紫胶桐酸是一种具有生物活性的长链羟基烷酸,可用于大环内酯的合成。以紫胶桐酸多羟基作为起始原料,利用高度稀释的合成策略,通过缩醛选择性保护邻二醇、直链前体内酯化环合及酸催化环缩醛脱保护三步反应制备得到了目标产物9,10-二羟基...紫胶桐酸是一种具有生物活性的长链羟基烷酸,可用于大环内酯的合成。以紫胶桐酸多羟基作为起始原料,利用高度稀释的合成策略,通过缩醛选择性保护邻二醇、直链前体内酯化环合及酸催化环缩醛脱保护三步反应制备得到了目标产物9,10-二羟基-环十六内酯,总收率为31%,所得产物经红外光谱(IR)、核磁共振氢谱和碳谱(1 H NMR和13C NMR)、电喷雾质谱(ESI-MS)表征得以证实。实验均在室温下进行,反应条件温和,简洁有效。展开更多
Key intermediate bis[2-amino-4,5-(15-crown-5)phenyl]diselenide was obtained by the convenient redox method. Crown-ether type host molecule containing Se-Se bond 2,11-dioxo-4,5:8,9-di(benzo[4',5']-15-crown-5)-6...Key intermediate bis[2-amino-4,5-(15-crown-5)phenyl]diselenide was obtained by the convenient redox method. Crown-ether type host molecule containing Se-Se bond 2,11-dioxo-4,5:8,9-di(benzo[4',5']-15-crown-5)-6,7-diselena-3,10,16-triazabicyclo[10,3,1]hexadeca-1(16), 4, 8, 12, 14-pentaene was synthesized with high dillution technique.展开更多
Novel macrocyclic oligomers were synthesized through the condensation of phenolphthalein and m phthaloyl dichloride with triethylamine as catalyst in the mixed solution of methylene chloride and THF via pseudo high di...Novel macrocyclic oligomers were synthesized through the condensation of phenolphthalein and m phthaloyl dichloride with triethylamine as catalyst in the mixed solution of methylene chloride and THF via pseudo high dilution technique. The oligomers were characterized by IR, 1H NMR , MS, WAXD, TGA and DSC. It was found that the 3∶3 adduct(molar ratio of phenolphthalein to m phthaloyl dichloride) and the 4∶4 adduct were the main products and there was a small amount of crystalline in the macrocyclic mixtures. When the mixtures were heated to 360 ℃ , the crystalline disappeared.展开更多
We present here the first synthesis of cyclic oligo（ethylene adipate）s （COEAs） via pseudo-high dilution condensation reaction of adipoyl chloride with ethylene glycol, and the synthesis of corresponding poly（ethy...We present here the first synthesis of cyclic oligo（ethylene adipate）s （COEAs） via pseudo-high dilution condensation reaction of adipoyl chloride with ethylene glycol, and the synthesis of corresponding poly（ethylene adipate） （PEA） via the melt polymerization of COEAs. The structure of COEAs was characterized and proved by 1H-NMR and MALDI-TOF mass measurements. The effects of organic base, reaction temperature and the ratio of adipoyl chloride to ethylene glycol on the yield of COEAs were studied, and the optimum reaction condition was revealed. PEA, a diacid and diol based semi-crystalline green aliphatic polyester, was synthesized by the melt polymerization of COEAs using Ti（n-C4H90）4 as catalyst and 1,10-decanediol as initiator at 200 ℃, which follows the polycondensation-coupling ring- opening polymerization method. Our strategy should be applicable to the synthesis of versatile aliphatic polyesters based on diacid and diol monomers, which have potential applications as biocompatible and biodegradable materials.展开更多
