目的探讨MRI分区定位联合双指引导经会阴前列腺穿刺活检在前列腺癌诊断中的应用价值。方法对15例临床前列腺特异性抗原(prostate specific antigen,PSA)升高患者行MRI检查并进行12分区,分区与经会阴穿刺方向、区域一致,然后行双指引导...目的探讨MRI分区定位联合双指引导经会阴前列腺穿刺活检在前列腺癌诊断中的应用价值。方法对15例临床前列腺特异性抗原(prostate specific antigen,PSA)升高患者行MRI检查并进行12分区,分区与经会阴穿刺方向、区域一致,然后行双指引导经会阴前列腺穿刺术,即在双指引导经会阴前列腺穿刺的基础上,增加MRI分区异常区域的穿刺点。分析前列腺穿刺针数、阳性率、并发症发生率。结果 15例中穿刺针数共计189针,阳性针数99针(52%),阳性病例12例(80%),术后血尿2例,发热1例。结论采用MRI分区定位联合双指引导经会阴前列腺穿刺活检的方法,提高了前列腺癌穿刺阳性率,避免了对直肠的直接损伤,同时降低了术后感染、肠瘘等并发症的发生率,操作简单,有利于在基层医院开展,是诊断前列腺癌的可靠、有效方法。展开更多
Objectives: Fluorescence spectroscopy which can be used for optical tissue diagnosis of tumor pathology?deserves special interest. The purpose of the work was to study blood plasma and tumor tissue of men with differe...Objectives: Fluorescence spectroscopy which can be used for optical tissue diagnosis of tumor pathology?deserves special interest. The purpose of the work was to study blood plasma and tumor tissue of men with different forms of prostate tumors by using laser induced fluorescence. Blood plasma and tumor tissue of the patients with benign hyperplasia of the prostate (BHP), BHP with inflammation, BHP with high grade PIN (BHP with HGPIN) and adenocarcinoma of prostate (CaP) have been studied. Results: In case of blood plasma fluorescence,?intensity of the plasma proteins corresponding peak (340 - 360 nm) was increasing in the following manner: control group → BHP → BHP with HGPIN → CaP. The intensity of the nicotinamide coenzymes correspond peak (440 - 460 nm) was increased in case of BHP with HGPIN and CaP patients, but decreased in case of BHP, compared to control. In case of tumor tissue, the changes of the collagen peak (390 - 400 nm) intensity have been revealed in all cases of prostate tumor tissues. These alterations point to altered collagen biosynthesis levels in different tumor tissues, that reflects the structural changes and characteristics of malignant transformation. Also the changes of the nicotinamide coenzymes peak (440 - 460 nm) intensity in all spectra of tumor tissues were observed. The highest intensity of the peak was observed in the spectra of BHP with HGPIN and in prostate cancer tissue. Conclusions: Alterations of the coenzymes peak intensities perfectly reflect and are in accordance with the specific energy metabolism of prostate epithelial cells. Normalization of fluorescent spectra from different forms of prostate tumor tissues has shown that, each form has typical spectral shape and ratio of fluorescence peaks intensities.展开更多
The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na+/K+-ATP-ase activity and permeability of Na+ and K+ ions, before and after...The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na+/K+-ATP-ase activity and permeability of Na+ and K+ ions, before and after the plastic orchiectomy. The results of the study revealed that activity of Na+/K+-ATP-ase was increased compared with the data before the orchiectomy, but this parameter was reduced compared with control group. The increased amounts of the Na+ as well as K+ ions were also observed in the extracellular area compared with the same data before the orchiectomy. The amount of cholesterol, after plastic orchiectomy, was reduced compared with the data gained before orchiectomy, but the data were greater than those of the control group. It may be presumed that one of the reasons for change of Na+/K+-ATP-ase activity is variation of cholesterol content in erythrocyte membrane. Changes of the active transport system, in turn, affect the transport function of the erythrocyte membrane. In spite of surgical intervention, full recovery of patients does not take place after the plastic orchiectomy. Comparative normalization and approaching to the control group of the given indices in post-operation period (~6 months after surgery) indicate strengthening of the immune system and correspondingly—protective abilities of an organism, which was proved by the anamneses of patients.展开更多
