt(Na_2SO_4–60 wt%V_2O_5) environment at 700°C under cyclic condi...The present work investigates the hot-corrosion behavior of carbon nanotube(CNT)-reinforced chromium oxide coatings on boiler steel in a molten salt(Na_2SO_4–60 wt%V_2O_5) environment at 700°C under cyclic conditions. The coatings were deposited via the high-velocity oxygen fuel process. The uncoated and coated steel samples were subjected to hot corrosion in a silicon tube furnace at 700°C for 50 cycles. The kinetics of the corrosion behavior was analyzed through mass-gain measurements after each cycle. The corrosion products were analyzed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray analysis techniques. The results revealed that uncoated steel suffered spallation of scale because of the formation of nonprotective Fe_2O_3 scale. The coated steel samples exhibited lower mass gains with better adhesiveness of oxide scale with the steel alloy until the end of exposure. The CNT-reinforced coatings were concluded to provide better corrosion resistance in the hot-corrosion environment because of the uniform dispersion of CNTs in the coating matrix and the formation of protective chromium oxides in the scale.展开更多
This study presents a simple methodology for implementation of all optical JK flip flop for future optical high speed networks.The scheme utilizes electronic model of JK flip flop for implementation of all optical JK ...This study presents a simple methodology for implementation of all optical JK flip flop for future optical high speed networks.The scheme utilizes electronic model of JK flip flop for implementation of all optical JK flip flop at the bit rate of 7 Gbit/s.Firstly,all-optical AND and NOR gates are implemented.Furthermore,with the combination of these basic gate structures,the optical model of JK flip flop is verified.This structure makes use of two optical AND gates and two optical NOR gates.This technique uses a semiconductor optical amplifier(SOA)as the nonlinear medium to produce considerable amount of cross gain and cross phase modulation to attain truth table conditions of optical JK flip flop.In this method,the number of gates is reduced as compared to earlier schemes.Rise time and fall time of 5.6 ps with contrast ratio more than 60 dB are achieved in this design.展开更多
Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this ...Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this epileptogenesis process into drug-resistant epilepsy.The lamotrigine-pentylenetetrazole kindled mice show resistance to lamotrigine,phenytoin,and carbamazepine.It may also be possible that other licensed antiseizure drugs,like the mentioned drugs,remain ineffective in this model;therefore,this was the subject of this study.Methods:Swiss albino mice were kindled with pentylenetetrazole for 35 days in the presence of either methylcellulose vehicle or lamotrigine(subtherapeutic dose,ie,5 mg/kg).Vehicle vs lamotrigine-kindled mice were compared in terms of(a)resistance/response toward nine antiseizure drugs applied as monotherapies and two drug combinations;(b)lamotrigine bioavailability in blood and brain;(c)blood-brain barrier integrity;and(d)amino acids and monoamines in the cerebral cortex and hippocampus.Results:Lamotrigine vs vehicle-kindled mice are similar(or not significantly different P>.05 from each other)in terms of(a)response toward drug combinations;(b)lamotrigine bioavailability;and(c)blood-brain barrier integrity except for,significantly(P<.05)reduced taurine and increased glutamate in the cerebral cortex and hippocampus.Aside from these,lamotrigine-kindled mice show significant(P<.05)resistant to lamotrigine(15 mg/kg),levetiracetam(40 mg/kg);carbamazepine(40 mg/kg),zonisamide(100 mg/kg),gabapentin(224 mg/kg),pregabalin(30 mg/kg),phenytoin(35 mg/kg),and topiramate(300 mg/kg).Conclusion:Lamotrigine-pentylenetetrazole kindling takes longer to develop(~5 weeks)in comparison to lamotrigine-amygdale(~4 weeks)and lamotriginecorneal(~2 weeks)kindling models.However,drug screening through this model may yield superior drugs with novel antiseizure mechanisms.展开更多
In machining processes,researchers are actively engaged in exploring minimum quantity lubrication(MQL)as a possible alternative to traditional flood cooling owing to economic and ecological concerns.The search for eco...In machining processes,researchers are actively engaged in exploring minimum quantity lubrication(MQL)as a possible alternative to traditional flood cooling owing to economic and ecological concerns.The search for ecologically safe lubricants has attracted the attention of scientists looking to use vegetable oil as a lubricant.The nanofluid MQL technique with biodegradable oils as the base is a relatively new method with the potential to replace mineral oils.In the present study,the grinding of Inconel-718 alloy was investigated using nanofluid MQL(NFMQL)with biodegradable oils as the base.Nanofluids