Valproic acid has been shown to exert neuroprotective effects and promote neurite outgrowth in several peripheral nerve injury models. However, whether valproic acid can exert its beneficial effect on neurons after br...Valproic acid has been shown to exert neuroprotective effects and promote neurite outgrowth in several peripheral nerve injury models. However, whether valproic acid can exert its beneficial effect on neurons after brachial plexus avulsion injury is currently unknown. In this study, brachial plexus root avulsion models, established in Wistar rats, were administered daily with valproic acid dis-solved in drinking water （300 mg/kg） or normal water. On days 1, 2, 3, 7, 14 and 28 after avulsion injury, tissues of the C 5-T 1 spinal cord segments of the avulsion injured side were harvested to in-vestigate the expression of Bcl-2, c-Jun and growth associated protein 43 by real-time PCR and western blot assay. Results showed that valproic acid significantly increased the expression of Bcl-2 and growth associated protein 43, and reduced the c-Jun expression after brachial plexus avulsion. Our findings indicate that valproic acid can protect neurons in the spinal cord and enhance neuronal regeneration fol owing brachial plexus root avulsion.展开更多
以美国科学情报研究所(ISI)出版的Web of Science中的SCI-EXPANDED数据来源为依据,针对检索到的1988年～2012年贵州师范大学SCI收录论文439篇,从论文数量、研究方向、合作机构、刊载期刊影响因子和被引次数5个方面进行了统计与分析。提...以美国科学情报研究所(ISI)出版的Web of Science中的SCI-EXPANDED数据来源为依据,针对检索到的1988年～2012年贵州师范大学SCI收录论文439篇,从论文数量、研究方向、合作机构、刊载期刊影响因子和被引次数5个方面进行了统计与分析。提出了进一步提高科技论文数量和质量的建议。展开更多
基金supported by Graduated Innovation Fund of Jilin University,No.20121115the National Natural Science Foundation of China,No.30872626+1 种基金Key Projects of Clinical Sciences by the Ministry of Health,No.439the Research Fund for the Doctoral Program of Higher Education,No.20070183143
文摘Valproic acid has been shown to exert neuroprotective effects and promote neurite outgrowth in several peripheral nerve injury models. However, whether valproic acid can exert its beneficial effect on neurons after brachial plexus avulsion injury is currently unknown. In this study, brachial plexus root avulsion models, established in Wistar rats, were administered daily with valproic acid dis-solved in drinking water （300 mg/kg） or normal water. On days 1, 2, 3, 7, 14 and 28 after avulsion injury, tissues of the C 5-T 1 spinal cord segments of the avulsion injured side were harvested to in-vestigate the expression of Bcl-2, c-Jun and growth associated protein 43 by real-time PCR and western blot assay. Results showed that valproic acid significantly increased the expression of Bcl-2 and growth associated protein 43, and reduced the c-Jun expression after brachial plexus avulsion. Our findings indicate that valproic acid can protect neurons in the spinal cord and enhance neuronal regeneration fol owing brachial plexus root avulsion.
文摘以美国科学情报研究所(ISI)出版的Web of Science中的SCI-EXPANDED数据来源为依据,针对检索到的1988年～2012年贵州师范大学SCI收录论文439篇,从论文数量、研究方向、合作机构、刊载期刊影响因子和被引次数5个方面进行了统计与分析。提出了进一步提高科技论文数量和质量的建议。
