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Mem Brain: An Easy-to-Use Online Webserver for Transmembrane Protein Structure Prediction 被引量:3
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作者 Xi Yin Jing Yang +2 位作者 Feng Xiao Yang Yang Hong-Bin Shen 《Nano-Micro Letters》 SCIE EI CAS 2018年第1期12-19,共8页
Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate t... Membrane proteins are an important kind of proteins embedded in the membranes of cells and play crucial roles in living organisms, such as ion channels,transporters, receptors. Because it is difficult to determinate the membrane protein's structure by wet-lab experiments,accurate and fast amino acid sequence-based computational methods are highly desired. In this paper, we report an online prediction tool called Mem Brain, whose input is the amino acid sequence. Mem Brain consists of specialized modules for predicting transmembrane helices, residue–residue contacts and relative accessible surface area of a-helical membrane proteins. Mem Brain achieves aprediction accuracy of 97.9% of ATMH, 87.1% of AP,3.2 ± 3.0 of N-score, 3.1 ± 2.8 of C-score. Mem BrainContact obtains 62%/64.1% prediction accuracy on training and independent dataset on top L/5 contact prediction,respectively. And Mem Brain-Rasa achieves Pearson correlation coefficient of 0.733 and its mean absolute error of13.593. These prediction results provide valuable hints for revealing the structure and function of membrane proteins.Mem Brain web server is free for academic use and available at www.csbio.sjtu.edu.cn/bioinf/Mem Brain/. 展开更多
关键词 Transmembrane a-helices Structure prediction Machine learning Contact map prediction Relative accessible surface area
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Parallel DNA Constrained by“CC^+Clamps”
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作者 LIU Ke-liang H.Todd Miles +2 位作者 Frank B.Howard Joe Frazier V.Sasisekharan 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1999年第2期42-47,共6页
Parallel DNA helices with reverse WatsonCrick pairing have been described in several papers.It has been pointed out,however,that the parallel structures may also be in equilibrium with antiparallel WatsonCrick helices... Parallel DNA helices with reverse WatsonCrick pairing have been described in several papers.It has been pointed out,however,that the parallel structures may also be in equilibrium with antiparallel WatsonCrick helices due to their closely similar properties.To avoid the problem we have prepared and characterized DNA helices which are constrained to possess parallel polarity by two dC residues,or CC+clamps,at both the ends of AT oligomer chains.The residues are hemiprotonated below neutral pH,forming two stable CC+base pairs with three hydrogen bonds at each end of the helix.The physical properties of these constructs can then be used to calibrate those of duplexes having the same sequences but lacking the terminal C residues.Though recent studies indicate that dC acid selfstructures are fourstranded with intercalated bases,gel electrophoresis indicates that these structures are not present in the molecules described here. 展开更多
关键词 Parallel DNA helices Reverse Watson-Crick pairing CC+ base pair Oligonucleotide helices Reverse WatsonCrick pairing CC+ base pair Oligonucleotide
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Interactions between Transmembrane Helices within Monomers of the Aquaporin AtPIP2;1 Play a Crucial Role in Tetramer Formation 被引量:1
