<strong>Background:</strong> <span style="font-family:Verdana;">Breast cancer (BC) is considered the most common women cancer worldwide. </span><span style="font-family:Verdan...<strong>Background:</strong> <span style="font-family:Verdana;">Breast cancer (BC) is considered the most common women cancer worldwide. </span><span style="font-family:Verdana;">The main clinicopathological prognostic factors are tumor size, lymph node status and estrogen/progesterone (ER/PR) receptor status</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> In addition, some factors are both prognostic and predictive as ER/PR receptors and HER2/neu overexpression. </span><span style="font-family:Verdana;">Axillary lymph node status is the most important prognostic factor for breast cancer. Node negative breast cancer patients had the best 5-year overall survival (OS) of 82.8% compared to 73%, 45.7%, and 28.4% for patients with 1</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">3, 4</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">12, and ≥13 positive nodes, respectively. </span><span style="font-family:Verdana;">The aim of this study was</span><span style="font-family:Verdana;"> to determine the association between different clinicopathological features and </span><span style="font-family:Verdana;">development</span><span style="font-family:Verdana;"> of metastasis in a group of Egyptian women with early breast cancer</span></span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> also, to assess patients’ Relapse-free survival (DFS) and OS and their correlation with different clinicopathological features. </span><b><span style="font-family:Verdana;">Patients and Methods: </span></b><span style="font-family:Verdana;">We retrospectively reviewed the files of breast cancer patients who were treated and </span><span style="font-family:Verdana;">followed-u展开更多
Background and aim of work: We aimed from this study to determine the response and local relapse free survival (RFS) of pediatric patients with localized Ewing’s sarcoma treated with accelerated hyper-fractionated RT...Background and aim of work: We aimed from this study to determine the response and local relapse free survival (RFS) of pediatric patients with localized Ewing’s sarcoma treated with accelerated hyper-fractionated RT. Patient and methods: This study was a nonrandomized uncontrolled phase II study and was conducted at clinical oncology department and south Egypt cancer institute;it involved 28 patients with histologically confirmed Ewing’s sarcoma;all of them were subjected to PET/CT whenever possible or MRI with contrast of the primary site, MSCT chest, bone scan, and LDH to ensure absence of metastasis followed by the protocol of accelerated hyper fractionated RT. Results: The overall response rate (ORR) was 92.9% by MRI with significant effect of the type of response on local RFS (P 0.002). The median local RFS of 28 patients with localized Ewing’s sarcoma was 30 ± 8.599 months with 95% CI = 13.147 - 46.853;the 3-year local control was 35%. Conclusion: Accelerated hyper fractionated RT didn’t achieve better results than standard fractionation RT, but it is recommended to be done on a large sample size, and multiple centers, and continued follow up is also recommended to evaluate 5-year LRFS, 5-year OS.展开更多
Background:Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma(HCC).However,few studies have examined the treatment of recurrent HCC in patients who received a prior hepatectomy.The p...Background:Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma(HCC).However,few studies have examined the treatment of recurrent HCC in patients who received a prior hepatectomy.The present prospective study compared the clinical efficacy of laparoscopic surgery with conventional open surgery in HCC patients with postoperative tumor recurrence.Methods:We conducted a prospective study of 64 patients,all of whom had undergone open surgery once before,who were diagnosed with recurrent HCC between June 2014 and November 2014.The laparoscopic group(n = 31)underwent laparoscopic