Nanoscale bimetallic Ni/Fe particles were synthesized from the reaction of sodium borohydride （NaBH4） with reduction of Ni^2＋ and Fe^2＋ in aqueous solution. The obtained Ni/Fe particles were characterized by TEM ...Nanoscale bimetallic Ni/Fe particles were synthesized from the reaction of sodium borohydride （NaBH4） with reduction of Ni^2＋ and Fe^2＋ in aqueous solution. The obtained Ni/Fe particles were characterized by TEM （transmission electron microscope）, XRD （X-ray diffractometer）, and N2-BET. The dechlorination activity of the Ni/Fe was investigated using p-chlorophenol （p-CP） as a probe agent. Results demonstrated that the nanoscale Ni/Fe could effectively dechlorinate p-CP at relatively low metal to solution ratio of 0.4 g/L （Ni 5 wt%）. The target with initial concentration ofp-CP 0.625 mmol/L was dechlorinted completely in 60 rain under ambient temperature and pressure. Factors affecting dechlorination efficiency, including reaction temperature, pH, Ni loading percentage over Fe, and metal to solution ratio, were investigated. The possible mechanism of dechlorination ofp-CP was proposed and discussed. The pseudo-first- order reaction took place on the surface of the Ni/Fe bimetallic particles, and the activation energy of the dechlorination reaction was determined to be 21.2 kJ/mol at the temperature rang of 287-313 K.展开更多
目的:观察"短刺法"对兔膝骨关节炎(osteoarthritis of the knee,KOA)软骨中Ⅱ型胶原及分子标记物Ⅱ型前胶原羧基端前肽(pro-collagen typeⅡC-terminal propeptide,PⅡCP)、Ⅱ型胶原羧基端端肽(C-telopeptide of typeⅡcollag...目的:观察"短刺法"对兔膝骨关节炎(osteoarthritis of the knee,KOA)软骨中Ⅱ型胶原及分子标记物Ⅱ型前胶原羧基端前肽(pro-collagen typeⅡC-terminal propeptide,PⅡCP)、Ⅱ型胶原羧基端端肽(C-telopeptide of typeⅡcollagen,CTX-Ⅱ)表达的影响。方法:40只新西兰兔取10只作为正常组,剩余30只复制KOA模型,X线检测评估造模结果。造模成功的新西兰兔随机分为模型组、短刺组和普通刺法组,每组10只。短刺组和普通刺法组均取"内膝眼""犊鼻""阴陵泉""足三里""梁丘"穴,短刺组采用贴骨进针,针刺深度以抵骨为准,普通刺法组常规针刺,除"梁丘"外均连接电针仪,每次20min,每日1次,5次为一疗程,疗程间休息2d,连续治疗4个疗程。正常组与模型组相同固定。治疗结束后采用磁共振成像(magnetic resonance imaging,MRI)进行膝关节影像学观察;透射电镜观察膝关节软骨细胞组织结构;HE染色观察膝关节病理学改变;TUNEL法检测膝关节软骨细胞凋亡情况;免疫印迹法(Western-blot)和逆转录聚合酶链式反应(reverse transcription-polymerase chain reaction,RT-PCR)检测Ⅱ型胶原蛋白和mRNA表达;酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测PⅡCP、CTX-Ⅱ表达。结果:治疗结束后,与模型组相比,短刺组与普通刺法组关节腔积液减少,无软骨下骨水肿;膝关节软骨细胞形态规则,凋亡减少;Ⅱ型胶原蛋白和mRNA表达显著升高(均P<0.05);PⅡCP水平上升(均P<0.05),而CTX-Ⅱ水平下降(均P<0.05)。短刺组Ⅱ型胶原蛋白及mRNA表达、PⅡCP、CTX-Ⅱ水平与普通刺法组比较差异均有统计学意义(均P<0.05);短刺组与正常组比较差异无统计学意义(均P>0.05)。结论:"短刺法"能显著改善膝骨关节炎关节软骨的病理状态,减少软骨细胞凋亡,可能通过调节PⅡCP、CTX-Ⅱ表达来促进Ⅱ型胶原的合成,且效果优于普通针刺。展开更多
目的探讨新血府逐瘀软胶囊对高血压病患者心肌纤维化的影响。方法入选确诊为高血压病合并心肌纤维化患者120例,随机分为西药组和中药组两组,每组60例,两组均以依那普利为基本降压药,如血压不能达到目标值140/90 mm Hg以下者,可选用钙拮...目的探讨新血府逐瘀软胶囊对高血压病患者心肌纤维化的影响。方法入选确诊为高血压病合并心肌纤维化患者120例,随机分为西药组和中药组两组,每组60例,两组均以依那普利为基本降压药,如血压不能达到目标值140/90 mm Hg以下者,可选用钙拮抗剂、利尿剂等;中药组在西药治疗基础上加服新血府逐瘀软胶囊4粒,3次.d-1。两组于服药前及服药12周后,分别抽取患者空腹血,应用ELISA法测定血清Ⅰ型前胶原羧基端肽(PⅠCP)、Ⅲ型前胶原(PCⅢ)和转化生长因子-β1(TGF-β1)水平。结果两组服药后PⅠCP、PCⅢ及TGF-β1水平均较本组治疗前明显下降(P<0.05或P<0.01)。服药后两组比较,中药组PⅠCP、PCⅢ及TGF-β1水平均明显低于西药组(P<0.01)。结论新血府逐瘀软胶囊能够改善高血压病患者心肌纤维化程度。展开更多
