To the Editor:Pituitary gonadotroph adenoma is a type of non-functioning pituitary adenoma of which approximately 35%ecrete biologically active luteinizing hormone(LH)or follicle-stimulating hormone(FSH),and these ade...To the Editor:Pituitary gonadotroph adenoma is a type of non-functioning pituitary adenoma of which approximately 35%ecrete biologically active luteinizing hormone(LH)or follicle-stimulating hormone(FSH),and these adenomas are named functioning gonadotroph adenoma(FGA).We present three cases of FSH-secreting adenomas who were admitted to our hospital between 2014 and 2016.Case 1:A 37-year-old woman was admitted due to menstrual irregularity and galactorrhea for 2 years.The laboratory tests showed a significantly elevated estradiol 2(E2)level,and multiple cyst fusions could be observed by transvaginal ultrasonography.The pituitary magnetic resonance imaging(MRI)revealed an upper-right wing distension and detected a mass with a size of approximately 7.5 mm×10.7 mm in the saddle area,and a pituitarymacroadenoma was considered.The patient underwent a transsphenoidal microsurgical resection of the pituitary adenoma.The pathologic examination showed a positive result for FSH,LH,and SF-1,and a negative result for growth hormone,insulin-like growth factor 1,TPIT,and PIT1.展开更多
Introduction: Gonadotroph adenomas are generally nonfunctioning. Hypersecretion of gonadotropins by gonadotroph adenomas rarely induced hypersecretion of testosterone. We report a case of functioning gonadotroph adeno...Introduction: Gonadotroph adenomas are generally nonfunctioning. Hypersecretion of gonadotropins by gonadotroph adenomas rarely induced hypersecretion of testosterone. We report a case of functioning gonadotroph adenoma with secondary hypersecretion of testosterone. Medical Observation: A 25-year-old patient who having had a progressive and bilateral loss of visual acuity for two years. The ophtalmologist’s examination concluded to bitemporal hemianopia. He had no other clinical manifestations of hyper or hypo hormonal secretion. The brain scan has revealed an intrasellar mass with suprasellar development that represses the optic chiasma and the carotids. The assessment carried out revealed an increase in FSH, LH and testosterone. The diagnosis of a functioning gonadotroph macroadenoma with secondary hypersecretion of testosterone was retained. Surgical excision of the adenoma was performed. Anatomo-pathological examination concluded to a pituitary adenoma. The patient showed an improvement in the right visual acuity and developed an adrenal corticotropic insufficiency substituted by hydrocortisone 20 mg per day. The postoperative hormonal profile revealed a normalization of FSH and testosterone. Conclusion: Functioning gonadotroph adenoma with secondary hypersecretion of testosterone is rare. The first-line treatment is surgical and allows an improvement of the cerebral tumor syndrome and the restoration of the gonadotropic function.展开更多
文摘To the Editor:Pituitary gonadotroph adenoma is a type of non-functioning pituitary adenoma of which approximately 35%ecrete biologically active luteinizing hormone(LH)or follicle-stimulating hormone(FSH),and these adenomas are named functioning gonadotroph adenoma(FGA).We present three cases of FSH-secreting adenomas who were admitted to our hospital between 2014 and 2016.Case 1:A 37-year-old woman was admitted due to menstrual irregularity and galactorrhea for 2 years.The laboratory tests showed a significantly elevated estradiol 2(E2)level,and multiple cyst fusions could be observed by transvaginal ultrasonography.The pituitary magnetic resonance imaging(MRI)revealed an upper-right wing distension and detected a mass with a size of approximately 7.5 mm×10.7 mm in the saddle area,and a pituitarymacroadenoma was considered.The patient underwent a transsphenoidal microsurgical resection of the pituitary adenoma.The pathologic examination showed a positive result for FSH,LH,and SF-1,and a negative result for growth hormone,insulin-like growth factor 1,TPIT,and PIT1.
文摘Introduction: Gonadotroph adenomas are generally nonfunctioning. Hypersecretion of gonadotropins by gonadotroph adenomas rarely induced hypersecretion of testosterone. We report a case of functioning gonadotroph adenoma with secondary hypersecretion of testosterone. Medical Observation: A 25-year-old patient who having had a progressive and bilateral loss of visual acuity for two years. The ophtalmologist’s examination concluded to bitemporal hemianopia. He had no other clinical manifestations of hyper or hypo hormonal secretion. The brain scan has revealed an intrasellar mass with suprasellar development that represses the optic chiasma and the carotids. The assessment carried out revealed an increase in FSH, LH and testosterone. The diagnosis of a functioning gonadotroph macroadenoma with secondary hypersecretion of testosterone was retained. Surgical excision of the adenoma was performed. Anatomo-pathological examination concluded to a pituitary adenoma. The patient showed an improvement in the right visual acuity and developed an adrenal corticotropic insufficiency substituted by hydrocortisone 20 mg per day. The postoperative hormonal profile revealed a normalization of FSH and testosterone. Conclusion: Functioning gonadotroph adenoma with secondary hypersecretion of testosterone is rare. The first-line treatment is surgical and allows an improvement of the cerebral tumor syndrome and the restoration of the gonadotropic function.