are composed by dispersing 0.5%(mass fraction)and 1%(mass fraction)of CuO nanoparticles in vegetable oil.The surface morphology,G-ratio,forces,and grinding energy were examined under pure MQL,NFMQL,and dry and flood lubrication conditions.The experimental results indicated that the nanofluid MQL significantly improved the machining performance.Owing to the polishing and rolling effect of nanoparticles on the tool work interface,a surface finish under a 0.5%(mass fraction)nanofluid was found to be better than pure MQL-dry and flood lubrication conditions.The NFMQL technique with 1%(mass fraction)CuO nanoparticles with palm oil as the base helped in achieving a better evacuation of chips from the grinding zone,leading to a better surface finish with a high material removal rate along with less energy consumption compared to flood and dry grinding.展开更多
Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism ...Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.展开更多
With the quick spread of pandemic disease,many individuals have lost their lives across different parts of the world.So,the need for a novel approach or model to overcome the problem becomes a necessity.In this paper,...With the quick spread of pandemic disease,many individuals have lost their lives across different parts of the world.So,the need for a novel approach or model to overcome the problem becomes a necessity.In this paper,a mechanism is proposed called DBCMS(Drone Based Covid-19 Medical Service)for the safety of medical em-ployees who are prone to Covid-19 infection.The proposed mechanism can effectively improve the treatment process of Covid-19 patients.Drones are nowadays commonly used in the field of medical emergency situations.The proposed model in this paper uses drone service to reduce the risk of infection to the doctors or other medical staff,thereby preventing the disease spread.This paper further assumes that the primary step is to isolate people at their home instead of admitting them to the hospitals,also called a situation of lockdown or curfew.Thus,in this way,the spread can be significantly reduced across the globe if DBCMS approach is implemented at cluster level.展开更多
Non-steroidal anti-inflammatory drugs(NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointest...Non-steroidal anti-inflammatory drugs(NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal(GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.展开更多
The early diagnosis of pre-existing coronary disorders helps to control complications such as pulmonary hypertension,irregular cardiac functioning,and heart failure.Machine-based learning of heart sound is an efficien...The early diagnosis of pre-existing coronary disorders helps to control complications such as pulmonary hypertension,irregular cardiac functioning,and heart failure.Machine-based learning of heart sound is an efficient technology which can help minimize the workload of manual auscultation by automatically identifying irregular cardiac sounds.Phonocardiogram(PCG)and electrocardiogram(ECG)waveforms provide the much-needed information for the diagnosis of these diseases.In this work,the researchers have converted the heart sound signal into its corresponding repeating pattern-based spectrogram.PhysioNet 2016 and PASCAL 2011 have been taken as the benchmark datasets to perform experimentation.The existing models,viz.MobileNet,Xception,Visual Geometry Group(VGG16),ResNet,DenseNet,and InceptionV3 of Transfer Learning have been used for classifying the heart sound signals as normal and abnormal.For PhysioNet 2016,DenseNet has outperformed its peer models with an accuracy of 89.04 percent,whereas for PASCAL 2011,VGG has outperformed its peer approaches with an accuracy of 92.96 percent.展开更多
基金Indo-Swiss Joint research Program (ISJRP)#17/2011
文摘Many plants contain ribosome inactivating proteins (RIPs) with N-glycosidase activity, which depurinate large ribosomal RNA and arrest protein synthesis. RIPs so far tested inhibit replication of mRNA as well as DNA viruses and these proteins, isolated from plants, are found to be effective against a broad range of viruses such as human immunodeficiency virus (HIV), hepatitis B virus (HBV) and herpes simplex virus (HSV). Most of the research work related to RIPs has been focused on antiviral activity against HIV; however, the exact mechanism of antiviral activity is still not clear. The mechanism of antiviral activity was thought to follow inactivation of the host cell ribosome, leading to inhibition of viral protein translation and host cell death. Enzymatic activity of RIPs is not limited to depurination of the large rRNA, in addition they can depurinate viral DNA as well as RNA. Recently, Phase I/II clinical trials have demonstrated the potential use of RIPs for treating patients with HIV disease. The aim of this review is to focus on various RIPs from plants associated with anti-HIV activity.