A left-right symmetric model with two Higgs bi-doublet is shown to be a consistent model for both spontaneous P and CP violation. The flavor changing neutral cur- rents can be suppressed by the mechanism of approximat...A left-right symmetric model with two Higgs bi-doublet is shown to be a consistent model for both spontaneous P and CP violation. The flavor changing neutral cur- rents can be suppressed by the mechanism of approximate global U(1) family symmetry. The constraints from neural K meson mass difference ΔmK are calcu- lated and it is demonstrated that a right-handed gauge boson W2 contribution in box-diagrams with mass well below 1 TeV is allowed due to a cancelation caused by a light-charged Higgs boson with a mass range of 150-300 GeV. The W2 con- tribution to εK can be suppressed from an appropriate choice of additional CP phases appearing in the right-handed Cabbibo-Kobayashi-Maskawa matrix. The model is also found to be fully consistent with B0 mass difference ΔmB and the mixing induced CP violation sin2βJ/ψ , which is usually difficult for the model with only one Higgs bi-doublet. The new physics beyond the standard model can be directly searched at the colliders LHC and ILC.展开更多
基金Project supported by the National Basic Research Program (973) of China(No. 2003CB415006)the National Natural Science Foundation of China (No. 20337020)
文摘Nanoscale bimetallic Ni/Fe particles were synthesized from the reaction of sodium borohydride （NaBH4） with reduction of Ni^2＋ and Fe^2＋ in aqueous solution. The obtained Ni/Fe particles were characterized by TEM （transmission electron microscope）, XRD （X-ray diffractometer）, and N2-BET. The dechlorination activity of the Ni/Fe was investigated using p-chlorophenol （p-CP） as a probe agent. Results demonstrated that the nanoscale Ni/Fe could effectively dechlorinate p-CP at relatively low metal to solution ratio of 0.4 g/L （Ni 5 wt%）. The target with initial concentration ofp-CP 0.625 mmol/L was dechlorinted completely in 60 rain under ambient temperature and pressure. Factors affecting dechlorination efficiency, including reaction temperature, pH, Ni loading percentage over Fe, and metal to solution ratio, were investigated. The possible mechanism of dechlorination ofp-CP was proposed and discussed. The pseudo-first- order reaction took place on the surface of the Ni/Fe bimetallic particles, and the activation energy of the dechlorination reaction was determined to be 21.2 kJ/mol at the temperature rang of 287-313 K.
