In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some ...In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.展开更多
The International Agency for Research on Cancer(IARC)has classified outdoor air pollution and the particulate matter(PM)in outdoor air pollution as carcinogenic to humans,as based on sufficient evidence of carcinogeni...The International Agency for Research on Cancer(IARC)has classified outdoor air pollution and the particulate matter(PM)in outdoor air pollution as carcinogenic to humans,as based on sufficient evidence of carcinogenicity in humans and experimental animals and strong support by mechanistic studies.The data with important contributions to the evaluation are reviewed,highlighting the data with particular relevance to China,and implications of the evaluation with respect to China are discussed.The air pollution levels in Chinese cities are among the highest observed in the world today and frequently exceed healthbased national and international guidelines.Data from high-quality epidemiologic studies in Asia,Europe,and North America consistently show positive associations between lung cancer and PM exposure and other indicators of air pollution,which persist after adjustment for important lung cancer risk factors,such as tobacco smoking.Epidemiologic data from China are limited but nevertheless indicate an increased risk of lung cancer associated with several air pollutants.Excess cancer risk is also observed in experimental animals exposed to polluted outdoor air or extracted PM.The exposure of several species to outdoor air pollution is associated with markers of genetic damage that have been linked to increased cancer risk in humans.Numerous studies from China,especially genetic biomarker studies in exposed populations,support that the polluted air in China is genotoxic and carcinogenic to humans.The evaluation by IARC indicates both the need for further research into the cancer risks associated with exposure to air pollution in China and the urgent need to act to reduce exposure to the population.展开更多
The Moderate Resolution Imaging Spectroradiometer （MODIS） is one of the key instruments for NASA＇s Earth Observing System （EOS）, currently operating on both the Terra and Aqua satellites. The MODIS is a major adv...The Moderate Resolution Imaging Spectroradiometer （MODIS） is one of the key instruments for NASA＇s Earth Observing System （EOS）, currently operating on both the Terra and Aqua satellites. The MODIS is a major advance over the previous generation of sensors in terms of its spectral, spatial, and temporal resolutions. It has 36 spectral bands： 20 reflective solar bands （RSB） with center wavelengths from 0.41 to 2.1 μm and 16 thermal emissive bands （TEB） with center wavelengths from 3.7 to 14.4 μm, making observations at three spatial resolutions： 250 m （bands 1-2）, 500 m （bands 3-7）, and lkm （bands 8-36）. MODIS is a cross-track scanning radiometer with a wide field-of-view, providing a complete global coverage of the Earth in less than 2 days. Both Terra and Aqua MODIS went through extensive pre-launch calibration and characterization at various levels. In orbit, the calibration and characterization tasks are performed using its on-board calibrators （OBCs） that include a solar diffuser （SD） and a solar diffuser stability monitor （SDSM）, a v-grooved flat panel blackbody （BB）, and a spectro-radiometric calibration assembly （SRCA）. In this paper, we present an overview of MODIS calibration and characterization activities, methodologies, and lessons learned from pre-launch characterization and in-orbit operation. Key issues discussed in this paper include in-orbit efforts of monitoring the noise characteristics of the detectors, tracking the solar diffuser and optics degradations, and updating the sensor＇s response versus scan angle. The experiences and lessons learned through MODIS have played and will continue to play major roles in the design and characterization of future sensors.展开更多
Nanocomposite coatings demonstrate improved friction and wear responses under severe sliding conditions in extreme environments. This paper provides a review how thin film multilayers and nanocomposites result in hard...Nanocomposite coatings demonstrate improved friction and wear responses under severe sliding conditions in extreme environments. This paper provides a review how thin film multilayers and nanocomposites result in hard, tough, low-friction coatings. Approaches to couple multilayered and nanocomposite materials with other surface engineering strategies to achieve higher levels of performance in a variety of tribological applications are also discussed. Encapsulating lubricious phases in hard nanocomposite matri- ces is one approach that is discussed in detail. Results from state-of-the-art ＂chameleon＂ nanocomposites that exhibit reversible adaptability to ambient humidity or temperature are presented.展开更多
Graphene oxide （GO） can be reduced to graphene in a normal aerobic setup under ambient conditions as mediated by microbial respiration of Shewanella cells. The microbially-reduced graphene （MRG） exhibited excellen...Graphene oxide （GO） can be reduced to graphene in a normal aerobic setup under ambient conditions as mediated by microbial respiration of Shewanella cells. The microbially-reduced graphene （MRG） exhibited excellent electrochemical properties. Extracellular electron transfer pathways at the cell/GO interface were systematically investigated, suggesting both direct electron transfer and electron mediators are involved in the GO reduction.展开更多
