The hippocampus which lies in the temporal lobe plays an important role in spatial navigation,learning and memory.Several studies have been made on the place cell activity,spatial memory,prediction of future locations...The hippocampus which lies in the temporal lobe plays an important role in spatial navigation,learning and memory.Several studies have been made on the place cell activity,spatial memory,prediction of future locations and various learning paradigms.However,there are no attempts which have focused on finding whether neurons which contribute largely to both spatial memory and learning about the reward exist.This paper proposes that there are neurons that can simultaneously engage in forming place memory and reward learning in a rat hippocampus' s CA1 area.With a trained rat,a reward experiment was conducted in a modified 8-shaped maze with five stages,and utterance information was obtained from a CA1 neuron.The firing rate which is the count of spikes per unit time was calculated.The decoding was conducted with log-maximum likelihood estimation(Log-MLE) using Gaussian distribution model.Our outcomes provide evidence of neurons which play a part in spatial memory and learning regarding reward.展开更多
基金The MSIP(Ministry of Science,ICT&Future Planning),Korea,under the ITRC(Information Technology Research Center)support program(NIPA-2013-H0301-13-2006)supervised by the NIPA(National IT Industry Promotion Agency)The Brain Research Program through the National Research Foundation of Korea funded by the Ministry of Science,ICT&Future Planning(2011-0019212)
文摘The hippocampus which lies in the temporal lobe plays an important role in spatial navigation,learning and memory.Several studies have been made on the place cell activity,spatial memory,prediction of future locations and various learning paradigms.However,there are no attempts which have focused on finding whether neurons which contribute largely to both spatial memory and learning about the reward exist.This paper proposes that there are neurons that can simultaneously engage in forming place memory and reward learning in a rat hippocampus' s CA1 area.With a trained rat,a reward experiment was conducted in a modified 8-shaped maze with five stages,and utterance information was obtained from a CA1 neuron.The firing rate which is the count of spikes per unit time was calculated.The decoding was conducted with log-maximum likelihood estimation(Log-MLE) using Gaussian distribution model.Our outcomes provide evidence of neurons which play a part in spatial memory and learning regarding reward.
文摘目的探讨不同严重度阴性症状的精神分裂症(schizophrenia,SZ)患者奖赏决策过程中预测误差和期待价值使用情况。方法纳入稳定期SZ患者80例,其中阴性症状低分组(low-negative symptom,LNS)和阴性症状高分组(high-negative symptom,HNS)各40例。并纳入健康对照(health control,HC)40例。使用汉化的强化学习任务范式,比较代表不同指标的图片的正确率在三组间是否有差异。结果HNS组在赢得奖励条件下的正确率低于HC组,差异具有统计学意义(P=0.04),而避免损失条件下与HC组相当,差异无统计学意义(P>0.05)。代表期待价值使用的高概率赢钱-高概率避免损失(frequent winners vs frequent loss avoiders,FW-FLA)图片的正确率在三组间差异无统计学意义(F=1.68,P=0.19)。结论阴性症状重的SZ患者在赢得奖励条件不能很好地运用预测误差指导奖赏决策,但在防止损失条件下可以。认知功能相对较好的SZ患者在期待价值使用方面没有明显受损。
