摘要
We report an enantioselective hydroarylation reaction of styrenes and 1,3-dienes with arylboronic acids catalyzed by nickel complexes bearing chiral spiro amino phosphine ligands.The reaction serves as an efficient,straightf orward,and mild method for the preparation of enantio enriched 1,1-diarylalkanes,which are important building blocks for the synthesis of many biologically active molecules.This redox neutral reaction uses only catalytic amounts of the reagents and is,therefore,atom economical and environmentally benign.
基金
The authors thank the National Natural Science Founda-tion of China(Grant#s.21790332 and 21532003)
the“111”project(Grant#B06005)of the Ministry of Educa-tion of China for their financial support.