Objective: To determine the kappa (κ) concordance coefficient between fine needle aspiration and serum prostatic antigen (PSA) coupled with digital rectal examination and prostatic ultrasound. Material and Methods: W...Objective: To determine the kappa (κ) concordance coefficient between fine needle aspiration and serum prostatic antigen (PSA) coupled with digital rectal examination and prostatic ultrasound. Material and Methods: We conducted a cross-sectional study covering the period from January 1st to June 30th, 2018 in the city of Pointe-Noire. It is a study of 31 cases of prostate tumors in Congolese subjects at the General Hospital of Loandjili in Pointe-Noire of Congo Brazzaville. The clinical, biological, ultrasound and cytological aspects were the variables of the study. Results: The mean age was 71.06 years with extremes of 57 and 93 years. One patient had a family history of prostate cancer that was found at his brother’s house at the age of 52. Dysuria was the most represented sign in all of our patients. Suspicion of prostate cancer was the most commonly talked in digital rectal examination. Prostate specific antigen (PSA) was greater than or equal to 10 ng/ml in more 74% of our patients. 61.3% of our patients had a heterogeneous prostatic ultrasound. 48.3% of malignant tumors and 32.3% of benign tumors were found cytologically. The association between digital rectal examination and prostatic ultrasound was statistically significant (p ≤ 0.05) and good agreement was found between cytological diagnosis coupled with digital rectal examination and prostatic echostructure (0.6 ≤ κ ≤ 0.8). A low concordance between prostatic specific antigen (PSA) and cytological concordance was noted (0.2 ≤ κ ≤ 0.4). Conclusion: Prostatic tumors in Congo in their diagnostic particularities are dominated by malignant tumors with a large number of patients to watch. The fine needle aspiration is suitable for orientation examinations of prostatic tumors and can be performed by any doctor and provides us a fast, effective diagnostic orientation with a strong clinico-morphological correlation in our low incomes countries.展开更多
目的探究腹腔镜前列腺癌根治术中应用个体化呼气末正压(PEEP)通气对患者术后肺部并发症的影响。方法采用随机数字表法将2021年8月至2022年2月该院收治的40例择期行腹腔镜前列腺癌根治术老年患者分为对照组(C组)和驱动压导向组(P组),每...目的探究腹腔镜前列腺癌根治术中应用个体化呼气末正压(PEEP)通气对患者术后肺部并发症的影响。方法采用随机数字表法将2021年8月至2022年2月该院收治的40例择期行腹腔镜前列腺癌根治术老年患者分为对照组(C组)和驱动压导向组(P组),每组20例。C组在气管插管后采用5 cm H_(2)O的PEEP,P组在气管插管后首先进行1次肺复张,然后以5 cm H_(2)O(1 cm H_(2)O=0.098 kPa)为起点,依次增加1 cm H_(2)O直至15 cm H_(2)O,保持10个呼吸循环后计算驱动压,并选择驱动压最低时对应的PEEP值维持至手术结束,手术结束后拔管前再进行1次肺复张。主要观察指标为两组患者术后7 d肺部并发症发生情况,次要观察指标为两组患者各时间点[气腹-Trendelenburg体位建立后即刻(T0)、PEEP滴定完成后30 min(T1)、1 h(T2)、2 h(T3)、术后30 min(T4)]呼吸力学变化和氧合指数等。结果与C组比较,P组患者拔管时间明显缩短,术中补液量、血管活性药使用比例均明显增多,T1~4时动脉血氧分压、氧合指数,T1~3时气道峰压、气道平台压、动态肺顺应性均明显升高,驱动压明显降低,差异均有统计学意义(P<0.05);术后7 d肺部并发症发生率虽然有所降低,但差异无统计学意义(P>0.05)。结论驱动压导向的个体化PEEP通气能改善患者术中呼吸力学,但两组患者术后肺部并发症发生率无明显差异。展开更多
文摘目的探讨MRI分区定位联合双指引导经会阴前列腺穿刺活检在前列腺癌诊断中的应用价值。方法对15例临床前列腺特异性抗原(prostate specific antigen,PSA)升高患者行MRI检查并进行12分区,分区与经会阴穿刺方向、区域一致,然后行双指引导经会阴前列腺穿刺术,即在双指引导经会阴前列腺穿刺的基础上,增加MRI分区异常区域的穿刺点。分析前列腺穿刺针数、阳性率、并发症发生率。结果 15例中穿刺针数共计189针,阳性针数99针(52%),阳性病例12例(80%),术后血尿2例,发热1例。结论采用MRI分区定位联合双指引导经会阴前列腺穿刺活检的方法,提高了前列腺癌穿刺阳性率,避免了对直肠的直接损伤,同时降低了术后感染、肠瘘等并发症的发生率,操作简单,有利于在基层医院开展,是诊断前列腺癌的可靠、有效方法。
文摘Objectives: Fluorescence spectroscopy which can be used for optical tissue diagnosis of tumor pathology?deserves special interest. The purpose of the work was to study blood plasma and tumor tissue of men with different forms of prostate tumors by using laser induced fluorescence. Blood plasma and tumor tissue of the patients with benign hyperplasia of the prostate (BHP), BHP with inflammation, BHP with high grade PIN (BHP with HGPIN) and adenocarcinoma of prostate (CaP) have been studied. Results: In case of blood plasma fluorescence,?intensity of the plasma proteins corresponding peak (340 - 360 nm) was increasing in the following manner: control group → BHP → BHP with HGPIN → CaP. The intensity of the nicotinamide coenzymes correspond peak (440 - 460 nm) was increased in case of BHP with HGPIN and CaP patients, but decreased in case of BHP, compared to control. In case of tumor tissue, the changes of the collagen peak (390 - 400 nm) intensity have been revealed in all cases of prostate tumor tissues. These alterations point to altered collagen biosynthesis levels in different tumor tissues, that reflects the structural changes and characteristics of malignant transformation. Also the changes of the nicotinamide coenzymes peak (440 - 460 nm) intensity in all spectra of tumor tissues were observed. The highest intensity of the peak was observed in the spectra of BHP with HGPIN and in prostate cancer tissue. Conclusions: Alterations of the coenzymes peak intensities perfectly reflect and are in accordance with the specific energy metabolism of prostate epithelial cells. Normalization of fluorescent spectra from different forms of prostate tumor tissues has shown that, each form has typical spectral shape and ratio of fluorescence peaks intensities.