Biologically active molecules create substitutes in liquid water by forming single-domain ferroelectric crystallites. These nanoparticles are spherical and constitute growing chains. The dipoles are aligned, but can b...Biologically active molecules create substitutes in liquid water by forming single-domain ferroelectric crystallites. These nanoparticles are spherical and constitute growing chains. The dipoles are aligned, but can be set in oscillation at the frequency of vibration of the charged part of active molecules. They are then automatically trimmed and become information carriers. Moreover, they produce an oscillating electric field, causing autocatalytic multiplication of identical chains in the course of successive dilutions. Active molecules are thus only required to initiate this process. Normally, they excite their specific receptors by resonance, but trimmed chains have the same effect. This theory is confirmed by many measurements.展开更多
目的探讨低中心静脉压(LCVP)联合急性高容量血液稀释(AHHD)在胸科手术单肺通气期间对肺内分流和动脉氧分压(PO_2)的影响。方法选择2015年1月~2017年12月汕头大学医学院附属粤北人民医院ASA分级为I~Ⅱ级择期全麻下行肺癌根治切除术的胸...目的探讨低中心静脉压(LCVP)联合急性高容量血液稀释(AHHD)在胸科手术单肺通气期间对肺内分流和动脉氧分压(PO_2)的影响。方法选择2015年1月~2017年12月汕头大学医学院附属粤北人民医院ASA分级为I~Ⅱ级择期全麻下行肺癌根治切除术的胸科患者50例,随机分为两组:LCVP联合AHHD组(LA组)和对照组(C组),每组25例。其中LA组麻醉后先行LCVP技术,采取限制晶体输液量并硝酸甘油持续微泵注射的方法,控制术中CVP在2~5 cm H_2O,随后再联合应用AHHD技术,快速输注6%羟乙基淀粉(130/0.4)15 m L/kg进行血液稀释,使血细胞比容维持在25%~30%;C组术中始终维持中心静脉压在正常水平6~12 cm H_2O。分别在平卧位双肺通气10 min(Tadb)、平卧位单肺通气10 min(T1)、侧卧位单肺通气10 min(T2)、肺叶切除后10 min(T3)等时间点采集肘静脉血测定血糖(GLU)和血清皮质醇(COR)水平;采集桡动脉血和右心房混合静脉血行血气分析,并记录GLU、COR水平、动脉血氧含量(CaO_2)、混合静脉血氧含量(CvO_2)、动脉血和混合静脉血氧分压PO_2、动脉血和混合静脉血血红蛋白氧饱和度(SO_2)、动脉血和混合静脉血血红蛋白等。根据肺血流分布标准三室模型计算各时间点肺内分流率(Qs/Qt),Qs/Qt=(CcO_2-CaO_2)/(CcO_2-CvO_2)×100%。结果两组患者各时点GLU、COR、SpO_2、HR、MAP、BIS、Pet CO_2基本稳定,但在单肺通气后,LA组和C组肺内分流明显增加(P<0.05),其中平卧位分别增加13.7%和14.9%,侧卧位分别增加11.4%和14.3%;两组动脉氧分压明显下降(P<0.05),且平卧位较侧卧位下降更明显,但两组间差异无统计学意义(P>0.05)。在肺叶切除后,LA组和C组肺内分流明显减少(P<0.05),分别减少7.2%和8.6%,两组动脉血氧分压明显升高(P<0.05),但两组间差异无统计学意义(P>0.05)。术中LA组输血比例明显低于C组(χ~2=4.902,P<0.05)。结论低中心静脉压联合急性高容量血液稀释在胸科手术单肺通�展开更多
文摘紫胶桐酸是一种具有生物活性的长链羟基烷酸,可用于大环内酯的合成。以紫胶桐酸多羟基作为起始原料,利用高度稀释的合成策略,通过缩醛选择性保护邻二醇、直链前体内酯化环合及酸催化环缩醛脱保护三步反应制备得到了目标产物9,10-二羟基-环十六内酯,总收率为31%,所得产物经红外光谱(IR)、核磁共振氢谱和碳谱(1 H NMR和13C NMR)、电喷雾质谱(ESI-MS)表征得以证实。实验均在室温下进行,反应条件温和,简洁有效。
文摘Key intermediate bis[2-amino-4,5-(15-crown-5)phenyl]diselenide was obtained by the convenient redox method. Crown-ether type host molecule containing Se-Se bond 2,11-dioxo-4,5:8,9-di(benzo[4',5']-15-crown-5)-6,7-diselena-3,10,16-triazabicyclo[10,3,1]hexadeca-1(16), 4, 8, 12, 14-pentaene was synthesized with high dillution technique.
文摘Novel macrocyclic oligomers were synthesized through the condensation of phenolphthalein and m phthaloyl dichloride with triethylamine as catalyst in the mixed solution of methylene chloride and THF via pseudo high dilution technique. The oligomers were characterized by IR, 1H NMR , MS, WAXD, TGA and DSC. It was found that the 3∶3 adduct(molar ratio of phenolphthalein to m phthaloyl dichloride) and the 4∶4 adduct were the main products and there was a small amount of crystalline in the macrocyclic mixtures. When the mixtures were heated to 360 ℃ , the crystalline disappeared.
