A series of 2 amino 3 cyano 4 aryl 4H benzochromenes were synehesized by the reaction of malononitrile and 1 naphthol with corresponding aromatic aldehydes in ethanol in the presence of piperidine as catalyst. The str...A series of 2 amino 3 cyano 4 aryl 4H benzochromenes were synehesized by the reaction of malononitrile and 1 naphthol with corresponding aromatic aldehydes in ethanol in the presence of piperidine as catalyst. The structures of all compounds obtained were characterized by elemental analysis, IR, 1H NMR and single crystal X ray diffractometry. X ray crystal structure analysis indicates compound 4b crystallizes in monoclinic, with space group C2/c, a = 2 422 1(6) nm , b = 0 901 6(2) nm , c = 1 700 3(5) nm , β =93 16(1)°, V = 3 707 4(15) nm 3 , Z =8, D c= 1 284 g/cm 3 , I≥2σ(I) =2 141, R = 0 043 2 , wR = 0 108 5 . Compared to other methods, this method has the advantages of simple operation and good yields.展开更多
Diammonium hydrogen phosphate and potassium carbonate-catalyzed one-pot synthesis of 1,4- phenylene-bis（2-amino-4H-pyran-3-carbonitrile and 2-amino-4-aryl-4H-pyran-3-carbonitrile deriva- tives has been achieved by a ...Diammonium hydrogen phosphate and potassium carbonate-catalyzed one-pot synthesis of 1,4- phenylene-bis（2-amino-4H-pyran-3-carbonitrile and 2-amino-4-aryl-4H-pyran-3-carbonitrile deriva- tives has been achieved by a three-component cyclocondensation of aldehydes, malononitrile, and different nucleophiles in aqueous medium in high yields.展开更多
A practical one-pot protocol for the synthesis of 2,5-disubstituted oxazoles from 1-aryl-2-nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1-aryl-2-nitroethanones with trimet...A practical one-pot protocol for the synthesis of 2,5-disubstituted oxazoles from 1-aryl-2-nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1-aryl-2-nitroethanones with trimethyl orthoacetate or trimethyl orthobenzoate delivered the corresponding 2,5-disubstituted oxazoles in moderate to good yields.展开更多
An efficient synthesis of substituted pyrroles via ultrasound assisted three component coupling reaction of amines with α,β unsaturated aldehydes and nitroalkanes is reported.
A microwave mediated solvent free one pot synthesis of formazans is developed using the solid acid, KHSO4. The products were obtained in a short reaction time in high yield. This study was undertaken to find an altern...A microwave mediated solvent free one pot synthesis of formazans is developed using the solid acid, KHSO4. The products were obtained in a short reaction time in high yield. This study was undertaken to find an alternative and green method for the synthesis of formazans in the absence of corrosive mineral acids, buffered solutions and volatile organic compounds (VOCs).展开更多
A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent with variable substituent groups at A, B, and AB rings. All the synthesized compounds were checked for antibacterial an...A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent with variable substituent groups at A, B, and AB rings. All the synthesized compounds were checked for antibacterial and antifungal activity. We report that many compounds were found active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, bacterial strains and, C. albicans, C. parapsilosisstrains and C. krusei fungal strains. Most of the synthesized 4-thioflavonols compounds were found to show enhanced antimicrobial activity than respective flavonol compounds.展开更多
Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- （silyl）phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results ...Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- （silyl）phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results indicated that the one pot approach produced target products in a comparable yield to that of the two-step method reported previously.展开更多
Herein we reported a one-pot synthesis of arylsubstituted imidazolin-2-ones by the cyclization of α-aminoacetophenone hydrochloride analogues 2 with arylisocyanates 3. Compared with other known synthetic route, this ...Herein we reported a one-pot synthesis of arylsubstituted imidazolin-2-ones by the cyclization of α-aminoacetophenone hydrochloride analogues 2 with arylisocyanates 3. Compared with other known synthetic route, this method resulted in higher yield.展开更多
文摘A series of 2 amino 3 cyano 4 aryl 4H benzochromenes were synehesized by the reaction of malononitrile and 1 naphthol with corresponding aromatic aldehydes in ethanol in the presence of piperidine as catalyst. The structures of all compounds obtained were characterized by elemental analysis, IR, 1H NMR and single crystal X ray diffractometry. X ray crystal structure analysis indicates compound 4b crystallizes in monoclinic, with space group C2/c, a = 2 422 1(6) nm , b = 0 901 6(2) nm , c = 1 700 3(5) nm , β =93 16(1)°, V = 3 707 4(15) nm 3 , Z =8, D c= 1 284 g/cm 3 , I≥2σ(I) =2 141, R = 0 043 2 , wR = 0 108 5 . Compared to other methods, this method has the advantages of simple operation and good yields.
