目的:观察电热砭石和抽气罐干预合穴对同经原穴血流灌注量(blood perfusion,BP)的影响,探索精确测量和调节经络气血平衡的"精准针灸学"途径。方法:使用激光多普勒线扫描仪(LDLS)对31名健康受试者的心包经、三焦经、胆经及肝经...目的:观察电热砭石和抽气罐干预合穴对同经原穴血流灌注量(blood perfusion,BP)的影响,探索精确测量和调节经络气血平衡的"精准针灸学"途径。方法:使用激光多普勒线扫描仪(LDLS)对31名健康受试者的心包经、三焦经、胆经及肝经的(厥阴–少阳小循环)左右原穴的BP进行测量,计算其偏离标准值的血流偏离率(bias ratio of blood perfusion,BPBR)。使用电热砭石和抽气罐对BPBR较大原穴所属经脉的合穴进行干预,BPBR低于–30%使用电热砭石,高于30%使用抽气罐,干预前重复测量两次血流量,干预后即刻及干预后20 min各测1次,计算干预前后的BP均值及干预前、干预后即刻和干预后20 min的血流量变化率(change ratio of blood perfusion,BPCR)。结果:(1)使用电热砭石后,BP均值由(103.51±41.21)PU升高至(121.97±56.22)PU(P<0.05);干预前、干预后即刻、干预后20 min的BPCR分别为(–0.58±16.18)%、(23.58±48.85)%、(25.62±65.89)%,干预后即刻比干预前显著增高(P<0.01),干预后20 min与干预前比较差异无统计学意义(P>0.05),但仍维持较高的变化率。(2)使用抽气罐后,BP均值由(194.83±81.14)PU降至(173.88±88.26)PU(P<0.01);干预前、干预后即刻、干预后20 min的BPCR分别为(7.62±30.49)%、(–12.12±18.20)%、(–14.35±21.25)%,干预后即刻和干预后20 min与干预前比较差异均有统计学意义(均P<0.01)。结论:电热砭石作用于合穴可使本经原穴的血流量升高,而抽气罐有相反的作用。展开更多
In reviewing and analyzing the study on the clinical selection of the acupoints for peptic ulcer in the recent ten years, it was found out that peptic ulcer was mostly treated by combination of multiple acupoints clin...In reviewing and analyzing the study on the clinical selection of the acupoints for peptic ulcer in the recent ten years, it was found out that peptic ulcer was mostly treated by combination of multiple acupoints clinically, by the combination of Front-mu point and Back-shu point of the spleen and stomach, and the combination of Front-mu point and Back-shu point of the spleen and stomach with Lower He-sea point, indicating that Front-mu point and Back-shu point of the spleen and stomach and Lower He-sea point have the important ftmctions in the treatment of peptic ulcer.展开更多
目的对比观察电针溃疡性结肠炎大鼠上巨虚、足三里、下巨虚、阳陵泉等穴后对结肠组织白介素-1β(IL-1β)及烟碱型乙酰胆碱受体a7信使核糖核酸(nchRa7mRNA)表达的影响,探讨大肠下合穴上巨虚治疗对应腑病是否存在相对特异性。方法将70只健...目的对比观察电针溃疡性结肠炎大鼠上巨虚、足三里、下巨虚、阳陵泉等穴后对结肠组织白介素-1β(IL-1β)及烟碱型乙酰胆碱受体a7信使核糖核酸(nchRa7mRNA)表达的影响,探讨大肠下合穴上巨虚治疗对应腑病是否存在相对特异性。方法将70只健康SD大鼠随机分为空白组、模型组、上巨虚组、足三里组、下巨虚组、阳陵泉组及承筋组,每组10只,雌雄各半。除空白组外均采用2-4-6三硝基苯磺酸/乙醇溶液灌肠诱导建立大鼠溃疡性结肠炎模型,造模成功并治疗10 d后,肉眼观察大鼠结肠黏膜溃疡及炎症情况,ELISA法检测大鼠结肠组织中IL-1b含量,RT-PCR检测nAchRa7mRNA的表达。结果与模型组比,各穴位组结肠损伤有不同程度好转,组织IL-1β含量明显偏低而n ACh Ra7m RNA表达均较高(P<0.05,P<0.01),且上巨虚组、足三里组结肠溃疡评分亦较低(P<0.05,P<0.01);与上巨虚组比,其他4个穴位组结肠n AChRa7mRNA表达均较低(P<0.01),而下巨虚组、阳陵泉组、承筋组结肠溃疡及炎症损伤较严重,结肠溃疡评分及IL-1b含量均偏高(P<0.05,P<0.01)。结论电针治疗溃疡性结肠炎的机制可能是通过影响IL-1β、n Ach Ra7m RNA等调节异常的免疫功能,改善结肠黏膜损伤等来实现的;上巨虚治疗溃疡性结肠炎的总体效应优于足三里、下巨虚、阳陵泉及承筋穴,说明上巨虚穴与对应大肠腑之间存在一定的相对特异性。展开更多
