Benzoic and salicylic acids in ointment sample were extracted with a 75% tehanol solution.The extracts are neutralized with tetramethylammonium hydroxide solution.Tetramethyl ammonium salts of benzoic and salicylic ac...Benzoic and salicylic acids in ointment sample were extracted with a 75% tehanol solution.The extracts are neutralized with tetramethylammonium hydroxide solution.Tetramethyl ammonium salts of benzoic and salicylic acids formed further react with 1 iodobutane directly in N,N dimethylformamide solution to form butyl esters of the corresponding acids.The separation of the butyl esters was carried out on column packed with 5% SE 30/102 Silanized white support.This method is simple and accurate.展开更多
目的:改进复方珊瑚姜溶液尿素咪康唑软膏复合制剂中水杨酸的含量测定方法。方法:采用十八烷基硅烷键合硅胶为填充剂的色谱柱,以甲醇-0.4%磷酸溶液(60∶40)为流动相,流速1.0 m L/min,检测波长为305 nm,柱温25℃。结果:水杨酸在(0.0619 g^...目的:改进复方珊瑚姜溶液尿素咪康唑软膏复合制剂中水杨酸的含量测定方法。方法:采用十八烷基硅烷键合硅胶为填充剂的色谱柱,以甲醇-0.4%磷酸溶液(60∶40)为流动相,流速1.0 m L/min,检测波长为305 nm,柱温25℃。结果:水杨酸在(0.0619 g^0.0746 g)范围内线性关系良好(R=1),方法回收率为101.12%(RSD=1.51%)。结论:该方法简便、快速、准确,可用于该制剂中水杨酸的定量测定。展开更多
文摘Benzoic and salicylic acids in ointment sample were extracted with a 75% tehanol solution.The extracts are neutralized with tetramethylammonium hydroxide solution.Tetramethyl ammonium salts of benzoic and salicylic acids formed further react with 1 iodobutane directly in N,N dimethylformamide solution to form butyl esters of the corresponding acids.The separation of the butyl esters was carried out on column packed with 5% SE 30/102 Silanized white support.This method is simple and accurate.
