Using 2-vinylnaphthalene,aza-BODIPYs with the naphthyl groups at 1,7-positions were prepared and their photophysical properties were characterized.Due to attachment of the naphthyl groups at1,7-positions,aza-BODIPYs s...Using 2-vinylnaphthalene,aza-BODIPYs with the naphthyl groups at 1,7-positions were prepared and their photophysical properties were characterized.Due to attachment of the naphthyl groups at1,7-positions,aza-BODIPYs show long-wavelength absorption and emission in the near-infrared region.The singlet oxygen generation of the dibromo substituted aza-BODIPY with the naphthyl groups at1,7-positions as a photosensitizer was more effective than that of the corresponding aza-BODIPY with the phenyl groups at 1,7-positions.No photobleaching of the naphthyl-containing aza-BODIPY was observed and such NIR aza-BODIPY could be used for the singlet oxygen generation.展开更多
Incorporating enzyme-resistant peptide sequences into self-assembled nanosystems is a promising strategy to enhance the stability and versatility of peptide-based antibacterial drugs,aiming to replace ineffective anti...Incorporating enzyme-resistant peptide sequences into self-assembled nanosystems is a promising strategy to enhance the stability and versatility of peptide-based antibacterial drugs,aiming to replace ineffective antibiotics.By combining newly designed enzymatic-resistant sequences with synthetically derived compounds bearing single,double,triple,or quadruple aromatic rings.A series of nanoscale antimicrobial self-assembled short peptides for the purpose of combating bacterial infections are generated.Nap^(*)(Nap–DNal–Nal–Dab–Dab–NH2,where Nap represents the 1-naphthylacetyl group)possesses the greatest clinical potential(GMSI=23.96)among the peptides in this series.At high concentrations in an aqueous environment,Nap^(*)spontaneously generates nanofibers to capture bacteria and prevent their evasion,exhibiting broad-spectrum antimicrobial effects and exceptional biocompatibility.In the presence of physiological salt ions and serum,the antimicrobial agent exhibits strong effectiveness and retains impressive resistance even when exposed to high levels of proteases(trypsin,chymotrypsin,pepsin).Nap^(*)exhibits negligible in vivo toxicity and effectively alleviates systemic bacterial infections in mice.Mechanistically,Nap^(*)initially captures bacteria and induces bacterial cell death primarily through membrane dissolution,achieved by multiple synergistic mechanisms.In summary,these advances have the potential to greatly expedite the clinical evolution of nanomaterials based on short peptides combined with naphthyl groups and foster the development of peptides integrated with self-assembled systems in this domain.展开更多
A novel non-coplanar aromatic diamine monomer, 3,3＇-ditertbutyl-4,4＇-diaminodiphenyl-4＂-naphthylmethane （TAPN） was synthesized by a condensation reaction of 2-tertbutylaniline and 1-naphthaldehyde under catalyst ...A novel non-coplanar aromatic diamine monomer, 3,3＇-ditertbutyl-4,4＇-diaminodiphenyl-4＂-naphthylmethane （TAPN） was synthesized by a condensation reaction of 2-tertbutylaniline and 1-naphthaldehyde under catalyst hydrochloric acid. The structure of the monomer was confirmed by FTIR, NMR, elementary analysis and mass spectrometry. A series of aromatic polyimides （PIs） were synthesized via conventional one-step polycondensation from TAPN and various commercial aromatic dianhydrides. All of the PIs exhibit excellent solubility in common organic solvents, even in low boiling point solvents such as chloroform （CHC13）, tetrahydrofuran （THF） and acetone. The PIs present outstanding thermal stability with the glass transition temperature （Tg） ranged from 299 ℃ to 350 ℃, and the temperature at 10% weight loss ranged from 490 ℃ to 504 ℃, and high optical transparency with the cutoff wavelengths of 306-356 nm. Moreover, the flexible and tough PI films have prominent mechanical properties with tensile strengths in the range of 77.6-90.5 MPa, tensile modulus in the range of 1.8-2.4 GPa and elongation at break in the range of 6.3%-9.5%, as well as lower dielectric constant （2.89-3.12 at 1 MHz） and lower moisture absorption （0.35%-0.66%）.展开更多
I.INTRODUCTION The theory about 3 stages of embryonic hemopoiesis has been accepted by most investigators. Yolk sac is the first hemopoietic organ at the early stage of embryonic.