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作者 Yun-Joo Yoo Hyun Kyung Lee +11 位作者 Wonhee Han Dae Heon Kim Myoung Hui Lee Jouhyun Jeon Dong Wook Lee Junho Lee Yongjik Lee Juhun Lee Jin Seok Kim Yunje Cho Jin-Kwan Han Inhwan Hwang 《Molecular Plant》 SCIE CAS CSCD 2016年第7期1004-1017,共14页
Aquaporin (AQP) is a water channel protein found in various subcellular membranes of both prokaryotic and eukaryotic cells. The physiological functions of AQPs have been elucidated in many organisms. However, unders... Aquaporin (AQP) is a water channel protein found in various subcellular membranes of both prokaryotic and eukaryotic cells. The physiological functions of AQPs have been elucidated in many organisms. However, understanding their biogenesis remains elusive, particularly regarding how they assemble into tetramers. Here, we investigated the amino acid residues involved in the tetramer formation of the Arabidopsis plasma membrane AQP AtPIP2;1 using extensive amino acid substitution mutagenesis. The mutant proteins V41A/ E44A, F51A/L52A, F87A/191A, F92A/193A, V95A/Y96A, and H216A/L217A, harboring alanine substitutions in the transmembrane (TM) helices of AtPIP2;1 polymerized into multiple oligomeric complexes with a vari- able number of subunits greater than four. Moreover, these mutant proteins failed to traffic to the plasma membrane, instead of accumulating in the endoplasmic reticulum (ER). Structure-based modeling revealed that these residues are largely involved in interactions between TM helices within monomers. These results suggest that inter-TM interactions occurring both within and between monomers play crucial roles in tetramer formation in the AtPIP2;1 complex. Moreover, the assembly of AtPIP2;1 tetramers is critical for their trafficking from the ER to the plasma membrane, as well as water permeability. 展开更多
关键词 AQUAPORIN AtPIP2 tetramer formation interaction between transmembrane helices
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A Novel Approach to the Prediction of Transmembrane Proteins
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作者 JianDingQIU RuPingLIANG +1 位作者 XiaoYongZOU JinYuanMO 《Chinese Chemical Letters》 SCIE CAS CSCD 2004年第6期711-713,共3页
A novel method based on continuous wavelet transform (CWT) for predicting the number and location of helices in membrane proteins is presented. The PDB code of lyst is chosen as an example to describe the prediction o... A novel method based on continuous wavelet transform (CWT) for predicting the number and location of helices in membrane proteins is presented. The PDB code of lyst is chosen as an example to describe the prediction of transmembrane helices (HTM) by using CWT. The results indicate that CWT is a promising approach for the prediction of HTM. 展开更多
关键词 Continuous wavelet transform transmembrane helices HYDROPHOBICITY prediction.
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Crystal Structure of a Ternary Copper(Ⅱ) Complex of N,N'-(p-Xylylene)dialanine Acid and 1,10-Phenanthroline
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作者 贾磊 徐君 +3 位作者 郝忠言 陈龙海 成飞翔 唐宁 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2010年第8期1270-1274,共5页
The compound [Cu2(bpy)2(PDIAla)(H2O)2](ClO4)2·H2O(H2PDIAla = N,N'-(p-xylylene)dialanine,bipy = 2,2'-bipyridine) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction... The compound [Cu2(bpy)2(PDIAla)(H2O)2](ClO4)2·H2O(H2PDIAla = N,N'-(p-xylylene)dialanine,bipy = 2,2'-bipyridine) 1 has been synthesized and structurally determined by single-crystal X-ray diffraction,elemental analyses and IR spectroscopy.The crystal belongs to the monoclinic system,space group P21 with a = 10.9772(6),b = 18.5464(9),c = 11.0790(6) ,β = 116.3110o,V = 2021.87(18) 3,Z = 2,Dc = 1.594 Mg/m3,Mr = 970.70,μ = 1.260 mm-1,F(000) = 996,λ(MoKα) = 0.71073 ,the final R = 0.0400 and wR = 0.1050 for all observed reflections.In the structure,the O(5)-H(52)…O(4) hydrogen bonding between aqua ligand and carbonyl oxygen of the H2PDIAla ligand along the c axis produce hydrogen-bonded helices which are assembled along the b axis through O(61)-H(61)…O(2) and N(6)-H(6N)…O(2) interactions to form 2-D layers that are further linked by π···π interactions between bpy ligands to yield a three-dimensional supramolecular network. 展开更多
