A simple and fast three-component diastereoselective synthesis of biologically important spiro scaffold 4 was carried out in reasonable purity starting from readily available 1H-indole-2,3-dione 1, ethyl cyanoacetate ...A simple and fast three-component diastereoselective synthesis of biologically important spiro scaffold 4 was carried out in reasonable purity starting from readily available 1H-indole-2,3-dione 1, ethyl cyanoacetate 2 and 4-hydroxycoumarin 3 under microwave in high yield （88%-92%） and short time.展开更多
Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromat...Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-dione.When the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]spirocyclization.When the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen source.In general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility.展开更多
Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenon...Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenone framework were designed and synthesized. Insecticidal evaluation showed that some of spirobenzofuranone containing neonicotinoids exhibited moderate activity against cowpea aphid, armyworm or brown planthopper.展开更多
Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or catalysts.Herein,we report the direct ...Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or catalysts.Herein,we report the direct synthesis of C—N axially chiral N-arylindoles through a Pd-catalyzed free amine-directed atroposelective C—H olefination enabled by a spiro phosphoric acid(SPA)ligand.A wide range of enantioenriched N-aromatic amine indoles were obtained in high yields with good enantioselectivities(35 examples,up to 91%yield and up to 96%ee).The chiral products with free amine group offer an effective functional handle for down-stream diversity-oriented synthesis.展开更多
Asymmetric hydrogenation of dialkyl imines to chiral amines is difficult because the two alkyls of imines are so similar in spatial and electronic structure that chiral catalysts are difficult to distinguish between t...Asymmetric hydrogenation of dialkyl imines to chiral amines is difficult because the two alkyls of imines are so similar in spatial and electronic structure that chiral catalysts are difficult to distinguish between them.In this study,we described an asymmetric hydrogenation of dialkyl imines by a chiral iridium catalyst containing spiro phosphine-amine-phosphine ligand.By precisely adjusting the chiral pocket of catalyst,a highly efficient catalyst was developed.Using this catalyst,a variety of dialkyl imines were hydrogenated to chiral amines with high yield and enantioselectivity.展开更多
Two novel spiro compounds,3-benzylidene-1,5-dioxaspiro[5.5]undecane-2,4-dione 1 and 3-（2-fluorobenzylidene）-1,5-dioxaspiro[5.5]undecane-2,4-dione 2,have been synthesized and characterized by X-ray single-crystal dif...Two novel spiro compounds,3-benzylidene-1,5-dioxaspiro[5.5]undecane-2,4-dione 1 and 3-（2-fluorobenzylidene）-1,5-dioxaspiro[5.5]undecane-2,4-dione 2,have been synthesized and characterized by X-ray single-crystal diffraction,IR and elemental analysis.Compound 1 belongs to the monoclinic system,space group P21/n with a=12.326（3）,b=5.6420（11）,c=20.089（4）,β= 101.79（3）o,C16H16O4,Mr= 272.29,V=1367.7（5）3,Z=4,Dc=1.322g/cm3,F（000）=576,μ（MoKa）=0.095 mm-1,the final R=0.0420 and wR=0.1159.Compound 2 is of monoclinic system,space group P21/n with a=12.283（3）,b=5.6367（11）,c=20.055（4）,β=102.00（3）o,C16H15FO4,Mr=290.28,V=1358.2（5）3,Z=4,Dc=1.420 g/cm3,F（000）=608,μ（MoKa）=0.110 mm-1,the final R=0.0353 and wR=0.0860.展开更多
The photochromic spiropyrans and spirooxazine having a succinimidyl ester or isothiocyanate pendant group can form covalent products with transaminated DNA. The absorption spectra and solid reflection spectra of modi...The photochromic spiropyrans and spirooxazine having a succinimidyl ester or isothiocyanate pendant group can form covalent products with transaminated DNA. The absorption spectra and solid reflection spectra of modified DNA with these photochromic spiro compounds were investigated.展开更多
A copper-catalyzed stereoselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N0-cyclic azomethine imines has been developed under mild reaction conditions.The spiro[pyrazolidin-3,30-oxindoles] were obtai...A copper-catalyzed stereoselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N0-cyclic azomethine imines has been developed under mild reaction conditions.The spiro[pyrazolidin-3,30-oxindoles] were obtained in moderate to high isolated yields（up to 82%） with good stereoselevtivities（up to 15：1） in the presence of 5 mol% of Cu（OAc）2at room temperature.展开更多
