目前,临床诊断癌症的金标准是病理学的检测。但是该操作需要进行活检或内镜活检,这是一种侵入性检查,且一定程度上受制于医师的经验水平,因此不能作为肺癌的早期诊断和常规体格检查。近年来,太赫兹光谱技术已应用于多种癌种的肿瘤组织...目前,临床诊断癌症的金标准是病理学的检测。但是该操作需要进行活检或内镜活检,这是一种侵入性检查,且一定程度上受制于医师的经验水平,因此不能作为肺癌的早期诊断和常规体格检查。近年来,太赫兹光谱技术已应用于多种癌种的肿瘤组织与正常组织之间的检测。因此,探索一种高分辨率的检测方法来区分癌组织和癌旁组织具有重要意义,可以实现癌症的早发现、早诊断、早治疗。在这项研究中,我们利用太赫兹时域光谱技术研究胃肠道肿瘤组织与正常组织之间的关系,以及胃肠道不同部位肿瘤组织之间的关系。通过测量折射率、吸收系数,我们发现肿瘤组织与正常组织的太赫兹光谱曲线存在显著差异。消化道不同部位肿瘤的太赫兹光谱曲线也表现出不同的趋势。因此,太赫兹时域光谱技术具有区分肿瘤和正常组织的潜力。At present, the golden standard for clinical diagnosis of cancer is pathological examination. However, this procedure requires a biopsy or endoscopic biopsy, which is invasive examinations and limited by physician’s level of experience. Therefore, it can not be used as an early diagnosis and routine physical examination for lung cancer. In recent years, terahertz spectroscopy has been applied to detect tumor tissues and normal tissues of many kinds of cancers. Therefore, it is of great significance to explore a high-resolution detection method to distinguish cancer tissues from para-cancer tissue, which can realize early detection, early diagnosis and early treatment of cancer. In this study, we use terahertz time-domain spectroscopy to investigate the relationship between gastrointestinal tumor tissue and normal tissue, as well as the relationship between tumor tissue at different sites of the gastrointestinal tract. By measuring the refractive index and absorption constant, we find that the terahertz spectra of tumor tissues are significantly different from those of展开更多
目的:血尿酸水平与膝骨关节炎之间的关联性尚存在争议,我们的研究目的是在确定血尿酸水平与膝骨关节炎之间的相关性。方法:基于中国健康与退休纵向研究(China Health and Retirement Longitudinal Study, CHARLS)进行的全国中老年基线...目的:血尿酸水平与膝骨关节炎之间的关联性尚存在争议,我们的研究目的是在确定血尿酸水平与膝骨关节炎之间的相关性。方法:基于中国健康与退休纵向研究(China Health and Retirement Longitudinal Study, CHARLS)进行的全国中老年基线数据调查,共纳入5176名中老年男性非住院患者(年龄 ≥ 45岁)。采用logistic回归模型、受试者工作特征(ROC)曲线对血尿酸水平与膝骨关节炎患病率进行相关性研究。结果:血尿酸与KOA发病具有显著相关性(P = 0.001, OR = 1.386, 95% CI 1.319~1.455)。结论:在中国中老年男性非住院患者人群中,血尿酸水平与膝骨关节炎具有相关性,血尿酸水平能预测膝骨关节炎发病率。展开更多
基金supported by grants from the National Key Basic Research Program of China (No. 2011CB504102)the National Natural Science Foundation of China (No. 31571054, 81430024)Excellent Innovative Team of Shandong Province and Taishan Scholars Construction Project, China
文摘目前,临床诊断癌症的金标准是病理学的检测。但是该操作需要进行活检或内镜活检,这是一种侵入性检查,且一定程度上受制于医师的经验水平,因此不能作为肺癌的早期诊断和常规体格检查。近年来,太赫兹光谱技术已应用于多种癌种的肿瘤组织与正常组织之间的检测。因此,探索一种高分辨率的检测方法来区分癌组织和癌旁组织具有重要意义,可以实现癌症的早发现、早诊断、早治疗。在这项研究中,我们利用太赫兹时域光谱技术研究胃肠道肿瘤组织与正常组织之间的关系,以及胃肠道不同部位肿瘤组织之间的关系。通过测量折射率、吸收系数,我们发现肿瘤组织与正常组织的太赫兹光谱曲线存在显著差异。消化道不同部位肿瘤的太赫兹光谱曲线也表现出不同的趋势。因此,太赫兹时域光谱技术具有区分肿瘤和正常组织的潜力。At present, the golden standard for clinical diagnosis of cancer is pathological examination. However, this procedure requires a biopsy or endoscopic biopsy, which is invasive examinations and limited by physician’s level of experience. Therefore, it can not be used as an early diagnosis and routine physical examination for lung cancer. In recent years, terahertz spectroscopy has been applied to detect tumor tissues and normal tissues of many kinds of cancers. Therefore, it is of great significance to explore a high-resolution detection method to distinguish cancer tissues from para-cancer tissue, which can realize early detection, early diagnosis and early treatment of cancer. In this study, we use terahertz time-domain spectroscopy to investigate the relationship between gastrointestinal tumor tissue and normal tissue, as well as the relationship between tumor tissue at different sites of the gastrointestinal tract. By measuring the refractive index and absorption constant, we find that the terahertz spectra of tumor tissues are significantly different from those of
文摘目的:血尿酸水平与膝骨关节炎之间的关联性尚存在争议,我们的研究目的是在确定血尿酸水平与膝骨关节炎之间的相关性。方法:基于中国健康与退休纵向研究(China Health and Retirement Longitudinal Study, CHARLS)进行的全国中老年基线数据调查,共纳入5176名中老年男性非住院患者(年龄 ≥ 45岁)。采用logistic回归模型、受试者工作特征(ROC)曲线对血尿酸水平与膝骨关节炎患病率进行相关性研究。结果:血尿酸与KOA发病具有显著相关性(P = 0.001, OR = 1.386, 95% CI 1.319~1.455)。结论:在中国中老年男性非住院患者人群中,血尿酸水平与膝骨关节炎具有相关性,血尿酸水平能预测膝骨关节炎发病率。
