[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alc...[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.展开更多
目的:比较右美托咪定与芬太尼类药物对清醒气管插管患者的麻醉诱导效果。方法:以陕西省第二人民医院2013年2月—2014年12月120例择期经鼻清醒气管插管麻醉患者为研究对象,按随机数字表法分为A、B组各60例,A组患者行右美托咪定麻醉,B组...目的:比较右美托咪定与芬太尼类药物对清醒气管插管患者的麻醉诱导效果。方法:以陕西省第二人民医院2013年2月—2014年12月120例择期经鼻清醒气管插管麻醉患者为研究对象,按随机数字表法分为A、B组各60例,A组患者行右美托咪定麻醉,B组行芬太尼麻醉,比较2组患者不同时间点心率、血压、血氧饱和度变化情况,同时记录患者插管反应及插管知晓情况。结果:A组患者插管成功即刻的心率为(73.0±15.2)次/min,收缩压为(121.0±11.6)mm Hg(1 mm Hg=0.133 k Pa);B组为(85.6±9.2)次/min、(131.6±8.0)mm Hg,2组的差异有统计学意义(P<0.05)。A组患者出现恶心2例(3.3%)、呛咳3例(5.0%);B组恶心12例(20.0%)、呛咳15例(25.0%)、躁动9例(15.0%),2组的差异有统计学意义(P<0.05)。A组患者插管知晓率为3.3%,B组为25.0%比较,2组的差异有统计学意义(P<0.05)。结论:右美托咪定在患者清醒气管插管麻醉中具有血流动力学稳定、插管反应少、插管知晓率低等特点,值得临床推广。展开更多
基金Supported by National Natural Science Foundation of China(31100987)Project of Shandong University of Technology(4040-306018)Young Teacher Development Plan of Shandong University of Technology~~
文摘[Objective] We aimed to investigate the preventive and therapeutical effect of compound of traditional Chinese drugs （Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root） on acute alcohol intoxication in mice. [Method] Acute alcohol intoxication was induced by administering alcohol to mice. Three different doses （low, middle and high） of compound of traditional Chinese drugs were administered to mice before and after administering alcohol respectively to investigate the preventive and therapeutical effect of drugs on acute alcohol intox-ication through doing statistical analysis about drunk mice and their sleeping time. The concentration of malondialdehyde （MDA）, reduced glutathione （GSH） and triglyc-erides （TG） in liver was also determined to investigate the protective effect of drugs on liver. [Result] The efficacy of compound of traditional Chinese drugs on acute al-cohol intoxication was dose-dependent. High-dose administration decreased the number of drunk mice significantly compared with control group; middle- and high-dose administration reduced the sleeping time of drunk mice and the concentration of MDA and TG in liver tissue; three doses al increased the concentration of GSH. [Conclusion] The compound of Japanese raisintree fruit, lobed kudzuvine flower bud and lightyel ow sophora root had preventive and therapeutical effect on hangover, and it also had certain preventive and therapeutical effect on liver damage caused by alcohol.
文摘目的:比较右美托咪定与芬太尼类药物对清醒气管插管患者的麻醉诱导效果。方法:以陕西省第二人民医院2013年2月—2014年12月120例择期经鼻清醒气管插管麻醉患者为研究对象,按随机数字表法分为A、B组各60例,A组患者行右美托咪定麻醉,B组行芬太尼麻醉,比较2组患者不同时间点心率、血压、血氧饱和度变化情况,同时记录患者插管反应及插管知晓情况。结果:A组患者插管成功即刻的心率为(73.0±15.2)次/min,收缩压为(121.0±11.6)mm Hg(1 mm Hg=0.133 k Pa);B组为(85.6±9.2)次/min、(131.6±8.0)mm Hg,2组的差异有统计学意义(P<0.05)。A组患者出现恶心2例(3.3%)、呛咳3例(5.0%);B组恶心12例(20.0%)、呛咳15例(25.0%)、躁动9例(15.0%),2组的差异有统计学意义(P<0.05)。A组患者插管知晓率为3.3%,B组为25.0%比较,2组的差异有统计学意义(P<0.05)。结论:右美托咪定在患者清醒气管插管麻醉中具有血流动力学稳定、插管反应少、插管知晓率低等特点,值得临床推广。
