The goal of the Human Genome Project (HGP) is to determine a complete and high-quality sequence of the human genome. China, as one of the six member states, takes a region between 3pter and D3S3397 of the human chromo...The goal of the Human Genome Project (HGP) is to determine a complete and high-quality sequence of the human genome. China, as one of the six member states, takes a region between 3pter and D3S3397 of the human chromosome 3 as its share of this historic project, referred as “Beijing Region”. The complete sequence of this region comprises of 17.4 megabasepairs (Mb) with an average GC content of 42% and an average recombination rate of 2.14 cM/Mb. Within Beijing Region, 122 known and 20 novel genes are identified, as well as 42607 single nucleotide polymorphisms (SNPs). Comprehensive analyses also reveal: (i) gene density and GC-content of Beijing Region are in agreement with human cytogenetic maps, i.e. G-minus bands are GC-rich and of a high gene density, whereas G-plus bands are GC-poor and of a relatively low gene density; (ii) the average recombination rate within Beijing Region is rela-tively high compared with other regions of chromosome 3, with the highest recombination rate of 6.06 cM/Mb in the subtelomeric area; (iii) it is most likely that a large gene, associated with the mammary gland, may reside in the 1.1 Mb gene-poor area near the telomere; (iv) many dis-ease-related genes are genetically mapped to Beijing Region, including those associated with cancers and metabolic syndromes. All make Beijing Region an important target for in-depth mo-lecular investigations with a purpose of medical applications.展开更多
The formation process and characteristics ofcloud physical structure of a severe thunderstorm accompa-nied with strong wind on 23 August, 2001 in Beijing wasstudied using PSU/NCAR mesoscale model ( MM5) couplingwith a...The formation process and characteristics ofcloud physical structure of a severe thunderstorm accompa-nied with strong wind on 23 August, 2001 in Beijing wasstudied using PSU/NCAR mesoscale model ( MM5) couplingwith a severe storm model with hail-bin microphysics. Theresults show that the specific topography and distributionfeatures of cold/warm current in the Beijing region playedprominent roles in forming, developing and maintaining thesevere storm. Due to solar radiation heating and topographiclifting, the convective cells were easily formed when thewesterly airflow passed over high mountainous regions inBeijing. The warm and wet air entered the cloud from itsfrontage and enhanced the convection, and formed a largeamount of graupel/hail particles at the middle and upperportion of the clouds. The precipitation was primarilyformed due to melting of graupel/hail particles. The strongdowndraft was mainly produced by negative buoyancy dueto loading, melting of graupel/hail particles as well asevaporative cooling of rain water. The divergent airflow in-duced by the strong downdraft led to the disastrous burstwinds at the surface and also forced lifting of warm and wetairflow in the moving direction of the storm and formed newclouds that further promoted and maintained the storm de-velopment.展开更多
The seasonal and interannual variations of Beijing urban heat island (UHI) are investigated in this paper using the temperature data from 1960 to 2000 at 20 meteorological stations in the Beijing region, and then the ...The seasonal and interannual variations of Beijing urban heat island (UHI) are investigated in this paper using the temperature data from 1960 to 2000 at 20 meteorological stations in the Beijing region, and then the relationship between the intensity and spatial scale of UHI and Beijing urbanization indices is analyzed and discussed. Main conclusions are the followings. First, Beijing UHI shows obvious seasonal variations, and it is strongest in winter, next in spring and autumn, and least in summer. The seasonal variation of the UHI mainly occurs in the urban area. The UHI intensity at the center of Beijing is more than 0.8℃ in winter, and only 0.5℃ in summer. Second, the intensity of Beijing HUI exhibits a clear interannual warming trend with its mean growth rate (MGR) being 0.3088℃/10 a. The MGR of HUI is largest in winter, next in spring and autumn, and least in summer, and the urban temperature increase makes a major contribution to the growth of HUI intensity. Third, since the Reform and Opening, the urbanization indices have grown several ten times or even one hundred times, the intensity of HUI has increased dramatically, and its spatial scale also expanded distinctively along with the expansion of urban architectural complexes. Fourth, the interannual variation of urbanization indices is very similar with that of HUI intensity, and their linear correlation coefficients are significant at a more than 0.001 confidence level.展开更多
