The basic research of tissue engineering is investigated over ten years old On the basis of understanding of the key techniques including isolation and culture of seeding cells, prefabrication of scaffold materials, t...The basic research of tissue engineering is investigated over ten years old On the basis of understanding of the key techniques including isolation and culture of seeding cells, prefabrication of scaffold materials, tissue construction in vitro and so on , the engineered tissue was transplanted into animals to repair tissue defect The research showed that engineered tissues could form new tissue and repair defects as well Recently, there were preliminary reports about clinical applications including engineered bone, cartilage, tendon and skin The preliminary clinical results were satisfactory However, it still needs to strengthen basic research and organize the multi center clinical studies, define the safety and efficacy of engineered tissue, the technical routes of clinical applications and others The extensive clinical applications should be approved by national government展开更多
Tendon tissue engineering is one of the research fields with longhistory, which has achieved dramatic advances This paper reviewed some recent original articles, mainly in sources of seeding cells of tendon tissue eng...Tendon tissue engineering is one of the research fields with longhistory, which has achieved dramatic advances This paper reviewed some recent original articles, mainly in sources of seeding cells of tendon tissue engineering, the level of immunological reaction with allogeneic tendon cells, preparation and screening of scaffold materials with specific mechanical and degenerating properties, the interaction of cells, scaffold materials, and so on To establish the standard tendon cell line for research has significance in the study of the biological characteristics of tendon cells, the cell model for immortalization, and screening the various scaffold materials The immunological reaction of the tissue engineered tendon with allogeneic cells in the research and future clinical applications must be clarified It is requested by tissue engineering research that the scaffold materials with specific mechanical and degenerating properties and the three dimensional culture technique mimic microenviroment in vivo, including the mechnical stress and strain All of those should be extensivly studied to lay a solid foundation for ultimate clinical展开更多
文摘The basic research of tissue engineering is investigated over ten years old On the basis of understanding of the key techniques including isolation and culture of seeding cells, prefabrication of scaffold materials, tissue construction in vitro and so on , the engineered tissue was transplanted into animals to repair tissue defect The research showed that engineered tissues could form new tissue and repair defects as well Recently, there were preliminary reports about clinical applications including engineered bone, cartilage, tendon and skin The preliminary clinical results were satisfactory However, it still needs to strengthen basic research and organize the multi center clinical studies, define the safety and efficacy of engineered tissue, the technical routes of clinical applications and others The extensive clinical applications should be approved by national government
文摘Tendon tissue engineering is one of the research fields with longhistory, which has achieved dramatic advances This paper reviewed some recent original articles, mainly in sources of seeding cells of tendon tissue engineering, the level of immunological reaction with allogeneic tendon cells, preparation and screening of scaffold materials with specific mechanical and degenerating properties, the interaction of cells, scaffold materials, and so on To establish the standard tendon cell line for research has significance in the study of the biological characteristics of tendon cells, the cell model for immortalization, and screening the various scaffold materials The immunological reaction of the tissue engineered tendon with allogeneic cells in the research and future clinical applications must be clarified It is requested by tissue engineering research that the scaffold materials with specific mechanical and degenerating properties and the three dimensional culture technique mimic microenviroment in vivo, including the mechnical stress and strain All of those should be extensivly studied to lay a solid foundation for ultimate clinical
