Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammato...Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer cachexia.Cancer cachexia factors are also a potential target for the diagnosis and treatment.The pathogenesis of cachexia is unclear and no clear effective treatment is available.Thus,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently needed.From the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and treatment.This review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia factors.This summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.展开更多
This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with small-scale networks where a centralized dynami...This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first designed.Then,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale networks.It is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event time.In addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable parameter.Furthermore,the results are extended to regional consensus of the MASs with the bounded control protocol.Numerical simulations show the effectiveness of the proposed approach.展开更多
Due to high data rates and reliability,inter-satellite laser communication has developed rapidly in these days.However,the stability of the laser beam pointing is still a key technique which needs to be solved;otherwi...Due to high data rates and reliability,inter-satellite laser communication has developed rapidly in these days.However,the stability of the laser beam pointing is still a key technique which needs to be solved;otherwise,the beam pointing jitter noise would reduce the communication quality or,even worse,would make the inter-satellite laser communication impossible.For this purpose,a bench-top of the fine beam pointing control system has been built and tested for inter-satellite laser communication.The pointing offset of more than 100rad is produced by the steering mirror.With beam pointing control system turned on,the offset could be rapidly suppressed to lower than 100 nrad in less than 0.5 s.Moreover,the pointing stability can be kept at 40 nrad for yaw motion and 62 nrad for pitch motion,when the received beam jitter is set at 20rad.展开更多
Mitochondria function as a hub of the cellular metabolic network.Mitochondrial stress is closely associated with aging and a variety of diseases,including neurodegeneration and cancer.Cells autonomously elicit specifi...Mitochondria function as a hub of the cellular metabolic network.Mitochondrial stress is closely associated with aging and a variety of diseases,including neurodegeneration and cancer.Cells autonomously elicit specific stress responses to cope with mitochondrial stress to maintain mitochondrial homeostasis.Interestingly,mitochondrial stress responses may also be induced in a non-autonomous manner in cells or tissues that are not directly experiencing such stress.Such non-autonomous mitochondrial stress responses are mediated by secreted molecules called mitokines.Due to their significant translational potential in improving human metabolic health,there has been a surge in mitokine-focused research.In this review,we summarize the findings regarding inter-tissue communication of mitochondrial stress in animal models.In addition,we discuss the possibility of mitokine-mediated intercellular mitochondrial communication originating from bacterial quorum sensing.展开更多
基金supported by the High-Level Talent Introduction Funds from the First Hospital of Lanzhou University.
文摘Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer cachexia.Cancer cachexia factors are also a potential target for the diagnosis and treatment.The pathogenesis of cachexia is unclear and no clear effective treatment is available.Thus,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently needed.From the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and treatment.This review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia factors.This summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.
基金supported in part by the National Natural Science Foundation of China(51939001,61976033,62273072)the Natural Science Foundation of Sichuan Province (2022NSFSC0903)。
文摘This paper investigates the consensus control of multi-agent systems(MASs) with constrained input using the dynamic event-triggered mechanism(ETM).Consider the MASs with small-scale networks where a centralized dynamic ETM with global information of the MASs is first designed.Then,a distributed dynamic ETM which only uses local information is developed for the MASs with large-scale networks.It is shown that the semi-global consensus of the MASs can be achieved by the designed bounded control protocol where the Zeno phenomenon is eliminated by a designable minimum inter-event time.In addition,it is easier to find a trade-off between the convergence rate and the minimum inter-event time by an adjustable parameter.Furthermore,the results are extended to regional consensus of the MASs with the bounded control protocol.Numerical simulations show the effectiveness of the proposed approach.
基金supported by the Space Science Research Projects in Advance(SSRPA:O930143XM1)the Scientific Equipment Development and Research Project of Chinese Academy of Sciences(SEDRP:Y231411YB1)
文摘Due to high data rates and reliability,inter-satellite laser communication has developed rapidly in these days.However,the stability of the laser beam pointing is still a key technique which needs to be solved;otherwise,the beam pointing jitter noise would reduce the communication quality or,even worse,would make the inter-satellite laser communication impossible.For this purpose,a bench-top of the fine beam pointing control system has been built and tested for inter-satellite laser communication.The pointing offset of more than 100rad is produced by the steering mirror.With beam pointing control system turned on,the offset could be rapidly suppressed to lower than 100 nrad in less than 0.5 s.Moreover,the pointing stability can be kept at 40 nrad for yaw motion and 62 nrad for pitch motion,when the received beam jitter is set at 20rad.
基金This work was generously supported by the following grants:H.Z.is supported by the Larry L.Hillblom Foundation Fellowship 2020-A-018-FELY.T is supported by the National Key R&D Program of China(2017YFA0506400)+2 种基金the National Natural Science Foundation of China(31930023)the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)A.D.is supported by R01ES021667 and R01AG059566 from the NIH and the Howard Hughes Medical Institute.
文摘Mitochondria function as a hub of the cellular metabolic network.Mitochondrial stress is closely associated with aging and a variety of diseases,including neurodegeneration and cancer.Cells autonomously elicit specific stress responses to cope with mitochondrial stress to maintain mitochondrial homeostasis.Interestingly,mitochondrial stress responses may also be induced in a non-autonomous manner in cells or tissues that are not directly experiencing such stress.Such non-autonomous mitochondrial stress responses are mediated by secreted molecules called mitokines.Due to their significant translational potential in improving human metabolic health,there has been a surge in mitokine-focused research.In this review,we summarize the findings regarding inter-tissue communication of mitochondrial stress in animal models.In addition,we discuss the possibility of mitokine-mediated intercellular mitochondrial communication originating from bacterial quorum sensing.
