防弹衣是用于保护人员免受弹头和破片伤害的重要防护装备。各国对防弹衣制定的标准较多,如英国警用防弹衣制定有HO1、HO2、HO3、HO4和SG1共5个等级的标准,俄罗斯防弹衣制定有1、2、2a、3、4、5、5a、6和6a共9个等级的标准。最有名的是...防弹衣是用于保护人员免受弹头和破片伤害的重要防护装备。各国对防弹衣制定的标准较多,如英国警用防弹衣制定有HO1、HO2、HO3、HO4和SG1共5个等级的标准,俄罗斯防弹衣制定有1、2、2a、3、4、5、5a、6和6a共9个等级的标准。最有名的是美国国家司法学院(National Institute of Justice)制定的防弹衣防弹标准(以下简称NIJ标准),该标准自1972年发布第1版NIJ0101.00标准以来,先后经历了6次修订,2008年发布了第7版NIJ0101.06标准,这一版是目前世界上使用范围最广的标准。展开更多
Objective： The aim of the study was to investigate the effect of SG1-1776 combination with DDP in sub-toxic concentration on induction of apoptosis of human ovarian cancer HO-8910 ceiis in vitro and to unravei the as...Objective： The aim of the study was to investigate the effect of SG1-1776 combination with DDP in sub-toxic concentration on induction of apoptosis of human ovarian cancer HO-8910 ceiis in vitro and to unravei the associated mechanisms. Methods： Human ovarian cancer HO-8910 cells were cultured in vitro. The inhibitory effect of SG1-1776 combination with DDP in sub-toxic concentration on induction on viability of human ovarian cancer HO-8910 cells was evaiuated by the MTT assay. Cell apoptosis rate was analyzed by flow cytometry. The proteins expression level related to apoptosis were analyzed by Western blot. Results： SG1-1776 combination with DDP in sub-toxic concentration significantiy inhibited the proliferation of human ovarian cancer HO-8910 cells, and proliferation inhibition rate was increased drastically compared with normai saline （NS） group or DDP group in sub-toxic concentration or SG1-1776 group in sub-toxic concentration （P 〈 0.01）. Apoptosis rate markedly increased after the treatment of SG1-1776 combination with DDP in sub-toxic concentration for 48 h. Western blot showed that the expression of bcl-2 protein was down-regulated and protein level of Bax and Cyto-c were depressed by SG1-1776 combination with DDP in sub-toxic concentration. Cenclusion： SG1-1776 combination with DDP in sub-toxic concentration could inhibit the cell proliferation and lead to cell apoptosis inhuman ovarian cancer HO-8910 cells, and its mechanism may be related to through mitochondrial apoptotic pathway.展开更多
文摘防弹衣是用于保护人员免受弹头和破片伤害的重要防护装备。各国对防弹衣制定的标准较多,如英国警用防弹衣制定有HO1、HO2、HO3、HO4和SG1共5个等级的标准,俄罗斯防弹衣制定有1、2、2a、3、4、5、5a、6和6a共9个等级的标准。最有名的是美国国家司法学院(National Institute of Justice)制定的防弹衣防弹标准(以下简称NIJ标准),该标准自1972年发布第1版NIJ0101.00标准以来,先后经历了6次修订,2008年发布了第7版NIJ0101.06标准,这一版是目前世界上使用范围最广的标准。
基金Supported by a grant from the Guangzhou Science and Technology Plan Project(No.2013 00000151)
文摘Objective： The aim of the study was to investigate the effect of SG1-1776 combination with DDP in sub-toxic concentration on induction of apoptosis of human ovarian cancer HO-8910 ceiis in vitro and to unravei the associated mechanisms. Methods： Human ovarian cancer HO-8910 cells were cultured in vitro. The inhibitory effect of SG1-1776 combination with DDP in sub-toxic concentration on induction on viability of human ovarian cancer HO-8910 cells was evaiuated by the MTT assay. Cell apoptosis rate was analyzed by flow cytometry. The proteins expression level related to apoptosis were analyzed by Western blot. Results： SG1-1776 combination with DDP in sub-toxic concentration significantiy inhibited the proliferation of human ovarian cancer HO-8910 cells, and proliferation inhibition rate was increased drastically compared with normai saline （NS） group or DDP group in sub-toxic concentration or SG1-1776 group in sub-toxic concentration （P 〈 0.01）. Apoptosis rate markedly increased after the treatment of SG1-1776 combination with DDP in sub-toxic concentration for 48 h. Western blot showed that the expression of bcl-2 protein was down-regulated and protein level of Bax and Cyto-c were depressed by SG1-1776 combination with DDP in sub-toxic concentration. Cenclusion： SG1-1776 combination with DDP in sub-toxic concentration could inhibit the cell proliferation and lead to cell apoptosis inhuman ovarian cancer HO-8910 cells, and its mechanism may be related to through mitochondrial apoptotic pathway.