The insertion of 1,1-bis (1′-naphthyl) ethylene monomer unit into the active polystyrene chain end greatly decreased the reactivity of the active chain end to the carbonyl group, and allowed the polymeric chain end t...The insertion of 1,1-bis (1′-naphthyl) ethylene monomer unit into the active polystyrene chain end greatly decreased the reactivity of the active chain end to the carbonyl group, and allowed the polymeric chain end to react only with the double bond in N-methacryloyl caprolactam, resulting in N-acylcaprolactam functionalized polystyrene in 100% conversion. New diblock copolymer of polystyrene with polycaprolactam was synthesized by direct reaction of the functionalized polymer with caprolactam without adding additional alkali metal or their caprolactam salts.展开更多
In order to investigate the mechanism of action of immunoenhancer, the effects of the traditional Chinese medicine immunopromoter on the quantity and the transformation rates of T lymphocytes in the chicken blood were...In order to investigate the mechanism of action of immunoenhancer, the effects of the traditional Chinese medicine immunopromoter on the quantity and the transformation rates of T lymphocytes in the chicken blood were determined. Total 120 chickens were randomly assigned into three groups. The 1% and the 0.5% of the Chinese medicine immunopromoter were added to the chicken drinking water, respectively. The quantity of T lymphocytes in each group was measured by a-Naphthyl acetate esterase （ANAE） staining. The results showed that the percentages of T lymphocytes of the treatment groups were significantly higher than that of the control group （P〈0.05）, and the percentage of the 1% group significantly higher than that of the 0.5% group （P〈0.05）. In conclusion, the transformation rates of T lymphocytes showed that the Chinese medicine immunopromoter had the significant enhancing effect on the transformation rates of T lymphocytes of the treated chickens. The traditional Chinese medicine immunopromoter had the distinct function to promote the quantity and the transformation rate of T lymphocytes.展开更多
Two poly（aryl ether）s containing naphthyl moieties were prepared from bis（3,5-dimethyl-4-hydroxyphenyl）naphthyl methane （monomer 1） via nucleophilic aromatic substitution polycondensation with bis（4-fluoropheny...Two poly（aryl ether）s containing naphthyl moieties were prepared from bis（3,5-dimethyl-4-hydroxyphenyl）naphthyl methane （monomer 1） via nucleophilic aromatic substitution polycondensation with bis（4-fluorophenyl） ketone and bis（4-fluorophenyl） sulfone. The structures of these polymers were confirmed by 1H NMR. The Mn values of the two polymers were 96,200 and 88,600, respectively. The polymers exhibited good thermal stabilities with 5% mass loss at T 〉 400 and high glass-transition temperature （Ts） of T 〉 250 ℃. Moreover, the resultant polymers were amorphous determined by wide angle X-ray diffraction （WAXD）. ？2009 Lei Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.展开更多
The organic light-emitting devices(OLEDs) using 4,4',4''-tris{N-(3-methylphenyl)-N-phenylamin}triphenylamine(m-MTDATA) and MoO_3 or 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-tetrachloride(TAPC) and MoO...The organic light-emitting devices(OLEDs) using 4,4',4''-tris{N-(3-methylphenyl)-N-phenylamin}triphenylamine(m-MTDATA) and MoO_3 or 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-tetrachloride(TAPC) and MoO_3 as the hole-injection layer(HIL) were fabricated. MoO_3 can be expected to be a good injection layer material and thus enhance the emission performance of OLED. The highest occupied molecular(HOMO) of MoO_3 is between those of m-MTDATA or TAPC and N,N'-bis-(1-naphthyl)-N,N'-diphenyl-1,1'-biphenyl-4,4'-diamine(NPB),which reduces the hole-injection barrier and improves the luminance of the OLEDs. The current efficiency is improved compared with that of the device without the MoO_3 layer. The highest luminous efficiency of the device with 2-nm-thick MoO_3 as HIL is achieved as 5.27 cd/A at 10 V,which is nearly 1.2 times larger than that of the device without it. Moreover,the highest current efficiency and power efficiency of the device with the structure indium-tin oxide(ITO)/TAPC(40 nm)/MoO_3(2 nm)/Tc Ta:Ir(ppy)3(10%,10 nm)/ tris-(8-hydroxyquinoline) aluminium(Alq)(60 nm)/Li F(1 nm)/Al are achieved as 37.15 cd/A and 41.23 lm/W at 3.2 V and 2.8 V,respectively.展开更多
The photochemical reaction of 1-naphthoquinone-2-diazide is very attractive and interesting. Süs and Huigens considered that the mechanism of photodecomposed reaction is as follows:
