In the process of ferromagnetic thermoseeds mediated magnetic induction hyperthermia,the temperature distribution in the tumor region is a key factor to determine the therapy effect.During the preoperative treatment p...In the process of ferromagnetic thermoseeds mediated magnetic induction hyperthermia,the temperature distribution in the tumor region is a key factor to determine the therapy effect.During the preoperative treatment planning,discrepancies of the treatment parameters may lead to the temperature distribution uncertainty within the target area.Inaccurate prediction of temperature distribution may induce the treatment failure;therefore,it would be significant to investigate the uncertainty of tissue temperature prediction caused by the disturbance of calculation parameters.In this paper,3D temperature field and necrosis zone of tissues in ferromagnetic thermoseeds hyperthermia are simulated by the finite volume algorithm,and effects of parameter uncertainties on the temperature distribution are revealed.Results show that selecting appropriate magnetic field parameters for treatment is a priority to guarantee therapeutic effect.Thermoseed properties and blood perfusion rate are the obvious disturbing terms for temperature distribution,while the metabolic heat of bio-tissues can often be ignored within limits.Our investigation is of importance for guiding reasonable and optimal preoperative treatment planning.展开更多
The biocompatibility and biodistribution of magnetic nanoparticles(MNPs)in vivo are essential to ensure their safely clinical application.We have studied these aspects with our 3-aminopropyltriethoxysilanecoated magne...The biocompatibility and biodistribution of magnetic nanoparticles(MNPs)in vivo are essential to ensure their safely clinical application.We have studied these aspects with our 3-aminopropyltriethoxysilanecoated magnetic nanoparticles(APTS-MNPs)formulation,which can be used as magnetic induction hyperthermia media.Changes in tissue iron levels were analyzed after intraperitoneal injection of APTS-MNPs to ICR mice.Liver and kidney functions were tested.Heart,liver,spleen,lung,kidney,testis,and brain were sectioned for pathological analysis.Biodistribution of iron in various body tissues changed with time but greater fraction of the injected iron localized in the liver and spleen than in other tissues.Serum showed an increase in AST and LDH following APTS-MNPs injection.Histological analyses of selected tissues showed no obvious abnormal changes.In conclusion,APTS-MNPs did not cause continuing changes in the liver and kidney function and thus can be safely used for in vivo application.展开更多
基金supported by the Beijing Municipal Science and Technology Commission(Z111100067311053)the Technology Support Program of China(2012BAI15B04)
文摘In the process of ferromagnetic thermoseeds mediated magnetic induction hyperthermia,the temperature distribution in the tumor region is a key factor to determine the therapy effect.During the preoperative treatment planning,discrepancies of the treatment parameters may lead to the temperature distribution uncertainty within the target area.Inaccurate prediction of temperature distribution may induce the treatment failure;therefore,it would be significant to investigate the uncertainty of tissue temperature prediction caused by the disturbance of calculation parameters.In this paper,3D temperature field and necrosis zone of tissues in ferromagnetic thermoseeds hyperthermia are simulated by the finite volume algorithm,and effects of parameter uncertainties on the temperature distribution are revealed.Results show that selecting appropriate magnetic field parameters for treatment is a priority to guarantee therapeutic effect.Thermoseed properties and blood perfusion rate are the obvious disturbing terms for temperature distribution,while the metabolic heat of bio-tissues can often be ignored within limits.Our investigation is of importance for guiding reasonable and optimal preoperative treatment planning.
基金supported by the National Natural Science Foundation of China (81071885)
文摘The biocompatibility and biodistribution of magnetic nanoparticles(MNPs)in vivo are essential to ensure their safely clinical application.We have studied these aspects with our 3-aminopropyltriethoxysilanecoated magnetic nanoparticles(APTS-MNPs)formulation,which can be used as magnetic induction hyperthermia media.Changes in tissue iron levels were analyzed after intraperitoneal injection of APTS-MNPs to ICR mice.Liver and kidney functions were tested.Heart,liver,spleen,lung,kidney,testis,and brain were sectioned for pathological analysis.Biodistribution of iron in various body tissues changed with time but greater fraction of the injected iron localized in the liver and spleen than in other tissues.Serum showed an increase in AST and LDH following APTS-MNPs injection.Histological analyses of selected tissues showed no obvious abnormal changes.In conclusion,APTS-MNPs did not cause continuing changes in the liver and kidney function and thus can be safely used for in vivo application.
