Musashi(MSI)是一个在进化上十分保守的RNA结合蛋白,MSI最初与造血干细胞等多种干细胞的维持控制相关。近年来研究显示,MSI在多种癌症中发挥癌蛋白作用,包括白血病(leukemia)、结直肠癌(carcinoma of colon and rectum)、胶质母细胞瘤(g...Musashi(MSI)是一个在进化上十分保守的RNA结合蛋白,MSI最初与造血干细胞等多种干细胞的维持控制相关。近年来研究显示,MSI在多种癌症中发挥癌蛋白作用,包括白血病(leukemia)、结直肠癌(carcinoma of colon and rectum)、胶质母细胞瘤(glioblastoma)、胰腺癌(pancreatic cancer)、前列腺癌(prostate cancer)、乳腺癌(breast cancer)、肺癌(lung cancer)和膀胱癌(bladder cancer)。MSI结合多个靶标分子并调节其稳定性和翻译,从而促进肿瘤的侵袭、转移及耐药等。虽然MSI被视为难以治疗的靶标,但基于RNA干扰的方法开发MSI特异性抑制剂已有初步进展。本文系统综述了MSI在肿瘤中的驱动作用以及靶向MSI抑制剂的研究进展,并对MSI抑制剂开发的挑战和方向进行讨论。展开更多
Oligodeoxynucleotide from SARS virus was selected and synthesized. Its complexes with alkaloid compounds were investigated by electrospray mass spectrometry. We found that three alkaloid compounds could interact with ...Oligodeoxynucleotide from SARS virus was selected and synthesized. Its complexes with alkaloid compounds were investigated by electrospray mass spectrometry. We found that three alkaloid compounds could interact with the DNA target molecule in five alkaloids analyzed. With increasing molar ratio of the three alkaloid compounds, the complexes between alkaloids and DNA with different stoichiometric ratios were found in their MS spectra. The order of the alkalinity of their gas phase corresponds to that of liquid phase, that is: Palmatine>Jatrorrhizine>Berberin. The relative abundance of these complexes in mass spectra can assess the relative affinities of above three alkaloid compounds with the DNA target molecule. In this paper, the binding sites between jatrorrhizine and DNA was deduced from the interaction experiments of jatrorrhizine with three nucleosides.展开更多
Resveratrol is a kind of polyphenolic compound that widely exists in plants and has extensive physiological pharmacological function and is very useful for human health. For the mechanism of action and function of RV,...Resveratrol is a kind of polyphenolic compound that widely exists in plants and has extensive physiological pharmacological function and is very useful for human health. For the mechanism of action and function of RV, people are doing a variety of groundbreaking researches. Results show that the molecular mechanism of RV is embodied in aspects such as oxidative stress and diseases of neuropathy, anti-oxygenation and pro-oxidant effect and RV target molecule, etc. This article mainly summarized the mechanism of action of resveratrol in these aspects.展开更多
文摘Musashi(MSI)是一个在进化上十分保守的RNA结合蛋白,MSI最初与造血干细胞等多种干细胞的维持控制相关。近年来研究显示,MSI在多种癌症中发挥癌蛋白作用,包括白血病(leukemia)、结直肠癌(carcinoma of colon and rectum)、胶质母细胞瘤(glioblastoma)、胰腺癌(pancreatic cancer)、前列腺癌(prostate cancer)、乳腺癌(breast cancer)、肺癌(lung cancer)和膀胱癌(bladder cancer)。MSI结合多个靶标分子并调节其稳定性和翻译,从而促进肿瘤的侵袭、转移及耐药等。虽然MSI被视为难以治疗的靶标,但基于RNA干扰的方法开发MSI特异性抑制剂已有初步进展。本文系统综述了MSI在肿瘤中的驱动作用以及靶向MSI抑制剂的研究进展,并对MSI抑制剂开发的挑战和方向进行讨论。
文摘Oligodeoxynucleotide from SARS virus was selected and synthesized. Its complexes with alkaloid compounds were investigated by electrospray mass spectrometry. We found that three alkaloid compounds could interact with the DNA target molecule in five alkaloids analyzed. With increasing molar ratio of the three alkaloid compounds, the complexes between alkaloids and DNA with different stoichiometric ratios were found in their MS spectra. The order of the alkalinity of their gas phase corresponds to that of liquid phase, that is: Palmatine>Jatrorrhizine>Berberin. The relative abundance of these complexes in mass spectra can assess the relative affinities of above three alkaloid compounds with the DNA target molecule. In this paper, the binding sites between jatrorrhizine and DNA was deduced from the interaction experiments of jatrorrhizine with three nucleosides.
文摘Resveratrol is a kind of polyphenolic compound that widely exists in plants and has extensive physiological pharmacological function and is very useful for human health. For the mechanism of action and function of RV, people are doing a variety of groundbreaking researches. Results show that the molecular mechanism of RV is embodied in aspects such as oxidative stress and diseases of neuropathy, anti-oxygenation and pro-oxidant effect and RV target molecule, etc. This article mainly summarized the mechanism of action of resveratrol in these aspects.