基金supported by the Russian Science Foundation grant 22-15-00048The section dedicated to the role of kinases in the cardioprotective effect of CH is framed within the framework of state assignments 122020300042-4.
文摘The acute myocardial infarction(AMI)and sudden cardiac death(SCD),both associated with acute cardiac ischemia,are one of the leading causes of adult death in economically developed countries.The development of new approaches for the treatment and prevention of AMI and SCD remains the highest priority for medicine.A study on the cardiovascular effects of chronic hypoxia(CH)may contribute to the development of these methods.Chronic hypoxia exerts both positive and adverse effects.The positive effects are the infarct-reducing,vasoprotective,and antiarrhythmic effects,which can lead to the improvement of cardiac contractility in reperfusion.The adverse effects are pulmonary hypertension and right ventricular hypertrophy.This review presents a comprehensive overview of how CH enhances cardiac tolerance to ischemia/reperfusion.It is an in-depth analysis of the published data on the underlying mechanisms,which can lead to future development of the cardioprotective effect of CH.A better understanding of the CH-activated protective signaling pathways may contribute to new therapeutic approaches in an increase of cardiac tolerance to ischemia/reperfusion.
基金The authors are also thankful to the AICTE,New Delhi(India)for providing fellowship to two of the authors(Radha Krishan Arora and Navneet Kaur).
文摘Inspired from occurrence of anti-inflammatory activity of 3-substituted coumarins and antiulcer activity of various 2-substituted benzimidazoles,novel compounds have been designed by coupling coumarin derivatives at 3-position directly or through amide linkage with benzimidazole nucleus at 2-position.The resultant compounds are expected to exhibit both anti-inflammatory and antioxidant activities along with less gastric toxicity profile.Two series of coumarin–benzimidazole derivatives(4a–e and 5a–e)were synthesized and evaluated for anti-inflammatory activity and antioxidant activity.Compounds 4c,4d and 5a displayed good anti-inflammatory(45.45%,46.75%and 42.85%inhibition,respectively,versus 54.54% inhibition by indomethacin)and antioxidant(IC_(50) of 19.7,13.9 and 1.2 mmol/L,respectively,versus 23.4 mmol/L for butylatedhydroxytoluene)activities.Evaluation of ulcer index and in vivo biochemical estimations for oxidative stress revealed that compounds 4d and 5a remain safe on gastric mucosa and did not induce oxidative stress in tissues.Calculation of various molecular properties suggests the compounds to be sufficiently bioavailable.
文摘In recent years, huge amounts of structured, unstructured, and semi-structured data have been generated by various institutions around the world and, collectively, this heterogeneous data is referred to as big data. The health industry sector has been confronted by the need to manage the big data being produced by various sources,which are well known for producing high volumes of heterogeneous data. Various big-data analytics tools and techniques have been developed for handling these massive amounts of data, in the healthcare sector. In this paper, we discuss the impact of big data in healthcare, and various tools available in the Hadoop ecosystem for handling it. We also explore the conceptual architecture of big data analytics for healthcare which involves the data gathering history of different branches, the genome database, electronic health records, text/imagery, and clinical decisions support system.
基金supported by the Science and Engineering Research Board,New Delhi for Research Grant Vide Sanction No:File No.EMR/2017/004162 dated 01-11-18。
文摘In this investigation,all-optical Toggle flip-flop event-driven memory is explored with data rate of 16 Gbit/s.Single mode optical fiber model is used as a nonlinear medium to generate the output set and reset pulses of a Toggle flip-flop,and the model is based on the bidirectional optical transmission principle,considering the fundamental effects of cross phase modulation and self-phase modulation with change in polarization state.The performance of a flip-flop is evaluated using truth table conditions and performance parameters such as Q factor,which is obtained as 380.92 d B for Q and 272.9 d B for■,and rising and falling times of 7.304 ps and 5.79 ps,respectively are obtained,which makes flip-flop design fast as compared to earlier design techniques.
