目的评价螺旋钢板微创内固定技术治疗肱骨干近段骨折的临床疗效,并探讨其可行性、安全性。方法回顾分析2009年12月-2015年5月采用螺旋钢板微创内固定技术治疗的16例肱骨干近段骨折患者临床资料。男11例,女5例;年龄18～56岁,平均34.6岁...目的评价螺旋钢板微创内固定技术治疗肱骨干近段骨折的临床疗效,并探讨其可行性、安全性。方法回顾分析2009年12月-2015年5月采用螺旋钢板微创内固定技术治疗的16例肱骨干近段骨折患者临床资料。男11例,女5例;年龄18～56岁,平均34.6岁。致伤原因：跌倒伤5例,高处坠落伤3例,交通事故伤4例,运动损伤3例,皮带绞伤1例。按美国创伤骨科协会（OTA）骨折分型：12-C1型6例,12-C2型3例,12-C3型7例。受伤至手术时间2～13 d,平均7.2 d。记录患者手术时间、术中出血量、术后早期并发症、骨折愈合时间;肩关节功能采用美国加州大学洛杉矶分校（UCLA）肩关节评分标准评价,肘关节功能采用Mayo肘关节功能评分系统（MEPs）评价。结果手术时间51～127 min,平均92 min;术中出血量100～450 m L,平均212 m L。术后切口均Ⅰ期愈合,未出现感染及神经损伤等并发症。16例均获随访,随访时间8～28个月,平均16.6个月。所有患者均获骨性愈合,愈合时间13～36周,平均19.2周。术后均未发生内固定物松动、断裂。末次随访时,肩关节功能UCLA评分为31～35分,平均34.6分;肘关节功能MEPs评分为90～100分,平均99分。结论螺旋钢板微创内固定技术具有创伤少、神经损伤风险低、临床疗效满意的优点,是一种安全有效的肱骨微创内固定技术,尤其适用于肱骨干近段骨折。展开更多
Corticotropin-releasing factor (CRF) is a peptide that is released from the hypothalamus into widespread areas of the brain. Evidence has suggested that CRF is involved as a neuromodulator outside of the hypothalamic-...Corticotropin-releasing factor (CRF) is a peptide that is released from the hypothalamus into widespread areas of the brain. Evidence has suggested that CRF is involved as a neuromodulator outside of the hypothalamic-pituitary-adrenal axis, playing an important role in fear, anxiety, depression and pain modulation. Our previous report demonstrated that CRF receptor activation in basolateral (BLA) or central nuclei of the amygdala (CeA) produces innate fear in guinea pigs. Inhibition of these receptors via administration of α-helical CRF9-41 (a nonspecific antagonist) into the CeA or BLA decreased innate fear behavior [1]. Additionally, there is strong evidence that emotional behavior and nociception can be modulated simultaneously. The present study was conducted to investigate the involvement of the CRF receptors of the BLA or CeA in nociception in guinea pigs. Guinea pigs were treated with CRF and α-helical CRF>9-41> in three different doses or injected with α-helical CRF9-41 preceded by CRF into the BLA or CeA, and they were evaluated using the hot plate test. Our findings indicated that activation of CRF receptors in the BLA and in the CeA promoted antinociception, and this effect was reversed by preadministration of α-helical CRF9-41 in the same area. The treatment with α-helical CRF>9-41> per se into the BLA and CeA did not alter nociception. Thus, nociception modulation occurs in a phasic manner, whereas defensive behavior can occur tonically because the α-helical CRF9-41 did not cause any modification on the index of analgesia in the hot plate test but did reduce innate fear behavior [1].展开更多
An investigation into the pullout response of helical soil nail using finite element subroutine Plaxis 2D is presented.The numerical modelling of actual pullout response is achieved by axisymmetric and horizontal load...An investigation into the pullout response of helical soil nail using finite element subroutine Plaxis 2D is presented.The numerical modelling of actual pullout response is achieved by axisymmetric and horizontal loading condition.The effect of varying number of helical plates,helical plate spacing and helical plate diameter is studied to understand the pullout capacity behaviour.The failure surfaces for various helical soil nail configurations and their pullout mechanisms are also analysed and discussed.The pullout capacity is found to increase with increase in number of helical plates.The helical plate spacing ratio（s/D;） and diameter ratio（D;/D;） are found to increase the pullout only up to a critical value.The response of helical soil nail using axisymmetric finite element simulation is found similar to the uplift behaviour of helical piles and helical soil anchors.In the absence of literature regarding numerical modelling of helical soil nail,simulation results are validated with uplift responses of helical piles and soil anchors.A good agreement in their comparative study for pullout response is also observed.展开更多