A series of spiro compounds have been synthesized via several steps. The structure of these compounds were confirmed by ^1H NMR, 13C NMR, IR, MS spectra and X-ray diffraction analysis. The possible mechanism to form t...A series of spiro compounds have been synthesized via several steps. The structure of these compounds were confirmed by ^1H NMR, 13C NMR, IR, MS spectra and X-ray diffraction analysis. The possible mechanism to form these products was also proposed.展开更多
A rapid and efficient, one pot synthesis of spirooxindole derivatives has been attempted by three- component reaction of isatin, malononitrile and carbonyl compound possessing a reactive c^-methylene group by using ta...A rapid and efficient, one pot synthesis of spirooxindole derivatives has been attempted by three- component reaction of isatin, malononitrile and carbonyl compound possessing a reactive c^-methylene group by using task specific ionic liquid, 1-butyl-3-methyl imidazolium hydroxide [bmim]OH as a catalyst. The important features of this methodology are straight forward route in short reaction time at room temperature and avoid any hazardous organic solvent, toxic catalyst, tedious purification step. Interestingly, this protocol is not only limited to mono-systems but also to the synthesis of newer bis- spirooxindole system. The separation of the product and reusability of the catalyst are easy with excellent yield. The [bmim]OH catalyst system could be reused up to five recycles without appreciable loss of activity.展开更多
The design and synthesis of spirochroman-2-on-4,1'-indan-7'-ol(SCIOL)and its application for synthesizing chiral monophosphinite ligands are reported.The synthesis features a tandem double Friedel-Crafts react...The design and synthesis of spirochroman-2-on-4,1'-indan-7'-ol(SCIOL)and its application for synthesizing chiral monophosphinite ligands are reported.The synthesis features a tandem double Friedel-Crafts reaction/lactonization to construct the spiro framework and the desired racemic SCiOL was obtained via 6 steps with a total yield of 44.5%.Using an inclusion resolution with N-benzylcinchonidinium chloride,the optical SCiOL could be obtained in good yields on a gram scale.The preliminary studies indicated that the corresponding chiral spiro monophosphinite ligands exhibit high catalytic activity and enantioselectivity(up to 94%ee)in the rhodium-catalyzed asymmetric hydrogenation of N-acetyl dehydroamino esters.These outcomes highlight the significant potential of SCiOLas a useful framework forthedevelopment of chiral spiro ligands.展开更多
We report an enantioselective hydroarylation reaction of styrenes and 1,3-dienes with arylboronic acids catalyzed by nickel complexes bearing chiral spiro amino phosphine ligands.The reaction serves as an efficient,st...We report an enantioselective hydroarylation reaction of styrenes and 1,3-dienes with arylboronic acids catalyzed by nickel complexes bearing chiral spiro amino phosphine ligands.The reaction serves as an efficient,straightf orward,and mild method for the preparation of enantio enriched 1,1-diarylalkanes,which are important building blocks for the synthesis of many biologically active molecules.This redox neutral reaction uses only catalytic amounts of the reagents and is,therefore,atom economical and environmentally benign.展开更多
Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications.Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives...Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications.Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C—H activation/annulation was reported.3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate,and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents,respectively.This strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner.展开更多