文摘In the age of online workload explosion,cloud users are increasing exponentialy.Therefore,large scale data centers are required in cloud environment that leads to high energy consumption.Hence,optimal resource utilization is essential to improve energy efficiency of cloud data center.Although,most of the existing literature focuses on virtual machine(VM)consolidation for increasing energy efficiency at the cost of service level agreement degradation.In order to improve the existing approaches,load aware three-gear THReshold(LATHR)as well as modified best fit decreasing(MBFD)algorithm is proposed for minimizing total energy consumption while improving the quality of service in terms of SLA.It offers promising results under dynamic workload and variable number of VMs(1-290)allocated on individual host.The outcomes of the proposed work are measured in terms of SLA,energy consumption,instruction energy ratio(IER)and the number of migrations against the varied numbers of VMs.From experimental results it has been concluded that the proposed technique reduced the SLA violations(55%,26%and 39%)and energy consumption(17%,12%and 6%)as compared to median absolute deviation(MAD),inter quartile range(IQR)and double threshold(THR)overload detection policies,respectively.
文摘Big data analytics and data mining are techniques used to analyze data and to extract hidden information.Traditional approaches to analysis and extraction do not work well for big data because this data is complex and of very high volume. A major data mining technique known as data clustering groups the data into clusters and makes it easy to extract information from these clusters. However, existing clustering algorithms, such as k-means and hierarchical, are not efficient as the quality of the clusters they produce is compromised. Therefore, there is a need to design an efficient and highly scalable clustering algorithm. In this paper, we put forward a new clustering algorithm called hybrid clustering in order to overcome the disadvantages of existing clustering algorithms. We compare the new hybrid algorithm with existing algorithms on the bases of precision, recall, F-measure, execution time, and accuracy of results. From the experimental results, it is clear that the proposed hybrid clustering algorithm is more accurate, and has better precision, recall, and F-measure values.
文摘Jasmonates are class of plant growth regulators act as signal molecule that intercede various components in physiological and metabolic regulation, stress responses and possibly communication through signal transduction. Oxidative stress due to heavy metal exposure stimulates synthesis and activity of antioxidant metabolites and enhances antioxidant enzyme activities that could protect plant tissues. The aim of this study was to investigate the exogenous effect of JA at seed level which can transduce throughout seedling growth and regulate antioxidant activities such as superoxide dismutase (SOD;EC 1.15.1.1) and guaiacol peroxidase (POD;EC 1.11.1.7) in 12 days old seedlings of pigeon pea (Cajanus cajan (L.) Millsp.) in presence and/or absence of copper. The activity of SOD and POD increased significantly in presence of Cu2+ after seed priming with JA. JA also helps in chlorophyll and carotenoid accumulation and neutralizes the toxic effect of Cu2+ on seedlings. This is the first report of JA effect on photosynthetic pigment accumulation and H2O2 mitigating enzymes i.e. SOD and POD and it could be recommended that seed priming with JA help in ameliorating toxic effect of Cu2+.
文摘Blur is produced in a digital image due to low passfiltering,moving objects or defocus of the camera lens during capture.Image viewers are annoyed by blur artefact and the image's perceived quality suffers as a result.The high-quality input is relevant to communication service providers and imaging product makers because it may help them improve their processes.Human-based blur assessment is time-consuming,expensive and must adhere to subjective evaluation standards.This paper presents a revolutionary no-reference blur assessment algorithm based on reblurring blurred images using a special mask developed with a Markov basis and Laplacefilter.Thefinal blur score of blurred images has been calculated from the local variation in horizontal and vertical pixel intensity of blurred and re-blurred images.The objective scores are generated by applying proposed algorithm on the two image databases i.e.,Laboratory for image and video engineering(LIVE)database and Tampere image database(TID 2013).Finally,on the basis of objective and subjective scores performance analysis is done in terms of Pearson linear correlation coefficient(PLCC),Spearman rank-order correlation coefficient(SROCC),Mean absolute error(MAE),Root mean square error(RMSE)and Outliers ratio(OR).The existing no-reference blur assessment algorithms have been used various methods for the evaluation of blur from no-reference image such as Just noticeable blur(JNB),Cumulative Probability Distribution of Blur Detection(CPBD)and Edge Model based Blur Metric(EMBM).The results illustrate that the proposed method was successful in predicting high blur scores with high accuracy as compared to existing no-reference blur assessment algorithms such as JNB,CPBD and EMBM algorithms.