Research to date indicates that the number of coronary artery bypass graft （CABG） surgery patients affected by depression （i.e., major, minor, dysthymia） approximates between 30% and 40% of all cases. A longstandi...Research to date indicates that the number of coronary artery bypass graft （CABG） surgery patients affected by depression （i.e., major, minor, dysthymia） approximates between 30% and 40% of all cases. A longstanding empirical interest on psychosocial factors in CABG surgery patients highlights an association with increased risk of morbidity in the short and longer term. Recent evidence suggests that both depression and anxiety increase the risk for mortality and morbidity after CABG surgery independent of medical factors, although the behavioral and biological mechanisms are poorly understood. Though neither depression nor anxiety seem to markedly affect neuropsy- chological dysfunction, depression confers a risk for incident delirium. Following a comprehensive overview of recent literature, practical advice is described for clinicians taking into consideration possible screening aids to improve recognition of anxiety and depression among CABG surgery patients. An overview of contemporary interventions and randomized, controlled trials are described, along with suggestions for future CABG surgery research.展开更多
During the past decades,major advances have been made in both the generation and detection of infrared light;however,its efficient wavefront manipulation and information processing still encounter great challenges.Eff...During the past decades,major advances have been made in both the generation and detection of infrared light;however,its efficient wavefront manipulation and information processing still encounter great challenges.Efficient and fast optoelectronic modulators and spatial light modulators are required for mid-infrared imaging,sensing,security screening,communication and navigation,to name a few.However,their development remains elusive,and prevailing methods reported so far have suffered from drawbacks that significantly limit their practical applications.In this study,by leveraging graphene and metasurfaces,we demonstrate a high-performance free-space mid-infrared modulator operating at gigahertz speeds,low gate voltage and room temperature.We further pixelate the hybrid graphene metasurface to form a prototype spatial light modulator for high frame rate single-pixel imaging,suggesting orders of magnitude improvement over conventional liquid crystal or micromirror-based spatial light modulators.This work opens up the possibility of exploring wavefront engineering for infrared technologies for which fast temporal and spatial modulations are indispensable.展开更多
The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and...The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)techniques.JARVIS is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment.展开更多
Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is slow.Our current research process is human-centred,where human rese...Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is slow.Our current research process is human-centred,where human researchers design,conduct,analyse and interpret experiments,and then decide what to do next.We have built an Autonomous Research System(ARES)—an autonomous research robot capable of first-of-its-kind closed-loop iterative materials experimentation.ARES exploits advances in autonomous robotics,artificial intelligence,data sciences,and high-throughput and in situ techniques,and is able to design,execute and analyse its own experiments orders of magnitude faster than current research methods.We applied ARES to study the synthesis of singlewalled carbon nanotubes,and show that it successfully learned to grow them at targeted growth rates.ARES has broad implications for the future roles of humans and autonomous research robots,and for human-machine partnering.We believe autonomous research robots like ARES constitute a disruptive advance in our ability to understand and develop complex materials at an unprecedented rate.展开更多
In the present study,the partial gene sequences of P32 protein,an immunogenic envelope protein of Capripoxviruses (CaPV),were analyzed to assess the genetic relationship among sheeppox and goatpox virus isolates,and r...In the present study,the partial gene sequences of P32 protein,an immunogenic envelope protein of Capripoxviruses (CaPV),were analyzed to assess the genetic relationship among sheeppox and goatpox virus isolates,and restriction enzyme specific PCR-RFLP was developed to differentiate CaPV strains.A total of six goatpox virus (GTPV) and nine sheeppox virus (SPPV) isolates of Indian origin were included in the sequence analysis of the attachment gene.The sequence analysis revealed a high degree of sequence identity among all the Indian SPPV and GTPV isolates at both nucleotide and amino acid levels.Phylogenetic analysis showed three distinct clusters of SPPV,GTPV and Lumpy skin disease virus (LSDV) isolates.Further,multiple sequence alignment revealed a unique change at G120A in all GTPV isolates resulting in the formation of Dra I restriction site in lieu of EcoR I,which is present in SPPV isolates studied.This change was unique and exploited to develop restriction enzyme specific PCR-RFLP for detection and differentiation of SPPV and GTPV strains.The optimized PCR-RFLP was validated using a total of fourteen (n=14) cell culture isolates and twenty two (n=22) known clinical samples of CaPV.The Restriction Enzyme specific PCR-RFLP to differentiate both species will allow a rapid differential diagnosis during CaPV outbreaks particularly in mixed flocks of sheep and goats and could be an adjunct/supportive tool for complete gene or virus genome sequencing methods.展开更多
