基于Arc GIS Enterprise、GIStack for Manager等系列软件,开发了包括通用化平台、专业化平台和个性化平台在内的智慧广州时空信息云平台,平台既面向一般用户,实现了其从无到有的搭建一个完整GIS应用的功能需求;也面向专业化和个性化的...基于Arc GIS Enterprise、GIStack for Manager等系列软件,开发了包括通用化平台、专业化平台和个性化平台在内的智慧广州时空信息云平台,平台既面向一般用户,实现了其从无到有的搭建一个完整GIS应用的功能需求;也面向专业化和个性化的用户,分别实现了其专业化和个性化的定制需求。展开更多
Skin lightening and tanning are two major areas dominating the market of skincare and cosmetic products. Though the demands are originated from two different communities, the two areas share a same goal—skin colour t...Skin lightening and tanning are two major areas dominating the market of skincare and cosmetic products. Though the demands are originated from two different communities, the two areas share a same goal—skin colour tuning. The known safe compounds with skin colour tuning activities are limited. In contrary, Chinese medicinal herb provides a pool of natural bioactive compounds, which have been used in Asian countries for long time and have been tested for its toxicity. Here, we demonstrate a high throughput screening platform for potential compounds usable for skin colour tuning. From 147 natural compounds, 26 of them showed potential in skin tanning functions by using the high throughput melanogenesis platform based on the melanogenesis assay on B16 melanocytes. Five of them promoted melanogenesis by over 50%. Moreover, apart from 1, 8-dihydroxyanthraquinone, the other four compounds showed enhancement effect on tyrosinase activity. From the result, the compounds increased the Vmax of tyrosinase without changing the Km in a dose-dependent manner. Thus, there should be no irreversible structural change of the enzyme. Definitely, this report contributes to the development of personalization in skincare and cosmetic products.展开更多
文摘基于Arc GIS Enterprise、GIStack for Manager等系列软件,开发了包括通用化平台、专业化平台和个性化平台在内的智慧广州时空信息云平台,平台既面向一般用户,实现了其从无到有的搭建一个完整GIS应用的功能需求;也面向专业化和个性化的用户,分别实现了其专业化和个性化的定制需求。
文摘Skin lightening and tanning are two major areas dominating the market of skincare and cosmetic products. Though the demands are originated from two different communities, the two areas share a same goal—skin colour tuning. The known safe compounds with skin colour tuning activities are limited. In contrary, Chinese medicinal herb provides a pool of natural bioactive compounds, which have been used in Asian countries for long time and have been tested for its toxicity. Here, we demonstrate a high throughput screening platform for potential compounds usable for skin colour tuning. From 147 natural compounds, 26 of them showed potential in skin tanning functions by using the high throughput melanogenesis platform based on the melanogenesis assay on B16 melanocytes. Five of them promoted melanogenesis by over 50%. Moreover, apart from 1, 8-dihydroxyanthraquinone, the other four compounds showed enhancement effect on tyrosinase activity. From the result, the compounds increased the Vmax of tyrosinase without changing the Km in a dose-dependent manner. Thus, there should be no irreversible structural change of the enzyme. Definitely, this report contributes to the development of personalization in skincare and cosmetic products.
