AIMS To study the pathologic classification of gastric neuroendocrine tumors and its clinicopathologic significance. METHODS Paraffin embedded sections of 52 gastric neuroendocrine tumors including 42 carcinoid tu...AIMS To study the pathologic classification of gastric neuroendocrine tumors and its clinicopathologic significance. METHODS Paraffin embedded sections of 52 gastric neuroendocrine tumors including 42 carcinoid tumors, and 10 cases of neuroendocrine carcinoma from 326 patients who underwent resection of stomach carcinomas were studied by immunohistochemical methods including 10 endocrine markers or hormones antibodies and endocrine cells in gastric neuroendocrine tumors and extratumoral mucosa were observed under electromicroscope. RESULTS The 52 gastric neuroendocrine tumors were divided into three types: ① Gastrin dependent type of carcinoid (26 cases) accompanied by chronic atrophic gastritis (CAG) and tumor extension limited to the mucosa or submucosa complicated with hypergastrinemia and G cell hyperplasia. This type was consistently preceded by and associated with generalized proliferation of endocrine cells in the extratomoral fundic mucosa. ② Non gastrin dependent type of carcinoids (16 cases) associated with neither CAG nor hypergastrinemia. This type was more aggressive; and ③ Neuroendocrie carcinomas (10 cases), which are highly aggressive tumors. CONCLUSIONS A correct identification of different types of gastric endocrine tumors has major implications for the treatment and prognosis of the patients.展开更多
Five cues of primary chondrosarcoma, a rare tumor of the lung, are reported. The diagnosis should be made by pathology. The diagnosis can not be made in some conditions including: (1) tumor from the chest wall; (2) ch...Five cues of primary chondrosarcoma, a rare tumor of the lung, are reported. The diagnosis should be made by pathology. The diagnosis can not be made in some conditions including: (1) tumor from the chest wall; (2) chondroaarcoma of bone discovered after operation; (3) ovarian teratoma found prior to operation; (4) patient with history of hamartoma of the lung; and (5) atypical pathology. It has no close relation tetween pathologic subtyping and prognosis of the disease. The main cause of death was intralobar spread of the lung. Extrathoracic metastasis was no observed and surgical resection is the primary option of therapeutic management for this tumor.展开更多
文摘AIMS To study the pathologic classification of gastric neuroendocrine tumors and its clinicopathologic significance. METHODS Paraffin embedded sections of 52 gastric neuroendocrine tumors including 42 carcinoid tumors, and 10 cases of neuroendocrine carcinoma from 326 patients who underwent resection of stomach carcinomas were studied by immunohistochemical methods including 10 endocrine markers or hormones antibodies and endocrine cells in gastric neuroendocrine tumors and extratumoral mucosa were observed under electromicroscope. RESULTS The 52 gastric neuroendocrine tumors were divided into three types: ① Gastrin dependent type of carcinoid (26 cases) accompanied by chronic atrophic gastritis (CAG) and tumor extension limited to the mucosa or submucosa complicated with hypergastrinemia and G cell hyperplasia. This type was consistently preceded by and associated with generalized proliferation of endocrine cells in the extratomoral fundic mucosa. ② Non gastrin dependent type of carcinoids (16 cases) associated with neither CAG nor hypergastrinemia. This type was more aggressive; and ③ Neuroendocrie carcinomas (10 cases), which are highly aggressive tumors. CONCLUSIONS A correct identification of different types of gastric endocrine tumors has major implications for the treatment and prognosis of the patients.
文摘Five cues of primary chondrosarcoma, a rare tumor of the lung, are reported. The diagnosis should be made by pathology. The diagnosis can not be made in some conditions including: (1) tumor from the chest wall; (2) chondroaarcoma of bone discovered after operation; (3) ovarian teratoma found prior to operation; (4) patient with history of hamartoma of the lung; and (5) atypical pathology. It has no close relation tetween pathologic subtyping and prognosis of the disease. The main cause of death was intralobar spread of the lung. Extrathoracic metastasis was no observed and surgical resection is the primary option of therapeutic management for this tumor.