Inferior cycling stability, poor safety, and gas generation are long lasting problems of Ni-rich Li Ni0.80 Co0.10 Mn0.10 O2(NCM811) cathode material. Although much effort has been made, mechanisms for the above proble...Inferior cycling stability, poor safety, and gas generation are long lasting problems of Ni-rich Li Ni0.80 Co0.10 Mn0.10 O2(NCM811) cathode material. Although much effort has been made, mechanisms for the above problems are poorly understood. Studying the cycling and float-charging characteristics of Li/NCM811 cells in high voltage conditions(4.5 V and 4.7 V, respectively), in this work we find that nearly all known problems with NCM811 material can be attributed to the oxidation of lattice oxygen occurring in the capacity region corresponding to H2 → H3 phase transition. While contributing to overall capacity,the oxidation of lattice oxygen results in a loss of oxygen through oxygen evolution and relative reactions between active oxygen evolution intermediates and electrolyte solvents. It is the loss of oxygen that results in irreversible layered-spinel-rocksalt phase transition, secondary particle cracking, and performance degradation. The conclusions of this work suggest that the priority for further research on NCM811 material should give to the suppression of oxygen evolution, followed by the use of the anti-oxygen electrolyte being chemically stable against the active oxygen evolution intermediates.展开更多
This article presents an up-to-date tutorial review of nonlinear Bayesian estimation. State estimation for nonlinear systems has been a challenge encountered in a wide range of engineering fields, attracting decades o...This article presents an up-to-date tutorial review of nonlinear Bayesian estimation. State estimation for nonlinear systems has been a challenge encountered in a wide range of engineering fields, attracting decades of research effort. To date,one of the most promising and popular approaches is to view and address the problem from a Bayesian probabilistic perspective,which enables estimation of the unknown state variables by tracking their probabilistic distribution or statistics(e.g., mean and covariance) conditioned on a system's measurement data.This article offers a systematic introduction to the Bayesian state estimation framework and reviews various Kalman filtering(KF)techniques, progressively from the standard KF for linear systems to extended KF, unscented KF and ensemble KF for nonlinear systems. It also overviews other prominent or emerging Bayesian estimation methods including Gaussian filtering, Gaussian-sum filtering, particle filtering and moving horizon estimation and extends the discussion of state estimation to more complicated problems such as simultaneous state and parameter/input estimation.展开更多
A sensitive and rapid single step real time （rt） RT-PCR was standardized using one-step Brilliant SYBR Green kit for detection and semi-quantitation ofpeste des petitis ruminants virus （PPRV） using the virus RNA a...A sensitive and rapid single step real time （rt） RT-PCR was standardized using one-step Brilliant SYBR Green kit for detection and semi-quantitation ofpeste des petitis ruminants virus （PPRV） using the virus RNA and matrix （M） protein gene-specific primers and compared with established conventional RT-PCR and TaqMan RT-PCR. The assay amplifies a 124 bp fragment of the PPRV M gene with Tm of 78.28 to 78.50. The assay was linear within a range of 50 ng to 0.5 fg total virus RNA with a detection limit （sensitivity） of 0.5 fg. Based on the serial dilution of the live-attenuated PPR vaccine virus, the detection limit was -0.0001 cell culture infectious dose 50% units （TCID50）. Additionally, swab materials spiked with known titre of vaccine virus were equally well detected in the assay. The standardized rt RT-PCR was easily employed for the detection of PPRV nucleic acid directly in the field and experimental clinical samples. The assay detected the PPRV nucleic acid as early as 3 day post infection （dpi） and up to 20 dpi in swab materials from the experimental samples. The assay was rapid and more sensitive than TaqMan and conventional RT-PCR in the detection of PPRV nucleic acid from the PPR suspected clinical samples of sheep and goats. Therefore, the established, simplified SYBR green rt RT-PCR is an alternative test to the already existing various diagnostic assays and could be useful for rapid clinical diagnosis with advantage in reducing risk of contamination.展开更多
Cancer is a leading cause of death worldwide, with breast cancer being the most common (2.26 million new cases and 685,000 deaths). In Saudi Arabia, breast cancer ranked the first among females in 2014, accounting for...Cancer is a leading cause of death worldwide, with breast cancer being the most common (2.26 million new cases and 685,000 deaths). In Saudi Arabia, breast cancer ranked the first among females in 2014, accounting for 15.9% of all cancers reported among Saudi nationals and 28.7% of all cancers reported among females of all ages. Early detection of breast cancer could decrease the risks, have a better prognosis, and have better outcomes/more successful treatments. Prevalence of breast cancer reached more than 25% of all diagnosed cancer in the kingdom among women. Aim: This study aims to assess the knowledge and performance of women attending primary care centers about breast self-examination and mammogram screening for prevention and early detection of breast cancer in Abha city primary healthcare centers, Kingdom of Saudi Arabia. Research Method: cross sectional design was conducted by using questionnaire, which was distributed to primary care center nurses. The collected data was statistically analyzed using the Statistical Package for Social Sciences, version 25. Results: The study found that participants had poor awareness and knowledge about breast self-examination, risk factors for breast cancer, and trends and practices in early diagnosis of breast cancer. Conclusion and Recommendations: It recommends increasing awareness campaigns and providing educational programs to improve knowledge and practices.展开更多