关键词 copper(Ⅱ) complex hydrogen-bonded helices π···π interactions crystal structure
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ER<i>β</i>interacting protein ERAP 140 shows age dependent alteration in its interaction and expression in male mouse brain
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作者 Vijay Paramanik Mahendra Kumar Thakur 《World Journal of Neuroscience》 2013年第1期1-9,共9页
Estrogen mediates multiple functions in the brain through the interaction of estrogen receptor (ER)α and ERβ with a host of nuclear proteins that regulate specific gene transcription. We have identified ERAP 140, AI... Estrogen mediates multiple functions in the brain through the interaction of estrogen receptor (ER)α and ERβ with a host of nuclear proteins that regulate specific gene transcription. We have identified ERAP 140, AIB 1, Trk A, Src, pCREB and CREB as ERβ interacting proteins in the mouse brain. Earlier we showed that the interaction of ERβ with ERAP 140 decreased whereas its expression increased with aging in the brain of female mice. Here we report that the pattern of interaction and expression is different in male mice as compared to females. The interaction of ERAP 140 with ERβ decreased in adult male mouse brain as compared to young and remained almost similar in old whereas its expression was higher in adult than young and old, which were almost similar. Further in silico secondary structure analysis by self-optimized prediction method alignment (SOPMA) and PSIPRED revealed that ERβ interacting proteins were rich in alpha helices and coils. Such findings might help to design ER modulators which can regulate specific functions of estrogen in the brain during aging and degenerative diseases. 展开更多
关键词 ESTROGEN Receptor β Alpha helices and Coils INTERACTING Proteins SOPMA PSIPRED Aging Brain
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Hydrothermal synthesis,structure,fluorescence property of a novel 3D metal-organic framework with high thermal stability 被引量:2
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作者 WU Lei XUE Ming +1 位作者 HUANG Lin QIU ShiLun 《Science China Chemistry》 SCIE EI CAS 2011年第9期1441-1445,共5页
A novel 3D metal-organic framework(MOF) with remarkable thermal stability,Ni(BIC)2.2·5H2O(JUC-86)(HBIC = 1-H-benzimidazole-5-carboxylic acid and JUC = Jilin University China),has been synthesized under hydrotherm... A novel 3D metal-organic framework(MOF) with remarkable thermal stability,Ni(BIC)2.2·5H2O(JUC-86)(HBIC = 1-H-benzimidazole-5-carboxylic acid and JUC = Jilin University China),has been synthesized under hydrothermal conditions.It crystallizes in tetragonal symmetry with P43212 space group.The 3D structure consists of channels assembled from triple helices with a 4.5 × 4.52 aperture,which are formed by the parallel alignment of three infinite helical chains.The thermogravimetric analysis(TGA) and powder X-ray diffractions(PXRD) indicate JUC-86 with high thermal stability(up to 350 ℃). 展开更多
关键词 metal-organic framework triple helices thermal stability FLUORESCENCE
