AIM: To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I(V1).·METHODS: Fourteen C57BL/6J mice were measured with pattern e...AIM: To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I(V1).·METHODS: Fourteen C57BL/6J mice were measured with pattern electroretinogram(PERG) and pattern visually evoked potential(PVEP) and fast Fourier transform has been used to analyze the frequency components of those signals.· RESULTS: The amplitude of PERG and PVEP was measured at about 36.7 μV and 112.5 μV respectively and the dominant frequency of PERG and PVEP, however,stay unchanged and both signals do not have second, or otherwise, harmonic generation.· CONCLUSION: The results suggested that retina encodes visual information in the way of frequency spectrum and then transfers it to primary visual cortex.The primary visual cortex accepts and deciphers the input visual information coded from retina. Frequency spectrum may act as communication code between retina and V1.展开更多
AIM： To determine if brain-derived neurotrophic factor （BDNF） could offer protention to retinal ganglion cells following a superior colliculus （SC） lesion in mice using pattern electroretinogram （PERG） and opti...AIM： To determine if brain-derived neurotrophic factor （BDNF） could offer protention to retinal ganglion cells following a superior colliculus （SC） lesion in mice using pattern electroretinogram （PERG） and optical coherence tomography （OCT） as a measures of ganglion cell response and retinal health. METHODS： Seven C57BIJ6J mice with BDNF protection were tested with PERG and OCT before and after SC lesions, RESULTS： Compared with baseline PERG, the amplitude of PERG decreased 11.7% after SC lesions, but not significantly（P〉0.05）. Through fast Fourier transform （FFT） analysis of the PERGs before and after SC lesions, it was found that dominant frequency of PERGs stayed unchanged, suggesting that the ganglion cells of the retina remained relatively healthy inspite of damage to the ends of the ganglion cell axons. Also, OCT showed no changes in retinal thickness after lesions. CONCLUSION： It was concluded that BDNF is essential component of normal retinal and helps retina keeping normal function. While retina lack of BDNF, ex vivo resource of BDNF provides protection to the sick retina. It implies that BDNF is a kind therapeutic neurotrophic factor to retina neurodegeneration diseases, such as glaucoma, age related macular degeneration.展开更多
目的:比较阻塞性睡眠窒息症(OSA)患者和正常人的图形视网膜电图(PERG)和图形视觉诱发电位(PVEP)。方法:前瞻性横断面研究。研究包含马来西亚医科大学的40例OSA患者和31例正常人。随机选取眼部未发生病变并确诊OSA的患者参与研究。通过...目的:比较阻塞性睡眠窒息症(OSA)患者和正常人的图形视网膜电图(PERG)和图形视觉诱发电位(PVEP)。方法:前瞻性横断面研究。研究包含马来西亚医科大学的40例OSA患者和31例正常人。随机选取眼部未发生病变并确诊OSA的患者参与研究。通过记录呼吸暂停低通气指数(AHI)以用于对OSA的严重程度分层。由马来西亚医科大学眼科电生理实验室内训练有素的技术人员对每位患者进行电生理检查(PVEP和PERG)。所得结果记录为中位数。使用IBM Statistics Version 21.0完成数据分析。结果:在OSA患者中,与正常人相比,我们观察到PERG的P50振幅(P<0.001)和PVEP的P100振幅(P<0.001)显著降低。OSA患者PVEP的P100(P=0.003)和N75的峰值时间(P=0.004)均显著升高。然而在OSA患者和正常人之间的PERG的峰值时间检测无显著差异。在不同疾病严重程度的OSA患者中PVEP或PERG也无显着差异。结论:OSA患者PVEP幅度和峰值时间及PERG幅度存在显著异常。这可能反映了OSA中的亚临床视神经功能障碍。展开更多
本文在国内统一的 DR 分期标准基础上,参照国际标准化委员会的临床 ERG 标准,检测 DR 各期48人81眼的 PERG 和 OPs,分析了 ERG 各参数在 DR 不同阶段时的改变特征,发现在 DR 早期即有视网膜电生理功能的异常。结合 DR 发病机理假说及 E...本文在国内统一的 DR 分期标准基础上,参照国际标准化委员会的临床 ERG 标准,检测 DR 各期48人81眼的 PERG 和 OPs,分析了 ERG 各参数在 DR 不同阶段时的改变特征,发现在 DR 早期即有视网膜电生理功能的异常。结合 DR 发病机理假说及 ERG 临床应用进行讨论,作者认为:(1)在 DR 发病过程中,视网膜代谢紊乱所致的组织损害和神经元功能减退可能先于微血管损害;(2)DR 的 ERG 异常可能是视网膜代谢紊乱、组织细胞损害及微血管病变等多因素作用的结果;(3)ERG 部分参数在 DR 早期功能诊断上具有较重要的临床价值。展开更多
基金Supported by 973 Program of the Ministry of Science and Technology of China (No.2013CB967101)Shanghai Science Committee Foundation (No.13PJ1433200)
文摘AIM: To explore changes and possible communication relationship of local potential signals recorded simultaneously from retina and visual cortex I(V1).·METHODS: Fourteen C57BL/6J mice were measured with pattern electroretinogram(PERG) and pattern visually evoked potential(PVEP) and fast Fourier transform has been used to analyze the frequency components of those signals.· RESULTS: The amplitude of PERG and PVEP was measured at about 36.7 μV and 112.5 μV respectively and the dominant frequency of PERG and PVEP, however,stay unchanged and both signals do not have second, or otherwise, harmonic generation.· CONCLUSION: The results suggested that retina encodes visual information in the way of frequency spectrum and then transfers it to primary visual cortex.The primary visual cortex accepts and deciphers the input visual information coded from retina. Frequency spectrum may act as communication code between retina and V1.