Introduction: Malnutrition is a major public health problem in Mali, despite the efforts of the government, its technical and financial partners. The aim of this study was to evaluate the integrated management program...Introduction: Malnutrition is a major public health problem in Mali, despite the efforts of the government, its technical and financial partners. The aim of this study was to evaluate the integrated management program for acute malnutrition (IMPAM). Methodology: This was a descriptive cross-sectional study that took place from January to December 2020 in the Douentza health district. The study included anyone with at least one malnourished child aged 6 to 59 months in their care who agreed to take part in the study, community health center staff who had given their consent, and the URENI manager at the Douentza reference health center. Data collected via questionnaires were entered into Excel and then analyzed using Epi-Info version 7 software. Results: A total of 138 acutely malnourished children aged 6 - 59 months, including 71 girls (51.45%), 138 accompanying mothers and 11 health workers, were included in our case study. Among the malnourished, 54.34% were in the 12 - 23 months age group and 69.57% had the severe form. 93% of the mothers interviewed were satisfied with the care provided, and all the health staff interviewed stated that community conflicts had an impact on IMPAM’s activities. Cure rates were 81% in Moderate Outpatient Nutritional Recovery and Education Unit (URENAM), 84% in Severe Ambulatory Nutritional Recovery and Education Unit (URENAS) and 92% in Recovery and Intensive Nutritional Education Unit (URENI). Drop-out rates were 19% in URENAM, 16% in URENAS and 0% in URENI. The death rate was 8% in URENI and 0% in URENAM and URENAS. Conclusion: This study confirms the high prevalence of malnutrition in the district (10.54%). It also reveals that factors such as inter-community conflict and insecurity have seriously affected the IMPAM program.展开更多
The electrolytes of Li-ion batteries consist mainly of a LiPF6 salt dissolved in a carbonate-based solvent mixture.Such electrolytes cannot support fast charge without detrimental impacts on performance and lifetime.F...The electrolytes of Li-ion batteries consist mainly of a LiPF6 salt dissolved in a carbonate-based solvent mixture.Such electrolytes cannot support fast charge without detrimental impacts on performance and lifetime.Fast charge aggravates parasitic reactions of the electrolyte solvents and structural degradation of the lithium layered transition metal oxide cathode materials.This leads to not only the depletion of electrolyte solvents but also the loss of cyclable Li+ions,accompanied by impedance growth and volumetric swelling of the battery.In this perspective,the design aspects of the electrolytes for fast charge of Li-ion batteries are discussed and proposed.展开更多
Many patients with spinal injures are confined to wheelchairs, leading to a sedentary lifestyle with secondary pathologies and increased dependence on a carer. Increasing evidence has shown that locomotor training red...Many patients with spinal injures are confined to wheelchairs, leading to a sedentary lifestyle with secondary pathologies and increased dependence on a carer. Increasing evidence has shown that locomotor training reduces the incidence of these secondary pathologies, but the physical effort involved in this training is such that there is poor compliance. This paper reports on the design and control of a new ＂human friendly＂ orthosis （exoskeleton）, powered by high power pneumatic Muscle Actuators （pMAs）. The combination of a highly compliant actuation system, with an intelligent embedded control mechanism which senses hip, knee, and ankle positions, velocity, acceleration and force, produces powerful yet inherently safe operation for paraplegic patients. This paper analyzes the motion of ankle, knee, and hip joints under zero loading, and loads which simulate human limb mass, showing that the use of ＂soft＂ actuators can provide a smooth user friendly motion. The application of this technology will greatly improve the rehabilitative protocols for paraplegic patients.展开更多
文摘In the 2015 review paper‘Petawatt Class Lasers Worldwide’a comprehensive overview of the current status of highpower facilities of>200 TW was presented.This was largely based on facility specifications,with some description of their uses,for instance in fundamental ultra-high-intensity interactions,secondary source generation,and inertial confinement fusion(ICF).With the 2018 Nobel Prize in Physics being awarded to Professors Donna Strickland and Gerard Mourou for the development of the technique of chirped pulse amplification(CPA),which made these lasers possible,we celebrate by providing a comprehensive update of the current status of ultra-high-power lasers and demonstrate how the technology has developed.We are now in the era of multi-petawatt facilities coming online,with 100 PW lasers being proposed and even under construction.In addition to this there is a pull towards development of industrial and multi-disciplinary applications,which demands much higher repetition rates,delivering high-average powers with higher efficiencies and the use of alternative wavelengths:mid-IR facilities.So apart from a comprehensive update of the current global status,we want to look at what technologies are to be deployed to get to these new regimes,and some of the critical issues facing their development.
