Terpyridine-capped poly（ethylene glycol） （PEG） was synthesized as a novel polymeric ligand and rare earth complex was prepared from Eu（NO3）3 and the telechelic macromolecules. The structure of the complex was ch...Terpyridine-capped poly（ethylene glycol） （PEG） was synthesized as a novel polymeric ligand and rare earth complex was prepared from Eu（NO3）3 and the telechelic macromolecules. The structure of the complex was characterized by 1H NMR, FT-IR, UV-vis and fluores-cence spectroscopy. Strong fluorescent emission of the complex was observed at 593 and 616 nm upon the excitation of 300 nm. The fluo-rescent emission was quenched upon addition of trace amount of diethyl chlorophosphate （DCP）. And the observed Ksv values for DCP were measured to be 0.568×10^3 and 0.89×10^3 L/mol for quenching at 593 and 616 nm, which indicated the detection limit for DCP was about 0.014 mmol/L. These results showed that the terpyridine-lanthanide complex could be an effective chemosensor with a potential application in the detection of organophosphates.展开更多
A modified poly(ethylene glycol) (PEG) has been developed as the solublepolymeric supports for liquid phase synthesis of novel thiourea derivatives. In each step of thesequence, the PEG-bound products were precipitate...A modified poly(ethylene glycol) (PEG) has been developed as the solublepolymeric supports for liquid phase synthesis of novel thiourea derivatives. In each step of thesequence, the PEG-bound products were precipitated in cold Et_2O and the unreacted materials andby-products were removed by simple filtration. The progress of reaction, purity of the isolation andthe structure of the PEG-bound products were easily monitored by TLC, IR and ~1H NMR spectra.Representative thiourea derivatives were obtained in moderate yields with excellent purity from thismodified PEG-bound product by the cleavage with 50% TFA/H_2O.展开更多
An efficient liquid-phase synthesis of isoxazolines through a 1,3-dipolar cycloaddition is described. Soluble polymer-supported acrylate reacted with nitrile oxides generated in-situ, followed by cleavage from the sup...An efficient liquid-phase synthesis of isoxazolines through a 1,3-dipolar cycloaddition is described. Soluble polymer-supported acrylate reacted with nitrile oxides generated in-situ, followed by cleavage from the support giving corresponding isoxazolines in high yields and excellent purities.展开更多
Recently,multifunctional polymers for protein conjugation have been facilely synthesized through the multicomponent reactions(MCRs).In this mini-review,current progress in the generation of multifuncti onal polymers w...Recently,multifunctional polymers for protein conjugation have been facilely synthesized through the multicomponent reactions(MCRs).In this mini-review,current progress in the generation of multifuncti onal polymers with protei n-reactive groups via MCRs is summarized.These mult functional polymers react with model therapeutic proteins,forming multifunctional polymer-protein conjugates,which are prototypes of sophisticated theranostic agents and antibacterial vaccine candidates.In comparison with the traditional multi-step synthesis,the preparation of multifunctional polymers for protein conjugation through MCRs is straightforward and convenient.Due to these properties,MCRs have the potential to become a new general strategy to achieve polymer-protein conjugates for biological and medical applications.展开更多
基金Project supported by Research Foundation of the General Armament Department (2008CD012)
文摘Terpyridine-capped poly（ethylene glycol） （PEG） was synthesized as a novel polymeric ligand and rare earth complex was prepared from Eu（NO3）3 and the telechelic macromolecules. The structure of the complex was characterized by 1H NMR, FT-IR, UV-vis and fluores-cence spectroscopy. Strong fluorescent emission of the complex was observed at 593 and 616 nm upon the excitation of 300 nm. The fluo-rescent emission was quenched upon addition of trace amount of diethyl chlorophosphate （DCP）. And the observed Ksv values for DCP were measured to be 0.568×10^3 and 0.89×10^3 L/mol for quenching at 593 and 616 nm, which indicated the detection limit for DCP was about 0.014 mmol/L. These results showed that the terpyridine-lanthanide complex could be an effective chemosensor with a potential application in the detection of organophosphates.
文摘A modified poly(ethylene glycol) (PEG) has been developed as the solublepolymeric supports for liquid phase synthesis of novel thiourea derivatives. In each step of thesequence, the PEG-bound products were precipitated in cold Et_2O and the unreacted materials andby-products were removed by simple filtration. The progress of reaction, purity of the isolation andthe structure of the PEG-bound products were easily monitored by TLC, IR and ~1H NMR spectra.Representative thiourea derivatives were obtained in moderate yields with excellent purity from thismodified PEG-bound product by the cleavage with 50% TFA/H_2O.
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 9972 0 37)
文摘An efficient liquid-phase synthesis of isoxazolines through a 1,3-dipolar cycloaddition is described. Soluble polymer-supported acrylate reacted with nitrile oxides generated in-situ, followed by cleavage from the support giving corresponding isoxazolines in high yields and excellent purities.
基金This research was supported by the National Science Founda-tion of China(21971141)"Chenguang Program 18CG01"supported by Shanghai Education Development Foundation and Shanghai Municipal Education.
文摘Recently,multifunctional polymers for protein conjugation have been facilely synthesized through the multicomponent reactions(MCRs).In this mini-review,current progress in the generation of multifuncti onal polymers with protei n-reactive groups via MCRs is summarized.These mult functional polymers react with model therapeutic proteins,forming multifunctional polymer-protein conjugates,which are prototypes of sophisticated theranostic agents and antibacterial vaccine candidates.In comparison with the traditional multi-step synthesis,the preparation of multifunctional polymers for protein conjugation through MCRs is straightforward and convenient.Due to these properties,MCRs have the potential to become a new general strategy to achieve polymer-protein conjugates for biological and medical applications.