基金supported by Russian Foundation of Basic Research(Grant No.21-515-53003)
文摘Acute myocardial infarction(AMI)is one of the main reasons of cardiovascular disease-related death.The introduction of percutaneous coronary intervention to clinical practice dramatically decreased the mortality rate in AMI.Adverse cardiac remodeling is a serious problem in cardiology.An increase in the effectiveness of AMI treatment and prevention of adverse cardiac remodeling is difficult to achieve without understanding the mechanisms of reperfusion cardiac injury and cardiac remodeling.Inhibition of pyroptosis prevents the development of postinfarction and pressure overload-induced cardiac remodeling,and mitigates cardiomyopathy induced by diabetes and metabolic syndrome.Therefore,it is reasonable to hypothesize that the pyroptosis inhibitors may find a role in clinical practice for treatment of AMI and prevention of cardiac remodeling,diabetes and metabolic syndrome-triggered cardiomyopathy.It was demonstrated that pyroptosis interacts closely with apoptosis and autophagy.Pyroptosis could be inhibited by nucleotide-binding oligomerization domain-like receptor with a pyrin domain 3 inhibitors,caspase-1 inhibitors,microRNA,angiotensin-converting enzyme inhibitors,angiotensinⅡreceptor blockers,and traditional Chinese herbal medicines.
文摘This study reports the investigations for repair of thermoplastic based automotive bumpers and bars with modified friction stir welding(MFSW)process.For MFSW,consumable tool of polyamide6(PA6)composite has been used for joining of acrylonitrile butadiene styrene(ABS)composites.The dissimilar thermoplastics were processed for maintaining a useful range of melt flow properties followed by preparation of feed stock filament for fused deposition modeling(FDM)process through screw extrusion.Finally,3D printed PA6 based consumable rapid tool(RT)was prepared for MFSW.The joints prepared were subjected to flexural,hardness,morphological and thermal testing.The study has suggested the that maximum mechanical strength was obtained for sample welded at 1400 r/min,50 mm/min transverse speed and 3 mm plunge depth,whereas the minimum mechanical strength was obtained for sample welded at 1000 r/min,30 mm/min transverse speed and 2 mm plunge depth.The results are also supported with thermal analysis and photomicrographs.
文摘In this study, aluminum oxide （Al2O3） nanoparticles （NPs） were synthesized via an electrochemical method. The effects of reac- tion parameters such as supporting electrolytes, solvent, current and electrolysis time on the shape and size of the resulting NPs were investi- gated. The Al2O3 NPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, transmission electron microscopy, thermogravimetric analysis/differential thermal analysis, energy-dispersive X-ray analysis, and ultraviolet-visible spectroscopy. Moreover, the Al2O3 NPs were explored for photocatalytic degradation of malachite green （MG） dye under sunlight irradiation via two processes： ad- sorption followed by photocatalysis; coupled adsorption and photocatalysis. The coupled process exhibited a higher photodegradation effi- ciency （45%） compared to adsorption followed by photocatalysis （32%）. The obtained kinetic data was well fitted using a pseudo-first-order model for MG degradation.