采煤机工作环境恶劣,并且煤层中夹杂着大量煤矸石等杂质,致使采煤机滚筒工作部件齿座、螺旋叶板、端盘板耐磨失效现象时常出现。根据采煤机滚筒工作部件实际工况及其性能要求,通过对当前国内外主要使用的齿座材料35Cr Mn Si A、20Cr Ni...采煤机工作环境恶劣,并且煤层中夹杂着大量煤矸石等杂质,致使采煤机滚筒工作部件齿座、螺旋叶板、端盘板耐磨失效现象时常出现。根据采煤机滚筒工作部件实际工况及其性能要求,通过对当前国内外主要使用的齿座材料35Cr Mn Si A、20Cr Ni Mo、42Cr Mo、ZG40Cr1,螺旋叶板、端盘板材料ZG270-500、Q235钢、16Mn做元素含量及其力学性能对比,选出了各部件最适合材料。展开更多
文摘目的评价螺旋钢板微创内固定技术治疗肱骨干近段骨折的临床疗效,并探讨其可行性、安全性。方法回顾分析2009年12月-2015年5月采用螺旋钢板微创内固定技术治疗的16例肱骨干近段骨折患者临床资料。男11例,女5例;年龄18～56岁,平均34.6岁。致伤原因：跌倒伤5例,高处坠落伤3例,交通事故伤4例,运动损伤3例,皮带绞伤1例。按美国创伤骨科协会（OTA）骨折分型：12-C1型6例,12-C2型3例,12-C3型7例。受伤至手术时间2～13 d,平均7.2 d。记录患者手术时间、术中出血量、术后早期并发症、骨折愈合时间;肩关节功能采用美国加州大学洛杉矶分校（UCLA）肩关节评分标准评价,肘关节功能采用Mayo肘关节功能评分系统（MEPs）评价。结果手术时间51～127 min,平均92 min;术中出血量100～450 m L,平均212 m L。术后切口均Ⅰ期愈合,未出现感染及神经损伤等并发症。16例均获随访,随访时间8～28个月,平均16.6个月。所有患者均获骨性愈合,愈合时间13～36周,平均19.2周。术后均未发生内固定物松动、断裂。末次随访时,肩关节功能UCLA评分为31～35分,平均34.6分;肘关节功能MEPs评分为90～100分,平均99分。结论螺旋钢板微创内固定技术具有创伤少、神经损伤风险低、临床疗效满意的优点,是一种安全有效的肱骨微创内固定技术,尤其适用于肱骨干近段骨折。
基金supported by CAPES/PROEX,FAPESP(2010/10936-5)A.F.Donatti has a doctorate scholarship from CAPESC.R.A.Leite-Panissi also received grants from the CNPq(Grant No.307383/2012-1).
文摘Corticotropin-releasing factor (CRF) is a peptide that is released from the hypothalamus into widespread areas of the brain. Evidence has suggested that CRF is involved as a neuromodulator outside of the hypothalamic-pituitary-adrenal axis, playing an important role in fear, anxiety, depression and pain modulation. Our previous report demonstrated that CRF receptor activation in basolateral (BLA) or central nuclei of the amygdala (CeA) produces innate fear in guinea pigs. Inhibition of these receptors via administration of α-helical CRF9-41 (a nonspecific antagonist) into the CeA or BLA decreased innate fear behavior [1]. Additionally, there is strong evidence that emotional behavior and nociception can be modulated simultaneously. The present study was conducted to investigate the involvement of the CRF receptors of the BLA or CeA in nociception in guinea pigs. Guinea pigs were treated with CRF and α-helical CRF>9-41> in three different doses or injected with α-helical CRF9-41 preceded by CRF into the BLA or CeA, and they were evaluated using the hot plate test. Our findings indicated that activation of CRF receptors in the BLA and in the CeA promoted antinociception, and this effect was reversed by preadministration of α-helical CRF9-41 in the same area. The treatment with α-helical CRF>9-41> per se into the BLA and CeA did not alter nociception. Thus, nociception modulation occurs in a phasic manner, whereas defensive behavior can occur tonically because the α-helical CRF9-41 did not cause any modification on the index of analgesia in the hot plate test but did reduce innate fear behavior [1].
文摘An investigation into the pullout response of helical soil nail using finite element subroutine Plaxis 2D is presented.The numerical modelling of actual pullout response is achieved by axisymmetric and horizontal loading condition.The effect of varying number of helical plates,helical plate spacing and helical plate diameter is studied to understand the pullout capacity behaviour.The failure surfaces for various helical soil nail configurations and their pullout mechanisms are also analysed and discussed.The pullout capacity is found to increase with increase in number of helical plates.The helical plate spacing ratio（s/D;） and diameter ratio（D;/D;） are found to increase the pullout only up to a critical value.The response of helical soil nail using axisymmetric finite element simulation is found similar to the uplift behaviour of helical piles and helical soil anchors.In the absence of literature regarding numerical modelling of helical soil nail,simulation results are validated with uplift responses of helical piles and soil anchors.A good agreement in their comparative study for pullout response is also observed.
文摘采煤机工作环境恶劣,并且煤层中夹杂着大量煤矸石等杂质,致使采煤机滚筒工作部件齿座、螺旋叶板、端盘板耐磨失效现象时常出现。根据采煤机滚筒工作部件实际工况及其性能要求,通过对当前国内外主要使用的齿座材料35Cr Mn Si A、20Cr Ni Mo、42Cr Mo、ZG40Cr1,螺旋叶板、端盘板材料ZG270-500、Q235钢、16Mn做元素含量及其力学性能对比,选出了各部件最适合材料。
