目的 研究女性泌尿生殖系统支原体感染状况及耐药性变迁,以指导临床合理应用抗菌药物.方法 采用病原培养法和荧光定量pcr法对2007年530例女性泌尿生殖道样本进行解脲支原体(uu)和人型支原体(mh)检测,同时进行体外药物敏感性试验,并与200...目的 研究女性泌尿生殖系统支原体感染状况及耐药性变迁,以指导临床合理应用抗菌药物.方法 采用病原培养法和荧光定量pcr法对2007年530例女性泌尿生殖道样本进行解脲支原体(uu)和人型支原体(mh)检测,同时进行体外药物敏感性试验,并与2000年的检测结果进行比较分析.结果 2000年共检出99例支原体感染,其中uu 65例,mh 15例,uu+mh 19例;2007年共检出344例支原体感染,其中uu 236例,mh 47例,uu+mh 61例.≤20岁年龄组支原体感染率由2000年的5.0%上升到2007年的12.8%,差异有统计学意义(χ2=4.682,p<0.05);21～30岁年龄组支原体感染率最高,两个年份分别为46.2%和50.5%.2000年和2007年,四环素和红霉素的耐药率均在80%以上;与2000年相比,2007年女性泌尿生殖系统支原体对左氧氟沙星、阿奇霉素和氧氟沙星的耐药率明显升高,差异有统计学意义(p均<0.05),而对强力霉素(dox)、米诺环素(min)和交沙霉素(jos)的耐药率最低且变化不显著.结论 女性泌尿生殖系统炎性反应以uu感染为主.女性泌尿生殖系统支原体感染有低龄化趋势,应引起社会各界的广泛关注.uu和mh对大部分大环内酯类和喹诺酮类药物的耐药性较高,临床上应尽量根据药物敏感性试验结果选择抗菌药物.dox、min和jos耐药率低且变化小,可在临床经验用药中作为首选药物.
abstract：
objective to investigate the infection of mycoplasma in female urogenital system and the evolution of drug resistance. methods ureaplasma urealyticum (uu) and mycoplasma hominis (mh) infections were examined by pathogen culture and fluorescence quantitative pcr in urogenital samples from 530 female patients in 2007, and drug sensitivity tests were performed in vitro. the results were compared with those in 2000. results in 2000, there were 99 patients with mycoplasma infections, in which 65 were of uu infections, 15 were of mh infections and 19 were of uu + mh infections. in 2007, there were 344 patient展开更多
文摘目的 研究女性泌尿生殖系统支原体感染状况及耐药性变迁,以指导临床合理应用抗菌药物.方法 采用病原培养法和荧光定量pcr法对2007年530例女性泌尿生殖道样本进行解脲支原体(uu)和人型支原体(mh)检测,同时进行体外药物敏感性试验,并与2000年的检测结果进行比较分析.结果 2000年共检出99例支原体感染,其中uu 65例,mh 15例,uu+mh 19例;2007年共检出344例支原体感染,其中uu 236例,mh 47例,uu+mh 61例.≤20岁年龄组支原体感染率由2000年的5.0%上升到2007年的12.8%,差异有统计学意义(χ2=4.682,p<0.05);21～30岁年龄组支原体感染率最高,两个年份分别为46.2%和50.5%.2000年和2007年,四环素和红霉素的耐药率均在80%以上;与2000年相比,2007年女性泌尿生殖系统支原体对左氧氟沙星、阿奇霉素和氧氟沙星的耐药率明显升高,差异有统计学意义(p均<0.05),而对强力霉素(dox)、米诺环素(min)和交沙霉素(jos)的耐药率最低且变化不显著.结论 女性泌尿生殖系统炎性反应以uu感染为主.女性泌尿生殖系统支原体感染有低龄化趋势,应引起社会各界的广泛关注.uu和mh对大部分大环内酯类和喹诺酮类药物的耐药性较高,临床上应尽量根据药物敏感性试验结果选择抗菌药物.dox、min和jos耐药率低且变化小,可在临床经验用药中作为首选药物.
abstract：
objective to investigate the infection of mycoplasma in female urogenital system and the evolution of drug resistance. methods ureaplasma urealyticum (uu) and mycoplasma hominis (mh) infections were examined by pathogen culture and fluorescence quantitative pcr in urogenital samples from 530 female patients in 2007, and drug sensitivity tests were performed in vitro. the results were compared with those in 2000. results in 2000, there were 99 patients with mycoplasma infections, in which 65 were of uu infections, 15 were of mh infections and 19 were of uu + mh infections. in 2007, there were 344 patient