Transparent organic light-emitting devices(TOLEDs) based on a stacked alloy cathode of LiF/Al:Ag are investigated. The devices have a structure of indium-tin-oxide(ITO)/4,4′,4′′-Tris[2-naphthyl(phenyl)amino]triphen...Transparent organic light-emitting devices(TOLEDs) based on a stacked alloy cathode of LiF/Al:Ag are investigated. The devices have a structure of indium-tin-oxide(ITO)/4,4′,4′′-Tris[2-naphthyl(phenyl)amino]triphenylamine(2T-NATA)(25 nm)/N,N'-Di-[(1-naphthyl)-N,N'-diphenyl]-1,1'-biphenyl-4,4'-diamine(NPB)(40 nm)/tris-(8-hydroxyquinoline) aluminum(Al_(q_3))(50 nm)/LiF(1 nm)/Al:Ag(1:3)(x), where the thicknesses of cathode metal layers(Al:Ag) are adjusted, respectively, from 70 nm to 100 nm. In the experiment, it is found that the Li F(1 nm)/Al:Ag(1:3)(75 nm) has good electron injection efficiency. Compared with an Al-only cathode, the turn-on voltage is lowered. At the voltage of 10 V, the luminances for bottom emission from ITO anode side and top emission from metal cathode side are 2 459 cd/m^2 and 1 729 cd/m^2, respectively. Thanks to electron injection enhancement by using Al:Ag cathode, we can obtain a better energy level matching between the cathode and the organic layer, thus the devices have lower turn-on voltage and higher luminance. The total transmittance of the devices can achieve about 40% at the wavelength of 550 nm.展开更多
The present work is concerned with the relationship of the different colors of NSE (non specific esterase) reaction product, in which alpha naphthyl acetate and diazotate of o dianisidine (Fast Blue B salt) were used ...The present work is concerned with the relationship of the different colors of NSE (non specific esterase) reaction product, in which alpha naphthyl acetate and diazotate of o dianisidine (Fast Blue B salt) were used as a substrate and a coupler respectively to describe the histochemical characteristics of NSE in chick embryonic mesonephros and metanephros. Our preliminary results throw light on the nature of NSE reaction produced colors, under light microscope, which were different in various sections for different air drying time length. The reaction product on the slices of the convoluted tubules of chick embryonic kidney was bright yellow after less than 30 min air drying time length, brown after 1.5～2 h air drying time length and black after more than 3 h of air drying. The color change process of NSE precipitates from bright yellow to black is progressive. The phenomennon has not been described previously.展开更多
2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones 4 and 5 were synthesized in 41%–67%yield by using microwave-assisted one-pot protocol.The structures of the new compounds 4l,4m,5c,5e,5g,5h,and 5j–5m were conf...2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones 4 and 5 were synthesized in 41%–67%yield by using microwave-assisted one-pot protocol.The structures of the new compounds 4l,4m,5c,5e,5g,5h,and 5j–5m were confirmed by IR,NMR,MS,and elemental analysis.The antimicrobial activities of the compounds against Pseudomonas syringae pv.lachrymans(Smith et Bryan)Young,Dye&Wilkie,Botrytis cinerea Pers.,and Sphaerotheca fusca Blum.were examined.Some of the compounds showed good antifungical activity against Sphaerotheca fusca Blum.展开更多
基金supported by the National Natural Science Foundation of China(Nos.21542004,21372156)Young and middle-aged scientific and technological innovation talents of Shenyang Science and Technology Bureau(No.RC170140)+3 种基金Liaoning Province Natural Science Foundation(No.20170540721)Basic research on the application of Industrial Development of Shenyang Science and Technology Bureau(No.18013027)the Distinguished Professor Project of Liaoning province.We thank the Chinese Scholarship Council(No.20183058)State Administration of Foreign Experts Affairs(No.P183008050)Programme for financial support
文摘Using 2-vinylnaphthalene,aza-BODIPYs with the naphthyl groups at 1,7-positions were prepared and their photophysical properties were characterized.Due to attachment of the naphthyl groups at1,7-positions,aza-BODIPYs show long-wavelength absorption and emission in the near-infrared region.The singlet oxygen generation of the dibromo substituted aza-BODIPY with the naphthyl groups at1,7-positions as a photosensitizer was more effective than that of the corresponding aza-BODIPY with the phenyl groups at 1,7-positions.No photobleaching of the naphthyl-containing aza-BODIPY was observed and such NIR aza-BODIPY could be used for the singlet oxygen generation.
