目的：探讨网络医疗健康管理对原发性肾癌手术患者应对方式、希望水平和生活质量的影响。方法选取2011年3月—2012年9月郑州大学附属肿瘤医院收治的肾癌患者77例为对照组，采用常规健康管理；选取2013年3月—2014年9月收治的肾癌患者79...目的：探讨网络医疗健康管理对原发性肾癌手术患者应对方式、希望水平和生活质量的影响。方法选取2011年3月—2012年9月郑州大学附属肿瘤医院收治的肾癌患者77例为对照组，采用常规健康管理；选取2013年3月—2014年9月收治的肾癌患者79例为干预组，在对照组的基础上实施网络医疗健康管理；比较两组患者干预前后的应对方式、希望水平与生活质量。结果干预前，两组患者的积极及消极应对评分组间差异无统计学意义（ P ＞0．05）；干预后干预组的积极应对评分为（25．44±2．61）分，高于对照组，消极应对评分为（9．76±1．89）分，低于对照组，组间差异有统计学意义（t值分别为－10．468，7．572；P＜0．01）。干预前两组的希望水平差异无统计学意义（P＞0．05），干预后，干预组在对现实与未来的积极态度、采取的积极行动、与他人保持亲密的关系上的得分比对照组高，分别为（14．5±2．6），（15．1±2．4），（15．6±2．1）分，差异有统计学意义（t值分别为4．965，5．569，3．659；P＜0．05）。生活质量方面，干预后，干预组与对照组患者在躯体功能、角色功能、气促3个维度上的评分差异无统计学意义（P＞0．05）；而在其余12个维度上的评分差异有统计学意义（P＜0．05），干预组优于对照组。结论应用网络医疗健康管理能明显改善原发性肾癌手术患者的应对方式，提高患者的希望水平和生活质量，值得临床推广。展开更多
目的:分析国内影像归档和通信系统(picture archiving and communication systems,PACS)的应用现状及存在问题,为PACS未来的设计和发展提供技术支持和依据。方法:回顾2015年6月至2016年5月某院介入诊疗科PACS运行情况,结合全院实际情况...目的:分析国内影像归档和通信系统(picture archiving and communication systems,PACS)的应用现状及存在问题,为PACS未来的设计和发展提供技术支持和依据。方法:回顾2015年6月至2016年5月某院介入诊疗科PACS运行情况,结合全院实际情况系统分析国内PACS的应用现状及问题。结果:介入诊疗科PACS运行存在问题较多,影像采集设备使用时间跨度长达13 a,6.8%的工作站、14.2%的影像采集设备未接入PACS,4.1%的患者、2.9%的影像未传至PACS。结论:国内PACS设计要适合未来发展预期,运行要稳定、高效、安全、可靠,应用要满足未来医疗、科研、教学需求,为PACS在互联网医疗时代奠定坚实基础。展开更多
Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, and then it is impossible to cure completely today and it should be individualized treatment. Immune system...Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, and then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in con-trolling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.展开更多
A disease phenotype generally reflects various pathobiological processes that interact in a complex network. The highly interconnected nature of the human protein interaction network（interactome） indicates that, at ...A disease phenotype generally reflects various pathobiological processes that interact in a complex network. The highly interconnected nature of the human protein interaction network（interactome） indicates that, at the molecular level, it is difficult to consider diseases as being independent of one another. Recently, genome-wide molecular measurements, data mining and bioinformatics approaches have provided the means to explore human diseases from a molecular basis. The exploration of diseases and a system of disease relationships based on the integration of genome-wide molecular data with the human interactome could offer a powerful perspective for understanding the molecular architecture of diseases. Recently, subnetwork markers have proven to be more robust and reliable than individual biomarker genes selected based on gene expression profiles alone, and achieve higher accuracy in disease classification. We have applied one of these methodologies to idiopathic dilated cardiomyopathy（IDCM） data that we have generated using a microarray and identified significant subnetworks associated with the disease. In this paper, we review the recent endeavours in this direction, and summarize the existing methodologies and computational tools for network-based analysis of complex diseases and molecular relationships among apparently different disorders and human disease network. We also discuss the future research trends and topics of this promising field.展开更多
Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain f...Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain functional connectivity network of acupuncture stimulation. Objective： To offer an overview of the different influences of acupuncture on the brain functional connec- tivity network from studies using resting-state fMRI. Search strategy： The authors performed a systematic search according to PRISMA guidelines, The database PubMed was searched from January 1, 2006 to December 31, 2016 with restriction to human studies in English language. Inclusion criteria： Electronic searches were conducted in PubMed using the keywords ＂acupuncture＂ and ＂neuroimaging＂ or ＂resting-state fMRI＂ or ＂functional connectivity＂, Data extraction and analysis： Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Results： Forty-four resting-state fMRI studies were included in this systematic review according to inclu- sion criteria. Thirteen studies applied manual acupuncture