文摘The present work investigates the hot-corrosion behavior of carbon nanotube(CNT)-reinforced chromium oxide coatings on boiler steel in a molten salt(Na_2SO_4–60 wt%V_2O_5) environment at 700°C under cyclic conditions. The coatings were deposited via the high-velocity oxygen fuel process. The uncoated and coated steel samples were subjected to hot corrosion in a silicon tube furnace at 700°C for 50 cycles. The kinetics of the corrosion behavior was analyzed through mass-gain measurements after each cycle. The corrosion products were analyzed by X-ray diffraction, scanning electron microscopy, and energy-dispersive X-ray analysis techniques. The results revealed that uncoated steel suffered spallation of scale because of the formation of nonprotective Fe_2O_3 scale. The coated steel samples exhibited lower mass gains with better adhesiveness of oxide scale with the steel alloy until the end of exposure. The CNT-reinforced coatings were concluded to provide better corrosion resistance in the hot-corrosion environment because of the uniform dispersion of CNTs in the coating matrix and the formation of protective chromium oxides in the scale.
基金supported by the Science&Engineering Research Board,New Delhi,India vide Sanction(No.EMR/2017/004162)。
文摘This study presents a simple methodology for implementation of all optical JK flip flop for future optical high speed networks.The scheme utilizes electronic model of JK flip flop for implementation of all optical JK flip flop at the bit rate of 7 Gbit/s.Firstly,all-optical AND and NOR gates are implemented.Furthermore,with the combination of these basic gate structures,the optical model of JK flip flop is verified.This structure makes use of two optical AND gates and two optical NOR gates.This technique uses a semiconductor optical amplifier(SOA)as the nonlinear medium to produce considerable amount of cross gain and cross phase modulation to attain truth table conditions of optical JK flip flop.In this method,the number of gates is reduced as compared to earlier schemes.Rise time and fall time of 5.6 ps with contrast ratio more than 60 dB are achieved in this design.
文摘Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure drugs.The presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this epileptogenesis process into drug-resistant epilepsy.The lamotrigine-pentylenetetrazole kindled mice show resistance to lamotrigine,phenytoin,and carbamazepine.It may also be possible that other licensed antiseizure drugs,like the mentioned drugs,remain ineffective in this model;therefore,this was the subject of this study.Methods:Swiss albino mice were kindled with pentylenetetrazole for 35 days in the presence of either methylcellulose vehicle or lamotrigine(subtherapeutic dose,ie,5 mg/kg).Vehicle vs lamotrigine-kindled mice were compared in terms of(a)resistance/response toward nine antiseizure drugs applied as monotherapies and two drug combinations;(b)lamotrigine bioavailability in blood and brain;(c)blood-brain barrier integrity;and(d)amino acids and monoamines in the cerebral cortex and hippocampus.Results:Lamotrigine vs vehicle-kindled mice are similar(or not significantly different P>.05 from each other)in terms of(a)response toward drug combinations;(b)lamotrigine bioavailability;and(c)blood-brain barrier integrity except for,significantly(P<.05)reduced taurine and increased glutamate in the cerebral cortex and hippocampus.Aside from these,lamotrigine-kindled mice show significant(P<.05)resistant to lamotrigine(15 mg/kg),levetiracetam(40 mg/kg);carbamazepine(40 mg/kg),zonisamide(100 mg/kg),gabapentin(224 mg/kg),pregabalin(30 mg/kg),phenytoin(35 mg/kg),and topiramate(300 mg/kg).Conclusion:Lamotrigine-pentylenetetrazole kindling takes longer to develop(~5 weeks)in comparison to lamotrigine-amygdale(~4 weeks)and lamotriginecorneal(~2 weeks)kindling models.However,drug screening through this model may yield superior drugs with novel antiseizure mechanisms.