文摘The International Agency for Research on Cancer(IARC)has classified outdoor air pollution and the particulate matter(PM)in outdoor air pollution as carcinogenic to humans,as based on sufficient evidence of carcinogenicity in humans and experimental animals and strong support by mechanistic studies.The data with important contributions to the evaluation are reviewed,highlighting the data with particular relevance to China,and implications of the evaluation with respect to China are discussed.The air pollution levels in Chinese cities are among the highest observed in the world today and frequently exceed healthbased national and international guidelines.Data from high-quality epidemiologic studies in Asia,Europe,and North America consistently show positive associations between lung cancer and PM exposure and other indicators of air pollution,which persist after adjustment for important lung cancer risk factors,such as tobacco smoking.Epidemiologic data from China are limited but nevertheless indicate an increased risk of lung cancer associated with several air pollutants.Excess cancer risk is also observed in experimental animals exposed to polluted outdoor air or extracted PM.The exposure of several species to outdoor air pollution is associated with markers of genetic damage that have been linked to increased cancer risk in humans.Numerous studies from China,especially genetic biomarker studies in exposed populations,support that the polluted air in China is genotoxic and carcinogenic to humans.The evaluation by IARC indicates both the need for further research into the cancer risks associated with exposure to air pollution in China and the urgent need to act to reduce exposure to the population.
文摘The Moderate Resolution Imaging Spectroradiometer （MODIS） is one of the key instruments for NASA＇s Earth Observing System （EOS）, currently operating on both the Terra and Aqua satellites. The MODIS is a major advance over the previous generation of sensors in terms of its spectral, spatial, and temporal resolutions. It has 36 spectral bands： 20 reflective solar bands （RSB） with center wavelengths from 0.41 to 2.1 μm and 16 thermal emissive bands （TEB） with center wavelengths from 3.7 to 14.4 μm, making observations at three spatial resolutions： 250 m （bands 1-2）, 500 m （bands 3-7）, and lkm （bands 8-36）. MODIS is a cross-track scanning radiometer with a wide field-of-view, providing a complete global coverage of the Earth in less than 2 days. Both Terra and Aqua MODIS went through extensive pre-launch calibration and characterization at various levels. In orbit, the calibration and characterization tasks are performed using its on-board calibrators （OBCs） that include a solar diffuser （SD） and a solar diffuser stability monitor （SDSM）, a v-grooved flat panel blackbody （BB）, and a spectro-radiometric calibration assembly （SRCA）. In this paper, we present an overview of MODIS calibration and characterization activities, methodologies, and lessons learned from pre-launch characterization and in-orbit operation. Key issues discussed in this paper include in-orbit efforts of monitoring the noise characteristics of the detectors, tracking the solar diffuser and optics degradations, and updating the sensor＇s response versus scan angle. The experiences and lessons learned through MODIS have played and will continue to play major roles in the design and characterization of future sensors.
文摘Nanocomposite coatings demonstrate improved friction and wear responses under severe sliding conditions in extreme environments. This paper provides a review how thin film multilayers and nanocomposites result in hard, tough, low-friction coatings. Approaches to couple multilayered and nanocomposite materials with other surface engineering strategies to achieve higher levels of performance in a variety of tribological applications are also discussed. Encapsulating lubricious phases in hard nanocomposite matri- ces is one approach that is discussed in detail. Results from state-of-the-art ＂chameleon＂ nanocomposites that exhibit reversible adaptability to ambient humidity or temperature are presented.