文摘The goal of the Human Genome Project (HGP) is to determine a complete and high-quality sequence of the human genome. China, as one of the six member states, takes a region between 3pter and D3S3397 of the human chromosome 3 as its share of this historic project, referred as “Beijing Region”. The complete sequence of this region comprises of 17.4 megabasepairs (Mb) with an average GC content of 42% and an average recombination rate of 2.14 cM/Mb. Within Beijing Region, 122 known and 20 novel genes are identified, as well as 42607 single nucleotide polymorphisms (SNPs). Comprehensive analyses also reveal: (i) gene density and GC-content of Beijing Region are in agreement with human cytogenetic maps, i.e. G-minus bands are GC-rich and of a high gene density, whereas G-plus bands are GC-poor and of a relatively low gene density; (ii) the average recombination rate within Beijing Region is rela-tively high compared with other regions of chromosome 3, with the highest recombination rate of 6.06 cM/Mb in the subtelomeric area; (iii) it is most likely that a large gene, associated with the mammary gland, may reside in the 1.1 Mb gene-poor area near the telomere; (iv) many dis-ease-related genes are genetically mapped to Beijing Region, including those associated with cancers and metabolic syndromes. All make Beijing Region an important target for in-depth mo-lecular investigations with a purpose of medical applications.
文摘The formation process and characteristics ofcloud physical structure of a severe thunderstorm accompa-nied with strong wind on 23 August, 2001 in Beijing wasstudied using PSU/NCAR mesoscale model ( MM5) couplingwith a severe storm model with hail-bin microphysics. Theresults show that the specific topography and distributionfeatures of cold/warm current in the Beijing region playedprominent roles in forming, developing and maintaining thesevere storm. Due to solar radiation heating and topographiclifting, the convective cells were easily formed when thewesterly airflow passed over high mountainous regions inBeijing. The warm and wet air entered the cloud from itsfrontage and enhanced the convection, and formed a largeamount of graupel/hail particles at the middle and upperportion of the clouds. The precipitation was primarilyformed due to melting of graupel/hail particles. The strongdowndraft was mainly produced by negative buoyancy dueto loading, melting of graupel/hail particles as well asevaporative cooling of rain water. The divergent airflow in-duced by the strong downdraft led to the disastrous burstwinds at the surface and also forced lifting of warm and wetairflow in the moving direction of the storm and formed newclouds that further promoted and maintained the storm de-velopment.
文摘The seasonal and interannual variations of Beijing urban heat island (UHI) are investigated in this paper using the temperature data from 1960 to 2000 at 20 meteorological stations in the Beijing region, and then the relationship between the intensity and spatial scale of UHI and Beijing urbanization indices is analyzed and discussed. Main conclusions are the followings. First, Beijing UHI shows obvious seasonal variations, and it is strongest in winter, next in spring and autumn, and least in summer. The seasonal variation of the UHI mainly occurs in the urban area. The UHI intensity at the center of Beijing is more than 0.8℃ in winter, and only 0.5℃ in summer. Second, the intensity of Beijing HUI exhibits a clear interannual warming trend with its mean growth rate (MGR) being 0.3088℃/10 a. The MGR of HUI is largest in winter, next in spring and autumn, and least in summer, and the urban temperature increase makes a major contribution to the growth of HUI intensity. Third, since the Reform and Opening, the urbanization indices have grown several ten times or even one hundred times, the intensity of HUI has increased dramatically, and its spatial scale also expanded distinctively along with the expansion of urban architectural complexes. Fourth, the interannual variation of urbanization indices is very similar with that of HUI intensity, and their linear correlation coefficients are significant at a more than 0.001 confidence level.