Through-space charge transfer(TSCT)is regarded as an effective way to develop thermally activated delayed fluorescence(TADF)emitters.Based on this strategy,many molecular frameworks have been proposed,among which spir...Through-space charge transfer(TSCT)is regarded as an effective way to develop thermally activated delayed fluorescence(TADF)emitters.Based on this strategy,many molecular frameworks have been proposed,among which spirobased scaffolds have been extensively studied due to their unique advantages.In this work,we developed three emitters SPS,SPO,and SPON,which were constructed with the same donor and various acceptors to explore the influence of acceptor modulation at the C9 position of fluorene for spirostructure TSCT emitters.The results show that the acceptor with too weak electronwithdrawing ability will cause the emitter to not have TADF properties,while the acceptor with too much steric hindrance will weaken the face-to-faceπ-πstacking interaction between donor/acceptor(D/A).Since SPO balances the electron-withdrawing strength and steric hindrance of the acceptor,it achieves the highest external quantum efficiency(EQE)of 17.75%.This work shows that appropriate acceptor selection is essential for the TADF properties and high efficiency of the spirobased scaffold TSCT emitter.展开更多
An efficient synthetic procedure for the functionalized spiro[furan-3,3＇-indoline] derivatives was successfully developed by domino reactions of N-phenacylpyridinium bromides or N-ethoxycarbonylmethylenepyridinium br...An efficient synthetic procedure for the functionalized spiro[furan-3,3＇-indoline] derivatives was successfully developed by domino reactions of N-phenacylpyridinium bromides or N-ethoxycarbonylmethylenepyridinium bro- mide with isatinylidene acetoacetate in the presence of triethylamine in ethanol at room temperature. The mecha- nism included sequential Michael addition of the in situ generated pyridinium ylide and intramolecular substitution of enolate.展开更多
A series of spiro, β-Lactams, and thiazolidinones incorporating compounds 4 have been synthesized by cycloaddition reaction of, chloroacetyl chloride and mercaptoacetic acid with the synthesized Shiff,s bases 5a-c to...A series of spiro, β-Lactams, and thiazolidinones incorporating compounds 4 have been synthesized by cycloaddition reaction of, chloroacetyl chloride and mercaptoacetic acid with the synthesized Shiff,s bases 5a-c to give new spiro β- Lactam 6a-c and spiro thiazolidinone 7a-c the cycloaddition were characterized by spectral data including HNMR, 13C-NMR, IR and elemental analysis.展开更多
Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy lin...Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg（II）-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications.展开更多
The spiro concept for chiral ligand design represents an important contribution to the area of asymmetric catalysis. Due to the considerable difficulties in the construction of enantiopure all-carbon spiro backbones, ...The spiro concept for chiral ligand design represents an important contribution to the area of asymmetric catalysis. Due to the considerable difficulties in the construction of enantiopure all-carbon spiro backbones, the development of catalytic asymmetric synthesis of chiral spiro structures via short steps is highly valuable. Herein we present our studies on the catalytic asymmetric synthesis of aromatic spiroketals and the corresponding diphos- phine （SKP） ligands.展开更多
A series of photo active azido analogues have been synthesized and their photochromic properties have also been investigated by UV-Vis spectrum. It will be used for the rapid and reliable preparation of large amounts ...A series of photo active azido analogues have been synthesized and their photochromic properties have also been investigated by UV-Vis spectrum. It will be used for the rapid and reliable preparation of large amounts of stable, non-radioactive labeled DNA and RNA hybridization probes. And it is supposed to be easily detected for its photochromic properties.展开更多
文摘A simple and fast three-component diastereoselective synthesis of biologically important spiro scaffold 4 was carried out in reasonable purity starting from readily available 1H-indole-2,3-dione 1, ethyl cyanoacetate 2 and 4-hydroxycoumarin 3 under microwave in high yield （88%-92%） and short time.
基金the National Natural Science Foundation of China(22101075,U2004189)Central Plains Science and Technology Innovation Leader Project(224200510009)+1 种基金Postdoctoral Research Grant in Henan Province(202103085)Henan Key Laboratory of Organic Functional Molecules and Drug Innovation,and 111 Project(D17007)for financial support.