基金Y. L. acknowledges the financial support of this work in part by national science foundation （NSF） （No. CBET 1034222） and faculty research funds granted by the University of California, Santa Cruz. XPS was performed at the Center for Nanoscale Systems at Harvard University, which is supported by the NSF （No. ECS-0335765）. We thank H. Lin of Harvard University for technical assistance. Work at Lawrence Livermore National Laboratory was conducted under Contract No. DE-AC52-07NA27344.
文摘Graphene oxide （GO） can be reduced to graphene in a normal aerobic setup under ambient conditions as mediated by microbial respiration of Shewanella cells. The microbially-reduced graphene （MRG） exhibited excellent electrochemical properties. Extracellular electron transfer pathways at the cell/GO interface were systematically investigated, suggesting both direct electron transfer and electron mediators are involved in the GO reduction.
文摘Research to date indicates that the number of coronary artery bypass graft （CABG） surgery patients affected by depression （i.e., major, minor, dysthymia） approximates between 30% and 40% of all cases. A longstanding empirical interest on psychosocial factors in CABG surgery patients highlights an association with increased risk of morbidity in the short and longer term. Recent evidence suggests that both depression and anxiety increase the risk for mortality and morbidity after CABG surgery independent of medical factors, although the behavioral and biological mechanisms are poorly understood. Though neither depression nor anxiety seem to markedly affect neuropsy- chological dysfunction, depression confers a risk for incident delirium. Following a comprehensive overview of recent literature, practical advice is described for clinicians taking into consideration possible screening aids to improve recognition of anxiety and depression among CABG surgery patients. An overview of contemporary interventions and randomized, controlled trials are described, along with suggestions for future CABG surgery research.
基金the Los Alamos National Laboratory LDRD ProgramAFOSR under contract no.FA9550-12-0491the AFOSR YIP program under Contract no.FA9550-16-1-0183.
文摘During the past decades,major advances have been made in both the generation and detection of infrared light;however,its efficient wavefront manipulation and information processing still encounter great challenges.Efficient and fast optoelectronic modulators and spatial light modulators are required for mid-infrared imaging,sensing,security screening,communication and navigation,to name a few.However,their development remains elusive,and prevailing methods reported so far have suffered from drawbacks that significantly limit their practical applications.In this study,by leveraging graphene and metasurfaces,we demonstrate a high-performance free-space mid-infrared modulator operating at gigahertz speeds,low gate voltage and room temperature.We further pixelate the hybrid graphene metasurface to form a prototype spatial light modulator for high frame rate single-pixel imaging,suggesting orders of magnitude improvement over conventional liquid crystal or micromirror-based spatial light modulators.This work opens up the possibility of exploring wavefront engineering for infrared technologies for which fast temporal and spatial modulations are indispensable.
基金K.C.thanks the computational support from XSEDE computational resources under allocation number TGDMR 190095Contributions from K.C.were supported by the financial assistance award 70NANB19H117 from the U.S.Department of Commerce,National Institute of Standards and Technology+3 种基金Contributions by S.M.,K.H.,K.R.,and D.V.were supported by NSF DMREF Grant No.DMR-1629059 and No.DMR-1629346X.Q.was supported by NSF Grant No.OAC-1835690A.A.acknowledges partial support by CHiMaD(NIST award#70NANB19H005)G.P.was supported by the Los Alamos National Laboratory’s Laboratory Directed Research and Development(LDRD)program’s Directed Research(DR)project#20200104DR。
文摘The Joint Automated Repository for Various Integrated Simulations(JARVIS)is an integrated infrastructure to accelerate materials discovery and design using density functional theory(DFT),classical force-fields(FF),and machine learning(ML)techniques.JARVIS is motivated by the Materials Genome Initiative(MGI)principles of developing open-access databases and tools to reduce the cost and development time of materials discovery,optimization,and deployment.
文摘Advances in materials are an important contributor to our technological progress,and yet the process of materials discovery and development itself is slow.Our current research process is human-centred,where human researchers design,conduct,analyse and interpret experiments,and then decide what to do next.We have built an Autonomous Research System(ARES)—an autonomous research robot capable of first-of-its-kind closed-loop iterative materials experimentation.ARES exploits advances in autonomous robotics,artificial intelligence,data sciences,and high-throughput and in situ techniques,and is able to design,execute and analyse its own experiments orders of magnitude faster than current research methods.We applied ARES to study the synthesis of singlewalled carbon nanotubes,and show that it successfully learned to grow them at targeted growth rates.ARES has broad implications for the future roles of humans and autonomous research robots,and for human-machine partnering.We believe autonomous research robots like ARES constitute a disruptive advance in our ability to understand and develop complex materials at an unprecedented rate.