基金supported by the National Natural Science Foundation of China(Nos.32030101,32272914,and 32002215)the Heilongjiang Provincial Collaborative Innovation Achievement Project for Universities—Incubation Project(LJGXCG2022-022)+1 种基金the Heilongjiang Touyan Innovation Team Program(No.54600112)the Natural Science Foundation of Heilongjiang Province(YQ2022C015).
文摘Incorporating enzyme-resistant peptide sequences into self-assembled nanosystems is a promising strategy to enhance the stability and versatility of peptide-based antibacterial drugs,aiming to replace ineffective antibiotics.By combining newly designed enzymatic-resistant sequences with synthetically derived compounds bearing single,double,triple,or quadruple aromatic rings.A series of nanoscale antimicrobial self-assembled short peptides for the purpose of combating bacterial infections are generated.Nap^(*)(Nap–DNal–Nal–Dab–Dab–NH2,where Nap represents the 1-naphthylacetyl group)possesses the greatest clinical potential(GMSI=23.96)among the peptides in this series.At high concentrations in an aqueous environment,Nap^(*)spontaneously generates nanofibers to capture bacteria and prevent their evasion,exhibiting broad-spectrum antimicrobial effects and exceptional biocompatibility.In the presence of physiological salt ions and serum,the antimicrobial agent exhibits strong effectiveness and retains impressive resistance even when exposed to high levels of proteases(trypsin,chymotrypsin,pepsin).Nap^(*)exhibits negligible in vivo toxicity and effectively alleviates systemic bacterial infections in mice.Mechanistically,Nap^(*)initially captures bacteria and induces bacterial cell death primarily through membrane dissolution,achieved by multiple synergistic mechanisms.In summary,these advances have the potential to greatly expedite the clinical evolution of nanomaterials based on short peptides combined with naphthyl groups and foster the development of peptides integrated with self-assembled systems in this domain.
基金financially supported by the National Natural Science Foundation of China(Nos.51163003 and 21264005)the fund of Guangxi Natural Science Foundation(Nos.2014GXNSFAA118040 and 2013GXNSFDA019008)Guangxi Funds for Specially-appointed Expert
文摘A novel non-coplanar aromatic diamine monomer, 3,3＇-ditertbutyl-4,4＇-diaminodiphenyl-4＂-naphthylmethane （TAPN） was synthesized by a condensation reaction of 2-tertbutylaniline and 1-naphthaldehyde under catalyst hydrochloric acid. The structure of the monomer was confirmed by FTIR, NMR, elementary analysis and mass spectrometry. A series of aromatic polyimides （PIs） were synthesized via conventional one-step polycondensation from TAPN and various commercial aromatic dianhydrides. All of the PIs exhibit excellent solubility in common organic solvents, even in low boiling point solvents such as chloroform （CHC13）, tetrahydrofuran （THF） and acetone. The PIs present outstanding thermal stability with the glass transition temperature （Tg） ranged from 299 ℃ to 350 ℃, and the temperature at 10% weight loss ranged from 490 ℃ to 504 ℃, and high optical transparency with the cutoff wavelengths of 306-356 nm. Moreover, the flexible and tough PI films have prominent mechanical properties with tensile strengths in the range of 77.6-90.5 MPa, tensile modulus in the range of 1.8-2.4 GPa and elongation at break in the range of 6.3%-9.5%, as well as lower dielectric constant （2.89-3.12 at 1 MHz） and lower moisture absorption （0.35%-0.66%）.
