TREATMENT OF DERMOPATHIESPrinciples of Treatment 1.According to the theory that theLung is reciprocally related with skin andhair, the points related to the Lung are oftenselected for dermopathies,such as Chize(Lu5),F...TREATMENT OF DERMOPATHIESPrinciples of Treatment 1.According to the theory that theLung is reciprocally related with skin andhair, the points related to the Lung are oftenselected for dermopathies,such as Chize(Lu5),Feishu(UB 13),Yintang(Extra 1),Lieque(Lu 7),and the lung area of the ear.Insertion of the needles should展开更多
The mechanism of antiahock effect of anisodamine (654-2) is still unknown. Experimental shock on rabbits showed that 654-2 had good preventive and therapeutic effect on superior mesenteric artery occlusion shock (SMAO...The mechanism of antiahock effect of anisodamine (654-2) is still unknown. Experimental shock on rabbits showed that 654-2 had good preventive and therapeutic effect on superior mesenteric artery occlusion shock (SMAO shock). It increased survival rate of shock animals and the recovery rate of the animals from shock condition, and at the same time, the amount of exudative fluid loss from the intestinal cavities was significantly decreased. It also exerted good preventive and therapeutic effect展开更多
Glucose transporter (GT), molecular weight 55 kd, is an important biological functional membrane protein, by which glucose is transported into the cell from the extracellular environment and used as a source of energy.
Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and m...Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,展开更多
OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal diseases.We also analyzed t...OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal diseases.We also analyzed the relationship between symptoms,drugs and therapies with data-excavating technology to aid management.METHODS:After retrieving relevant clinical articles,we set up a database,used Microsoft Structured Query Language Server 2005 Analysis Services as a data-excavating tool,and applied the association rule to study the relationship between the symptoms,drugs and therapies of intestinal diseases.RESULTS:The key symptoms of dyschesia,constipation,abdominal fullness,fatigue and pale tongue could be treated with Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)and Gualou(Fructus et Semen Trichosanthis)to invigorate Qi and moisten the intestine.Among these agents,Kuxingren(Semen Armeniacae Amarum)was used most frequently.Clearing Fu-organs was the most prevalent therapy for abdominal fullness,dyschesia,constipation and red tongue.Clearing Fu-organs could be achieved with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),whereas Qi could be invigorated using Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae)and Kuxingren(Semen Armeniacae Amarum).Moistening the intestine was possible with Kuxingren(SemenArmeniacae Amarum),Huomaren(Fructus Cannabis)and Jiegeng(Radix Platycodi).Also,moistening the lungs was done with Kuxingren(Semen Armeniacae Amarum),ventilating the lungs with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),and nourishing the lungs with Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae)and Kuxingren(Semen Armeniacae Amarum).These data demonstrated that Kuxingren(SemenArmeniacaeAmarum)was a key agent.CONCLUSION:Our analyses of the literature showed clear relationships between symptoms(constipation,dyschesia,abdominal fullness),drugs[Gualou(Fructus et Semen展开更多
Metabolic health is highly dependent on intestinal and hepatic handling of dietary and endogenous lipids and lipoproteins.Disorders of lipid and lipoprotein metabolism are commonly observed in patients with insulin re...Metabolic health is highly dependent on intestinal and hepatic handling of dietary and endogenous lipids and lipoproteins.Disorders of lipid and lipoprotein metabolism are commonly observed in patients with insulin resistant states such as obesity,metabolic syndrome,and type 2 diabetes.Ev-idence from both animal models and human studies indicates that a major underlying factor in metabolic or diabetic dysli-pidemia is the overproduction of hepatic and intestinal apoli-poprotein(apo)B-containing lipoprotein particles.These particles are catabolized down into highly proatherogenic remnants,which can be taken up into the arterial intima and promote plaque development.Several gut-derived peptides have been identified as key regulators of energy metabolism;one such peptide is the incretin hormone glucagon-like peptide(GLP)-1.Our laboratory has previously demonstrated that GLP-1 can signal both centrally and peripherally to reduce postprandial and fasting lipoprotein secretion.Moreover,we have demonstrated that GLP-1 receptor(GLP-1R)agonists can ameliorate diet-induced dyslipidemia.Recently,we published evidence for a novel vagal neuroendocrine signalling pathway by which native GLP-1 may exert its anti-lipemic effects.Furthermore,we demonstrated a novel role for other gut-derived peptides in regulating intestinal lipoprotein produc-tion.Overall,ample evidence supports a key role for GLP-1R on the portal vein afferent neurons and nodose ganglion in modulating intestinal fat absorption and lipoprotein produc-tion and identifies other gut-derived peptides as novel regula-tors of postprandial lipemia.Insights from these data may support identification of potential drug targets and the development of new therapeutics targeting treatment of dia-betic dyslipidemia.展开更多
文摘TREATMENT OF DERMOPATHIESPrinciples of Treatment 1.According to the theory that theLung is reciprocally related with skin andhair, the points related to the Lung are oftenselected for dermopathies,such as Chize(Lu5),Feishu(UB 13),Yintang(Extra 1),Lieque(Lu 7),and the lung area of the ear.Insertion of the needles should
文摘The mechanism of antiahock effect of anisodamine (654-2) is still unknown. Experimental shock on rabbits showed that 654-2 had good preventive and therapeutic effect on superior mesenteric artery occlusion shock (SMAO shock). It increased survival rate of shock animals and the recovery rate of the animals from shock condition, and at the same time, the amount of exudative fluid loss from the intestinal cavities was significantly decreased. It also exerted good preventive and therapeutic effect
文摘Glucose transporter (GT), molecular weight 55 kd, is an important biological functional membrane protein, by which glucose is transported into the cell from the extracellular environment and used as a source of energy.
