Studies of non-invasive glucose measurement with optical coherence tomography(OCT)in tissue-simulating phantoms and biological tissues show that glucose has an effect on the OCT signal slope.Choosing an efficient fitt...Studies of non-invasive glucose measurement with optical coherence tomography(OCT)in tissue-simulating phantoms and biological tissues show that glucose has an effect on the OCT signal slope.Choosing an efficient fitting range to calculate the OCT signal slope is important because it helps to improve the precision of glucose measurement.In this paper,we study the problem in two ways:(1)scattering-induced change of OCT signal slope versus depth in intralipid suspensions with different concentrations based on Monte Carlo(MC)simulations and experiments and(2)efficient fitting range for glucose measurement in 3%and 10%intralipid.The results show that the OCT signal slope expresses a contrary change with scattering coefficient below a certain depth in high intralipid concentrations,so that there is an effective fitting depth.With an efficient fitting range from 100μm to the effective fitting depth,the precision of glucose measurement can be 4.4mM for 10%intralipid and 2.2mM for 3%intralipid.展开更多
Quantum channels in free-space,an essential prerequisite for fundamental tests of quantum mechanics and quantum technologies in open space,have so far been based on direct line-of-sight because the predominant approac...Quantum channels in free-space,an essential prerequisite for fundamental tests of quantum mechanics and quantum technologies in open space,have so far been based on direct line-of-sight because the predominant approaches for photon-encoding,including polarization and spatial modes,are not compatible with randomly scattered photons.Here we demonstrate a novel approach to transfer and recover quantum coherence from scattered,non-line-of-sight photons analyzed in a multimode and imaging interferometer for time-bins,combined with photon detection based on a 8×8 single-photon-detector-array.The observed time-bin visibility for scattered photons remained at a high 95%over a wide scattering angle range of−45^(0) to+45^(0),while the individual pixels in the detector array resolve or track an image in its field of view of ca.0.5°.Using our method,we demonstrate the viability of two novel applications.Firstly,using scattered photons as an indirect channel for quantum communication thereby enabling non-line-of-sight quantum communication with background suppression,and secondly,using the combined arrival time and quantum coherence to enhance the contrast of low-light imaging and laser ranging under high background light.We believe our method will instigate new lines for research and development on applying photon coherence from scattered signals to quantum sensing,imaging,and communication in free-space environments.展开更多
文摘Studies of non-invasive glucose measurement with optical coherence tomography(OCT)in tissue-simulating phantoms and biological tissues show that glucose has an effect on the OCT signal slope.Choosing an efficient fitting range to calculate the OCT signal slope is important because it helps to improve the precision of glucose measurement.In this paper,we study the problem in two ways:(1)scattering-induced change of OCT signal slope versus depth in intralipid suspensions with different concentrations based on Monte Carlo(MC)simulations and experiments and(2)efficient fitting range for glucose measurement in 3%and 10%intralipid.The results show that the OCT signal slope expresses a contrary change with scattering coefficient below a certain depth in high intralipid concentrations,so that there is an effective fitting depth.With an efficient fitting range from 100μm to the effective fitting depth,the precision of glucose measurement can be 4.4mM for 10%intralipid and 2.2mM for 3%intralipid.
基金supported by the National Research Council CanadaDefence Research Development Canada+5 种基金Industry CanadaCanada Fund for InnovationOntario MRIOntario Research FundNSERC(programs Discovery,CryptoWorks21,Strategic Partnership Grant)Canada First Research Excellence Fund(TQT).
文摘Quantum channels in free-space,an essential prerequisite for fundamental tests of quantum mechanics and quantum technologies in open space,have so far been based on direct line-of-sight because the predominant approaches for photon-encoding,including polarization and spatial modes,are not compatible with randomly scattered photons.Here we demonstrate a novel approach to transfer and recover quantum coherence from scattered,non-line-of-sight photons analyzed in a multimode and imaging interferometer for time-bins,combined with photon detection based on a 8×8 single-photon-detector-array.The observed time-bin visibility for scattered photons remained at a high 95%over a wide scattering angle range of−45^(0) to+45^(0),while the individual pixels in the detector array resolve or track an image in its field of view of ca.0.5°.Using our method,we demonstrate the viability of two novel applications.Firstly,using scattered photons as an indirect channel for quantum communication thereby enabling non-line-of-sight quantum communication with background suppression,and secondly,using the combined arrival time and quantum coherence to enhance the contrast of low-light imaging and laser ranging under high background light.We believe our method will instigate new lines for research and development on applying photon coherence from scattered signals to quantum sensing,imaging,and communication in free-space environments.