hepatectomy,and the control group(n = 33) underwent conventional open surgery.Operation time,intraoperative blood loss,surgical margins,postoperative pain scores,postoperative time until the patient could walk,anal exsufflation time,length of hospital stay,and inpatient costs were compared between the two groups.The patients were followed up for 1 year after surgery,and relapse-free survival was compared between the two groups.Results:All surgeries were successfully completed.No conversion to open surgery occurred in the laparoscopic group,and no serious postoperative complications occurred in either group.No significant difference in inpatient costs was found between the laparoscopic group and the control group(P = 0.079),but significant differences between the two groups were observed for operation time(116.7 ± 37.5 vs.148.2 ± 46.7 min,P = 0.031),intraoperative blood loss(117.5 ± 35.5 vs.265.9 ± 70.3 mL,P = 0.012),postoperative time until the patient could walk(1.6 ± 0.6vs.2.2 ± 0.8 days,P < 0.05),anal exsufflation time(2.1 ± 0.3 vs.2.8 ± 0.7 days,P = 0.041),visual analogue scale pain score(P < 0.05),postoperative hepatic function(P < 0.05),and length of hospital stay(4.5 ± 1.3 vs.6.0 ± 1.2 days,P = 0.014).During the 1-year postoperative follow-up period,6 patients in each group had recurrent HCC on the side of the initial operation,but no significant difference between groups was observed in the re展开更多
AIM To detect the mechanisms of Helicobacter pylori(H. pylori) infection in the invasion and metastasis of gastric cancer(GC).METHODS Specimens from 99 patients with GC were collected. The correlation among H. pylori ...AIM To detect the mechanisms of Helicobacter pylori(H. pylori) infection in the invasion and metastasis of gastric cancer(GC).METHODS Specimens from 99 patients with GC were collected. The correlation among H. pylori infection, heparanase(HPA) and mitogen-activated protein kinase(MAPK) expression, which was determined by immunohistochemistry, and the clinical features of GC was analysed using SPSS 22.0. Overall survival(OS) and relapse-free survival(RFS) of GC patients were estimated by the KaplanMeier method. Independent and multiple factors of HPA and MAPK with prognosis were determined with COX proportional hazards models. HPA and MAPK expression in MKN-45 cells infected with H. pylori was analysed using Western blot. RESULTS H. pylori infection was observed in 70 of 99 patients with GC(70.7%), which was significantly higher than that in healthy controls. H. pylori infection was related to lymph metastasis and expression of HPA and MAPK(P < 0.05); HPA expression was relevant to MAPK expression(P = 0.024). HPA and MAPK expression in MKN-45 cells was significantly upregulated following H. pylori infection and peaked at 24 h and 60 min, before decreasing(P < 0.05). SB203580, an inhibitor of MAPK, significantly decreased HPA expression. HPA was related to lymph metastasis and invasive depth. HPA positive GC cases and H. pylori positive GC cases showed poorer prognosis than HPA negative cases(P < 0.05). COX models showed that the prognosis of GC was connected with HPA expression, lymph metastasis, tissue differentiation, and invasive depth. CONCLUSION H. pylori may promote the invasion and metastasis of GC by increasing HPA expression that may associate with MAPK activation, thus causing a poorer prognosis of GC.展开更多
目的:探讨8色流式细胞术动态监测急性髓系白血病(AML)患者微小残留病(MRD)的预后意义。方法:使用8色流式细胞术对282例初治缓解的AML患者进行MRD动态监测,通过受试者工作特征曲线(ROC)确定预测复发的MRD阈值,分析患者从出现MRD;到临床...目的:探讨8色流式细胞术动态监测急性髓系白血病(AML)患者微小残留病(MRD)的预后意义。方法:使用8色流式细胞术对282例初治缓解的AML患者进行MRD动态监测,通过受试者工作特征曲线(ROC)确定预测复发的MRD阈值,分析患者从出现MRD;到临床复发的时间,比较不同MRD变化情况的患者总生存时间(OS)和无复发生存时间(RFS)的差异,对影响MRD;患者复发的相关因素进行单因素和Logistic回归分析。结果:ROC曲线确定预测复发的MFC-MRD阈值为0.105%,MRD;患者复发率明显高于MRD;患者[52.45%(75/143例) vs 35.97%(50/139例),P=0.005]。MRD持续阳性组和阴性转阳性组患者比阳性转阴性组和阴性阳性波动组患者在出现MRD;后更早出现复发(P<0.005)。生存分析结果表明,MRD持续阳性组患者的OS、RFS时间较持续阴性组、阳性转阴性组和阴性阳性波动组患者明显缩短(P<0.005)。MRD阴性转阳性组与持续阳性组患者的OS、RFS比较差异无统计学意义(P>0.005),MRD持续阴性组与MRD阳性转阴性组患者的OS、RFS比较差异亦无统计学意义(P>0.005)。139例MRD;患者中50例复发,单因素和Logistic回归分析表明,随着白细胞水平增加,患者的复发风险增加(95%CI:1.000-1.013,P=0.045),未接受造血干细胞移植患者的复发风险是接受造血干细胞移植患者的9.694倍(95%CI:1.720-54.651,P=0.010),危险度分层高危组患者的复发风险是低危组患者的5.848倍(95%CI:1.418-24.121,P=0.015)。结论:不同MRD变化情况的AML患者预后存在明显差异,无论患者初次缓解时MRD阳性或阴性,治疗后监测MRD动态变化情况更有助于精准指导治疗。展开更多
