摘要
Bacterial infections are a major cause for impulsive deaths in human beings.Bacterial infections of the respiratory,gastrointestinal and central nervous system account for the majority of cases of sudden casualties.Readily available drugs are getting ineffective by each passing day as the mutation is very fast in these pathogenic microbes resulting in drug resistance.The growing resistance of bacteria necessitates the development of new and effective compounds of desired characteristics that could bar the rapid development of bacterial cell inside of the host body.Along with cellular resistance for clinical antibiotics,co-bacterial infections during microbial attacks(viz.virus,fungus,protozoans etc.)also demand for some novel antibacterial drugs having high efficacy and minimal side effects on human body.These antibiotics should also be compatible with remedies ongoing for core microbial infections.So,in demand of search for effective antibacterial moieties,the scope of transition metal complexes as drug gives a good signal against the pathogenic bacteria by inhibiting their growth.The action of metal complexes on bacterial cell may be due to impremiablity,enzymatic interruptions,ribosomal interactions,disturbance in the path of protein synthesis,denaturing of genetic materials etc.inside the cell.Metals in complexes may interrupt the lipophilisity through the bacterial cell wall.Inclusion of metal ions in organic moieties behaving as ligand delocalizeπ-electrons upon the entire chelate ring and this chelation results in overlapping of ligand orbital and partial sharing of(+)ve charge of metal ion with donor atoms.These structural modifications in metal and organic lone pair donor species are the supposed reasons for their enhanced antimicrobial activities against pathogenic microbes.The present review focuses on the impact of recently synthesized,well characterized mono and binuclear transition metal complexes of Cu ions that have the potential to be the drug of the decade in medicinal inorganic chemistry for t
