Solasodine rhamnosyl glycosides (SRGs) are chemotherapeutic agents for the treatment of cancer. SRGs in a cream formulation, CuradermBEC5, is very effective for the treatment of nonmelanoma skin cancers with excellent...Solasodine rhamnosyl glycosides (SRGs) are chemotherapeutic agents for the treatment of cancer. SRGs in a cream formulation, CuradermBEC5, is very effective for the treatment of nonmelanoma skin cancers with excellent cosmetic end results. Intralesion injection of SRGs successfully dispose of very large tumours in animals without any clinical adverse effects. The mode of action of SRGs is by apoptosis. In this study, it is shown that small to large basal cell carcinomas are effectively treated only with topical application of CuradermBEC5. Here it is reported for the first time that combination of intralesion SRG injection and topical application with CuradermBEC5 in humans reduces the treatment time period by more than half when compared with topical application as the sole treatment regime. Two intralesion injections of very low doses of SRGs rapidly and effectively remove a large melanoma on a horse. If rapid removal of large troublesome skin cancers is required then this can be achieved by intralesion and topical treatments. Intralesion or combination therapy with SRGs may have some applications for melanomas in situ such as lentigo maligna.展开更多
Introducing the surface properties [initial vortex, ground temperature and surface momentum impact height （SMIH）] for the boundary conditions, dust-devil-scale large eddy simulations （LES） were carried out. Given ...Introducing the surface properties [initial vortex, ground temperature and surface momentum impact height （SMIH）] for the boundary conditions, dust-devil-scale large eddy simulations （LES） were carried out. Given three parameters of initial vortex, ground temperature and the SMIH based on Sinclair＇s observation, the dust devil physical characteristics, such as maximum tangential velocity, updraft velocity, pressure drop in the inner core region, and even reverse flow at the top of the core region, are predicted, and are found to be close to the observations, thus demonstrating the ability of the simulation. The physical characteristics of different modeled dust devils are reproduced and compared to the values predicted by Renno et al.＇ theory. Even for smaller temperature differences or weaker buoyancy, severe dust devils may be formed by strong incipient vortices. It is also indicated that SMIH substantially affects the near-surface shape of terrestrial dust devils.展开更多
William Faulkner worte a great number of works taking American south as the setting.The Hamlet is one of these works.The paper is aimed to analyze its major female character Eula Varner based upon the theory of person...William Faulkner worte a great number of works taking American south as the setting.The Hamlet is one of these works.The paper is aimed to analyze its major female character Eula Varner based upon the theory of personality structure.There is a corresponding relationship between the id,the ego and the superego and Eula s different aspects of being devil,human and saint.According to the theory,the three parts of personality structure are unified and coordinated mutually.Therefore,It could be concluded that Eula is the trinity of devil,human and saint.展开更多
The frequent attacks of strong and extraordinarily strong dust devil in the northern China in recent years are closely related to the serious destruction of the vegetation in the region in recent decades, the increasi...The frequent attacks of strong and extraordinarily strong dust devil in the northern China in recent years are closely related to the serious destruction of the vegetation in the region in recent decades, the increasing expansion of the desertification area, the increase of sand sources due to eco environmental deterioration, the warming up of climate and the weakening of the resisting capacity of our natural environment against dust devil. Measures for preventing and controlling dust devil are to improve the eco environment by increasing vegetation, establish a dust devil pre warning system and a dynamic monitoring & forecast system for dust dveil frequent areas, and enhance the enforcement of laws and administrative efforts so as to bring the eco environment construction of dust devil afflicted areas into the orbit of laws.展开更多
This paper is a further work of the authors＇ paper published previously （Liao T H and Gao Q 2005 Chin. Phys. Lett. 22 2316）. The amplitudes of fractional Fourier transform of Cantor sets are analysed from the viewp...This paper is a further work of the authors＇ paper published previously （Liao T H and Gao Q 2005 Chin. Phys. Lett. 22 2316）. The amplitudes of fractional Fourier transform of Cantor sets are analysed from the viewpoint of multifractal by wavelet transform maxima method （WTMM）. An integral operation is carried out before the application of WTMM, such that the function obtained can be considered as the perturbed devil staircase. Also, wavelets with large number of vanishing moments are used, which makes the complete singularity spectrum more accessible. The validity of multifractal formalism is guaranteed by restricting parameter q to a proper range, so that the phenomenon of multifractal phase transition can be explained reasonably. Particularly, the method of determining the range of parameter q in the above paper is developed to be more operational and rigorous.展开更多
Background: Psoriasis is a chronic disease that can have significant effects on quality of life. Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can ...Background: Psoriasis is a chronic disease that can have significant effects on quality of life. Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can treat psoriasis. Case Presentation: We report a case of a 54-year-old French-Vietnamese male who presented with diagnosed erythematous scaly annular recalcitrant psoriasis scattered throughout his body. Method: After failing conventional treatment regimens for over 10 years the patient received a trial with a topical cream formulation PsorendBEC, containing solasodine glycosides, for his psoriasis. Result: Topical applications of PsorendBEC twice daily resulted in complete resolution of cutaneous lesions after 4 weeks of treatment with no recurrence post 1 year after therapy. Conclusion: Topical PsorendBEC therapy rapidly removes recalcitrant psoriasis with no apparent side effects.展开更多
文摘Solasodine rhamnosyl glycosides (SRGs) are chemotherapeutic agents for the treatment of cancer. SRGs in a cream formulation, CuradermBEC5, is very effective for the treatment of nonmelanoma skin cancers with excellent cosmetic end results. Intralesion injection of SRGs successfully dispose of very large tumours in animals without any clinical adverse effects. The mode of action of SRGs is by apoptosis. In this study, it is shown that small to large basal cell carcinomas are effectively treated only with topical application of CuradermBEC5. Here it is reported for the first time that combination of intralesion SRG injection and topical application with CuradermBEC5 in humans reduces the treatment time period by more than half when compared with topical application as the sole treatment regime. Two intralesion injections of very low doses of SRGs rapidly and effectively remove a large melanoma on a horse. If rapid removal of large troublesome skin cancers is required then this can be achieved by intralesion and topical treatments. Intralesion or combination therapy with SRGs may have some applications for melanomas in situ such as lentigo maligna.