文摘<strong>Background:</strong> <span style="font-family:Verdana;">Breast cancer (BC) is considered the most common women cancer worldwide. </span><span style="font-family:Verdana;">The main clinicopathological prognostic factors are tumor size, lymph node status and estrogen/progesterone (ER/PR) receptor status</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> In addition, some factors are both prognostic and predictive as ER/PR receptors and HER2/neu overexpression. </span><span style="font-family:Verdana;">Axillary lymph node status is the most important prognostic factor for breast cancer. Node negative breast cancer patients had the best 5-year overall survival (OS) of 82.8% compared to 73%, 45.7%, and 28.4% for patients with 1</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">3, 4</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">12, and ≥13 positive nodes, respectively. </span><span style="font-family:Verdana;">The aim of this study was</span><span style="font-family:Verdana;"> to determine the association between different clinicopathological features and </span><span style="font-family:Verdana;">development</span><span style="font-family:Verdana;"> of metastasis in a group of Egyptian women with early breast cancer</span></span><span style="font-family:Verdana;">,</span><span style="font-family:;" "=""><span style="font-family:Verdana;"> also, to assess patients’ Relapse-free survival (DFS) and OS and their correlation with different clinicopathological features. </span><b><span style="font-family:Verdana;">Patients and Methods: </span></b><span style="font-family:Verdana;">We retrospectively reviewed the files of breast cancer patients who were treated and </span><span style="font-family:Verdana;">followed-u
文摘Background and aim of work: We aimed from this study to determine the response and local relapse free survival (RFS) of pediatric patients with localized Ewing’s sarcoma treated with accelerated hyper-fractionated RT. Patient and methods: This study was a nonrandomized uncontrolled phase II study and was conducted at clinical oncology department and south Egypt cancer institute;it involved 28 patients with histologically confirmed Ewing’s sarcoma;all of them were subjected to PET/CT whenever possible or MRI with contrast of the primary site, MSCT chest, bone scan, and LDH to ensure absence of metastasis followed by the protocol of accelerated hyper fractionated RT. Results: The overall response rate (ORR) was 92.9% by MRI with significant effect of the type of response on local RFS (P 0.002). The median local RFS of 28 patients with localized Ewing’s sarcoma was 30 ± 8.599 months with 95% CI = 13.147 - 46.853;the 3-year local control was 35%. Conclusion: Accelerated hyper fractionated RT didn’t achieve better results than standard fractionation RT, but it is recommended to be done on a large sample size, and multiple centers, and continued follow up is also recommended to evaluate 5-year LRFS, 5-year OS.
基金supported by the Foundation for Guangdong Medical Science and Technology(No.B2012137)
文摘Background:Laparoscopic hepatectomy is increasingly being used to treat hepatocellular carcinoma(HCC).However,few studies have examined the treatment of recurrent HCC in patients who received a prior hepatectomy.The present prospective study compared the clinical efficacy of laparoscopic surgery with conventional open surgery in HCC patients with postoperative tumor recurrence.Methods:We conducted a prospective study of 64 patients,all of whom had undergone open surgery once before,who were diagnosed with recurrent HCC between June 2014 and November 2014.The laparoscopic group(n = 31)underwent laparoscopic hepatectomy,and the control group(n = 33) underwent conventional open surgery.Operation time,intraoperative blood loss,surgical margins,postoperative pain scores,postoperative time until the patient could