AIM: To investigate the molecular mechanisms of miRNA in advanced gastric cancers (AGCs) before and after cytoreductive surgery (CRS) + hyperthermic intraperitoneal chemotherapy (HIPEC).
The introduction of a new technology or innovation is often accompanied by“ups and downs”in its fortunes.Gartner Inc.defined a so-called hype cycle to describe a general pattern that many innovations experience:tech...The introduction of a new technology or innovation is often accompanied by“ups and downs”in its fortunes.Gartner Inc.defined a so-called hype cycle to describe a general pattern that many innovations experience:technology trigger,peak of inflated expectations,trough of disillusionment,slope of enlightenment,and plateau of productivity.This article will compare the ongoing introduction of Open Science(OS)with the hype cycle model and speculate on the relevance of that model to OS.Lest the title of this article mislead the reader,be assured that the author believes that OS should happen and that it will happen.However,I also believe that the path to OS will be longer than many of us had hoped.I will give a brief history of the today’s“semi-open”science,define what I mean by OS,define the hype cycle and where OS is now on that cycle,and finally speculate what it will take to traverse the cycle and rise to its plateau of productivity(as described by Gartner).展开更多
Hepatocellular carcinoma (HCC) often develops in patients with underlying liver disease, yet HCC with syncytial giant cells (SGCs) is extremely rare. Herein, we report a 55-year-old man with a 6-year history of alcoho...Hepatocellular carcinoma (HCC) often develops in patients with underlying liver disease, yet HCC with syncytial giant cells (SGCs) is extremely rare. Herein, we report a 55-year-old man with a 6-year history of alcoholic cirrhosis who during his regular checkup presented with marked elevation of alpha-fetoprotein. Clinical examination and imaging analyses revealed a tumor-like lesion in segment 4 of the liver, which was removed by limited wedge resection. Histological analysis by hematoxylin and eosin staining indicated pleomorphic and atypical nodules, with some SGCs, embedded within the boundaries of the neoplastic lesion. The adjacent liver parenchyma showed microvesicular steatosis, pericellular fibrosis, and moderate hemosiderin accumulation (grade 2, as determined by Prussian blue iron stain) in hepatocytes and Kupffer cells but no copper accumulation (as determined by orcein stain). Immunohistochemical analysis showed hepatocyte antigen-positive staining for the neoplastic cells and SGCs. The diagnosis was made for cirrhosis-related HCC with SGCs. The previous reports of pleomorphic HCC have featured osteoclast-like (i.e., mesenchymal type) giant cells, making this case of epithelial type giant cells very rare. The patient’s 6-month history of hypericum perforatum/St John’s wort self-medication may have prompted the cirrhosis or HCC progression or the unusual SGC manifestation.展开更多
The first part of the paper presents the philosophical concept of Jean Baudrillard in which the issues of death and dying constitute an essential theme. Contemporary times in which the human condition seems to be extr...The first part of the paper presents the philosophical concept of Jean Baudrillard in which the issues of death and dying constitute an essential theme. Contemporary times in which the human condition seems to be extremely difficult are presented in a somber way. Isolation from nature results in the existence filled with fear of death. Natural death is a mentally inconceivable occurrence, an embarrassing phenomenon, and therefore unworthy of being remembered. Only sudden, spectacular death creating media hype seems to be meaningful and worth paying attention to. Instant death is set in opposition to slow death which is also called postponed death. Death in the heat of work, duties, obligations, and prohibitions is the death inflicted at the request of both an employee and an employer. Work rewarded with payment is an act of temporary suspension of death. Burdened with work, people forget about the debt they have incurred from nature. A contemporary employee does not deserve death and instant death is only act of salvation, the act of free will. The second part of the paper focuses on artistic activity of Zuzanna Janin and Bogna Burska. Both artists deal with an issue of media death using different means of expression. Spinning their narratives of intimate decaying and media rage in a public space, they correspond with the Baudrillard＇s philosophical thought.展开更多
基金Supported by The PhD Start-up Funds of Guangzhou Medical College,Guangdong Province,China,No.2012C66 and No.2012C69Guangdong Province Natural Science Fund,No.S2013010016662the National Natural Science Foundation of China,No.81201932 and No.81372493
文摘AIM: To investigate the molecular mechanisms of miRNA in advanced gastric cancers (AGCs) before and after cytoreductive surgery (CRS) + hyperthermic intraperitoneal chemotherapy (HIPEC).
文摘The introduction of a new technology or innovation is often accompanied by“ups and downs”in its fortunes.Gartner Inc.defined a so-called hype cycle to describe a general pattern that many innovations experience:technology trigger,peak of inflated expectations,trough of disillusionment,slope of enlightenment,and plateau of productivity.This article will compare the ongoing introduction of Open Science(OS)with the hype cycle model and speculate on the relevance of that model to OS.Lest the title of this article mislead the reader,be assured that the author believes that OS should happen and that it will happen.However,I also believe that the path to OS will be longer than many of us had hoped.I will give a brief history of the today’s“semi-open”science,define what I mean by OS,define the hype cycle and where OS is now on that cycle,and finally speculate what it will take to traverse the cycle and rise to its plateau of productivity(as described by Gartner).
文摘Hepatocellular carcinoma (HCC) often develops in patients with underlying liver disease, yet HCC with syncytial giant cells (SGCs) is extremely rare. Herein, we report a 55-year-old man with a 6-year history of alcoholic cirrhosis who during his regular checkup presented with marked elevation of alpha-fetoprotein. Clinical examination and imaging analyses revealed a tumor-like lesion in segment 4 of the liver, which was removed by limited wedge resection. Histological analysis by hematoxylin and eosin staining indicated pleomorphic and atypical nodules, with some SGCs, embedded within the boundaries of the neoplastic lesion. The adjacent liver parenchyma showed microvesicular steatosis, pericellular fibrosis, and moderate hemosiderin accumulation (grade 2, as determined by Prussian blue iron stain) in hepatocytes and Kupffer cells but no copper accumulation (as determined by orcein stain). Immunohistochemical analysis showed hepatocyte antigen-positive staining for the neoplastic cells and SGCs. The diagnosis was made for cirrhosis-related HCC with SGCs. The previous reports of pleomorphic HCC have featured osteoclast-like (i.e., mesenchymal type) giant cells, making this case of epithelial type giant cells very rare. The patient’s 6-month history of hypericum perforatum/St John’s wort self-medication may have prompted the cirrhosis or HCC progression or the unusual SGC manifestation.
文摘The first part of the paper presents the philosophical concept of Jean Baudrillard in which the issues of death and dying constitute an essential theme. Contemporary times in which the human condition seems to be extremely difficult are presented in a somber way. Isolation from nature results in the existence filled with fear of death. Natural death is a mentally inconceivable occurrence, an embarrassing phenomenon, and therefore unworthy of being remembered. Only sudden, spectacular death creating media hype seems to be meaningful and worth paying attention to. Instant death is set in opposition to slow death which is also called postponed death. Death in the heat of work, duties, obligations, and prohibitions is the death inflicted at the request of both an employee and an employer. Work rewarded with payment is an act of temporary suspension of death. Burdened with work, people forget about the debt they have incurred from nature. A contemporary employee does not deserve death and instant death is only act of salvation, the act of free will. The second part of the paper focuses on artistic activity of Zuzanna Janin and Bogna Burska. Both artists deal with an issue of media death using different means of expression. Spinning their narratives of intimate decaying and media rage in a public space, they correspond with the Baudrillard＇s philosophical thought.