vs. sham, four studies applied electro- acupuncture vs. sham, two studies also compared transcutaneous electrical acupoint stimulation vs. sham, and nine applied sham acupoint as control. Nineteen studies with a total number of 574 healthy subjects selected to perform fMRI only considered healthy adult volunteers. The brain functional connec- tivity of the patients had varying degrees of change. Compared with sham acupuncture, verum acupunc- ture could increase default mode network and sensorimotor network connectivity with pain-, affective- and memory-related brain areas. It has significantly greater connectivity of genuine acupuncture between the periaqueductal gray, anterior cingulate cortex, left posterior cingulate cortex, right anterior insula, limbic/paralimbic and precuneus compared with sham acupuncture. Some research had also shown th展开更多
Objective：To explore the pharmacological anti-inflammatory mechanism of Chinese formula Qingwen Baidu Decoction（清瘟败毒饮,QBD） from the view of holistic biology.Methods：The rats were randomly divided into a norma...Objective：To explore the pharmacological anti-inflammatory mechanism of Chinese formula Qingwen Baidu Decoction（清瘟败毒饮,QBD） from the view of holistic biology.Methods：The rats were randomly divided into a normal conrol group,a lipopolysaccharide（LPS） group,the low- and high-dose QBD groups,and a dexamethasone（DXM） group.NR8383 cells were treated with culture fluid containing 6%serum from rats of each group respectively.Inflammatory mediators were detected by reverse transcription polymerase chain reaction（RT-PCR）,Western blotting hybridization,enzyme linked immunosorbent assay（ELISA）,polymerase chain reaction（PCR） gene array and antibody array.Results：It is showed that the levels of interleukin（IL）-1 α,IL-4 and IL-12 were enhanced in the low-dose QBD group;levels of IL-1 α,IL-12 and IL-18 were augmented in the high-dose QBD group,compared with the LPS group after ELISA detection.Western blot showed that IL-1β and tumor necrosis factor（TNF）-α expression of the control group were lower than other groups.IL-1 βlevel of the low-dose and high-dose QBD groups detected by RT-PCR was higher in early stage but lower after24 h than that of the control group（P〈0.01）.Expression of 84 main inflammatory cytokines and receptors was detected by rat inflammatory cytokines and receptors PCR array.Up-regulation genes were 22 in both the LPS group and the low-dose QBD group,among which 16 up-regulating genes were the same.In these 16 genes,the up-regulating amplitude of 9 genes in the low-dose QBD group was less than that in the LPS group,4 were similar to and 3 were more.Twenty-nine main cytokines were inspected by rat cytokine antibody array.Intergroup gray value differences were found in 7 expressed cytokines.The levels of these 7 cytokines in the lowdose QBD group were all lower than those in the the LPS group.Conclusions：QBD has anti-inflammatory effect on sepsis by changing the level of inflammatory mediators.展开更多
文摘目的：探讨网络医疗健康管理对原发性肾癌手术患者应对方式、希望水平和生活质量的影响。方法选取2011年3月—2012年9月郑州大学附属肿瘤医院收治的肾癌患者77例为对照组，采用常规健康管理；选取2013年3月—2014年9月收治的肾癌患者79例为干预组，在对照组的基础上实施网络医疗健康管理；比较两组患者干预前后的应对方式、希望水平与生活质量。结果干预前，两组患者的积极及消极应对评分组间差异无统计学意义（ P ＞0．05）；干预后干预组的积极应对评分为（25．44±2．61）分，高于对照组，消极应对评分为（9．76±1．89）分，低于对照组，组间差异有统计学意义（t值分别为－10．468，7．572；P＜0．01）。干预前两组的希望水平差异无统计学意义（P＞0．05），干预后，干预组在对现实与未来的积极态度、采取的积极行动、与他人保持亲密的关系上的得分比对照组高，分别为（14．5±2．6），（15．1±2．4），（15．6±2．1）分，差异有统计学意义（t值分别为4．965，5．569，3．659；P＜0．05）。生活质量方面，干预后，干预组与对照组患者在躯体功能、角色功能、气促3个维度上的评分差异无统计学意义（P＞0．05）；而在其余12个维度上的评分差异有统计学意义（P＜0．05），干预组优于对照组。结论应用网络医疗健康管理能明显改善原发性肾癌手术患者的应对方式，提高患者的希望水平和生活质量，值得临床推广。
文摘目的:分析国内影像归档和通信系统(picture archiving and communication systems,PACS)的应用现状及存在问题,为PACS未来的设计和发展提供技术支持和依据。方法:回顾2015年6月至2016年5月某院介入诊疗科PACS运行情况,结合全院实际情况系统分析国内PACS的应用现状及问题。结果:介入诊疗科PACS运行存在问题较多,影像采集设备使用时间跨度长达13 a,6.8%的工作站、14.2%的影像采集设备未接入PACS,4.1%的患者、2.9%的影像未传至PACS。结论:国内PACS设计要适合未来发展预期,运行要稳定、高效、安全、可靠,应用要满足未来医疗、科研、教学需求,为PACS在互联网医疗时代奠定坚实基础。
文摘Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, and then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in con-trolling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.
基金funded by the National Plan for Science,Technology and Innovation program (NSTIP/KACST, No.11-BIO2072-20 to D.C.)