文摘Herein,we report a condition-controlled divergent synthesis of spiro indene-2,1'-isoindolinones and spiro isochroman-3,1'-isoindolinones through cobalt-catalyzed formal[4+1]and[4+1+1]spirocyclization of aromatic amides with 2-diazo-1H-indene-1,3(2H)-dione.When the reaction is carried out under air in ethyl acetate,spiro indene-2,1'-isoindolinones are formed through Co(II)-catalyzed C—H/N—H[4+1]spirocyclization.When the reaction is run under O2 in CH3CN,on the other hand,spiro isochroman-3,1'-isoindolinones are generated through Baeyer-Villiger oxidation of the in situ formed spiro indene-2,1'-isoindolinones with O2 as a cheaper and environmental-friendly oxygen source.In general,these protocols have advantages such as using non-precious and earth-abundant metal catalyst,no extra additive,high efficiency and regioselectivity.A gram-scale synthesis and the removal of the directing group further highlight its utility.
基金financial supported by National Basic Research Program of China(973 Program,No.2010CB126100)National High Technology Research Development Program of China(863 Program,No.2011AA10A207)+4 种基金Key Projects in the National Science & Technology Pillar Program(No.2011BAE06B05)National Natural Science Foundation of China(No.21372079)Shanghai Education Committee(No.12ZZ057)the Fundamental Research Funds for the Central Universitiespartly supported by Australia DC Foundation
文摘Spiro heterocycles frequently occur in bioactive molecules. In the pursuit of neonicotinoids with spiro hererocycles, three types of novel neonicotinoids with spirobenzofuranone, spirooxindole or spiroacenaphythylenone framework were designed and synthesized. Insecticidal evaluation showed that some of spirobenzofuranone containing neonicotinoids exhibited moderate activity against cowpea aphid, armyworm or brown planthopper.
基金We thank the support from National Key R&D Program of China(2022YFA1504302,2021YFF0701603)National Natural Science Foundation of China(U22A20388,92256302,21925109 for B.-F.S.,22271250 for T.Z.)+1 种基金Fundamental Research Funds for the Central Universities(226-2023-00115,226-2022-00224,226-2022-00175)Zhejiang Provincial NSFC(LD22B030003)。
文摘Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or catalysts.Herein,we report the direct synthesis of C—N axially chiral N-arylindoles through a Pd-catalyzed free amine-directed atroposelective C—H olefination enabled by a spiro phosphoric acid(SPA)ligand.A wide range of enantioenriched N-aromatic amine indoles were obtained in high yields with good enantioselectivities(35 examples,up to 91%yield and up to 96%ee).The chiral products with free amine group offer an effective functional handle for down-stream diversity-oriented synthesis.
基金supported by the National Key R&D Program of China(grant no.2022YFA1504302)the National Natural Science Foundation of China(grant nos.22188101,91956000,and 92256301)the Fundamental Research Funds for the Central Universities,and the Haihe Laboratory of Sustainable Chemical Transformations.
文摘Asymmetric hydrogenation of dialkyl imines to chiral amines is difficult because the two alkyls of imines are so similar in spatial and electronic structure that chiral catalysts are difficult to distinguish between them.In this study,we described an asymmetric hydrogenation of dialkyl imines by a chiral iridium catalyst containing spiro phosphine-amine-phosphine ligand.By precisely adjusting the chiral pocket of catalyst,a highly efficient catalyst was developed.Using this catalyst,a variety of dialkyl imines were hydrogenated to chiral amines with high yield and enantioselectivity.
基金supported by the Natural Science Foundation of Shandong Province (No. Y2008B29)
文摘Two novel spiro compounds,3-benzylidene-1,5-dioxaspiro[5.5]undecane-2,4-dione 1 and 3-（2-fluorobenzylidene）-1,5-dioxaspiro[5.5]undecane-2,4-dione 2,have been synthesized and characterized by X-ray single-crystal diffraction,IR and elemental analysis.Compound 1 belongs to the monoclinic system,space group P21/n with a=12.326（3）,b=5.6420（11）,c=20.089（4）,β= 101.79（3）o,C16H16O4,Mr= 272.29,V=1367.7（5）3,Z=4,Dc=1.322g/cm3,F（000）=576,μ（MoKa）=0.095 mm-1,the final R=0.0420 and wR=0.1159.Compound 2 is of monoclinic system,space group P21/n with a=12.283（3）,b=5.6367（11）,c=20.055（4）,β=102.00（3）o,C16H15FO4,Mr=290.28,V=1358.2（5）3,Z=4,Dc=1.420 g/cm3,F（000）=608,μ（MoKa）=0.110 mm-1,the final R=0.0353 and wR=0.0860.
