背景青年卒中可导致长期残疾,造成沉重的社会、家庭负担。研究认为超敏C反应蛋白(hs-CRP)和应激性血糖升高可增加缺血性卒中发生及其预后不良等风险,但截至目前,尚缺乏青年卒中人群的研究证据。目的分别探讨hs-CRP和随机血糖与青年卒中...背景青年卒中可导致长期残疾,造成沉重的社会、家庭负担。研究认为超敏C反应蛋白(hs-CRP)和应激性血糖升高可增加缺血性卒中发生及其预后不良等风险,但截至目前,尚缺乏青年卒中人群的研究证据。目的分别探讨hs-CRP和随机血糖与青年卒中患者神经功能缺损及长、短期预后的关系。方法回顾性选取2019—2021年首都医科大学附属北京天坛医院神经病学中心收治的发病72 h内到院的18~45岁首次缺血性卒中患者。收集患者的人口学信息、危险因素、实验室结果、并发症等。根据hs-CRP四分位数将患者分为4组,即Q1组(n=160)、Q2组(n=156)、Q3组(n=157)、Q4组(n=157);又根据随机血糖四分位数将患者分为4组,即q1组(n=158)、q2组(n=158)、q3组(n=157)、q4组(n=157)。以出院时美国国立卫生研究院卒中量表(NIHSS)评分>4分作为神经功能缺损标准,出院时改良Rankin量表(mRS)评分2~5分作为短期预后不良标准,90 d mRS评分2~5分作为长期预后不良标准。采用多因素Logistic回归分析探讨hs-CRP、随机血糖与神经功能缺损、短期预后不良、长期预后不良的关系。结果630例患者中神经功能缺损154例(24.4%),短期预后不良217例(34.4%),长期预后不良144例(22.9%)。Logistic回归分析结果显示,与Q1组相比,Q3组和Q4组神经功能缺损〔OR=2.86,95%CI(1.56,5.22);OR=2.99,95%CI(1.63,5.50)〕、短期预后不良〔OR=2.14,95%CI(1.25,3.66);OR=2.80,95%CI(1.62,4.83)〕、长期预后不良〔OR=3.17,95%CI(1.67,6.01);OR=3.61,95%CI(1.90,6.86)〕的发生风险均增加(P<0.01)。Logistic回归分析结果显示,与q1组相比,q3组长期预后不良的发生风险增加〔OR=1.94,95%CI(1.07,3.53)〕,q4组短期预后不良〔OR=2.05,95%CI(1.11,3.82)〕、长期预后不良〔OR=2.62,95%CI(1.31,5.24)〕的发生风险均增加(P<0.05)。且在进一步排除肺部感染、泌尿系感染及感染性腹泻人群后仍得到一致结果。结论hs-CRP>1.18 mg/L是青年卒中患�展开更多
Introduction: Diabetes mellitus type 2 is a growing threat in developing countries already burdened with high levels of infectious disease. Screening the general population has debatable advantages. This study aims to...Introduction: Diabetes mellitus type 2 is a growing threat in developing countries already burdened with high levels of infectious disease. Screening the general population has debatable advantages. This study aims to determine whether spouses of patients with diabetes mellitus have higher random blood glucose (RBG) levels as well as the benefit of RBG testing as a targetted screening tool. Methodology: The survey employed a cross-sectional comparative study of spouses’ of diabetics and non-diabetics attending the general out-patient department of the LagosStateUniversityTeaching Hospital (LASUTH), Ikeja. A modified WHO STEPS Surveillance Instrument and a one-touch Glucometer were used to collect data. Blood pressures and BMI were measured and correlated to blood glucose levels. Results: Prevalence of high RBG was found to be 7% among spouses of diabetics and 3.3% among spouses of non-diabetic patients. Mean RBG was 5.57 mmol/L and 7.7 mmol/L within the age group 40 - 49 years and 50 - 59 years respectively among spouses of diabetic patients compared to 5.4 mmol/L and 5.5 mmol/L within the same age group among the spouses non-diabetics. Spouses of patients with diabetes mellitus had higher systolic and diastolic blood pressures and BMI compared to spouses of non-diabetics. Conclusion: Being male, married to a diabetic patient, lower educational levels and higher body mass index are significantly associated with higher random blood glucose in the spouses of diabetic patients. Random blood glucose measurements are an effective screening tool and spouses of diabetic patients can benefit from targeted screening in controlled clinical settings.展开更多