文摘目的:观察电热砭石和抽气罐干预合穴对同经原穴血流灌注量(blood perfusion,BP)的影响,探索精确测量和调节经络气血平衡的"精准针灸学"途径。方法:使用激光多普勒线扫描仪(LDLS)对31名健康受试者的心包经、三焦经、胆经及肝经的(厥阴–少阳小循环)左右原穴的BP进行测量,计算其偏离标准值的血流偏离率(bias ratio of blood perfusion,BPBR)。使用电热砭石和抽气罐对BPBR较大原穴所属经脉的合穴进行干预,BPBR低于–30%使用电热砭石,高于30%使用抽气罐,干预前重复测量两次血流量,干预后即刻及干预后20 min各测1次,计算干预前后的BP均值及干预前、干预后即刻和干预后20 min的血流量变化率(change ratio of blood perfusion,BPCR)。结果:(1)使用电热砭石后,BP均值由(103.51±41.21)PU升高至(121.97±56.22)PU(P<0.05);干预前、干预后即刻、干预后20 min的BPCR分别为(–0.58±16.18)%、(23.58±48.85)%、(25.62±65.89)%,干预后即刻比干预前显著增高(P<0.01),干预后20 min与干预前比较差异无统计学意义(P>0.05),但仍维持较高的变化率。(2)使用抽气罐后,BP均值由(194.83±81.14)PU降至(173.88±88.26)PU(P<0.01);干预前、干预后即刻、干预后20 min的BPCR分别为(7.62±30.49)%、(–12.12±18.20)%、(–14.35±21.25)%,干预后即刻和干预后20 min与干预前比较差异均有统计学意义(均P<0.01)。结论:电热砭石作用于合穴可使本经原穴的血流量升高,而抽气罐有相反的作用。
文摘In reviewing and analyzing the study on the clinical selection of the acupoints for peptic ulcer in the recent ten years, it was found out that peptic ulcer was mostly treated by combination of multiple acupoints clinically, by the combination of Front-mu point and Back-shu point of the spleen and stomach, and the combination of Front-mu point and Back-shu point of the spleen and stomach with Lower He-sea point, indicating that Front-mu point and Back-shu point of the spleen and stomach and Lower He-sea point have the important ftmctions in the treatment of peptic ulcer.
文摘目的对比观察电针溃疡性结肠炎大鼠上巨虚、足三里、下巨虚、阳陵泉等穴后对结肠组织白介素-1β(IL-1β)及烟碱型乙酰胆碱受体a7信使核糖核酸(nchRa7mRNA)表达的影响,探讨大肠下合穴上巨虚治疗对应腑病是否存在相对特异性。方法将70只健康SD大鼠随机分为空白组、模型组、上巨虚组、足三里组、下巨虚组、阳陵泉组及承筋组,每组10只,雌雄各半。除空白组外均采用2-4-6三硝基苯磺酸/乙醇溶液灌肠诱导建立大鼠溃疡性结肠炎模型,造模成功并治疗10 d后,肉眼观察大鼠结肠黏膜溃疡及炎症情况,ELISA法检测大鼠结肠组织中IL-1b含量,RT-PCR检测nAchRa7mRNA的表达。结果与模型组比,各穴位组结肠损伤有不同程度好转,组织IL-1β含量明显偏低而n ACh Ra7m RNA表达均较高(P<0.05,P<0.01),且上巨虚组、足三里组结肠溃疡评分亦较低(P<0.05,P<0.01);与上巨虚组比,其他4个穴位组结肠n AChRa7mRNA表达均较低(P<0.01),而下巨虚组、阳陵泉组、承筋组结肠溃疡及炎症损伤较严重,结肠溃疡评分及IL-1b含量均偏高(P<0.05,P<0.01)。结论电针治疗溃疡性结肠炎的机制可能是通过影响IL-1β、n Ach Ra7m RNA等调节异常的免疫功能,改善结肠黏膜损伤等来实现的;上巨虚治疗溃疡性结肠炎的总体效应优于足三里、下巨虚、阳陵泉及承筋穴,说明上巨虚穴与对应大肠腑之间存在一定的相对特异性。