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Tubular/helical architecture construction based on rolled-up AlN nanomembranes and resonance as optical microcavity 被引量:2
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作者 Jinyu Yang Yang Wang +3 位作者 Lu Wang Ziao Tian Zengfeng Di Yongfeng Mei 《Journal of Semiconductors》 EI CAS CSCD 2020年第4期89-94,101,102,共8页
Aluminum nitride(AlN)has attracted a great amount of interest due to the fact that these group III–V semiconductors present direct band gap behavior and are compatible with current micro-electro-mechanical systems.In... Aluminum nitride(AlN)has attracted a great amount of interest due to the fact that these group III–V semiconductors present direct band gap behavior and are compatible with current micro-electro-mechanical systems.In this work,three dimensional(3D)AlN architectures including tubes and helices were constructed by rolling up AlN nanomembranes grown on a silicon-on-insulator wafer via magnetron sputtering.The properties of the AlN membrane were characterized through transmission electron microscopy and X-ray diffraction.The thickness of AlN nanomembranes could be tuned via the RIE thinning method,and thus micro-tubes with different diameters were fabricated.The intrinsic strain in AlN membranes was investigated via micro-Raman spectroscopy,which agrees well with theory prediction.Whispering gallery mode was observed in AlN tubular optical microcavity in photoluminescence spectrum.A postprocess involving atomic layer deposition and R6G immersion were employed on as-fabricated AlN tubes to promote the Q-factor.The AlN tubular micro-resonators could offer a novel design route for Si-based integrated light sources.In addition,the rolled-up technology paves a new way for AlN 3D structure fabrication,which is promising for AlN application in MEMS and photonics fields. 展开更多
关键词 ALN NANOMEMBRANES rolled-up technology helices optical MICROCAVITY
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β-甘露聚糖酶理化性质与其最适pH的相关性 被引量:1
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作者 林源清 王粲 张光亚 《计算机与应用化学》 CAS CSCD 北大核心 2014年第8期929-933,共5页
为了探究影响GH5家族β-甘露聚糖酶最适pH的各种因素,利用该酶的序列信息,构建了基于氨基酸组成的β-甘露聚糖酶理化性质与其最适pH的相关性模型。结果表明:该酶N端氨基酸序列是影响其最适pH的重要因素,在243个理化性质中有17个呈极显... 为了探究影响GH5家族β-甘露聚糖酶最适pH的各种因素,利用该酶的序列信息,构建了基于氨基酸组成的β-甘露聚糖酶理化性质与其最适pH的相关性模型。结果表明:该酶N端氨基酸序列是影响其最适pH的重要因素,在243个理化性质中有17个呈极显著相关,其中7个呈正相关。优化的转移能量参数相关性最高,为0.78:7个正相关的理化性质中,与螺旋相关的理化性质占3个。优化的转移能量参数和螺旋是影响pH稳定性的最重要的因素。所建立的模型为研究该酶酸碱适应性机理提供了一种简单有效的方法。 展开更多
关键词 Β-甘露聚糖酶 最适PH 理化性质 优化的转移能量参数 螺旋
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慢性结节性耳轮软骨皮炎 被引量:1
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作者 汪丹 何永萍 汪盛 《临床皮肤科杂志》 CSCD 北大核心 2017年第11期788-790,共3页
报告1例慢性结节性耳轮软骨皮炎。患者男,62岁。右耳轮结节伴压痛1年余。皮肤科检查:右耳轮上缘一约黄豆大暗红色圆形结节,上覆少量粘着性灰白色鳞屑,触痛明显。皮损组织病理检查:表皮角化过度伴角化不全,棘层增生肥厚,真皮浅层小血管... 报告1例慢性结节性耳轮软骨皮炎。患者男,62岁。右耳轮结节伴压痛1年余。皮肤科检查:右耳轮上缘一约黄豆大暗红色圆形结节,上覆少量粘着性灰白色鳞屑,触痛明显。皮损组织病理检查:表皮角化过度伴角化不全,棘层增生肥厚,真皮浅层小血管周围较多淋巴细胞浸润,下方真皮胶原纤维纤维蛋白样坏死,可见黏液沉积,其下方软骨陷窝减少,可见钙化。诊断:慢性结节性耳轮软骨皮炎。 展开更多
关键词 软骨皮炎 耳轮 结节性 慢性
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新型长链芳香酰胺聚合物的合成
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作者 刘静媛 曹金鑫 +4 位作者 黄睛菲 陈中祝 王启卫 邓金根 朱槿 《合成化学》 CAS CSCD 北大核心 2013年第2期193-196,226,共5页
3,5-二胺基苯甲酰胺与4,6-二烷氧基-1,3-苯二甲酰氯经缩合反应合成了两个新型的长链芳香酰胺聚合物,其结构经1H NMR,IR和GPC表征。
关键词 芳香酰胺聚合物 螺旋 合成
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On the Ruled surfaces in Minkowski 3-space R1^3
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作者 ■RENM■■ Alper Osman BALGET■R Handan ERGüT Mahmut 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2006年第3期326-329,共4页