基金supported by the National Natural Science Foundation of China(No.29872015,29832030)
文摘The photochromic spiropyrans and spirooxazine having a succinimidyl ester or isothiocyanate pendant group can form covalent products with transaminated DNA. The absorption spectra and solid reflection spectra of modified DNA with these photochromic spiro compounds were investigated.
基金the National Natural Science Foundation of China (No.21172023)Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD) and STD of Jiangsu Province for their financial supports
文摘A copper-catalyzed stereoselective 1,3-dipolar cycloaddition of methyleneindolinones and N,N0-cyclic azomethine imines has been developed under mild reaction conditions.The spiro[pyrazolidin-3,30-oxindoles] were obtained in moderate to high isolated yields（up to 82%） with good stereoselevtivities（up to 15：1） in the presence of 5 mol% of Cu（OAc）2at room temperature.
基金Project supported by the National Natural Science Foundation of China （No. 20472047）.
文摘A series of spiro compounds have been synthesized via several steps. The structure of these compounds were confirmed by ^1H NMR, 13C NMR, IR, MS spectra and X-ray diffraction analysis. The possible mechanism to form these products was also proposed.
文摘A rapid and efficient, one pot synthesis of spirooxindole derivatives has been attempted by three- component reaction of isatin, malononitrile and carbonyl compound possessing a reactive c^-methylene group by using task specific ionic liquid, 1-butyl-3-methyl imidazolium hydroxide [bmim]OH as a catalyst. The important features of this methodology are straight forward route in short reaction time at room temperature and avoid any hazardous organic solvent, toxic catalyst, tedious purification step. Interestingly, this protocol is not only limited to mono-systems but also to the synthesis of newer bis- spirooxindole system. The separation of the product and reusability of the catalyst are easy with excellent yield. The [bmim]OH catalyst system could be reused up to five recycles without appreciable loss of activity.
基金We thank the National Key R&D Program of China(2021YFA1500200)the National Natural Science Foundation of China(92056105,92256303,22221002,and 22188101)the Haihe Laboratory of Sustainable Chemical Transformations,the Fundamental Research Funds for the Central Universities,and the Frontiers Sciences Center for New Organic Matter at Nankai University(63181206)for financial support.
文摘The design and synthesis of spirochroman-2-on-4,1'-indan-7'-ol(SCIOL)and its application for synthesizing chiral monophosphinite ligands are reported.The synthesis features a tandem double Friedel-Crafts reaction/lactonization to construct the spiro framework and the desired racemic SCiOL was obtained via 6 steps with a total yield of 44.5%.Using an inclusion resolution with N-benzylcinchonidinium chloride,the optical SCiOL could be obtained in good yields on a gram scale.The preliminary studies indicated that the corresponding chiral spiro monophosphinite ligands exhibit high catalytic activity and enantioselectivity(up to 94%ee)in the rhodium-catalyzed asymmetric hydrogenation of N-acetyl dehydroamino esters.These outcomes highlight the significant potential of SCiOLas a useful framework forthedevelopment of chiral spiro ligands.
基金The authors thank the National Natural Science Founda-tion of China(Grant#s.21790332 and 21532003)the“111”project(Grant#B06005)of the Ministry of Educa-tion of China for their financial support.
文摘We report an enantioselective hydroarylation reaction of styrenes and 1,3-dienes with arylboronic acids catalyzed by nickel complexes bearing chiral spiro amino phosphine ligands.The reaction serves as an efficient,straightf orward,and mild method for the preparation of enantio enriched 1,1-diarylalkanes,which are important building blocks for the synthesis of many biologically active molecules.This redox neutral reaction uses only catalytic amounts of the reagents and is,therefore,atom economical and environmentally benign.
