TRESK is the most recently reported two-pore domain K^＋ channel, and different from other two-pore domain channels in gene, molecular structure, electrophysiological and pharmacological properties. Although the curre...TRESK is the most recently reported two-pore domain K^＋ channel, and different from other two-pore domain channels in gene, molecular structure, electrophysiological and pharmacological properties. Although the current knowledge of this potassium channel is inadequate, researches have demonstrated that TRESK is remarkablely linked to acute and chronic pain by activation of calcineurin. The fact that TRESK is sensitive to volatile anesthetics and localization in central nerve system implies that TRESK may play a very important role in the mechanism mediating general anesthesia. The further research of TRESK may contribute to explore the underlying mechanism of some pathological conditions and yield novel treatments for some diseases.展开更多
双孔通道(two-pore channels,TPCs)是一类位于内溶酶体膜上的非选择性阳离子渗透性通道,也是电压门控离子通道(voltage-gated ion channel,VGICs)超家族中进化上的重要成员。双孔通道广泛存在于动植物中,主要以酸性储存的方式表达。该...双孔通道(two-pore channels,TPCs)是一类位于内溶酶体膜上的非选择性阳离子渗透性通道,也是电压门控离子通道(voltage-gated ion channel,VGICs)超家族中进化上的重要成员。双孔通道广泛存在于动植物中,主要以酸性储存的方式表达。该文综述了TPCs的结构、分布以及TPCs激活机制研究进展,并将目前有关TPCs与相关配体激活研究过程中存在的问题加以总结,旨在为今后研究和治疗以TPCs为靶向的相关疾病提供参考。展开更多
基金This work was supported by the National Natural Science Foundation of China （No. 30672020）；the B. Braun Anesthesia Foundation of B. Braun Medical （Shanghai） International Trading Co., Ltd.
文摘TRESK is the most recently reported two-pore domain K^＋ channel, and different from other two-pore domain channels in gene, molecular structure, electrophysiological and pharmacological properties. Although the current knowledge of this potassium channel is inadequate, researches have demonstrated that TRESK is remarkablely linked to acute and chronic pain by activation of calcineurin. The fact that TRESK is sensitive to volatile anesthetics and localization in central nerve system implies that TRESK may play a very important role in the mechanism mediating general anesthesia. The further research of TRESK may contribute to explore the underlying mechanism of some pathological conditions and yield novel treatments for some diseases.
文摘双孔通道(two-pore channels,TPCs)是一类位于内溶酶体膜上的非选择性阳离子渗透性通道,也是电压门控离子通道(voltage-gated ion channel,VGICs)超家族中进化上的重要成员。双孔通道广泛存在于动植物中,主要以酸性储存的方式表达。该文综述了TPCs的结构、分布以及TPCs激活机制研究进展,并将目前有关TPCs与相关配体激活研究过程中存在的问题加以总结,旨在为今后研究和治疗以TPCs为靶向的相关疾病提供参考。
