目的:探讨血清髓鞘碱性蛋白(myelin base protein,MBP)、促红细胞生成素受体(erythropoietin receptor,EPOR)联合头颅超声在新生儿窒息后脑损伤早期诊断中的意义。方法:选择内蒙古自治区妇幼保健院新生儿科收治的足月窒息新生儿,按照Ap...目的:探讨血清髓鞘碱性蛋白(myelin base protein,MBP)、促红细胞生成素受体(erythropoietin receptor,EPOR)联合头颅超声在新生儿窒息后脑损伤早期诊断中的意义。方法:选择内蒙古自治区妇幼保健院新生儿科收治的足月窒息新生儿,按照Apgar评分分为轻度窒息组与重度窒息组,同期该院产科分娩的正常足月新生儿作为对照组。分别比较各组新生儿血清MBP、EPOR含量及脑室内出血率、脑水肿发生率的差异。结果:窒息组血清MBP、EPOR水平及脑室内出血率均高于对照组,重度窒息组的头颅超声脑水肿检出率均显著高于对照组和轻度窒息组,差异均有统计学意义,轻度窒息组与重度窒息组之间差异无统计学意义。头颅超声异常新生儿血清MBP、EPOR水平均高于头颅超声正常者。结论:血清MBP及EPOR检测联合头颅超声检查可以为新生儿窒息后脑损伤早期诊断提供依据。展开更多
Objective To provide epidemiological data for revising the diagnostic criteria of neonatal hyperbilirubinemia in China Methods A survey was performed among full term infants in multiple centers throughout the coun...Objective To provide epidemiological data for revising the diagnostic criteria of neonatal hyperbilirubinemia in China Methods A survey was performed among full term infants in multiple centers throughout the country From less than 24 hours after birth, the infants' bilirubin levels were measured every day until the peak level fell to less than 68 4?μmol/L Auditory brainstem responses were assessed in 56 infants randomly chosen from those with serum bilirubin levels of higher than 220 5?μmol/L Results Jaundice in most infants was detected at 2-3 days after birth The bilirubin level usually reached a peak level of 204±54 69?μmol/L at 5 days after birth and then fell Among the 875 infants, the serum bilirubin levels in 34 4% of neonates were higher than 220 5?μmol/L The mean serum bilirubin level of the infants during the first week after birth varied with geography ( P <0 001) and season ( P <0 001) The serum bilirubin level was significantly associated with gestation age ( P <0 01), delivery method ( P <0 01), weight loss ( P <0 001), and PCV elevation ( P <0 001) during the first three days after birth Conclusions The start time of neonatal jaundice was similar to that reported elsewhere, but the mean peak level in our study was higher than the reported It is suggested that the diagnostic criteria for neonatal hyperbilirubinemia in China should be strict展开更多
文摘目的:探讨血清髓鞘碱性蛋白(myelin base protein,MBP)、促红细胞生成素受体(erythropoietin receptor,EPOR)联合头颅超声在新生儿窒息后脑损伤早期诊断中的意义。方法:选择内蒙古自治区妇幼保健院新生儿科收治的足月窒息新生儿,按照Apgar评分分为轻度窒息组与重度窒息组,同期该院产科分娩的正常足月新生儿作为对照组。分别比较各组新生儿血清MBP、EPOR含量及脑室内出血率、脑水肿发生率的差异。结果:窒息组血清MBP、EPOR水平及脑室内出血率均高于对照组,重度窒息组的头颅超声脑水肿检出率均显著高于对照组和轻度窒息组,差异均有统计学意义,轻度窒息组与重度窒息组之间差异无统计学意义。头颅超声异常新生儿血清MBP、EPOR水平均高于头颅超声正常者。结论:血清MBP及EPOR检测联合头颅超声检查可以为新生儿窒息后脑损伤早期诊断提供依据。
文摘Objective To provide epidemiological data for revising the diagnostic criteria of neonatal hyperbilirubinemia in China Methods A survey was performed among full term infants in multiple centers throughout the country From less than 24 hours after birth, the infants' bilirubin levels were measured every day until the peak level fell to less than 68 4?μmol/L Auditory brainstem responses were assessed in 56 infants randomly chosen from those with serum bilirubin levels of higher than 220 5?μmol/L Results Jaundice in most infants was detected at 2-3 days after birth The bilirubin level usually reached a peak level of 204±54 69?μmol/L at 5 days after birth and then fell Among the 875 infants, the serum bilirubin levels in 34 4% of neonates were higher than 220 5?μmol/L The mean serum bilirubin level of the infants during the first week after birth varied with geography ( P <0 001) and season ( P <0 001) The serum bilirubin level was significantly associated with gestation age ( P <0 01), delivery method ( P <0 01), weight loss ( P <0 001), and PCV elevation ( P <0 001) during the first three days after birth Conclusions The start time of neonatal jaundice was similar to that reported elsewhere, but the mean peak level in our study was higher than the reported It is suggested that the diagnostic criteria for neonatal hyperbilirubinemia in China should be strict