Izumiya and Takeuchi (2003) obtained some characterizations for Ruled surfaces. Turgut and Haclsalihoglu (1998) defined timelike Ruled surfaces and obtained some characterizations in timelike Ruled surfaces. Choi ... Izumiya and Takeuchi (2003) obtained some characterizations for Ruled surfaces. Turgut and Haclsalihoglu (1998) defined timelike Ruled surfaces and obtained some characterizations in timelike Ruled surfaces. Choi (1995) and Jung and Pak (1996) studied Ruled surfaces. This study uses the method in (lzumiya and Takeuchi, 2003) to investigate cylindrical helices and Bertrand curves as curves on timelike Ruled surfaces in Minkowski 3-space R1^3. We have studied singularities of the rectifying developable (surface) of a timelike curve. We observed that the rectifying developable along a timelike curve a is non-singular if and only if a is a cylindrical helice. In this case the rectifying developable is a cylindrical surface. 展开更多
关键词 Timelike Ruled surfaces Bertrand curve Cylindrical helices
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6H-SiC单晶中的蜷线
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作者 程基宽 高积强 +3 位作者 刘军林 蒋仙 杨建峰 乔冠军 《稀有金属材料与工程》 SCIE EI CAS CSCD 北大核心 2007年第A02期184-186,共3页
用PVT法制备了6H-SiC。用光学显微镜观察了晶体生长面的原生形貌。讨论了6H-SiC中蜷线的形状及其形成机理。蜷线起源于螺旋位错,它们的形状则决定于这些位错的符号与相对位置。在(0001)Si面上,蜷线表现为圆形螺旋,而在(0001)C面上则表... 用PVT法制备了6H-SiC。用光学显微镜观察了晶体生长面的原生形貌。讨论了6H-SiC中蜷线的形状及其形成机理。蜷线起源于螺旋位错,它们的形状则决定于这些位错的符号与相对位置。在(0001)Si面上,蜷线表现为圆形螺旋,而在(0001)C面上则表现为六角形螺旋。通常情况下,蜷线的极点没有任何包裹物。然而在某些情况下,蜷线的极点会出现包裹物,如夹杂、微管、孔洞或者负晶等。当(0001)Si面作为生长面时,6H-SiC单晶的生长机制符合螺旋位错模型(BCF理论模型)。 展开更多
关键词 蜷线 碳化硅 位错 生长机制
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面向“卡脖子”问题的知识创新生态系统分析:核心挑战、理论构建与现实路径 被引量:26
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作者 王璐瑶 曲冠楠 Juan Rogers 《科研管理》 CSSCI CSCD 北大核心 2022年第4期94-102,共9页
新形势下,面对关键核心技术“卡脖子”问题的挑战,系统提升我国科技研究的整体水平迫在眉睫。然而,我国现有知识创新生态研究的基本思路仍是以“大学、企业、政府”构成的“三螺旋”框架,无法体现新时代多元化主体、多样化路径、多种创... 新形势下,面对关键核心技术“卡脖子”问题的挑战,系统提升我国科技研究的整体水平迫在眉睫。然而,我国现有知识创新生态研究的基本思路仍是以“大学、企业、政府”构成的“三螺旋”框架,无法体现新时代多元化主体、多样化路径、多种创新模式的平行共存与协同演化特征,致使研究者破题“卡脖子”难题时缺乏整合性视角与适用性框架的支撑。本研究基于知识创新范式转型背景下影响我国以系统工具解决“卡脖子”问题的核心挑战,深入探究新时代“模式3”知识创新“多重螺旋”(N-tuple helices)生态系统的主体特征与拓扑结构。以之为基础,讨论系统性提升我国科研创新能力,应对“卡脖子”挑战的可行路径与具体措施。 展开更多
关键词 “卡脖子”问题 知识创新 关键核心技术突破 创新生态系统 多重螺旋
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膜蛋白跨膜区段的预测分析 被引量:18
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作者 邱建丁 梁汝萍 +2 位作者 谭学才 邹小勇 莫金垣 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2004年第5期831-836,共6页
将连续小波变换技术的时频局部化特点和氨基酸的疏水特性相结合 ,提出了一种用于预测膜蛋白跨膜区段数目和位置的新方法 ,以代码为 1 YST的膜蛋白为例 ,对小波尺度和疏水值的种类进行了选择 ,同时描述了该法对跨膜螺旋区数目和位置的预... 将连续小波变换技术的时频局部化特点和氨基酸的疏水特性相结合 ,提出了一种用于预测膜蛋白跨膜区段数目和位置的新方法 ,以代码为 1 YST的膜蛋白为例 ,对小波尺度和疏水值的种类进行了选择 ,同时描述了该法对跨膜螺旋区数目和位置的预测分析过程 .从膜蛋白数据库中随机抽取 3 6个蛋白质 (含跨膜螺旋区 2 3 2 )作为测试集 ,采用该方法对其跨膜螺旋区进行预测 ,其中 2 2 2个跨膜螺旋区能被准确预测 ,准确率为 96.1 % .结果表明 。 展开更多
关键词 膜蛋白 跨膜螺旋区 预测 连续小波变换 疏水性 细胞
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载脂蛋白的结构和功能与病毒病的预防和治疗 被引量:13
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作者 陈保生 《中国医学科学院学报》 CAS CSCD 北大核心 2007年第3期448-451,共4页
载脂蛋白(apo)是脂蛋白的重要组成成分,其主要功能是调节酶活性,介导细胞受体与脂蛋白结合,保持脂蛋白结构的稳定性。目前已发现数十种载脂蛋白,其结构的显著特点是分子中具有多个双性alpha螺旋及Beta-折叠结构。载脂蛋白的这种双性alph... 载脂蛋白(apo)是脂蛋白的重要组成成分,其主要功能是调节酶活性,介导细胞受体与脂蛋白结合,保持脂蛋白结构的稳定性。目前已发现数十种载脂蛋白,其结构的显著特点是分子中具有多个双性alpha螺旋及Beta-折叠结构。载脂蛋白的这种双性alpha螺旋结构是其结合及转运脂质的结构基础。在HIV外壳结构中的一种糖蛋白(gp)也具有这种alpha螺旋结构。近年研究表明,载脂蛋白和由载脂蛋白组成的脂质体还具有抗肝炎病毒、抗HIV病毒、抗单纯疱疹和中和细菌内毒素的功能。以脂蛋白和载脂蛋白为主要成分构成的脂质体已成为运载抗病毒和抗肿瘤药物受体的靶向性载体。 展开更多
关键词 载脂蛋白A1 双性alpha螺旋 冠状病毒 抗病毒
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从劳厄发现晶体X射线衍射谈起 被引量:11
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作者 唐有祺 《物理》 CAS 北大核心 2003年第7期424-426,共3页
文章从劳厄发现晶体X射线衍射的前因后果谈起 .劳厄的这个发现产生了两个新学科 ,即X射线谱学和X射线晶体学 .文中还回顾了布拉格父子对这两个新学科所作的重大贡献 ,并阐述了X射线晶体学的深远影响 .