文摘The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na+/K+-ATP-ase activity and permeability of Na+ and K+ ions, before and after the plastic orchiectomy. The results of the study revealed that activity of Na+/K+-ATP-ase was increased compared with the data before the orchiectomy, but this parameter was reduced compared with control group. The increased amounts of the Na+ as well as K+ ions were also observed in the extracellular area compared with the same data before the orchiectomy. The amount of cholesterol, after plastic orchiectomy, was reduced compared with the data gained before orchiectomy, but the data were greater than those of the control group. It may be presumed that one of the reasons for change of Na+/K+-ATP-ase activity is variation of cholesterol content in erythrocyte membrane. Changes of the active transport system, in turn, affect the transport function of the erythrocyte membrane. In spite of surgical intervention, full recovery of patients does not take place after the plastic orchiectomy. Comparative normalization and approaching to the control group of the given indices in post-operation period (~6 months after surgery) indicate strengthening of the immune system and correspondingly—protective abilities of an organism, which was proved by the anamneses of patients.
文摘Objective: To determine the kappa (κ) concordance coefficient between fine needle aspiration and serum prostatic antigen (PSA) coupled with digital rectal examination and prostatic ultrasound. Material and Methods: We conducted a cross-sectional study covering the period from January 1st to June 30th, 2018 in the city of Pointe-Noire. It is a study of 31 cases of prostate tumors in Congolese subjects at the General Hospital of Loandjili in Pointe-Noire of Congo Brazzaville. The clinical, biological, ultrasound and cytological aspects were the variables of the study. Results: The mean age was 71.06 years with extremes of 57 and 93 years. One patient had a family history of prostate cancer that was found at his brother’s house at the age of 52. Dysuria was the most represented sign in all of our patients. Suspicion of prostate cancer was the most commonly talked in digital rectal examination. Prostate specific antigen (PSA) was greater than or equal to 10 ng/ml in more 74% of our patients. 61.3% of our patients had a heterogeneous prostatic ultrasound. 48.3% of malignant tumors and 32.3% of benign tumors were found cytologically. The association between digital rectal examination and prostatic ultrasound was statistically significant (p ≤ 0.05) and good agreement was found between cytological diagnosis coupled with digital rectal examination and prostatic echostructure (0.6 ≤ κ ≤ 0.8). A low concordance between prostatic specific antigen (PSA) and cytological concordance was noted (0.2 ≤ κ ≤ 0.4). Conclusion: Prostatic tumors in Congo in their diagnostic particularities are dominated by malignant tumors with a large number of patients to watch. The fine needle aspiration is suitable for orientation examinations of prostatic tumors and can be performed by any doctor and provides us a fast, effective diagnostic orientation with a strong clinico-morphological correlation in our low incomes countries.
文摘目的探究腹腔镜前列腺癌根治术中应用个体化呼气末正压(PEEP)通气对患者术后肺部并发症的影响。方法采用随机数字表法将2021年8月至2022年2月该院收治的40例择期行腹腔镜前列腺癌根治术老年患者分为对照组(C组)和驱动压导向组(P组),每组20例。C组在气管插管后采用5 cm H_(2)O的PEEP,P组在气管插管后首先进行1次肺复张,然后以5 cm H_(2)O(1 cm H_(2)O=0.098 kPa)为起点,依次增加1 cm H_(2)O直至15 cm H_(2)O,保持10个呼吸循环后计算驱动压,并选择驱动压最低时对应的PEEP值维持至手术结束,手术结束后拔管前再进行1次肺复张。主要观察指标为两组患者术后7 d肺部并发症发生情况,次要观察指标为两组患者各时间点[气腹-Trendelenburg体位建立后即刻(T0)、PEEP滴定完成后30 min(T1)、1 h(T2)、2 h(T3)、术后30 min(T4)]呼吸力学变化和氧合指数等。结果与C组比较,P组患者拔管时间明显缩短,术中补液量、血管活性药使用比例均明显增多,T1~4时动脉血氧分压、氧合指数,T1~3时气道峰压、气道平台压、动态肺顺应性均明显升高,驱动压明显降低,差异均有统计学意义(P<0.05);术后7 d肺部并发症发生率虽然有所降低,但差异无统计学意义(P>0.05)。结论驱动压导向的个体化PEEP通气能改善患者术中呼吸力学,但两组患者术后肺部并发症发生率无明显差异。