文摘In machining processes,researchers are actively engaged in exploring minimum quantity lubrication(MQL)as a possible alternative to traditional flood cooling owing to economic and ecological concerns.The search for ecologically safe lubricants has attracted the attention of scientists looking to use vegetable oil as a lubricant.The nanofluid MQL technique with biodegradable oils as the base is a relatively new method with the potential to replace mineral oils.In the present study,the grinding of Inconel-718 alloy was investigated using nanofluid MQL(NFMQL)with biodegradable oils as the base.Nanofluids are composed by dispersing 0.5%(mass fraction)and 1%(mass fraction)of CuO nanoparticles in vegetable oil.The surface morphology,G-ratio,forces,and grinding energy were examined under pure MQL,NFMQL,and dry and flood lubrication conditions.The experimental results indicated that the nanofluid MQL significantly improved the machining performance.Owing to the polishing and rolling effect of nanoparticles on the tool work interface,a surface finish under a 0.5%(mass fraction)nanofluid was found to be better than pure MQL-dry and flood lubrication conditions.The NFMQL technique with 1%(mass fraction)CuO nanoparticles with palm oil as the base helped in achieving a better evacuation of chips from the grinding zone,leading to a better surface finish with a high material removal rate along with less energy consumption compared to flood and dry grinding.
基金the UGC,New Delhi awarding Maulana Azad National Fellowship to Ms.Gaganjot[Grant No.F1-17.1/2015-16/MANF-2015-17-PUN-53869]The authors would like to extend their sincere appreciation to the Researchers Supporting Project No.(RSP-2021/19),King Saud University,Riyadh,Saudi Arabia.
文摘Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.
文摘With the quick spread of pandemic disease,many individuals have lost their lives across different parts of the world.So,the need for a novel approach or model to overcome the problem becomes a necessity.In this paper,a mechanism is proposed called DBCMS(Drone Based Covid-19 Medical Service)for the safety of medical em-ployees who are prone to Covid-19 infection.The proposed mechanism can effectively improve the treatment process of Covid-19 patients.Drones are nowadays commonly used in the field of medical emergency situations.The proposed model in this paper uses drone service to reduce the risk of infection to the doctors or other medical staff,thereby preventing the disease spread.This paper further assumes that the primary step is to isolate people at their home instead of admitting them to the hospitals,also called a situation of lockdown or curfew.Thus,in this way,the spread can be significantly reduced across the globe if DBCMS approach is implemented at cluster level.
文摘Non-steroidal anti-inflammatory drugs(NSAIDs) have been successfully used for the alleviation of pain and inflammation in the past and continue to be used daily by millions of patients worldwide. However, gastrointestinal(GI) toxicity associated with NSAIDs is an important medical and socioeconomic problem. Local generation of various reactive oxygen species plays a significant role in the formation of gastric ulceration associated with NSAIDs therapy. Co-medication of antioxidants along with NSAIDs has been found to be beneficial in the prevention of GI injury. This paper describes the synthesis and biological evaluation of N-1-(phenylsulfonyl)-2-methylamino-substituted-1H-benzimidazole derivatives as anti-inflammatory analgesic agents with lower GI toxicity. Studies in vitro and in vivo demonstrated that the antioxidant activity of the test compounds decreased GI toxicity.
基金This work was supported by the National Research Foundation of Korea(NRF)Grant Funded by the Korea government(Ministry of Science and ICT)(No.2017R1E1A1A01077913)by the Institute of Information&Communications Technology Planning&Evaluation(IITP)funded by the Korea Government(MSIT)(Development of Smart Signage Technology for Automatic Classification of Untact Examination and Patient Status Based on AI)under Grant 2020-0-01907.
文摘The early diagnosis of pre-existing coronary disorders helps to control complications such as pulmonary hypertension,irregular cardiac functioning,and heart failure.Machine-based learning of heart sound is an efficient technology which can help minimize the workload of manual auscultation by automatically identifying irregular cardiac sounds.Phonocardiogram(PCG)and electrocardiogram(ECG)waveforms provide the much-needed information for the diagnosis of these diseases.In this work,the researchers have converted the heart sound signal into its corresponding repeating pattern-based spectrogram.PhysioNet 2016 and PASCAL 2011 have been taken as the benchmark datasets to perform experimentation.The existing models,viz.MobileNet,Xception,Visual Geometry Group(VGG16),ResNet,DenseNet,and InceptionV3 of Transfer Learning have been used for classifying the heart sound signals as normal and abnormal.For PhysioNet 2016,DenseNet has outperformed its peer models with an accuracy of 89.04 percent,whereas for PASCAL 2011,VGG has outperformed its peer approaches with an accuracy of 92.96 percent.
