Purpose:To evaluate the postoperative effect of the lateral tarsal strip(LTS)procedure in treating lower eyelid involutional ectropion.Methods:A retrospective study was performed on 85 eyelids in 67 patients with invo...Purpose:To evaluate the postoperative effect of the lateral tarsal strip(LTS)procedure in treating lower eyelid involutional ectropion.Methods:A retrospective study was performed on 85 eyelids in 67 patients with involutional ectropion who underwent LTS procedure.Pre-and postoperative lower eyelid laxity and ocular symptoms as well as perioperative complications were evaluated.Snap back test was performed to evaluate the elasticity of lateral canthal tendon loosening and,a lower lid distraction test was performed to evaluate the degree of severity before surgery.Ocular surface diseases were evaluated by the Ocular Surface Disease Index(OSDI),and symptoms including conjunctivitis,corneal ulcer,dry eye syndrome,and ocular pain were recorded.All patients were evaluated within one week and during the follow-up period of 4.28.3 months.Furthermore,we reviewed the studies that also investigated the surgical effect of the LTS procedure in the literature from 1979 to 2019.Results:The success rate was 95%.Only four eyelids required a second surgical intervention.Seventy-three(86%)eyelids had an excellent position after surgery,9(11%)only little improvement,and three had no improvement.No significant difference was found in the postoperative effects between different degrees of ectropion(p>0.05).No statistical correlation was found between surgical improvements and the ectropion severity(P>0.05).Fiftytwo out of 85 eyes had no discomfort after the surgery.Mild complications included epiphora in 13 eyes(three cases caused by lacrimal punctum eversion),ocular pain in 12 eyes,wound hemorrhage in 12 eyes,and edema in 9 eyelids immediately after surgery,in which 91.2%(n=21)disappeared within one week and did not need any further treatment.Conclusions:The lateral tarsal strip procedure can provide an aesthetically pleasing result for correcting the mild to moderate lower eyelid ectropion while maintaining decent eyelid function.展开更多
AIM: To investigate the reliability of a modified threedimensional distraction test(3D-DT) and three-dimensional pinch test(3D-PT) for assessing lower eyelid tension(LET).METHODS: A cross-sectional study was conducted...AIM: To investigate the reliability of a modified threedimensional distraction test(3D-DT) and three-dimensional pinch test(3D-PT) for assessing lower eyelid tension(LET).METHODS: A cross-sectional study was conducted among 97 volunteer s including 97 eyelids with no history of trauma, tumor, or reconstructive surgeries. Six three-dimensional photographs were acquired for each par ticipant, including two photographs obtained in a neutral position(NP), two using a modified 3D-DT with a 15.9-grammes stainless steel eyelid hook performed, and two using 3D-PT.RESULTS: The mean absolute differences between NP, 3D-DT, and 3D-PT measurements varied between 0.07 and 7.42, 0.10 and 13.10, and 0.07 and 15.97, respectively;technical error of measurement varied between 0.05 and 7.81, 0.09 and 10.19, and 0.07 and 12.47, respectively;and relative error measurements varied between 0.10% and 11.50%, 0.16% and 30.51%, and 0.11% and 38.75%, respectively. For intra-rater reliability, the intraclass correlation coefficients(ICCs) were more than 0.80 in seven out of eight measurements obtained in the NP and 3D-DT, whereas those obtained in the 3D-PT were as low as less than 0.30 by rater 1;the ICCs of all the measurements obtained in all the positions(NP, 3D-DT, and 3D-PT) were more than 0.80 by rater 2. For inter-rater reliability six out of eight NP and 3D-DT measurements had an ICC greater than 0.80, whereas those of 3D-PT measurements were less than 0.30. For intra-method reliability, the ICCs of all the NP measurements were more than 0.87, whereas those of the six 3D-DT measurements and four 3D-PT measurements were more than 0.80.CONCLUSION: Our study results prove that the modified 3D-DT, which involves the use of an eyelid hook, can be a highly reliable method for evaluating LET. Furthermore, this novel and simple method may be utilized as the basis for further investigation and routine pre-and postoperative clinical evaluation.展开更多
