Objectives: To study the effect of sulfotanshinone sodium (SS) injection in the treatment of non-ischemic retinal vein occlusion (RVO). Methods: Sixty-two RVO patients treated in our hospital between Jan. 2013 and Oct...Objectives: To study the effect of sulfotanshinone sodium (SS) injection in the treatment of non-ischemic retinal vein occlusion (RVO). Methods: Sixty-two RVO patients treated in our hospital between Jan. 2013 and Oct. 2014 were randomly divided into Control Group (30 patients;Bendazol tablets) and Treatment Group (32 patients, Bendazol tablets + SS injections), each with a follow-up period of 6 months. Statistical analysis was then performed on changes in visual acuity, central retinal thickness (CRT) and retinal circulation time (RCT) before and after the treatment. Results: After treatment, both Control Group and Treatment Group witnessed an improvement on visual acuity (Control Group: t = 2.103, p = 0.044;Treatment Group: t = 8.021, p = 0.000). Visual acuity could be greatly improved in Treatment Group when compared with Control Group, with significant differences (p < 0.01). Macular edema could be greatly relieved in Treatment Group measured by CRT (t = 2.571, p = 0.007) while the difference was of no statistical significance in Control Group (t = 1.016, p = 0.070). RCT were remarkably shortened in both groups (Control Group: t = 43.83, p = 0.000;Treatment Group: t = 27.34, p = 0.000), and when compared with Control group, the changes in Treatment Group were more significant (p < 0.05). Conclusion: SS injection could effectively improve the therapeutic effect in patients with non-ischemic retinal vein occlusion.展开更多
目的 评价玻璃体腔注射雷珠单抗联合黄斑区格栅样光凝（MLG）治疗视网膜中央静脉阻塞继发黄斑水肿的疗效与安全性.方法 临床病例对照研究.将上海市第一人民医院眼科2013年3月～6月期间诊治的非缺血型视网膜中央静脉阻塞继发黄斑水肿患...目的 评价玻璃体腔注射雷珠单抗联合黄斑区格栅样光凝（MLG）治疗视网膜中央静脉阻塞继发黄斑水肿的疗效与安全性.方法 临床病例对照研究.将上海市第一人民医院眼科2013年3月～6月期间诊治的非缺血型视网膜中央静脉阻塞继发黄斑水肿患者30例30只眼,分为联合组（16例）和对照组（14例）.联合组使用玻璃体腔注射雷珠单抗联合MLG治疗,每月注射一次雷珠单抗0.05 ml （0.5 mg）共3次,在第3次注射的2周后进行MLG治疗;对照组使用单纯MLG治疗.比较治疗后1、2、3、6个月两组患眼的最佳矫正视力（BCVA）和黄斑中心凹厚度（CMT）.结果 联合组在治疗后1、2、3、6个月时BCVA （ETDRS）与对照组相比差异有统计学意义（1月：48.7 vs 44.2,P =0.036;2月：49.1 vs 44.6,P=0.032;3月：49.7 vs 45.0,P=0.026;6月：50.1 vs 45.1, P=0.025）.联合组在治疗后1、2、3、6个月时CMT和对照组相比早期差异无统计学意义,后期差异有统计学意义（1月：457.6 μm vs 402.5 μm,P=0.146,2月：352.2 μm vs 385.3 μm,P=0.337;3月：276.1 μm vs 357.1 μm,P=0.030;6月：209.8 μm vs 334.1 μm P=0.001）.联合组曾有一只眼出现一过性高眼压.结论 玻璃体腔注射雷珠单抗联合MLG治疗非缺型血视网膜中央静脉阻塞继发黄斑水肿在治疗后1～6个月疗效恢复优于单纯MLG治疗,并且安全。展开更多
·AIM:To describe a case in which vitrectomy was required for vitreous hemorrhage and fibrovascular proliferation after laser-induced chorioretinal venous anastomosis (LCVA) for non-ischemic central retinal vein o...·AIM:To describe a case in which vitrectomy was required for vitreous hemorrhage and fibrovascular proliferation after laser-induced chorioretinal venous anastomosis (LCVA) for non-ischemic central retinal vein occlusion (CRVO).·METHODS:Observational case report.·RESULTS:A 72-year-old man complained of central scotoma in the left eye,and was diagnosed as suffering from non-ischemic CRVO.LCVA was performed in another hospital.Although favorable visual function was briefly maintained postoperatively,severe vitreous hemorrhage developed in his left eye,necessitating vitrectomy.·CONCLUSION:Considering that LCVA carries a risk of serious complications,we must apply this treatment with caution,especially in ethnic groups,such as the Japanese,in whom pigmentation reacts to photocoagulation excessively.·展开更多
