In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-dec...In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-decanoyl phorbol derivatives stood out,demonstrating remarkable anti-HIV-1 activities and inhibitory effects on syncytia formation.These derivatives exhibited a higher safety index compared with the positive control drug.Among them,12-(trans-4-fluorocinnamoyl)-13-decanoyl phorbol,designated as compound 3c,exhibited the most potent anti-HIV-1 activity(EC_(50)2.9 nmol·L^(−1),CC50/EC_(50)11117.24)and significantly inhibited the formation of syncytium(EC_(50)7.0 nmol·L^(−1),CC50/EC_(50)4891.43).Moreover,compound 3c is hypothesized to act both as an HIV-1 entry inhibitor and as an HIV-1 reverse transcriptase inhibitor.Isothermal titration calorimetry and molecular docking studies indicated that compound 3c may also function as a natural activator of protein kinase C(PKC).Therefore,compound 3c emerges as a potential candidate for developing new anti-HIV drugs.展开更多
Protecting the security of sensitive information has become a matter of great concern to everyone. Data hiding technique solves the problem to some extent, but still, some shortcomings remain for researching. To impro...Protecting the security of sensitive information has become a matter of great concern to everyone. Data hiding technique solves the problem to some extent, but still, some shortcomings remain for researching. To improve the capability of hiding huge data file in disk with high efficiency. In this paper, we propose a novel approach called CryptFS, which is achieved by utilizing the file access mechanism and modifying the cluster chain structure to hide data. CryptFS can quickly hide data file with G bytes size in less than 0.1s. The time used for hiding and recovering data is irrelevant to the size of data file, and the reliability of the hidden file is high, which will not be overlaid by new created file and disk defragment.展开更多
基金supported by the National Natural Science Foundation of China(Nos.81202882,82060670)Suzhou Science and Technology Planning Project in Jiangsu Province of China(No.SNG2021022)+1 种基金the Priority Academic Program Development of the Jiangsu Higher Education Institutes,China(PAPD)and the Project of Innovative Research Team of Yunnan Province(No.202005AE160005).
文摘In this study,37 derivatives of phorbol esters were synthesized and their anti-HIV-1 activities evaluated,building upon our previous synthesis of 51 phorbol derivatives.12-Para-electron-acceptor-trans-cinnamoyl-13-decanoyl phorbol derivatives stood out,demonstrating remarkable anti-HIV-1 activities and inhibitory effects on syncytia formation.These derivatives exhibited a higher safety index compared with the positive control drug.Among them,12-(trans-4-fluorocinnamoyl)-13-decanoyl phorbol,designated as compound 3c,exhibited the most potent anti-HIV-1 activity(EC_(50)2.9 nmol·L^(−1),CC50/EC_(50)11117.24)and significantly inhibited the formation of syncytium(EC_(50)7.0 nmol·L^(−1),CC50/EC_(50)4891.43).Moreover,compound 3c is hypothesized to act both as an HIV-1 entry inhibitor and as an HIV-1 reverse transcriptase inhibitor.Isothermal titration calorimetry and molecular docking studies indicated that compound 3c may also function as a natural activator of protein kinase C(PKC).Therefore,compound 3c emerges as a potential candidate for developing new anti-HIV drugs.
基金Supported by the National High Technology Research and Development Program of China (863 Program) (2009AA01Z434)the "Core Electronic Devices, High_End General Chip, and Fundamental Software" Major Project (2013JH00103)
文摘Protecting the security of sensitive information has become a matter of great concern to everyone. Data hiding technique solves the problem to some extent, but still, some shortcomings remain for researching. To improve the capability of hiding huge data file in disk with high efficiency. In this paper, we propose a novel approach called CryptFS, which is achieved by utilizing the file access mechanism and modifying the cluster chain structure to hide data. CryptFS can quickly hide data file with G bytes size in less than 0.1s. The time used for hiding and recovering data is irrelevant to the size of data file, and the reliability of the hidden file is high, which will not be overlaid by new created file and disk defragment.