文摘Diammonium hydrogen phosphate and potassium carbonate-catalyzed one-pot synthesis of 1,4- phenylene-bis（2-amino-4H-pyran-3-carbonitrile and 2-amino-4-aryl-4H-pyran-3-carbonitrile deriva- tives has been achieved by a three-component cyclocondensation of aldehydes, malononitrile, and different nucleophiles in aqueous medium in high yields.
基金Supporting information for this article is available on the WWW under http：//dx.cloi.org/10, 1002/cjoc.201100683 or from the author. AcknowledgementWe thank the National Natural Science Foundationof China （Nos. 20872087, 21002061, 20902057, 21142012）, the State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Leading Academic Discipline Project of Shanghai Municipal Education Commission （No. J50101）, and the Graduate Innovation Fund of Shanghai University for financial support. We thank Dr. Hongmei Deng （Laboratory for Microstructures, Shanghai University） for NMR measurements. We are indebted to Professor Ran Hong of SIOC for enlightening discussions.
文摘A practical one-pot protocol for the synthesis of 2,5-disubstituted oxazoles from 1-aryl-2-nitroethanones was reported. In the presence of iron/AcOH in acetonitrile, the reaction of 1-aryl-2-nitroethanones with trimethyl orthoacetate or trimethyl orthobenzoate delivered the corresponding 2,5-disubstituted oxazoles in moderate to good yields.
基金ProjectsupportedbytheNationalNaturalScienceFoundationofChina (No .2 9972 0 3 7)
文摘An efficient synthesis of substituted pyrroles via ultrasound assisted three component coupling reaction of amines with α,β unsaturated aldehydes and nitroalkanes is reported.
文摘A microwave mediated solvent free one pot synthesis of formazans is developed using the solid acid, KHSO4. The products were obtained in a short reaction time in high yield. This study was undertaken to find an alternative and green method for the synthesis of formazans in the absence of corrosive mineral acids, buffered solutions and volatile organic compounds (VOCs).
文摘A series of 4-thioflavonols compounds were synthesized by treating flavonols with lawsons reagent with variable substituent groups at A, B, and AB rings. All the synthesized compounds were checked for antibacterial and antifungal activity. We report that many compounds were found active against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus, bacterial strains and, C. albicans, C. parapsilosisstrains and C. krusei fungal strains. Most of the synthesized 4-thioflavonols compounds were found to show enhanced antimicrobial activity than respective flavonol compounds.
文摘Bis-silicon-bridged stilbene derivatives were synthesized in a modified procedure that combined the preparation of bis[2- （silyl）phenyl]acetylene and its intramolecular reductive cyclization in one pot. The results indicated that the one pot approach produced target products in a comparable yield to that of the two-step method reported previously.
文摘Herein we reported a one-pot synthesis of arylsubstituted imidazolin-2-ones by the cyclization of α-aminoacetophenone hydrochloride analogues 2 with arylisocyanates 3. Compared with other known synthetic route, this method resulted in higher yield.