文摘I.INTRODUCTION The theory about 3 stages of embryonic hemopoiesis has been accepted by most investigators. Yolk sac is the first hemopoietic organ at the early stage of embryonic.
文摘The insertion of 1,1-bis (1′-naphthyl) ethylene monomer unit into the active polystyrene chain end greatly decreased the reactivity of the active chain end to the carbonyl group, and allowed the polymeric chain end to react only with the double bond in N-methacryloyl caprolactam, resulting in N-acylcaprolactam functionalized polystyrene in 100% conversion. New diblock copolymer of polystyrene with polycaprolactam was synthesized by direct reaction of the functionalized polymer with caprolactam without adding additional alkali metal or their caprolactam salts.
基金Hebei Science and Technology Office Programme (07220401D)Guangdong Science and Technology Office Programme (2006B203010 1020)
文摘In order to investigate the mechanism of action of immunoenhancer, the effects of the traditional Chinese medicine immunopromoter on the quantity and the transformation rates of T lymphocytes in the chicken blood were determined. Total 120 chickens were randomly assigned into three groups. The 1% and the 0.5% of the Chinese medicine immunopromoter were added to the chicken drinking water, respectively. The quantity of T lymphocytes in each group was measured by a-Naphthyl acetate esterase （ANAE） staining. The results showed that the percentages of T lymphocytes of the treatment groups were significantly higher than that of the control group （P〈0.05）, and the percentage of the 1% group significantly higher than that of the 0.5% group （P〈0.05）. In conclusion, the transformation rates of T lymphocytes showed that the Chinese medicine immunopromoter had the significant enhancing effect on the transformation rates of T lymphocytes of the treated chickens. The traditional Chinese medicine immunopromoter had the distinct function to promote the quantity and the transformation rate of T lymphocytes.
基金supported by Natural Science Foundation of Guangdong Province(No.7301357)Science and Technology Projects of Shenzhen City(No.200724).
文摘Two poly（aryl ether）s containing naphthyl moieties were prepared from bis（3,5-dimethyl-4-hydroxyphenyl）naphthyl methane （monomer 1） via nucleophilic aromatic substitution polycondensation with bis（4-fluorophenyl） ketone and bis（4-fluorophenyl） sulfone. The structures of these polymers were confirmed by 1H NMR. The Mn values of the two polymers were 96,200 and 88,600, respectively. The polymers exhibited good thermal stabilities with 5% mass loss at T 〉 400 and high glass-transition temperature （Ts） of T 〉 250 ℃. Moreover, the resultant polymers were amorphous determined by wide angle X-ray diffraction （WAXD）. ？2009 Lei Wang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.
基金supported by the Major Project of Science and Technology Office of Fujian Province of China(No.2014H0042)the Natural Science Foundation of Fujian Province of China(No.2015J01664)the Project of Science and Technology Research of Quanzhou City in Fujian Province of China(Nos.2013Z125 and 2014Z137)
文摘The organic light-emitting devices(OLEDs) using 4,4',4''-tris{N-(3-methylphenyl)-N-phenylamin}triphenylamine(m-MTDATA) and MoO_3 or 1,3,5-triazo-2,4,6-triphosphorine-2,2,4,4,6,6-tetrachloride(TAPC) and MoO_3 as the hole-injection layer(HIL) were fabricated. MoO_3 can be expected to be a good injection layer material and thus enhance the emission performance of OLED. The highest occupied molecular(HOMO) of MoO_3 is between those of m-MTDATA or TAPC and N,N'-bis-(1-naphthyl)-N,N'-diphenyl-1,1'-biphenyl-4,4'-diamine(NPB),which reduces the hole-injection barrier and improves the luminance of the OLEDs. The current efficiency is improved compared with that of the device without the MoO_3 layer. The highest luminous efficiency of the device with 2-nm-thick MoO_3 as HIL is achieved as 5.27 cd/A at 10 V,which is nearly 1.2 times larger than that of the device without it. Moreover,the highest current efficiency and power efficiency of the device with the structure indium-tin oxide(ITO)/TAPC(40 nm)/MoO_3(2 nm)/Tc Ta:Ir(ppy)3(10%,10 nm)/ tris-(8-hydroxyquinoline) aluminium(Alq)(60 nm)/Li F(1 nm)/Al are achieved as 37.15 cd/A and 41.23 lm/W at 3.2 V and 2.8 V,respectively.