文摘Objectives: To study the effect of sulfotanshinone sodium (SS) injection in the treatment of non-ischemic retinal vein occlusion (RVO). Methods: Sixty-two RVO patients treated in our hospital between Jan. 2013 and Oct. 2014 were randomly divided into Control Group (30 patients;Bendazol tablets) and Treatment Group (32 patients, Bendazol tablets + SS injections), each with a follow-up period of 6 months. Statistical analysis was then performed on changes in visual acuity, central retinal thickness (CRT) and retinal circulation time (RCT) before and after the treatment. Results: After treatment, both Control Group and Treatment Group witnessed an improvement on visual acuity (Control Group: t = 2.103, p = 0.044;Treatment Group: t = 8.021, p = 0.000). Visual acuity could be greatly improved in Treatment Group when compared with Control Group, with significant differences (p < 0.01). Macular edema could be greatly relieved in Treatment Group measured by CRT (t = 2.571, p = 0.007) while the difference was of no statistical significance in Control Group (t = 1.016, p = 0.070). RCT were remarkably shortened in both groups (Control Group: t = 43.83, p = 0.000;Treatment Group: t = 27.34, p = 0.000), and when compared with Control group, the changes in Treatment Group were more significant (p < 0.05). Conclusion: SS injection could effectively improve the therapeutic effect in patients with non-ischemic retinal vein occlusion.
文摘目的 评价玻璃体腔注射雷珠单抗联合黄斑区格栅样光凝（MLG）治疗视网膜中央静脉阻塞继发黄斑水肿的疗效与安全性.方法 临床病例对照研究.将上海市第一人民医院眼科2013年3月～6月期间诊治的非缺血型视网膜中央静脉阻塞继发黄斑水肿患者30例30只眼,分为联合组（16例）和对照组（14例）.联合组使用玻璃体腔注射雷珠单抗联合MLG治疗,每月注射一次雷珠单抗0.05 ml （0.5 mg）共3次,在第3次注射的2周后进行MLG治疗;对照组使用单纯MLG治疗.比较治疗后1、2、3、6个月两组患眼的最佳矫正视力（BCVA）和黄斑中心凹厚度（CMT）.结果 联合组在治疗后1、2、3、6个月时BCVA （ETDRS）与对照组相比差异有统计学意义（1月：48.7 vs 44.2,P =0.036;2月：49.1 vs 44.6,P=0.032;3月：49.7 vs 45.0,P=0.026;6月：50.1 vs 45.1, P=0.025）.联合组在治疗后1、2、3、6个月时CMT和对照组相比早期差异无统计学意义,后期差异有统计学意义（1月：457.6 μm vs 402.5 μm,P=0.146,2月：352.2 μm vs 385.3 μm,P=0.337;3月：276.1 μm vs 357.1 μm,P=0.030;6月：209.8 μm vs 334.1 μm P=0.001）.联合组曾有一只眼出现一过性高眼压.结论 玻璃体腔注射雷珠单抗联合MLG治疗非缺型血视网膜中央静脉阻塞继发黄斑水肿在治疗后1～6个月疗效恢复优于单纯MLG治疗,并且安全。
文摘·AIM:To describe a case in which vitrectomy was required for vitreous hemorrhage and fibrovascular proliferation after laser-induced chorioretinal venous anastomosis (LCVA) for non-ischemic central retinal vein occlusion (CRVO).·METHODS:Observational case report.·RESULTS:A 72-year-old man complained of central scotoma in the left eye,and was diagnosed as suffering from non-ischemic CRVO.LCVA was performed in another hospital.Although favorable visual function was briefly maintained postoperatively,severe vitreous hemorrhage developed in his left eye,necessitating vitrectomy.·CONCLUSION:Considering that LCVA carries a risk of serious complications,we must apply this treatment with caution,especially in ethnic groups,such as the Japanese,in whom pigmentation reacts to photocoagulation excessively.·
