In the present paper, blood lipids peroxide(LPO) level and activities of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) were investigated before and after combined treatment of acupuncture and moxibustio...In the present paper, blood lipids peroxide(LPO) level and activities of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) were investigated before and after combined treatment of acupuncture and moxibustion and Chinese drugs in patients of vascular dementia(VD), and their results were compared with those in healthy persons with the similar ages to the patients. The results showed that the blood LPO level increased significantly, and the activities of SOD and GSH-Px reduced significantly in patients of VD as compared with those in the control group. Degrees of patient’s condition were related with amplitudes of the increase of LPO and the reduction of activities of GSHPx and SOD. Combined treatment of acupuncture and moxibustion and Chinese drugs could raise markedly activitles of blood GSH-Px and SOD, and lowered LPO level in the patients of VD, which are related to clinical therapeutic effects. It is considered that combination of acupuncture and moxibustion with Chinese drugs can increase the action of the antiperoxidative system in the patients of VD, exerting anti-peroxidative ability and clearing LPO and reducing the oxidative injury of the organism by oxygen free radical, which is one of mechanisms of combined treatment of acupuncture and moxibustion with Chinese drugs.展开更多
研究了2,4-二氯苯胺、3,4-二氯苯胺、2,5-二氯苯胺、2,3-二氯苯胺对斑马鱼的急性毒性,96 h LC50分别为7.79、6.08、5.23、0.49 mg/L.为阐明二氯苯胺类化合物对水生生物抗氧化酶的早期影响,将鲫鱼暴露于不同浓度的4种化合物中,研究鲫鱼血...研究了2,4-二氯苯胺、3,4-二氯苯胺、2,5-二氯苯胺、2,3-二氯苯胺对斑马鱼的急性毒性,96 h LC50分别为7.79、6.08、5.23、0.49 mg/L.为阐明二氯苯胺类化合物对水生生物抗氧化酶的早期影响,将鲫鱼暴露于不同浓度的4种化合物中,研究鲫鱼血清SOD和GSH-PX活性短期(48h)内的变化,结果表明,在实验设置浓度下,随着暴露浓度升高,与空白对照组相比,4种化合物对SOD活性抑制作用明显,对GSH-PX活性先激活后抑制,表明4种化合物对鲫鱼血清SOD和GSH-PX活性有显著影响,与4种化合物96h LC50相比,引起生化效应的暴露浓度明显降低、且反应快速,SOD和GSH-PX相结合作为该类化合物对水环境污染胁迫的敏感生物指示物具有一定的可行性.展开更多
文摘In the present paper, blood lipids peroxide(LPO) level and activities of glutathione peroxidase(GSH-Px) and superoxide dismutase(SOD) were investigated before and after combined treatment of acupuncture and moxibustion and Chinese drugs in patients of vascular dementia(VD), and their results were compared with those in healthy persons with the similar ages to the patients. The results showed that the blood LPO level increased significantly, and the activities of SOD and GSH-Px reduced significantly in patients of VD as compared with those in the control group. Degrees of patient’s condition were related with amplitudes of the increase of LPO and the reduction of activities of GSHPx and SOD. Combined treatment of acupuncture and moxibustion and Chinese drugs could raise markedly activitles of blood GSH-Px and SOD, and lowered LPO level in the patients of VD, which are related to clinical therapeutic effects. It is considered that combination of acupuncture and moxibustion with Chinese drugs can increase the action of the antiperoxidative system in the patients of VD, exerting anti-peroxidative ability and clearing LPO and reducing the oxidative injury of the organism by oxygen free radical, which is one of mechanisms of combined treatment of acupuncture and moxibustion with Chinese drugs.
文摘研究了2,4-二氯苯胺、3,4-二氯苯胺、2,5-二氯苯胺、2,3-二氯苯胺对斑马鱼的急性毒性,96 h LC50分别为7.79、6.08、5.23、0.49 mg/L.为阐明二氯苯胺类化合物对水生生物抗氧化酶的早期影响,将鲫鱼暴露于不同浓度的4种化合物中,研究鲫鱼血清SOD和GSH-PX活性短期(48h)内的变化,结果表明,在实验设置浓度下,随着暴露浓度升高,与空白对照组相比,4种化合物对SOD活性抑制作用明显,对GSH-PX活性先激活后抑制,表明4种化合物对鲫鱼血清SOD和GSH-PX活性有显著影响,与4种化合物96h LC50相比,引起生化效应的暴露浓度明显降低、且反应快速,SOD和GSH-PX相结合作为该类化合物对水环境污染胁迫的敏感生物指示物具有一定的可行性.