文摘Introducing the surface properties [initial vortex, ground temperature and surface momentum impact height （SMIH）] for the boundary conditions, dust-devil-scale large eddy simulations （LES） were carried out. Given three parameters of initial vortex, ground temperature and the SMIH based on Sinclair＇s observation, the dust devil physical characteristics, such as maximum tangential velocity, updraft velocity, pressure drop in the inner core region, and even reverse flow at the top of the core region, are predicted, and are found to be close to the observations, thus demonstrating the ability of the simulation. The physical characteristics of different modeled dust devils are reproduced and compared to the values predicted by Renno et al.＇ theory. Even for smaller temperature differences or weaker buoyancy, severe dust devils may be formed by strong incipient vortices. It is also indicated that SMIH substantially affects the near-surface shape of terrestrial dust devils.
文摘William Faulkner worte a great number of works taking American south as the setting.The Hamlet is one of these works.The paper is aimed to analyze its major female character Eula Varner based upon the theory of personality structure.There is a corresponding relationship between the id,the ego and the superego and Eula s different aspects of being devil,human and saint.According to the theory,the three parts of personality structure are unified and coordinated mutually.Therefore,It could be concluded that Eula is the trinity of devil,human and saint.
文摘The frequent attacks of strong and extraordinarily strong dust devil in the northern China in recent years are closely related to the serious destruction of the vegetation in the region in recent decades, the increasing expansion of the desertification area, the increase of sand sources due to eco environmental deterioration, the warming up of climate and the weakening of the resisting capacity of our natural environment against dust devil. Measures for preventing and controlling dust devil are to improve the eco environment by increasing vegetation, establish a dust devil pre warning system and a dynamic monitoring & forecast system for dust dveil frequent areas, and enhance the enforcement of laws and administrative efforts so as to bring the eco environment construction of dust devil afflicted areas into the orbit of laws.
文摘This paper is a further work of the authors＇ paper published previously （Liao T H and Gao Q 2005 Chin. Phys. Lett. 22 2316）. The amplitudes of fractional Fourier transform of Cantor sets are analysed from the viewpoint of multifractal by wavelet transform maxima method （WTMM）. An integral operation is carried out before the application of WTMM, such that the function obtained can be considered as the perturbed devil staircase. Also, wavelets with large number of vanishing moments are used, which makes the complete singularity spectrum more accessible. The validity of multifractal formalism is guaranteed by restricting parameter q to a proper range, so that the phenomenon of multifractal phase transition can be explained reasonably. Particularly, the method of determining the range of parameter q in the above paper is developed to be more operational and rigorous.
文摘Background: Psoriasis is a chronic disease that can have significant effects on quality of life. Aim: To test whether the antineoplastic, antipathogenic plant derived secondary metabolites, solasodine glycosides, can treat psoriasis. Case Presentation: We report a case of a 54-year-old French-Vietnamese male who presented with diagnosed erythematous scaly annular recalcitrant psoriasis scattered throughout his body. Method: After failing conventional treatment regimens for over 10 years the patient received a trial with a topical cream formulation PsorendBEC, containing solasodine glycosides, for his psoriasis. Result: Topical applications of PsorendBEC twice daily resulted in complete resolution of cutaneous lesions after 4 weeks of treatment with no recurrence post 1 year after therapy. Conclusion: Topical PsorendBEC therapy rapidly removes recalcitrant psoriasis with no apparent side effects.