walk,anal exsufflation time,length of hospital stay,and inpatient costs were compared between the two groups.The patients were followed up for 1 year after surgery,and relapse-free survival was compared between the two groups.Results:All surgeries were successfully completed.No conversion to open surgery occurred in the laparoscopic group,and no serious postoperative complications occurred in either group.No significant difference in inpatient costs was found between the laparoscopic group and the control group(P = 0.079),but significant differences between the two groups were observed for operation time(116.7 ± 37.5 vs.148.2 ± 46.7 min,P = 0.031),intraoperative blood loss(117.5 ± 35.5 vs.265.9 ± 70.3 mL,P = 0.012),postoperative time until the patient could walk(1.6 ± 0.6vs.2.2 ± 0.8 days,P < 0.05),anal exsufflation time(2.1 ± 0.3 vs.2.8 ± 0.7 days,P = 0.041),visual analogue scale pain score(P < 0.05),postoperative hepatic function(P < 0.05),and length of hospital stay(4.5 ± 1.3 vs.6.0 ± 1.2 days,P = 0.014).During the 1-year postoperative follow-up period,6 patients in each group had recurrent HCC on the side of the initial operation,but no significant difference between groups was observed in the re
基金Supported by the Natural Science Foundation of Gansu Province,No.1506RJZA255the National Natural Science Foundation of China,No.81572437+1 种基金the Open Topics of the Key Laboratory of Biological Treatment and Regenerative Medicine in Gansu Province,No.zdsyskfkt-201702the Fund of Donggang Branch,The First Hospital of Lanzhou University,No.ldyydgyn-201705
文摘AIM To detect the mechanisms of Helicobacter pylori(H. pylori) infection in the invasion and metastasis of gastric cancer(GC).METHODS Specimens from 99 patients with GC were collected. The correlation among H. pylori infection, heparanase(HPA) and mitogen-activated protein kinase(MAPK) expression, which was determined by immunohistochemistry, and the clinical features of GC was analysed using SPSS 22.0. Overall survival(OS) and relapse-free survival(RFS) of GC patients were estimated by the KaplanMeier method. Independent and multiple factors of HPA and MAPK with prognosis were determined with COX proportional hazards models. HPA and MAPK expression in MKN-45 cells infected with H. pylori was analysed using Western blot. RESULTS H. pylori infection was observed in 70 of 99 patients with GC(70.7%), which was significantly higher than that in healthy controls. H. pylori infection was related to lymph metastasis and expression of HPA and MAPK(P < 0.05); HPA expression was relevant to MAPK expression(P = 0.024). HPA and MAPK expression in MKN-45 cells was significantly upregulated following H. pylori infection and peaked at 24 h and 60 min, before decreasing(P < 0.05). SB203580, an inhibitor of MAPK, significantly decreased HPA expression. HPA was related to lymph metastasis and invasive depth. HPA positive GC cases and H. pylori positive GC cases showed poorer prognosis than HPA negative cases(P < 0.05). COX models showed that the prognosis of GC was connected with HPA expression, lymph metastasis, tissue differentiation, and invasive depth. CONCLUSION H. pylori may promote the invasion and metastasis of GC by increasing HPA expression that may associate with MAPK activation, thus causing a poorer prognosis of GC.
文摘目的:探讨8色流式细胞术动态监测急性髓系白血病(AML)患者微小残留病(MRD)的预后意义。方法:使用8色流式细胞术对282例初治缓解的AML患者进行MRD动态监测,通过受试者工作特征曲线(ROC)确定预测复发的MRD阈值,分析患者从出现MRD;到临床复发的时间,比较不同MRD变化情况的患者总生存时间(OS)和无复发生存时间(RFS)的差异,对影响MRD;患者复发的相关因素进行单因素和Logistic回归分析。结果:ROC曲线确定预测复发的MFC-MRD阈值为0.105%,MRD;患者复发率明显高于MRD;患者[52.45%(75/143例) vs 35.97%(50/139例),P=0.005]。MRD持续阳性组和阴性转阳性组患者比阳性转阴性组和阴性阳性波动组患者在出现MRD;后更早出现复发(P<0.005)。生存分析结果表明,MRD持续阳性组患者的OS、RFS时间较持续阴性组、阳性转阴性组和阴性阳性波动组患者明显缩短(P<0.005)。MRD阴性转阳性组与持续阳性组患者的OS、RFS比较差异无统计学意义(P>0.005),MRD持续阴性组与MRD阳性转阴性组患者的OS、RFS比较差异亦无统计学意义(P>0.005)。139例MRD;患者中50例复发,单因素和Logistic回归分析表明,随着白细胞水平增加,患者的复发风险增加(95%CI:1.000-1.013,P=0.045),未接受造血干细胞移植患者的复发风险是接受造血干细胞移植患者的9.694倍(95%CI:1.720-54.651,P=0.010),危险度分层高危组患者的复发风险是低危组患者的5.848倍(95%CI:1.418-24.121,P=0.015)。结论:不同MRD变化情况的AML患者预后存在明显差异,无论患者初次缓解时MRD阳性或阴性,治疗后监测MRD动态变化情况更有助于精准指导治疗。