文摘A disease phenotype generally reflects various pathobiological processes that interact in a complex network. The highly interconnected nature of the human protein interaction network（interactome） indicates that, at the molecular level, it is difficult to consider diseases as being independent of one another. Recently, genome-wide molecular measurements, data mining and bioinformatics approaches have provided the means to explore human diseases from a molecular basis. The exploration of diseases and a system of disease relationships based on the integration of genome-wide molecular data with the human interactome could offer a powerful perspective for understanding the molecular architecture of diseases. Recently, subnetwork markers have proven to be more robust and reliable than individual biomarker genes selected based on gene expression profiles alone, and achieve higher accuracy in disease classification. We have applied one of these methodologies to idiopathic dilated cardiomyopathy（IDCM） data that we have generated using a microarray and identified significant subnetworks associated with the disease. In this paper, we review the recent endeavours in this direction, and summarize the existing methodologies and computational tools for network-based analysis of complex diseases and molecular relationships among apparently different disorders and human disease network. We also discuss the future research trends and topics of this promising field.
基金supported by the National Natural Science Foundation of China(No.81473784)University Science Research Project of Anhui Province of China(No.KJ2017A298)+1 种基金the Key Project of the Youth Elite Support Plan in Universities of Anhui Province of China(No.gxyq ZD2016134)Construction Project of Scientific Research Innovation Platform of Anhui Province of China(No.2015TD033)
文摘Background： Functional magnetic resonance imaging （fMRI） is a novel method for studying the changes of brain networks due to acupuncture treatment. In recent years, more and more studies have focused on the brain functional connectivity network of acupuncture stimulation. Objective： To offer an overview of the different influences of acupuncture on the brain functional connec- tivity network from studies using resting-state fMRI. Search strategy： The authors performed a systematic search according to PRISMA guidelines, The database PubMed was searched from January 1, 2006 to December 31, 2016 with restriction to human studies in English language. Inclusion criteria： Electronic searches were conducted in PubMed using the keywords ＂acupuncture＂ and ＂neuroimaging＂ or ＂resting-state fMRI＂ or ＂functional connectivity＂, Data extraction and analysis： Selection of included articles, data extraction and methodological quality assessments were respectively conducted by two review authors. Results： Forty-four resting-state fMRI studies were included in this systematic review according to inclu- sion criteria. Thirteen studies applied manual acupuncture vs. sham, four studies applied electro- acupuncture vs. sham, two studies also compared transcutaneous electrical acupoint stimulation vs. sham, and nine applied sham acupoint as control. Nineteen studies with a total number of 574 healthy subjects selected to perform fMRI only considered healthy adult volunteers. The brain functional connec- tivity of the patients had varying degrees of change. Compared with sham acupuncture, verum acupunc- ture could increase default mode network and sensorimotor network connectivity with pain-, affective- and memory-related brain areas. It has significantly greater connectivity of genuine acupuncture between the periaqueductal gray, anterior cingulate cortex, left posterior cingulate cortex, right anterior insula, limbic/paralimbic and precuneus compared with sham acupuncture. Some research had also shown th
基金Supported by National Natural Science Foundation of China(No.30801468)
文摘Objective：To explore the pharmacological anti-inflammatory mechanism of Chinese formula Qingwen Baidu Decoction（清瘟败毒饮,QBD） from the view of holistic biology.Methods：The rats were randomly divided into a normal conrol group,a lipopolysaccharide（LPS） group,the low- and high-dose QBD groups,and a dexamethasone（DXM） group.NR8383 cells were treated with culture fluid containing 6%serum from rats of each group respectively.Inflammatory mediators were detected by reverse transcription polymerase chain reaction（RT-PCR）,Western blotting hybridization,enzyme linked immunosorbent assay（ELISA）,polymerase chain reaction（PCR） gene array and antibody array.Results：It is showed that the levels of interleukin（IL）-1 α,IL-4 and IL-12 were enhanced in the low-dose QBD group;levels of IL-1 α,IL-12 and IL-18 were augmented in the high-dose QBD group,compared with the LPS group after ELISA detection.Western blot showed that IL-1β and tumor necrosis factor（TNF）-α expression of the control group were lower than other groups.IL-1 βlevel of the low-dose and high-dose QBD groups detected by RT-PCR was higher in early stage but lower after24 h than that of the control group（P〈0.01）.Expression of 84 main inflammatory cytokines and receptors was detected by rat inflammatory cytokines and receptors PCR array.Up-regulation genes were 22 in both the LPS group and the low-dose QBD group,among which 16 up-regulating genes were the same.In these 16 genes,the up-regulating amplitude of 9 genes in the low-dose QBD group was less than that in the LPS group,4 were similar to and 3 were more.Twenty-nine main cytokines were inspected by rat cytokine antibody array.Intergroup gray value differences were found in 7 expressed cytokines.The levels of these 7 cytokines in the lowdose QBD group were all lower than those in the the LPS group.Conclusions：QBD has anti-inflammatory effect on sepsis by changing the level of inflammatory mediators.