文摘背景青年卒中可导致长期残疾,造成沉重的社会、家庭负担。研究认为超敏C反应蛋白(hs-CRP)和应激性血糖升高可增加缺血性卒中发生及其预后不良等风险,但截至目前,尚缺乏青年卒中人群的研究证据。目的分别探讨hs-CRP和随机血糖与青年卒中患者神经功能缺损及长、短期预后的关系。方法回顾性选取2019—2021年首都医科大学附属北京天坛医院神经病学中心收治的发病72 h内到院的18~45岁首次缺血性卒中患者。收集患者的人口学信息、危险因素、实验室结果、并发症等。根据hs-CRP四分位数将患者分为4组,即Q1组(n=160)、Q2组(n=156)、Q3组(n=157)、Q4组(n=157);又根据随机血糖四分位数将患者分为4组,即q1组(n=158)、q2组(n=158)、q3组(n=157)、q4组(n=157)。以出院时美国国立卫生研究院卒中量表(NIHSS)评分>4分作为神经功能缺损标准,出院时改良Rankin量表(mRS)评分2~5分作为短期预后不良标准,90 d mRS评分2~5分作为长期预后不良标准。采用多因素Logistic回归分析探讨hs-CRP、随机血糖与神经功能缺损、短期预后不良、长期预后不良的关系。结果630例患者中神经功能缺损154例(24.4%),短期预后不良217例(34.4%),长期预后不良144例(22.9%)。Logistic回归分析结果显示,与Q1组相比,Q3组和Q4组神经功能缺损〔OR=2.86,95%CI(1.56,5.22);OR=2.99,95%CI(1.63,5.50)〕、短期预后不良〔OR=2.14,95%CI(1.25,3.66);OR=2.80,95%CI(1.62,4.83)〕、长期预后不良〔OR=3.17,95%CI(1.67,6.01);OR=3.61,95%CI(1.90,6.86)〕的发生风险均增加(P<0.01)。Logistic回归分析结果显示,与q1组相比,q3组长期预后不良的发生风险增加〔OR=1.94,95%CI(1.07,3.53)〕,q4组短期预后不良〔OR=2.05,95%CI(1.11,3.82)〕、长期预后不良〔OR=2.62,95%CI(1.31,5.24)〕的发生风险均增加(P<0.05)。且在进一步排除肺部感染、泌尿系感染及感染性腹泻人群后仍得到一致结果。结论hs-CRP>1.18 mg/L是青年卒中患�
文摘Introduction: Diabetes mellitus type 2 is a growing threat in developing countries already burdened with high levels of infectious disease. Screening the general population has debatable advantages. This study aims to determine whether spouses of patients with diabetes mellitus have higher random blood glucose (RBG) levels as well as the benefit of RBG testing as a targetted screening tool. Methodology: The survey employed a cross-sectional comparative study of spouses’ of diabetics and non-diabetics attending the general out-patient department of the LagosStateUniversityTeaching Hospital (LASUTH), Ikeja. A modified WHO STEPS Surveillance Instrument and a one-touch Glucometer were used to collect data. Blood pressures and BMI were measured and correlated to blood glucose levels. Results: Prevalence of high RBG was found to be 7% among spouses of diabetics and 3.3% among spouses of non-diabetic patients. Mean RBG was 5.57 mmol/L and 7.7 mmol/L within the age group 40 - 49 years and 50 - 59 years respectively among spouses of diabetic patients compared to 5.4 mmol/L and 5.5 mmol/L within the same age group among the spouses non-diabetics. Spouses of patients with diabetes mellitus had higher systolic and diastolic blood pressures and BMI compared to spouses of non-diabetics. Conclusion: Being male, married to a diabetic patient, lower educational levels and higher body mass index are significantly associated with higher random blood glucose in the spouses of diabetic patients. Random blood glucose measurements are an effective screening tool and spouses of diabetic patients can benefit from targeted screening in controlled clinical settings.