文摘目的:观察"短刺法"对兔膝骨关节炎(osteoarthritis of the knee,KOA)软骨中Ⅱ型胶原及分子标记物Ⅱ型前胶原羧基端前肽(pro-collagen typeⅡC-terminal propeptide,PⅡCP)、Ⅱ型胶原羧基端端肽(C-telopeptide of typeⅡcollagen,CTX-Ⅱ)表达的影响。方法:40只新西兰兔取10只作为正常组,剩余30只复制KOA模型,X线检测评估造模结果。造模成功的新西兰兔随机分为模型组、短刺组和普通刺法组,每组10只。短刺组和普通刺法组均取"内膝眼""犊鼻""阴陵泉""足三里""梁丘"穴,短刺组采用贴骨进针,针刺深度以抵骨为准,普通刺法组常规针刺,除"梁丘"外均连接电针仪,每次20min,每日1次,5次为一疗程,疗程间休息2d,连续治疗4个疗程。正常组与模型组相同固定。治疗结束后采用磁共振成像(magnetic resonance imaging,MRI)进行膝关节影像学观察;透射电镜观察膝关节软骨细胞组织结构;HE染色观察膝关节病理学改变;TUNEL法检测膝关节软骨细胞凋亡情况;免疫印迹法(Western-blot)和逆转录聚合酶链式反应(reverse transcription-polymerase chain reaction,RT-PCR)检测Ⅱ型胶原蛋白和mRNA表达;酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测PⅡCP、CTX-Ⅱ表达。结果:治疗结束后,与模型组相比,短刺组与普通刺法组关节腔积液减少,无软骨下骨水肿;膝关节软骨细胞形态规则,凋亡减少;Ⅱ型胶原蛋白和mRNA表达显著升高(均P<0.05);PⅡCP水平上升(均P<0.05),而CTX-Ⅱ水平下降(均P<0.05)。短刺组Ⅱ型胶原蛋白及mRNA表达、PⅡCP、CTX-Ⅱ水平与普通刺法组比较差异均有统计学意义(均P<0.05);短刺组与正常组比较差异无统计学意义(均P>0.05)。结论:"短刺法"能显著改善膝骨关节炎关节软骨的病理状态,减少软骨细胞凋亡,可能通过调节PⅡCP、CTX-Ⅱ表达来促进Ⅱ型胶原的合成,且效果优于普通针刺。
文摘目的探讨新血府逐瘀软胶囊对高血压病患者心肌纤维化的影响。方法入选确诊为高血压病合并心肌纤维化患者120例,随机分为西药组和中药组两组,每组60例,两组均以依那普利为基本降压药,如血压不能达到目标值140/90 mm Hg以下者,可选用钙拮抗剂、利尿剂等;中药组在西药治疗基础上加服新血府逐瘀软胶囊4粒,3次.d-1。两组于服药前及服药12周后,分别抽取患者空腹血,应用ELISA法测定血清Ⅰ型前胶原羧基端肽(PⅠCP)、Ⅲ型前胶原(PCⅢ)和转化生长因子-β1(TGF-β1)水平。结果两组服药后PⅠCP、PCⅢ及TGF-β1水平均较本组治疗前明显下降(P<0.05或P<0.01)。服药后两组比较,中药组PⅠCP、PCⅢ及TGF-β1水平均明显低于西药组(P<0.01)。结论新血府逐瘀软胶囊能够改善高血压病患者心肌纤维化程度。
基金the National Natural Science Foundation of China (NSFC) (Grant Nos. 10475105 and 10491306) the Key Project of Chinese Academy of Sciences (CAS)
文摘A left-right symmetric model with two Higgs bi-doublet is shown to be a consistent model for both spontaneous P and CP violation. The flavor changing neutral cur- rents can be suppressed by the mechanism of approximate global U(1) family symmetry. The constraints from neural K meson mass difference ΔmK are calcu- lated and it is demonstrated that a right-handed gauge boson W2 contribution in box-diagrams with mass well below 1 TeV is allowed due to a cancelation caused by a light-charged Higgs boson with a mass range of 150-300 GeV. The W2 con- tribution to εK can be suppressed from an appropriate choice of additional CP phases appearing in the right-handed Cabbibo-Kobayashi-Maskawa matrix. The model is also found to be fully consistent with B0 mass difference ΔmB and the mixing induced CP violation sin2βJ/ψ , which is usually difficult for the model with only one Higgs bi-doublet. The new physics beyond the standard model can be directly searched at the colliders LHC and ILC.