文摘In the present study,the partial gene sequences of P32 protein,an immunogenic envelope protein of Capripoxviruses (CaPV),were analyzed to assess the genetic relationship among sheeppox and goatpox virus isolates,and restriction enzyme specific PCR-RFLP was developed to differentiate CaPV strains.A total of six goatpox virus (GTPV) and nine sheeppox virus (SPPV) isolates of Indian origin were included in the sequence analysis of the attachment gene.The sequence analysis revealed a high degree of sequence identity among all the Indian SPPV and GTPV isolates at both nucleotide and amino acid levels.Phylogenetic analysis showed three distinct clusters of SPPV,GTPV and Lumpy skin disease virus (LSDV) isolates.Further,multiple sequence alignment revealed a unique change at G120A in all GTPV isolates resulting in the formation of Dra I restriction site in lieu of EcoR I,which is present in SPPV isolates studied.This change was unique and exploited to develop restriction enzyme specific PCR-RFLP for detection and differentiation of SPPV and GTPV strains.The optimized PCR-RFLP was validated using a total of fourteen (n=14) cell culture isolates and twenty two (n=22) known clinical samples of CaPV.The Restriction Enzyme specific PCR-RFLP to differentiate both species will allow a rapid differential diagnosis during CaPV outbreaks particularly in mixed flocks of sheep and goats and could be an adjunct/supportive tool for complete gene or virus genome sequencing methods.
文摘Inferior cycling stability, poor safety, and gas generation are long lasting problems of Ni-rich Li Ni0.80 Co0.10 Mn0.10 O2(NCM811) cathode material. Although much effort has been made, mechanisms for the above problems are poorly understood. Studying the cycling and float-charging characteristics of Li/NCM811 cells in high voltage conditions(4.5 V and 4.7 V, respectively), in this work we find that nearly all known problems with NCM811 material can be attributed to the oxidation of lattice oxygen occurring in the capacity region corresponding to H2 → H3 phase transition. While contributing to overall capacity,the oxidation of lattice oxygen results in a loss of oxygen through oxygen evolution and relative reactions between active oxygen evolution intermediates and electrolyte solvents. It is the loss of oxygen that results in irreversible layered-spinel-rocksalt phase transition, secondary particle cracking, and performance degradation. The conclusions of this work suggest that the priority for further research on NCM811 material should give to the suppression of oxygen evolution, followed by the use of the anti-oxygen electrolyte being chemically stable against the active oxygen evolution intermediates.
文摘This article presents an up-to-date tutorial review of nonlinear Bayesian estimation. State estimation for nonlinear systems has been a challenge encountered in a wide range of engineering fields, attracting decades of research effort. To date,one of the most promising and popular approaches is to view and address the problem from a Bayesian probabilistic perspective,which enables estimation of the unknown state variables by tracking their probabilistic distribution or statistics(e.g., mean and covariance) conditioned on a system's measurement data.This article offers a systematic introduction to the Bayesian state estimation framework and reviews various Kalman filtering(KF)techniques, progressively from the standard KF for linear systems to extended KF, unscented KF and ensemble KF for nonlinear systems. It also overviews other prominent or emerging Bayesian estimation methods including Gaussian filtering, Gaussian-sum filtering, particle filtering and moving horizon estimation and extends the discussion of state estimation to more complicated problems such as simultaneous state and parameter/input estimation.
基金Indian Council of Agricultural Research,New Delhi,India under Niche Area of Excellence:Production and Quality control of Veterinary Immunodiganostics and immunoprophylactics(F.No.10(11)2005-EP&D.dated 15.12.2005)
文摘A sensitive and rapid single step real time （rt） RT-PCR was standardized using one-step Brilliant SYBR Green kit for detection and semi-quantitation ofpeste des petitis ruminants virus （PPRV） using the virus RNA and matrix （M） protein gene-specific primers and compared with established conventional RT-PCR and TaqMan RT-PCR. The assay amplifies a 124 bp fragment of the PPRV M gene with Tm of 78.28 to 78.50. The assay was linear within a range of 50 ng to 0.5 fg total virus RNA with a detection limit （sensitivity） of 0.5 fg. Based on the serial dilution of the live-attenuated PPR vaccine virus, the detection limit was -0.0001 cell culture infectious dose 50% units （TCID50）. Additionally, swab materials spiked with known titre of vaccine virus were equally well detected in the assay. The standardized rt RT-PCR was easily employed for the detection of PPRV nucleic acid directly in the field and experimental clinical samples. The assay detected the PPRV nucleic acid as early as 3 day post infection （dpi） and up to 20 dpi in swab materials from the experimental samples. The assay was rapid and more sensitive than TaqMan and conventional RT-PCR in the detection of PPRV nucleic acid from the PPR suspected clinical samples of sheep and goats. Therefore, the established, simplified SYBR green rt RT-PCR is an alternative test to the already existing various diagnostic assays and could be useful for rapid clinical diagnosis with advantage in reducing risk of contamination.