In the first and second parts of this study,5-hydroxytryptamine(5HT)receptors,including 5-HT3 and 5-HT4 with the highest expression level,were found in clasp and sling fibres of the lower esophageal sphincter(LES).Spe...In the first and second parts of this study,5-hydroxytryptamine(5HT)receptors,including 5-HT3 and 5-HT4 with the highest expression level,were found in clasp and sling fibres of the lower esophageal sphincter(LES).Specific 5-HT3 and 5-HT4 receptor agonists can induce the contraction effect of clasp and sling fibres of the LES while specific 5-HT7 receptor agonists showed no effects.In the study of this part,the in-vitro muscle tension measurement technology and EFS methods were used to detect the effect of the selective 5-HT receptor antagonist on the clasp and sling fibres of the in-vitro LES under the electrical field stimulation(EFS),and further to ensure the effect of 5-HT receptor in the LES neuroregulatory pathway,and deeply explore the effect of 5-HT receptor in the systolic and diastolic function regulation of the LES.展开更多
目的脑卒中已成为我国第一死亡原因,是中国成年人残疾的首要原因。本研究探究等速肌力训练对脑卒中偏瘫患者下肢肌张力及步行能力的影响。方法选取2017-06-01—2018-12-01在南阳市第二人民医院接受治疗的脑卒中偏瘫患者为研究对象,根据...目的脑卒中已成为我国第一死亡原因,是中国成年人残疾的首要原因。本研究探究等速肌力训练对脑卒中偏瘫患者下肢肌张力及步行能力的影响。方法选取2017-06-01—2018-12-01在南阳市第二人民医院接受治疗的脑卒中偏瘫患者为研究对象,根据组间性别、年龄、病程等因素均衡可比的原则分为两组,每组33例。对照组采用常规训练,观察组采用等速肌力训练,对比分析两组患者下肢肌力〔伸膝肌群肌力(muscle strength of extensor muscles of knee,FKE)、屈髋肌群肌力(flexor hip muscle strength,FHF)〕、下肢肌肉功能〔伸、屈肌峰力矩(peak torque,PT)、总功率(total work,TW)〕和步行能力(10m步行时间、6min步行距离)。结果训练后,观察组FKE平均为(39.64±24.75)N·m,大于对照组的(28.04±21.24)N·m,t=2.043,P=0.045;FHF平均为(51.64±24.54)N·m,大于对照组的(39.43±21.34)N·m,t=2.157,P=0.035。训练后,观察组屈肌PT平均为(26.82±6.82)N-M,大于对照组的(21.27±4.13)N-M,t=3.999,P<0.001;伸肌PT平均为(50.72±13.75)N-M,大于对照组的(44.04±9.16)N-M,t=2.324,P=0.023;屈肌TW平均为(50.93±5.89)J,大于对照组的(43.64±4.18)J,t=5.798,P<0.001;伸肌TW平均为(67.99±5.82)J,大于对照组的(60.38±5.31)J,t=5.549,P<0.001。训练后,观察组10m步行时间平均为(45.21±29.53)s,少于对照组的(58.54±21.63)s,t=2.092,P=0.040;6min步行距离平均为(80.53±15.56)m,大于对照组的(66.53±19.64)m,t=3.210,P=0.002。结论采用等速肌力训练可增强脑卒中偏瘫患者下肢肌张力及肌肉能力,改善其步行能力。展开更多
基金supported by the Fundamental Research Funds for the Central Universities(grant No.2021FZZX005-15)the Koeln Fortune Program/Faculty of Medicine,University of Cologne,Germany(grant No.2680148101)+2 种基金National Natural Science Foundation of China(grant No.81970834)Science and Technology Commission of Shanghai Municipality(grant No.19441900800)GEROK program of the University of Cologne.
文摘Purpose:To evaluate the postoperative effect of the lateral tarsal strip(LTS)procedure in treating lower eyelid involutional ectropion.Methods:A retrospective study was performed on 85 eyelids in 67 patients with involutional ectropion who underwent LTS procedure.Pre-and postoperative lower eyelid laxity and ocular symptoms as well as perioperative complications were evaluated.Snap back test was performed to evaluate the elasticity of lateral canthal tendon loosening and,a lower lid distraction test was performed to evaluate the degree of severity before surgery.Ocular surface diseases were evaluated by the Ocular Surface Disease Index(OSDI),and symptoms including conjunctivitis,corneal ulcer,dry eye syndrome,and ocular pain were recorded.All patients were evaluated within one week and during the follow-up period of 4.28.3 months.Furthermore,we reviewed the studies that also investigated the surgical effect of the LTS procedure in the literature from 1979 to 2019.Results:The success rate was 95%.Only four eyelids required a second surgical intervention.Seventy-three(86%)eyelids had an excellent position after surgery,9(11%)only little improvement,and three had no improvement.No significant difference was found in the postoperative effects between different degrees of ectropion(p>0.05).No statistical correlation was found between surgical improvements and the ectropion severity(P>0.05).Fiftytwo out of 85 eyes had no discomfort after the surgery.Mild complications included epiphora in 13 eyes(three cases caused by lacrimal punctum eversion),ocular pain in 12 eyes,wound hemorrhage in 12 eyes,and edema in 9 eyelids immediately after surgery,in which 91.2%(n=21)disappeared within one week and did not need any further treatment.Conclusions:The lateral tarsal strip procedure can provide an aesthetically pleasing result for correcting the mild to moderate lower eyelid ectropion while maintaining decent eyelid function.
基金Supported by the Project of National Key Research and Development (No.2018YFC1106103)Chongqing Science and Health Joint Medical Research Project-Youth Project (No.2022QNXM016)The Fundamental Research Funds for the Central Universities (No.2021FZZX005-15)。
文摘AIM: To investigate the reliability of a modified threedimensional distraction test(3D-DT) and three-dimensional pinch test(3D-PT) for assessing lower eyelid tension(LET).METHODS: A cross-sectional study was conducted among 97 volunteer s including 97 eyelids with no history of trauma, tumor, or reconstructive surgeries. Six three-dimensional photographs were acquired for each par ticipant, including two photographs obtained in a neutral position(NP), two using a modified 3D-DT with a 15.9-grammes stainless steel eyelid hook performed, and two using 3D-PT.RESULTS: The mean absolute differences between NP, 3D-DT, and 3D-PT measurements varied between 0.07 and 7.42, 0.10 and 13.10, and 0.07 and 15.97, respectively;technical error of measurement varied between 0.05 and 7.81, 0.09 and 10.19, and 0.07 and 12.47, respectively;and relative error measurements varied between 0.10% and 11.50%, 0.16% and 30.51%, and 0.11% and 38.75%, respectively. For intra-rater reliability, the intraclass correlation coefficients(ICCs) were more than 0.80 in seven out of eight measurements obtained in the NP and 3D-DT, whereas those obtained in the 3D-PT were as low as less than 0.30 by rater 1;the ICCs of all the measurements obtained in all the positions(NP, 3D-DT, and 3D-PT) were more than 0.80 by rater 2. For inter-rater reliability six out of eight NP and 3D-DT measurements had an ICC greater than 0.80, whereas those of 3D-PT measurements were less than 0.30. For intra-method reliability, the ICCs of all the NP measurements were more than 0.87, whereas those of the six 3D-DT measurements and four 3D-PT measurements were more than 0.80.CONCLUSION: Our study results prove that the modified 3D-DT, which involves the use of an eyelid hook, can be a highly reliable method for evaluating LET. Furthermore, this novel and simple method may be utilized as the basis for further investigation and routine pre-and postoperative clinical evaluation.
基金Effect of 5-hydroxytryptamine Receptor in the Lower Esophageal Sphincter Regulation Mechanism(Number:18ZF23)。
文摘In the first and second parts of this study,5-hydroxytryptamine(5HT)receptors,including 5-HT3 and 5-HT4 with the highest expression level,were found in clasp and sling fibres of the lower esophageal sphincter(LES).Specific 5-HT3 and 5-HT4 receptor agonists can induce the contraction effect of clasp and sling fibres of the LES while specific 5-HT7 receptor agonists showed no effects.In the study of this part,the in-vitro muscle tension measurement technology and EFS methods were used to detect the effect of the selective 5-HT receptor antagonist on the clasp and sling fibres of the in-vitro LES under the electrical field stimulation(EFS),and further to ensure the effect of 5-HT receptor in the LES neuroregulatory pathway,and deeply explore the effect of 5-HT receptor in the systolic and diastolic function regulation of the LES.
文摘目的脑卒中已成为我国第一死亡原因,是中国成年人残疾的首要原因。本研究探究等速肌力训练对脑卒中偏瘫患者下肢肌张力及步行能力的影响。方法选取2017-06-01—2018-12-01在南阳市第二人民医院接受治疗的脑卒中偏瘫患者为研究对象,根据组间性别、年龄、病程等因素均衡可比的原则分为两组,每组33例。对照组采用常规训练,观察组采用等速肌力训练,对比分析两组患者下肢肌力〔伸膝肌群肌力(muscle strength of extensor muscles of knee,FKE)、屈髋肌群肌力(flexor hip muscle strength,FHF)〕、下肢肌肉功能〔伸、屈肌峰力矩(peak torque,PT)、总功率(total work,TW)〕和步行能力(10m步行时间、6min步行距离)。结果训练后,观察组FKE平均为(39.64±24.75)N·m,大于对照组的(28.04±21.24)N·m,t=2.043,P=0.045;FHF平均为(51.64±24.54)N·m,大于对照组的(39.43±21.34)N·m,t=2.157,P=0.035。训练后,观察组屈肌PT平均为(26.82±6.82)N-M,大于对照组的(21.27±4.13)N-M,t=3.999,P<0.001;伸肌PT平均为(50.72±13.75)N-M,大于对照组的(44.04±9.16)N-M,t=2.324,P=0.023;屈肌TW平均为(50.93±5.89)J,大于对照组的(43.64±4.18)J,t=5.798,P<0.001;伸肌TW平均为(67.99±5.82)J,大于对照组的(60.38±5.31)J,t=5.549,P<0.001。训练后,观察组10m步行时间平均为(45.21±29.53)s,少于对照组的(58.54±21.63)s,t=2.092,P=0.040;6min步行距离平均为(80.53±15.56)m,大于对照组的(66.53±19.64)m,t=3.210,P=0.002。结论采用等速肌力训练可增强脑卒中偏瘫患者下肢肌张力及肌肉能力,改善其步行能力。
