摘要
为在甲状腺癌模型仿真研究中探究磁感应热疗的效果,本研究选用亥姆霍兹线圈作为交变磁场发生装置,并以磁流体为磁性加热材料,根据Pennes生物传热方程,在COMSOL有限元仿真软件中进行三维建模,实现电场和温度场的耦合计算,得到磁感应热疗作用于甲状腺癌区域的电磁场和热场分布。仿真实验结果表明,甲状腺癌组织磁感应强度最大值为8 350.86 A/m,感应电场强度最大值为122.764 V/m,最小值为0.758 V/m。当在甲状腺癌组织中加入磁流体后,在外加交变磁场的影响下,组织温度急剧上升,400 s左右体温趋于稳定。肿瘤的中央组织温度为46.929℃,整个肿瘤温度均在42℃以上,其周围的健康组织温度均在42℃以下。本研究将为甲状腺癌磁感应热疗的临床应用提供重要依据。
To explore the effect of magnetic induction hyperthermia in thyroid cancer model simulation study,we selected Helmholtz coil as the alternating magnetic field generating device and magnetic fluid as the magnetic heating material.According to Pennes bioheat transfer equation,three-dimensional modeling was carried out in COMSOL finite element simulation software to realize the coupling calculation of electric field and temperature field,and the distribution of electromagnetic field and heat field under magnetic induction hyperthermia in thyroid cancer area was obtained.The results showed that the maximum magnetic induction intensity of thyroid cancer tissue was 8350.86 A/m,the maximum electric field intensity was 122.764 V/m,and the minimum electric field intensity was 0.758 V/m.When the magnetic fluid was added to thyroid cancer tissue,the tissue temperature rised sharply under the influence of the external alternating magnetic field,and the temperature became stable at about 400 s.The temperature of the whole thyroid cancer tissue reached more than 42℃,while the temperature of the central tissue of the tumor was about 46.929℃,and the temperature of the surrounding healthy tissue was within 42℃.This conclusion will provide an important basis for clinical application of magnetic induction hyperthermia for thyroid cancer.
作者
方紫薇
逯迈
张云飞
FANG Ziwei;LU Mai;ZHANG Yunfei(Key Laboratory of Optoelectronic Technology and Intelligent Control Ministry of Education,Lanzhou Jiaotong University,Lanzhou 730070,China)
出处
《生物医学工程研究》
2024年第4期285-292,共8页
Journal Of Biomedical Engineering Research
基金
国家自然科学基金资助项目(51867014)
甘肃省教育厅项目(2024CXPT-11)。
关键词
甲状腺肿瘤
磁感应热疗
有限元分析
磁性纳米颗粒
亥姆霍兹线圈
多物理场
Thyroid tumors
Magnetic induction hyperthermia
Finite element analysis
Magnetic nanoparticles
Helmholtz coils
Multiphysics field