文摘Cancer is a leading cause of death worldwide, with breast cancer being the most common (2.26 million new cases and 685,000 deaths). In Saudi Arabia, breast cancer ranked the first among females in 2014, accounting for 15.9% of all cancers reported among Saudi nationals and 28.7% of all cancers reported among females of all ages. Early detection of breast cancer could decrease the risks, have a better prognosis, and have better outcomes/more successful treatments. Prevalence of breast cancer reached more than 25% of all diagnosed cancer in the kingdom among women. Aim: This study aims to assess the knowledge and performance of women attending primary care centers about breast self-examination and mammogram screening for prevention and early detection of breast cancer in Abha city primary healthcare centers, Kingdom of Saudi Arabia. Research Method: cross sectional design was conducted by using questionnaire, which was distributed to primary care center nurses. The collected data was statistically analyzed using the Statistical Package for Social Sciences, version 25. Results: The study found that participants had poor awareness and knowledge about breast self-examination, risk factors for breast cancer, and trends and practices in early diagnosis of breast cancer. Conclusion and Recommendations: It recommends increasing awareness campaigns and providing educational programs to improve knowledge and practices.
文摘Introduction: Malnutrition is a major public health problem in Mali, despite the efforts of the government, its technical and financial partners. The aim of this study was to evaluate the integrated management program for acute malnutrition (IMPAM). Methodology: This was a descriptive cross-sectional study that took place from January to December 2020 in the Douentza health district. The study included anyone with at least one malnourished child aged 6 to 59 months in their care who agreed to take part in the study, community health center staff who had given their consent, and the URENI manager at the Douentza reference health center. Data collected via questionnaires were entered into Excel and then analyzed using Epi-Info version 7 software. Results: A total of 138 acutely malnourished children aged 6 - 59 months, including 71 girls (51.45%), 138 accompanying mothers and 11 health workers, were included in our case study. Among the malnourished, 54.34% were in the 12 - 23 months age group and 69.57% had the severe form. 93% of the mothers interviewed were satisfied with the care provided, and all the health staff interviewed stated that community conflicts had an impact on IMPAM’s activities. Cure rates were 81% in Moderate Outpatient Nutritional Recovery and Education Unit (URENAM), 84% in Severe Ambulatory Nutritional Recovery and Education Unit (URENAS) and 92% in Recovery and Intensive Nutritional Education Unit (URENI). Drop-out rates were 19% in URENAM, 16% in URENAS and 0% in URENI. The death rate was 8% in URENI and 0% in URENAM and URENAS. Conclusion: This study confirms the high prevalence of malnutrition in the district (10.54%). It also reveals that factors such as inter-community conflict and insecurity have seriously affected the IMPAM program.
基金Army Research Laboratory,Grant/Award Number:N/A。
文摘The electrolytes of Li-ion batteries consist mainly of a LiPF6 salt dissolved in a carbonate-based solvent mixture.Such electrolytes cannot support fast charge without detrimental impacts on performance and lifetime.Fast charge aggravates parasitic reactions of the electrolyte solvents and structural degradation of the lithium layered transition metal oxide cathode materials.This leads to not only the depletion of electrolyte solvents but also the loss of cyclable Li+ions,accompanied by impedance growth and volumetric swelling of the battery.In this perspective,the design aspects of the electrolytes for fast charge of Li-ion batteries are discussed and proposed.
文摘Many patients with spinal injures are confined to wheelchairs, leading to a sedentary lifestyle with secondary pathologies and increased dependence on a carer. Increasing evidence has shown that locomotor training reduces the incidence of these secondary pathologies, but the physical effort involved in this training is such that there is poor compliance. This paper reports on the design and control of a new ＂human friendly＂ orthosis （exoskeleton）, powered by high power pneumatic Muscle Actuators （pMAs）. The combination of a highly compliant actuation system, with an intelligent embedded control mechanism which senses hip, knee, and ankle positions, velocity, acceleration and force, produces powerful yet inherently safe operation for paraplegic patients. This paper analyzes the motion of ankle, knee, and hip joints under zero loading, and loads which simulate human limb mass, showing that the use of ＂soft＂ actuators can provide a smooth user friendly motion. The application of this technology will greatly improve the rehabilitative protocols for paraplegic patients.