基金Sichuan Science and Technology Program(No:2020YJ0221)the Natural Science Foundation of Shandong Province,China(No.ZR2021QH362).
文摘Comprehensive Summary Benzothiadiazine-1,1-dioxide scaffold is bioactive framework with wild utility and applications.Synthesis of benzothiadiazine-fused isoquinoline derivatives and spiro benzothiadiazine derivatives through transition metal-catalyzed C—H activation/annulation was reported.3-Phenyl-2H-benzothiadiazine-1,1-dioxide was used as the reaction substrate,and vinylene carbonate and 4-diazopyrazolone were used as the coupling reagents,respectively.This strategy provides straightforward access to complex N-heterocycles in a highly efficient and simple manner.
基金financial support from the National Natural Science Foundation of China(Nos.51773141,51873139,61961160731,62175171 and 22175124)funded by the Suzhou Science and Technology Plan Project(No.SYG202010)+2 种基金supported by Suzhou Key Laboratory of Functional Nano&Soft Materials,Collaborative Innovation Center of Suzhou Nano Science&Technologythe 111 ProjectJoint International Research Laboratory of Carbon-Based Functional Materials and Devices。
文摘Through-space charge transfer(TSCT)is regarded as an effective way to develop thermally activated delayed fluorescence(TADF)emitters.Based on this strategy,many molecular frameworks have been proposed,among which spirobased scaffolds have been extensively studied due to their unique advantages.In this work,we developed three emitters SPS,SPO,and SPON,which were constructed with the same donor and various acceptors to explore the influence of acceptor modulation at the C9 position of fluorene for spirostructure TSCT emitters.The results show that the acceptor with too weak electronwithdrawing ability will cause the emitter to not have TADF properties,while the acceptor with too much steric hindrance will weaken the face-to-faceπ-πstacking interaction between donor/acceptor(D/A).Since SPO balances the electron-withdrawing strength and steric hindrance of the acceptor,it achieves the highest external quantum efficiency(EQE)of 17.75%.This work shows that appropriate acceptor selection is essential for the TADF properties and high efficiency of the spirobased scaffold TSCT emitter.
文摘An efficient synthetic procedure for the functionalized spiro[furan-3,3＇-indoline] derivatives was successfully developed by domino reactions of N-phenacylpyridinium bromides or N-ethoxycarbonylmethylenepyridinium bro- mide with isatinylidene acetoacetate in the presence of triethylamine in ethanol at room temperature. The mecha- nism included sequential Michael addition of the in situ generated pyridinium ylide and intramolecular substitution of enolate.
文摘A series of spiro, β-Lactams, and thiazolidinones incorporating compounds 4 have been synthesized by cycloaddition reaction of, chloroacetyl chloride and mercaptoacetic acid with the synthesized Shiff,s bases 5a-c to give new spiro β- Lactam 6a-c and spiro thiazolidinone 7a-c the cycloaddition were characterized by spectral data including HNMR, 13C-NMR, IR and elemental analysis.
基金Project supported by the National Natural Science Foundation 0f China （Nos. 20025207, 20272071, 20372075, 20321202, 20672129, and 20621062）, and the Chinese Academy of Sciences （Nos. NKGCX2-SW-209 and KJCX2.YW.H08）.
文摘Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg（II）-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications.
文摘The spiro concept for chiral ligand design represents an important contribution to the area of asymmetric catalysis. Due to the considerable difficulties in the construction of enantiopure all-carbon spiro backbones, the development of catalytic asymmetric synthesis of chiral spiro structures via short steps is highly valuable. Herein we present our studies on the catalytic asymmetric synthesis of aromatic spiroketals and the corresponding diphos- phine （SKP） ligands.
基金the National Natural Science Foundation of China for financial support.(Grant Nos.20072018 and 20372039).
文摘A series of photo active azido analogues have been synthesized and their photochromic properties have also been investigated by UV-Vis spectrum. It will be used for the rapid and reliable preparation of large amounts of stable, non-radioactive labeled DNA and RNA hybridization probes. And it is supposed to be easily detected for its photochromic properties.