文摘The photochemical reaction of 1-naphthoquinone-2-diazide is very attractive and interesting. Süs and Huigens considered that the mechanism of photodecomposed reaction is as follows:
基金supported by the National Natural Science Foundation of China(Nos.61076066 and 61605105)Shaanxi Science&Technology Development Program(No.2011KTCQ01-09)
文摘Transparent organic light-emitting devices(TOLEDs) based on a stacked alloy cathode of LiF/Al:Ag are investigated. The devices have a structure of indium-tin-oxide(ITO)/4,4′,4′′-Tris[2-naphthyl(phenyl)amino]triphenylamine(2T-NATA)(25 nm)/N,N'-Di-[(1-naphthyl)-N,N'-diphenyl]-1,1'-biphenyl-4,4'-diamine(NPB)(40 nm)/tris-(8-hydroxyquinoline) aluminum(Al_(q_3))(50 nm)/LiF(1 nm)/Al:Ag(1:3)(x), where the thicknesses of cathode metal layers(Al:Ag) are adjusted, respectively, from 70 nm to 100 nm. In the experiment, it is found that the Li F(1 nm)/Al:Ag(1:3)(75 nm) has good electron injection efficiency. Compared with an Al-only cathode, the turn-on voltage is lowered. At the voltage of 10 V, the luminances for bottom emission from ITO anode side and top emission from metal cathode side are 2 459 cd/m^2 and 1 729 cd/m^2, respectively. Thanks to electron injection enhancement by using Al:Ag cathode, we can obtain a better energy level matching between the cathode and the organic layer, thus the devices have lower turn-on voltage and higher luminance. The total transmittance of the devices can achieve about 40% at the wavelength of 550 nm.
文摘The present work is concerned with the relationship of the different colors of NSE (non specific esterase) reaction product, in which alpha naphthyl acetate and diazotate of o dianisidine (Fast Blue B salt) were used as a substrate and a coupler respectively to describe the histochemical characteristics of NSE in chick embryonic mesonephros and metanephros. Our preliminary results throw light on the nature of NSE reaction produced colors, under light microscope, which were different in various sections for different air drying time length. The reaction product on the slices of the convoluted tubules of chick embryonic kidney was bright yellow after less than 30 min air drying time length, brown after 1.5～2 h air drying time length and black after more than 3 h of air drying. The color change process of NSE precipitates from bright yellow to black is progressive. The phenomennon has not been described previously.
基金The financial supports from the National Natural Science Foundation of China(Grant No.20672027)the Natural Science Foundation of Hebei(2005000106,2008000588)+1 种基金the Research Foundation of the Ministry of Education of China(206013)the Postdoctoral Foundation of China are gratefully acknowledged.
文摘2-aryl-3-(naphthalene-1 or 2-yl)-1,3-thiazolidin-4-ones 4 and 5 were synthesized in 41%–67%yield by using microwave-assisted one-pot protocol.The structures of the new compounds 4l,4m,5c,5e,5g,5h,and 5j–5m were confirmed by IR,NMR,MS,and elemental analysis.The antimicrobial activities of the compounds against Pseudomonas syringae pv.lachrymans(Smith et Bryan)Young,Dye&Wilkie,Botrytis cinerea Pers.,and Sphaerotheca fusca Blum.were examined.Some of the compounds showed good antifungical activity against Sphaerotheca fusca Blum.
