Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden casualties.Re...Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden casualties.Readily available drugs are getting ineffective by each passing day as the mutation is very fast in these pathogenic microbes resulting in drug resistance.The growing resistance of bacteria necessitates the development of new and effective compounds of desired characteristics that could bar the rapid development of bacterial cell inside of the host body.Along with cellular resistance for clinical antibiotics,co-bacterial infections during microbial attacks(viz.virus,fungus,protozoans etc.)also demand for some novel antibacterial drugs having high efficacy and minimal side effects on human body.These antibiotics should also be compatible with remedies ongoing for core microbial infections.So,in demand of search for effective antibacterial moieties,the scope of transition metal complexes as drug gives a good signal against the pathogenic bacteria by inhibiting their growth.The action of metal complexes on bacterial cell may be due to impremiablity,enzymatic interruptions,ribosomal interactions,disturbance in the path of protein synthesis,denaturing of genetic materials etc.inside the cell.Metals in complexes may interrupt the lipophilisity through the bacterial cell wall.Inclusion of metal ions in organic moieties behaving as ligand delocalizeπ-electrons upon the entire chelate ring and this chelation results in overlapping of ligand orbital and partial sharing of(+)ve charge of metal ion with donor atoms.These structural modifications in metal and organic lone pair donor species are the supposed reasons for their enhanced antimicrobial activities against pathogenic microbes.The present review focuses on the impact of recently synthesized,well characterized mono and binuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for t展开更多
This article explains ongoing changes in global climate and their effect on the resurgence of vector and pathogen populations in various parts of the world.Today,major prevailing changes are the elevation of global te...This article explains ongoing changes in global climate and their effect on the resurgence of vector and pathogen populations in various parts of the world.Today,major prevailing changes are the elevation of global temperature and accidental torrent rains,floods,droughts,and loss of productivity and food commodities.Due to the increase in water surface area and the longer presence of flood water,the breeding of insect vectors becomes very high;it is responsible for the emergence and re-emergence of so many communicable diseases.Due to the development of resistance to chemicals in insect pests,and pathogens and lack of control measures,communicable zoonotic diseases are remerging with high infectivity and mortality.This condition is becoming more alarming as the climate is favoring pathogen-host interactions and vector populations.Rapid changes seen in meteorology are promoting an unmanageable array of vector-borne infectious diseases,such as malaria,Japanese encephalitis,filarial,dengue,and leishmaniasis.Similarly,due to unhygienic conditions,poor sanitation,and infected ground and surface water outbreak of enteric infections such as cholera,vibriosis,and rotavirus is seen on the rise.In addition,parasitic infection ascariasis,fasciolosis,schistosomiasis,and dysentery cases are increasing.Today climate change is a major issue and challenge that needs timely quick solutions.Climate change is imposing non-adaptive forced human migration territorial conflicts,decreasing ecosystem productivity,disease outbreaks,and impelling unequal resource utilization.Rapid climate changes,parasites,pathogens,and vector populations are on the rise,which is making great threats to global health and the environment.This article highlighted the necessity to develop new strategies and control measures to cut down rising vector and pathogen populations in endemic areas.For finding quick solutions educational awareness,technology up-gradation,new vaccines,and safety measures have to be adopted to break the cycle of dreadful communicable 展开更多
The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of micro...The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of microwave technology. Elemental analyses, electrical conductance, magnetic moment and electronic, infrared, far-infrared, 1H and 13C NMR spectral studies were used to characterize the complexes. The molecular weights of few complexes were determined by FAB-mass spectra. Nephelauxetic ratio, covalency parameter and bonding parameter for these complexes were also calculated. The probable structures of the complexes were proposed. The antifungal and antibacterial activities of the complexes were evaluated. The activities were correlated with the structures of the compounds.展开更多
文摘Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden casualties.Readily available drugs are getting ineffective by each passing day as the mutation is very fast in these pathogenic microbes resulting in drug resistance.The growing resistance of bacteria necessitates the development of new and effective compounds of desired characteristics that could bar the rapid development of bacterial cell inside of the host body.Along with cellular resistance for clinical antibiotics,co-bacterial infections during microbial attacks(viz.virus,fungus,protozoans etc.)also demand for some novel antibacterial drugs having high efficacy and minimal side effects on human body.These antibiotics should also be compatible with remedies ongoing for core microbial infections.So,in demand of search for effective antibacterial moieties,the scope of transition metal complexes as drug gives a good signal against the pathogenic bacteria by inhibiting their growth.The action of metal complexes on bacterial cell may be due to impremiablity,enzymatic interruptions,ribosomal interactions,disturbance in the path of protein synthesis,denaturing of genetic materials etc.inside the cell.Metals in complexes may interrupt the lipophilisity through the bacterial cell wall.Inclusion of metal ions in organic moieties behaving as ligand delocalizeπ-electrons upon the entire chelate ring and this chelation results in overlapping of ligand orbital and partial sharing of(+)ve charge of metal ion with donor atoms.These structural modifications in metal and organic lone pair donor species are the supposed reasons for their enhanced antimicrobial activities against pathogenic microbes.The present review focuses on the impact of recently synthesized,well characterized mono and binuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for t
文摘This article explains ongoing changes in global climate and their effect on the resurgence of vector and pathogen populations in various parts of the world.Today,major prevailing changes are the elevation of global temperature and accidental torrent rains,floods,droughts,and loss of productivity and food commodities.Due to the increase in water surface area and the longer presence of flood water,the breeding of insect vectors becomes very high;it is responsible for the emergence and re-emergence of so many communicable diseases.Due to the development of resistance to chemicals in insect pests,and pathogens and lack of control measures,communicable zoonotic diseases are remerging with high infectivity and mortality.This condition is becoming more alarming as the climate is favoring pathogen-host interactions and vector populations.Rapid changes seen in meteorology are promoting an unmanageable array of vector-borne infectious diseases,such as malaria,Japanese encephalitis,filarial,dengue,and leishmaniasis.Similarly,due to unhygienic conditions,poor sanitation,and infected ground and surface water outbreak of enteric infections such as cholera,vibriosis,and rotavirus is seen on the rise.In addition,parasitic infection ascariasis,fasciolosis,schistosomiasis,and dysentery cases are increasing.Today climate change is a major issue and challenge that needs timely quick solutions.Climate change is imposing non-adaptive forced human migration territorial conflicts,decreasing ecosystem productivity,disease outbreaks,and impelling unequal resource utilization.Rapid climate changes,parasites,pathogens,and vector populations are on the rise,which is making great threats to global health and the environment.This article highlighted the necessity to develop new strategies and control measures to cut down rising vector and pathogen populations in endemic areas.For finding quick solutions educational awareness,technology up-gradation,new vaccines,and safety measures have to be adopted to break the cycle of dreadful communicable
文摘The new lanthanum (Ⅲ) and praseodymium (Ⅲ) complexes of the general formula [Ln(L)3] (Ln=La(Ⅲ) or Pr(Ⅲ); LK=potassium salt of dithiocarbazinates) were prepared by both, conventional thermal and by the use of microwave technology. Elemental analyses, electrical conductance, magnetic moment and electronic, infrared, far-infrared, 1H and 13C NMR spectral studies were used to characterize the complexes. The molecular weights of few complexes were determined by FAB-mass spectra. Nephelauxetic ratio, covalency parameter and bonding parameter for these complexes were also calculated. The probable structures of the complexes were proposed. The antifungal and antibacterial activities of the complexes were evaluated. The activities were correlated with the structures of the compounds.
