背景:近些年,肝脏类器官的发展使其成为国际肝病研究领域的热点,但目前仍未有文献对其进行文献计量学分析。目的:基于文献计量学与可视化分析探索近20年肝脏类器官的热点趋势。方法:从Web of Science(科学网,WOS)核心合集中检索2002-01-...背景:近些年,肝脏类器官的发展使其成为国际肝病研究领域的热点,但目前仍未有文献对其进行文献计量学分析。目的:基于文献计量学与可视化分析探索近20年肝脏类器官的热点趋势。方法:从Web of Science(科学网,WOS)核心合集中检索2002-01-01/2022-11-12肝脏类器官的相关文献,运行Origin、Office和CiteSpace软件进行文献计量与可视化分析,通过生成图表的方式来统计分析文献的年发文量、国家、机构、作者、期刊和关键词等内容。结果与结论:肝脏类器官研究领域近20年的发文量、被引频次、加入研究的机构和人员总体呈现上升趋势,说明该领域发展迅速关注度也逐渐升高。在该领域中,美国的发文量最多、影响力最强,虽然投入大量的时间与精力,但是在众多研究机构中美国单个研究机构的发文量并非最高;中国发文量仅次于美国,中国科学院和复旦大学是国内发文量最多的机构。荷兰乌得勒支大学是发文量最多的机构,发文量最高的作者是Clevers H,共引频次最高的文章是“Long-term culture of genome-stable bipotent stem cells from adult human liver”,分子学、生物学、免疫学是肝脏类器官研究的主流学科,出现次数最高的关键词包括stem cell(干细胞)、in vitro(体外)和culture(培养),肝脏类器官领域的研究热点主要集中在体外干细胞三维培养、分化及基因表达。展开更多
BACKGROUND Pleomorphic leiomyosarcomas make up around 8.6%of all leiomyosarcomas.They behave aggressively and often have poor prognoses.They can affect the gastrointestinal tract and retroperitoneum.To date,pleomorphi...BACKGROUND Pleomorphic leiomyosarcomas make up around 8.6%of all leiomyosarcomas.They behave aggressively and often have poor prognoses.They can affect the gastrointestinal tract and retroperitoneum.To date,pleomorphic leiomyosarcoma involving the mesocolon have been reported in nine patients.CASE SUMMARY The patient was a 44-year-old man with a history of pleomorphic leiomyosarcoma of the left maxilla with metastasis to the lung and liver.His most recent positron emission tomography-computed tomography(PET-CT)scan showed uptake in the ascending and transverse colons.A colonoscopy revealed a 5.0 cm×3.5 cm×3.0 cm pedunculated polyp in the ascending colon.The polyp was removed using hot snare polypectomy technique and retrieved with Rothnet.Histopathologic examination of the polyp showed a metastatic pleomorphic leiomyosarcoma.CONCLUSION Uptake(s)on PET-CT in a patient with pleomorphic leiomyosarcoma should raise suspicion for metastasis.展开更多
文摘背景:近些年,肝脏类器官的发展使其成为国际肝病研究领域的热点,但目前仍未有文献对其进行文献计量学分析。目的:基于文献计量学与可视化分析探索近20年肝脏类器官的热点趋势。方法:从Web of Science(科学网,WOS)核心合集中检索2002-01-01/2022-11-12肝脏类器官的相关文献,运行Origin、Office和CiteSpace软件进行文献计量与可视化分析,通过生成图表的方式来统计分析文献的年发文量、国家、机构、作者、期刊和关键词等内容。结果与结论:肝脏类器官研究领域近20年的发文量、被引频次、加入研究的机构和人员总体呈现上升趋势,说明该领域发展迅速关注度也逐渐升高。在该领域中,美国的发文量最多、影响力最强,虽然投入大量的时间与精力,但是在众多研究机构中美国单个研究机构的发文量并非最高;中国发文量仅次于美国,中国科学院和复旦大学是国内发文量最多的机构。荷兰乌得勒支大学是发文量最多的机构,发文量最高的作者是Clevers H,共引频次最高的文章是“Long-term culture of genome-stable bipotent stem cells from adult human liver”,分子学、生物学、免疫学是肝脏类器官研究的主流学科,出现次数最高的关键词包括stem cell(干细胞)、in vitro(体外)和culture(培养),肝脏类器官领域的研究热点主要集中在体外干细胞三维培养、分化及基因表达。
文摘BACKGROUND Pleomorphic leiomyosarcomas make up around 8.6%of all leiomyosarcomas.They behave aggressively and often have poor prognoses.They can affect the gastrointestinal tract and retroperitoneum.To date,pleomorphic leiomyosarcoma involving the mesocolon have been reported in nine patients.CASE SUMMARY The patient was a 44-year-old man with a history of pleomorphic leiomyosarcoma of the left maxilla with metastasis to the lung and liver.His most recent positron emission tomography-computed tomography(PET-CT)scan showed uptake in the ascending and transverse colons.A colonoscopy revealed a 5.0 cm×3.5 cm×3.0 cm pedunculated polyp in the ascending colon.The polyp was removed using hot snare polypectomy technique and retrieved with Rothnet.Histopathologic examination of the polyp showed a metastatic pleomorphic leiomyosarcoma.CONCLUSION Uptake(s)on PET-CT in a patient with pleomorphic leiomyosarcoma should raise suspicion for metastasis.
