目的:分析血清神经元特异性烯醇化酶(neuron specific enolase,NSE)联合颅脑MRI在预测新生儿高胆红素血症脑损伤中的应用价值。方法:将225例高胆红素血症新生儿纳入研究范围,均有完整颅脑MRI影像资料及血清NSE检查结果,以临床最终诊断...目的:分析血清神经元特异性烯醇化酶(neuron specific enolase,NSE)联合颅脑MRI在预测新生儿高胆红素血症脑损伤中的应用价值。方法:将225例高胆红素血症新生儿纳入研究范围,均有完整颅脑MRI影像资料及血清NSE检查结果,以临床最终诊断为结局,分析血清NSE联合颅脑MRI对新生儿高胆红素血症脑病的预测价值。结果:225例高胆红素血症新生儿中,30例在病理性黄疸基础上脑干听觉诱发电位异常,并伴神经系统症状,临床综合诊断为新生儿高胆红素血症脑损伤;高胆红素血症新生儿血清NSE、MRI检查所得苍白球与壳核T1WI信号强度比值(G/P比值)显著低于高胆红素血症脑损伤新生儿,差异有统计学意义(P<0.05);以G/P比值、血清NSE水平、G/P比值联合血清NSE为检验变量,结局(是否发生新生儿高胆红素血症脑病)为状态变量,绘制ROC曲线,结果显示,G/P比值、血清NSE水平、G/P比值联合血清NSE曲线下面积依次为0.806、0.635、0.814,提示G/P比值联合血清NSE预测新生儿高胆红素血症脑损伤效能最佳;其中,G/P比值、血清NSE的Cut-off分别为1.894、63.7924,单一诊断的灵敏度依次为66.70%、36.70%;特异度依次为87.70%、86.20%,联合诊断时灵敏度、特异度分别为70.00%、88.70%。结论:血清NSE联合颅脑MRI对新生儿高胆红素血症脑损伤具优势预测价值,可进一步提升单一指标或辅助检查手段预测的灵敏度及特异度,值得临床重视。展开更多
Objective:To evaluate the diagnostic value of serum neuron specific enolase and Video EEG in Febrile Convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day after seizure in 40...Objective:To evaluate the diagnostic value of serum neuron specific enolase and Video EEG in Febrile Convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day after seizure in 40 children with simple febrile convulsion and 18 with complex febrile convulsion. Video EEG was performed at 1st, 7th and 30th day in all the patients. Results: There were significant differences between NSE levels at 24th hour and on 7th day after convulsion (P＜0.01). NSE concentrations in patients with SFC and CFC were also different (P ＜ 0.01). The more slowly NSE restored, the higher the abnormal ratio of EGG was . Conclusion: NSE increased in patients within 24hours after seizure, especially in CFC patients. The abnormal ratio of VideoEEG was related to the change of NSE concentration.展开更多
文摘目的:分析血清神经元特异性烯醇化酶(neuron specific enolase,NSE)联合颅脑MRI在预测新生儿高胆红素血症脑损伤中的应用价值。方法:将225例高胆红素血症新生儿纳入研究范围,均有完整颅脑MRI影像资料及血清NSE检查结果,以临床最终诊断为结局,分析血清NSE联合颅脑MRI对新生儿高胆红素血症脑病的预测价值。结果:225例高胆红素血症新生儿中,30例在病理性黄疸基础上脑干听觉诱发电位异常,并伴神经系统症状,临床综合诊断为新生儿高胆红素血症脑损伤;高胆红素血症新生儿血清NSE、MRI检查所得苍白球与壳核T1WI信号强度比值(G/P比值)显著低于高胆红素血症脑损伤新生儿,差异有统计学意义(P<0.05);以G/P比值、血清NSE水平、G/P比值联合血清NSE为检验变量,结局(是否发生新生儿高胆红素血症脑病)为状态变量,绘制ROC曲线,结果显示,G/P比值、血清NSE水平、G/P比值联合血清NSE曲线下面积依次为0.806、0.635、0.814,提示G/P比值联合血清NSE预测新生儿高胆红素血症脑损伤效能最佳;其中,G/P比值、血清NSE的Cut-off分别为1.894、63.7924,单一诊断的灵敏度依次为66.70%、36.70%;特异度依次为87.70%、86.20%,联合诊断时灵敏度、特异度分别为70.00%、88.70%。结论:血清NSE联合颅脑MRI对新生儿高胆红素血症脑损伤具优势预测价值,可进一步提升单一指标或辅助检查手段预测的灵敏度及特异度,值得临床重视。
文摘Objective:To evaluate the diagnostic value of serum neuron specific enolase and Video EEG in Febrile Convulsion of childen. Method:Serum NSE was detected by RIA on the first day and the seventh day after seizure in 40 children with simple febrile convulsion and 18 with complex febrile convulsion. Video EEG was performed at 1st, 7th and 30th day in all the patients. Results: There were significant differences between NSE levels at 24th hour and on 7th day after convulsion (P＜0.01). NSE concentrations in patients with SFC and CFC were also different (P ＜ 0.01). The more slowly NSE restored, the higher the abnormal ratio of EGG was . Conclusion: NSE increased in patients within 24hours after seizure, especially in CFC patients. The abnormal ratio of VideoEEG was related to the change of NSE concentration.