文摘AIM： To determine if brain-derived neurotrophic factor （BDNF） could offer protention to retinal ganglion cells following a superior colliculus （SC） lesion in mice using pattern electroretinogram （PERG） and optical coherence tomography （OCT） as a measures of ganglion cell response and retinal health. METHODS： Seven C57BIJ6J mice with BDNF protection were tested with PERG and OCT before and after SC lesions, RESULTS： Compared with baseline PERG, the amplitude of PERG decreased 11.7% after SC lesions, but not significantly（P〉0.05）. Through fast Fourier transform （FFT） analysis of the PERGs before and after SC lesions, it was found that dominant frequency of PERGs stayed unchanged, suggesting that the ganglion cells of the retina remained relatively healthy inspite of damage to the ends of the ganglion cell axons. Also, OCT showed no changes in retinal thickness after lesions. CONCLUSION： It was concluded that BDNF is essential component of normal retinal and helps retina keeping normal function. While retina lack of BDNF, ex vivo resource of BDNF provides protection to the sick retina. It implies that BDNF is a kind therapeutic neurotrophic factor to retina neurodegeneration diseases, such as glaucoma, age related macular degeneration.
文摘目的:比较阻塞性睡眠窒息症(OSA)患者和正常人的图形视网膜电图(PERG)和图形视觉诱发电位(PVEP)。方法:前瞻性横断面研究。研究包含马来西亚医科大学的40例OSA患者和31例正常人。随机选取眼部未发生病变并确诊OSA的患者参与研究。通过记录呼吸暂停低通气指数(AHI)以用于对OSA的严重程度分层。由马来西亚医科大学眼科电生理实验室内训练有素的技术人员对每位患者进行电生理检查(PVEP和PERG)。所得结果记录为中位数。使用IBM Statistics Version 21.0完成数据分析。结果:在OSA患者中,与正常人相比,我们观察到PERG的P50振幅(P<0.001)和PVEP的P100振幅(P<0.001)显著降低。OSA患者PVEP的P100(P=0.003)和N75的峰值时间(P=0.004)均显著升高。然而在OSA患者和正常人之间的PERG的峰值时间检测无显著差异。在不同疾病严重程度的OSA患者中PVEP或PERG也无显着差异。结论:OSA患者PVEP幅度和峰值时间及PERG幅度存在显著异常。这可能反映了OSA中的亚临床视神经功能障碍。
文摘本文在国内统一的 DR 分期标准基础上,参照国际标准化委员会的临床 ERG 标准,检测 DR 各期48人81眼的 PERG 和 OPs,分析了 ERG 各参数在 DR 不同阶段时的改变特征,发现在 DR 早期即有视网膜电生理功能的异常。结合 DR 发病机理假说及 ERG 临床应用进行讨论,作者认为:(1)在 DR 发病过程中,视网膜代谢紊乱所致的组织损害和神经元功能减退可能先于微血管损害;(2)DR 的 ERG 异常可能是视网膜代谢紊乱、组织细胞损害及微血管病变等多因素作用的结果;(3)ERG 部分参数在 DR 早期功能诊断上具有较重要的临床价值。