关键词 X射线衍射 x射线谱学 X射线晶体学 α-螺旋体 DNA双螺旋 劳厄
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DNA纤维的X射线衍射分析与双螺旋结构的发现 被引量:11
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作者 向义和 《大学物理》 北大核心 2005年第1期50-58,共9页
概述了DNA化学结构式确立的过程,介绍了X射线衍射分析的概念、原理和方法,阐述了物理学家威尔金斯和物理化学家富兰克林在用实验事实证明DNA双螺旋结构方面所作出的巨大贡献.
关键词 DNA化学结构 X射线衍射 晶体 布拉格方程 倒易格点 贝塞尔函数 帕特森函数 DNA双螺旋结构
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应用连续小波变换预测蛋白质的二级结构 被引量:6
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作者 邱建丁 梁汝萍 +1 位作者 邹小勇 莫金垣 《化学学报》 SCIE CAS CSCD 北大核心 2003年第5期748-754,共7页
将代码为 1gca蛋白质的氨基酸序列映射为疏水值序列 ,在合适的尺度下 ,通过连续小波变换法分别对其α螺旋 ,α螺旋和 β折叠之间的连接多肽 (即部分规则和无规则二级结构 )进行预测 ,准确率分别为 76.5 %和 85 .7% .从PDBsum数据库中随... 将代码为 1gca蛋白质的氨基酸序列映射为疏水值序列 ,在合适的尺度下 ,通过连续小波变换法分别对其α螺旋 ,α螺旋和 β折叠之间的连接多肽 (即部分规则和无规则二级结构 )进行预测 ,准确率分别为 76.5 %和 85 .7% .从PDBsum数据库中随机抽取 10 0个蛋白质作为测试对象 ,其中全α螺旋、全 β折叠、α/β以及α +β蛋白质各 2 5个 .在 10 0个蛋白质中共有 1618个连接多肽和 747个α螺旋 .本法预测到的连接多肽共有 15 3 6个 ,其中 13 0 8个与实际结构一致 ,平均预测准确率为 85 .2 % ;预测到的α螺旋有 770个 ,其中 5 81个与实际结构一致 ,平均预测准确率为 75 .5 % .结果表明 :该法可较好地预测蛋白质的α螺旋、连接多肽 。 展开更多
关键词 连续小波变换 预测 蛋白质 二级结构 多肽 疏水性
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基于疏水性小波分析的膜蛋白结构预测 被引量:7
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作者 邱建丁 荣联清 +3 位作者 梁汝萍 谭学才 邹小勇 莫金垣 《分析测试学报》 CAS CSCD 北大核心 2004年第6期1-4,8,共5页
膜蛋白在细胞膜上具有重要的生理功能 ,大部分膜蛋白在药物设计、转运蛋白和免疫识别等方面起着关键的作用 ,从分子水平上预测这类蛋白质的结构具有非常重要的意义。本文提出一种基于氨基酸疏水性小波变换技术预测膜蛋白跨膜区段数目和... 膜蛋白在细胞膜上具有重要的生理功能 ,大部分膜蛋白在药物设计、转运蛋白和免疫识别等方面起着关键的作用 ,从分子水平上预测这类蛋白质的结构具有非常重要的意义。本文提出一种基于氨基酸疏水性小波变换技术预测膜蛋白跨膜区段数目和位置的新方法。以代码为upkb_bovin的膜蛋白为例 ,对跨膜螺旋区数目和位置的预测分析进行了描述。从膜蛋白数据库中随机抽取36个蛋白质 (含跨膜螺旋区232)作为测试集检验小波分析的预测方法 ,其中226个跨膜螺旋区能被准确预测 ,准确率为96.8%。结果表明 。 展开更多
关键词 疏水性 小波变换 膜蛋白 结构 预测 跨膜螺旋区
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