基金the National Natural Science Foundation of China(No.21474067)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘We present here the first synthesis of cyclic oligo（ethylene adipate）s （COEAs） via pseudo-high dilution condensation reaction of adipoyl chloride with ethylene glycol, and the synthesis of corresponding poly（ethylene adipate） （PEA） via the melt polymerization of COEAs. The structure of COEAs was characterized and proved by 1H-NMR and MALDI-TOF mass measurements. The effects of organic base, reaction temperature and the ratio of adipoyl chloride to ethylene glycol on the yield of COEAs were studied, and the optimum reaction condition was revealed. PEA, a diacid and diol based semi-crystalline green aliphatic polyester, was synthesized by the melt polymerization of COEAs using Ti（n-C4H90）4 as catalyst and 1,10-decanediol as initiator at 200 ℃, which follows the polycondensation-coupling ring- opening polymerization method. Our strategy should be applicable to the synthesis of versatile aliphatic polyesters based on diacid and diol monomers, which have potential applications as biocompatible and biodegradable materials.
文摘Biologically active molecules create substitutes in liquid water by forming single-domain ferroelectric crystallites. These nanoparticles are spherical and constitute growing chains. The dipoles are aligned, but can be set in oscillation at the frequency of vibration of the charged part of active molecules. They are then automatically trimmed and become information carriers. Moreover, they produce an oscillating electric field, causing autocatalytic multiplication of identical chains in the course of successive dilutions. Active molecules are thus only required to initiate this process. Normally, they excite their specific receptors by resonance, but trimmed chains have the same effect. This theory is confirmed by many measurements.
文摘目的探讨低中心静脉压(LCVP)联合急性高容量血液稀释(AHHD)在胸科手术单肺通气期间对肺内分流和动脉氧分压(PO_2)的影响。方法选择2015年1月~2017年12月汕头大学医学院附属粤北人民医院ASA分级为I~Ⅱ级择期全麻下行肺癌根治切除术的胸科患者50例,随机分为两组:LCVP联合AHHD组(LA组)和对照组(C组),每组25例。其中LA组麻醉后先行LCVP技术,采取限制晶体输液量并硝酸甘油持续微泵注射的方法,控制术中CVP在2~5 cm H_2O,随后再联合应用AHHD技术,快速输注6%羟乙基淀粉(130/0.4)15 m L/kg进行血液稀释,使血细胞比容维持在25%~30%;C组术中始终维持中心静脉压在正常水平6~12 cm H_2O。分别在平卧位双肺通气10 min(Tadb)、平卧位单肺通气10 min(T1)、侧卧位单肺通气10 min(T2)、肺叶切除后10 min(T3)等时间点采集肘静脉血测定血糖(GLU)和血清皮质醇(COR)水平;采集桡动脉血和右心房混合静脉血行血气分析,并记录GLU、COR水平、动脉血氧含量(CaO_2)、混合静脉血氧含量(CvO_2)、动脉血和混合静脉血氧分压PO_2、动脉血和混合静脉血血红蛋白氧饱和度(SO_2)、动脉血和混合静脉血血红蛋白等。根据肺血流分布标准三室模型计算各时间点肺内分流率(Qs/Qt),Qs/Qt=(CcO_2-CaO_2)/(CcO_2-CvO_2)×100%。结果两组患者各时点GLU、COR、SpO_2、HR、MAP、BIS、Pet CO_2基本稳定,但在单肺通气后,LA组和C组肺内分流明显增加(P<0.05),其中平卧位分别增加13.7%和14.9%,侧卧位分别增加11.4%和14.3%;两组动脉氧分压明显下降(P<0.05),且平卧位较侧卧位下降更明显,但两组间差异无统计学意义(P>0.05)。在肺叶切除后,LA组和C组肺内分流明显减少(P<0.05),分别减少7.2%和8.6%,两组动脉血氧分压明显升高(P<0.05),但两组间差异无统计学意义(P>0.05)。术中LA组输血比例明显低于C组(χ~2=4.902,P<0.05)。结论低中心静脉压联合急性高容量血液稀释在胸科手术单肺通�
