We report the novel synthesis of azetidin-2-one derivatives containing aryl sulfonate moiety from the reaction of 2-hydroxy benzaldehyde with p-toluene sulfonyl chloride afforded firstly 2-formylphenyl 4-methylbenzene...We report the novel synthesis of azetidin-2-one derivatives containing aryl sulfonate moiety from the reaction of 2-hydroxy benzaldehyde with p-toluene sulfonyl chloride afforded firstly 2-formylphenyl 4-methylbenzene sulfonate (2). The compound (2) on reaction with p-aminobenzoic acid or 2-aminopyridine gave the corresponding aldimines (3). Furthermore, the aldimines are on reaction with chloroacetyl chloride gives corresponding azetidin-2-ones in good to moderate yield. Among the eight synthesized azetidin-2-ones, five selected compounds have been screened for the an-ti-inflammatory activity, few of them showed good anti-inflammatory activity compared with standard drugs. Anti- microbial activity of all synthesized compounds has been tested and most of the compounds showed good anti-bacterial and anti-fungal activities.展开更多
The effect of pulp potential on activity of p amino phenol and its electrochemical mechanism on sulfide minerals have been researched. Results of test show that pulp potential can affect the depression activity of p a...The effect of pulp potential on activity of p amino phenol and its electrochemical mechanism on sulfide minerals have been researched. Results of test show that pulp potential can affect the depression activity of p amino phenol. The separation of sulfide minerals can be carried out by controlling dosage of p amino phenol, pulp pH and pulp potential. The mechanism of p amino phenol depressing sulfide minerals is not an electrostatic interaction but an electrochemical interaction. p amino phenol can lower the edge level of sulfide minerals, which leads the density of electron of mineral surface increased, as a result, the collector’s coatings on the mineral surface become unstable.展开更多
A new series of azo were derived from 2,5-di（p-amino phenyl）-3,6-diphenyl pyrazine in the presence of benzoic acid, salicylic acid, p-amino salicylic acid, p-methoxy phenol and pmethyl phenol. The structures of the ...A new series of azo were derived from 2,5-di（p-amino phenyl）-3,6-diphenyl pyrazine in the presence of benzoic acid, salicylic acid, p-amino salicylic acid, p-methoxy phenol and pmethyl phenol. The structures of the synthesized compounds were determined on the basis of their FTIR, UV （ultraviolet）, elemental analysis and H-NMR （H-nuclear magnetic resonance） spectral date. The purity of synthesized compounds was checked by performing TLC （thin layer chromatography）. The antibacterial activity was evaluated in DMSO （dimethyl sulfoxide）.展开更多
The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isol...The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess （up to 99%）.展开更多
In this present, a new series of Schiffbases from 2,5-di（p-aminophenyl）-3,6-diphenyl pyrazine in the presence of the benzil, 4-bromo benzaldehyde, 4-chlor benzaldehyde, 4-hydroxy benzaldehyde, 4-nitro benzaldehyde a...In this present, a new series of Schiffbases from 2,5-di（p-aminophenyl）-3,6-diphenyl pyrazine in the presence of the benzil, 4-bromo benzaldehyde, 4-chlor benzaldehyde, 4-hydroxy benzaldehyde, 4-nitro benzaldehyde and 4-methyl benzaldehyde were studied. The structures of the synthesized compounds were determined on the basis of their Infra-red spectra, H-nuclear magnetic resonase and analysis elemental analysis spectral data. The purity of the synthesized compounds was checked by performing thin layer chromatography. The antibacterial activity was evaluated by paper disc diffusion method.展开更多
文摘We report the novel synthesis of azetidin-2-one derivatives containing aryl sulfonate moiety from the reaction of 2-hydroxy benzaldehyde with p-toluene sulfonyl chloride afforded firstly 2-formylphenyl 4-methylbenzene sulfonate (2). The compound (2) on reaction with p-aminobenzoic acid or 2-aminopyridine gave the corresponding aldimines (3). Furthermore, the aldimines are on reaction with chloroacetyl chloride gives corresponding azetidin-2-ones in good to moderate yield. Among the eight synthesized azetidin-2-ones, five selected compounds have been screened for the an-ti-inflammatory activity, few of them showed good anti-inflammatory activity compared with standard drugs. Anti- microbial activity of all synthesized compounds has been tested and most of the compounds showed good anti-bacterial and anti-fungal activities.
文摘The effect of pulp potential on activity of p amino phenol and its electrochemical mechanism on sulfide minerals have been researched. Results of test show that pulp potential can affect the depression activity of p amino phenol. The separation of sulfide minerals can be carried out by controlling dosage of p amino phenol, pulp pH and pulp potential. The mechanism of p amino phenol depressing sulfide minerals is not an electrostatic interaction but an electrochemical interaction. p amino phenol can lower the edge level of sulfide minerals, which leads the density of electron of mineral surface increased, as a result, the collector’s coatings on the mineral surface become unstable.
文摘A new series of azo were derived from 2,5-di（p-amino phenyl）-3,6-diphenyl pyrazine in the presence of benzoic acid, salicylic acid, p-amino salicylic acid, p-methoxy phenol and pmethyl phenol. The structures of the synthesized compounds were determined on the basis of their FTIR, UV （ultraviolet）, elemental analysis and H-NMR （H-nuclear magnetic resonance） spectral date. The purity of synthesized compounds was checked by performing TLC （thin layer chromatography）. The antibacterial activity was evaluated in DMSO （dimethyl sulfoxide）.
文摘The cinchona alkaloids catalyzed the direct asymmetric Mannich reactions of 1, 3-dicarbonyl compounds with acyl imines to produce novel β-amino ester derivatives containing a quinazoline moiety. The adducts were isolated with high enantiomeric excess （up to 99%）.
文摘In this present, a new series of Schiffbases from 2,5-di（p-aminophenyl）-3,6-diphenyl pyrazine in the presence of the benzil, 4-bromo benzaldehyde, 4-chlor benzaldehyde, 4-hydroxy benzaldehyde, 4-nitro benzaldehyde and 4-methyl benzaldehyde were studied. The structures of the synthesized compounds were determined on the basis of their Infra-red spectra, H-nuclear magnetic resonase and analysis elemental analysis spectral data. The purity of the synthesized compounds was checked by performing thin layer chromatography. The antibacterial activity was evaluated by paper disc diffusion method.
