Four new sesquiterpenoids,artemyrianins A-D(1-4),and three new norlignans,artemyrianins E-G(5-7),together with five known compounds(8-12),were isolated from the aerial parts of Artemisia myriantha(Asteraceae).The new ...Four new sesquiterpenoids,artemyrianins A-D(1-4),and three new norlignans,artemyrianins E-G(5-7),together with five known compounds(8-12),were isolated from the aerial parts of Artemisia myriantha(Asteraceae).The new compounds were established by spectroscopic data analyses(HRMS,IR,1D and 2D NMR),and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations.The isolates showed cytotoxicity against HepG2 cells with IC50 values ranging from 33.3 to 145.2μM.展开更多
Ten new germacrane-type sesquiterpenoids,artemyrianosins A-J(1-10),were isolated from the aerial parts of Arte-misia myriantha.Their structures were elucidated by spectral analyses including UV,IR,HRESIMS,1D and 2D NM...Ten new germacrane-type sesquiterpenoids,artemyrianosins A-J(1-10),were isolated from the aerial parts of Arte-misia myriantha.Their structures were elucidated by spectral analyses including UV,IR,HRESIMS,1D and 2D NMR,ECD and the absolute configurations of compounds 1 and 7-9 were characterized using X-ray crystallography.All isolates were tested their cytotoxicity against three human hepatoma cell lines(HepG2,Huh7,and SK-Hep-1),and com-pounds 1-3,7,and 10 showed cytotoxicity with IC50 values ranging from 43.7 to 89.3μM.Among them,the most active compound 3 exhibited activity against three human hepatoma cell lines with IC50 values of 43.7μM(HepG2),47.9μM(Huh7),and 44.9μM(SK-Hep-1).展开更多
基金supported by the Yunnan Wanren Project(YNWR-KJLJ-2019-002)the Program of Yunling Scholarship,the Reserve Talents of Young and Middle-aged Academic and Technical Leaders in Yunnan Province,and the Youth Innovation Promotion Association,CAS(2013252).
文摘Four new sesquiterpenoids,artemyrianins A-D(1-4),and three new norlignans,artemyrianins E-G(5-7),together with five known compounds(8-12),were isolated from the aerial parts of Artemisia myriantha(Asteraceae).The new compounds were established by spectroscopic data analyses(HRMS,IR,1D and 2D NMR),and their absolute configurations were confirmed by the single-crystal X-ray diffraction or ECD calculations.The isolates showed cytotoxicity against HepG2 cells with IC50 values ranging from 33.3 to 145.2μM.
基金supported by the Key Program of the National Natural Science Foundation of China (22137008)the Yunnan Wanren Project (YNWR-KJLJ-2019-002).
文摘Ten new germacrane-type sesquiterpenoids,artemyrianosins A-J(1-10),were isolated from the aerial parts of Arte-misia myriantha.Their structures were elucidated by spectral analyses including UV,IR,HRESIMS,1D and 2D NMR,ECD and the absolute configurations of compounds 1 and 7-9 were characterized using X-ray crystallography.All isolates were tested their cytotoxicity against three human hepatoma cell lines(HepG2,Huh7,and SK-Hep-1),and com-pounds 1-3,7,and 10 showed cytotoxicity with IC50 values ranging from 43.7 to 89.3μM.Among them,the most active compound 3 exhibited activity against three human hepatoma cell lines with IC50 values of 43.7μM(HepG2),47.9μM(Huh7),and 44.9μM(SK-Hep-1).