文摘Drugs of this category have the effectsof nourishing the lung to relieve cough andlowering the adverse flow of q(?) to relieveasthma.They are indicated for syndrome ofcough and dyspnea which is very complicat-ed and may be manifested as cough withoutsputum,cough with watery thin sputum orwith yellow thick sputum,cough withdyspnea due to affection by exopathogens,or cough with dyspnea due to consumptivediseases.Appropriate drugs should be chos-en with regard to the different syndromes,
基金Supported by the National Plan on Development of Key Basic Research(973 plan)(No.2009CB522701)
文摘OBJECTIVE:To evaluate clinical articles published in the past 30 years using the Traditional Chinese Medicine(TCM)theory of the lung being connected with large intestine to treat intestinal diseases.We also analyzed the relationship between symptoms,drugs and therapies with data-excavating technology to aid management.METHODS:After retrieving relevant clinical articles,we set up a database,used Microsoft Structured Query Language Server 2005 Analysis Services as a data-excavating tool,and applied the association rule to study the relationship between the symptoms,drugs and therapies of intestinal diseases.RESULTS:The key symptoms of dyschesia,constipation,abdominal fullness,fatigue and pale tongue could be treated with Kuxingren(Semen Armeniacae Amarum),Huangqi(Radix Astragali Mongolici)and Gualou(Fructus et Semen Trichosanthis)to invigorate Qi and moisten the intestine.Among these agents,Kuxingren(Semen Armeniacae Amarum)was used most frequently.Clearing Fu-organs was the most prevalent therapy for abdominal fullness,dyschesia,constipation and red tongue.Clearing Fu-organs could be achieved with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),whereas Qi could be invigorated using Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae),Baizhu(Rhizoma Atractylodis Macrocephalae)and Kuxingren(Semen Armeniacae Amarum).Moistening the intestine was possible with Kuxingren(SemenArmeniacae Amarum),Huomaren(Fructus Cannabis)and Jiegeng(Radix Platycodi).Also,moistening the lungs was done with Kuxingren(Semen Armeniacae Amarum),ventilating the lungs with Kuxingren(Semen Armeniacae Amarum)and Gualou(Fructus et Semen Trichosanthis),and nourishing the lungs with Huangqi(Radix Astragali Mongolici),Gancao(Radix Glycyrrhizae)and Kuxingren(Semen Armeniacae Amarum).These data demonstrated that Kuxingren(SemenArmeniacaeAmarum)was a key agent.CONCLUSION:Our analyses of the literature showed clear relationships between symptoms(constipation,dyschesia,abdominal fullness),drugs[Gualou(Fructus et Semen
基金Canadian Institutes of Health Research (CIHR) (FDN-148396).
文摘Metabolic health is highly dependent on intestinal and hepatic handling of dietary and endogenous lipids and lipoproteins.Disorders of lipid and lipoprotein metabolism are commonly observed in patients with insulin resistant states such as obesity,metabolic syndrome,and type 2 diabetes.Ev-idence from both animal models and human studies indicates that a major underlying factor in metabolic or diabetic dysli-pidemia is the overproduction of hepatic and intestinal apoli-poprotein(apo)B-containing lipoprotein particles.These particles are catabolized down into highly proatherogenic remnants,which can be taken up into the arterial intima and promote plaque development.Several gut-derived peptides have been identified as key regulators of energy metabolism;one such peptide is the incretin hormone glucagon-like peptide(GLP)-1.Our laboratory has previously demonstrated that GLP-1 can signal both centrally and peripherally to reduce postprandial and fasting lipoprotein secretion.Moreover,we have demonstrated that GLP-1 receptor(GLP-1R)agonists can ameliorate diet-induced dyslipidemia.Recently,we published evidence for a novel vagal neuroendocrine signalling pathway by which native GLP-1 may exert its anti-lipemic effects.Furthermore,we demonstrated a novel role for other gut-derived peptides in regulating intestinal lipoprotein produc-tion.Overall,ample evidence supports a key role for GLP-1R on the portal vein afferent neurons and nodose ganglion in modulating intestinal fat absorption and lipoprotein produc-tion and identifies other gut-derived peptides as novel regula-tors of postprandial lipemia.Insights from these data may support identification of potential drug targets and the development of new therapeutics targeting treatment of dia-betic dyslipidemia.
